The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Tandem AAA-ATPase domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 5: Photoperiod-independent early flowering 1

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 8 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
5 Q05471 (/IPI) Q05471 (/IPI) Q6ZRS2 (/IPI) Q7X9V2 (/IPI) Q9NDJ2 (/IPI)
Structural molecule activity GO:0005198
The action of a molecule that contributes to the structural integrity of a complex or its assembly within or outside a cell.
2 Q05471 (/IMP) Q05471 (/IMP)
DNA binding GO:0003677
Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
1 O13682 (/IC)
DNA helicase activity GO:0003678
Catalysis of the reaction: ATP + H2O = ADP + phosphate; this reaction drives the unwinding of the DNA helix.
1 O13682 (/ISM)
Transcription coactivator activity GO:0003713
A protein or a member of a complex that interacts specifically and non-covalently with a DNA-bound DNA-binding transcription factor to activate the transcription of specific genes. Coactivators often act by altering chromatin structure and modifications. For example, one class of transcription coregulators modifies chromatin structure through covalent modification of histones. A second ATP-dependent class modifies the conformation of chromatin. Another type of coregulator activity is the bridging of a DNA-binding transcription factor to the basal transcription machinery. The Mediator complex, which bridges transcription factors and RNA polymerase, is also a transcription coactivator.
1 Q6ZRS2 (/TAS)
Histone acetyltransferase activity GO:0004402
Catalysis of the reaction: acetyl-CoA + histone = CoA + acetyl-histone.
1 Q6ZRS2 (/TAS)
ATP binding GO:0005524
Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
1 O13682 (/ISM)
DNA-dependent ATPase activity GO:0008094
Catalysis of the reaction: ATP + H2O = ADP + phosphate; this reaction requires the presence of single- or double-stranded DNA, and it drives another reaction.
1 Q9NDJ2 (/ISS)

There are 26 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Histone exchange GO:0043486
The replacement, within chromatin, of resident histones or histone subunits with alternative, sometimes variant, histones or subunits.
4 Q05471 (/IMP) Q05471 (/IMP) Q59U81 (/IMP) Q9NDJ2 (/IMP)
Chromatin remodeling GO:0006338
Dynamic structural changes to eukaryotic chromatin occurring throughout the cell division cycle. These changes range from the local changes necessary for transcriptional regulation to global changes necessary for chromosome segregation.
2 Q05471 (/IDA) Q05471 (/IDA)
Chromatin remodeling GO:0006338
Dynamic structural changes to eukaryotic chromatin occurring throughout the cell division cycle. These changes range from the local changes necessary for transcriptional regulation to global changes necessary for chromosome segregation.
2 Q05471 (/IMP) Q05471 (/IMP)
Regulation of alternative mRNA splicing, via spliceosome GO:0000381
Any process that modulates the frequency, rate or extent of alternative splicing of nuclear mRNAs.
1 Q9NDJ2 (/HMP)
Instar larval or pupal development GO:0002165
The process whose specific outcome is the progression of the instar larva or pupa over time, from its formation to the mature structure. An example of this process is found in Drosophila melanogaster.
1 Q9NDJ2 (/IMP)
Chromatin organization GO:0006325
Any process that results in the specification, formation or maintenance of the physical structure of eukaryotic chromatin.
1 Q9NDJ2 (/IMP)
Chromatin remodeling GO:0006338
Dynamic structural changes to eukaryotic chromatin occurring throughout the cell division cycle. These changes range from the local changes necessary for transcriptional regulation to global changes necessary for chromosome segregation.
1 O13682 (/IPI)
Regulation of transcription by RNA polymerase II GO:0006357
Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II.
1 Q6ZRS2 (/TAS)
Negative regulation of cell fate specification GO:0009996
Any process that restricts, stops or prevents a cell from adopting a specific cell fate.
1 Q9NEL2 (/IMP)
Negative regulation of gene expression GO:0010629
Any process that decreases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
1 Q9NDJ2 (/IMP)
Gene silencing GO:0016458
Any process carried out at the cellular level that results in either long-term transcriptional repression via action on chromatin structure or RNA mediated, post-transcriptional repression of gene expression.
1 Q9NDJ2 (/IGI)
Histone acetylation GO:0016573
The modification of a histone by the addition of an acetyl group.
1 Q9NDJ2 (/IDA)
Hemopoiesis GO:0030097
The process whose specific outcome is the progression of the myeloid and lymphoid derived organ/tissue systems of the blood and other parts of the body over time, from formation to the mature structure. The site of hemopoiesis is variable during development, but occurs primarily in bone marrow or kidney in many adult vertebrates.
1 Q9NDJ2 (/TAS)
Somatic stem cell population maintenance GO:0035019
Any process by which an organism retains a population of somatic stem cells, undifferentiated cells in the embryo or adult which can undergo unlimited division and give rise to cell types of the body other than those of the germ-line.
1 Q9NDJ2 (/IMP)
Negative regulation of hemocyte proliferation GO:0035207
Any process that stops, prevents or reduces the rate or extent of hemocyte proliferation. Hemocytes are blood cells associated with a hemocoel (the cavity containing most of the major organs of the arthropod body) which are involved in defense and clotting of hemolymph, but not involved in transport of oxygen. An example of this is found in Drosophila melanogaster.
1 Q9NDJ2 (/TAS)
Wing disc pattern formation GO:0035222
The process giving rise to the pattern of cell differentiation in the wing imaginal disc.
1 Q9NDJ2 (/IGI)
Male germ-line stem cell population maintenance GO:0036098
The process by which an organism or tissue maintains a population of male germ-line stem cells.
1 Q9NDJ2 (/IMP)
Defense response to bacterium GO:0042742
Reactions triggered in response to the presence of a bacterium that act to protect the cell or organism.
1 Q7X9V2 (/IGI)
Histone exchange GO:0043486
The replacement, within chromatin, of resident histones or histone subunits with alternative, sometimes variant, histones or subunits.
1 Q9NDJ2 (/IDA)
Histone exchange GO:0043486
The replacement, within chromatin, of resident histones or histone subunits with alternative, sometimes variant, histones or subunits.
1 O13682 (/ISO)
Response to cadmium ion GO:0046686
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cadmium (Cd) ion stimulus.
1 Q7X9V2 (/IEP)
Oogenesis GO:0048477
The complete process of formation and maturation of an ovum or female gamete from a primordial female germ cell. Examples of this process are found in Mus musculus and Drosophila melanogaster.
1 Q9NDJ2 (/IMP)
Dendrite morphogenesis GO:0048813
The process in which the anatomical structures of a dendrite are generated and organized.
1 Q9NDJ2 (/IMP)
Dendrite guidance GO:0070983
The process in which the migration of a dendrite is directed to a specific target site in response to a combination of attractive and repulsive cues.
1 Q9NDJ2 (/IMP)
Regulation of phenotypic switching by regulation of transcription from RNA polymerase II promoter GO:1900545
A regulation of transcription from RNA polymerase II promoter that results in regulation of phenotypic switching.
1 Q59U81 (/IMP)
Positive regulation of gene silencing by miRNA GO:2000637
Any process that activates or increases the frequency, rate or extent of gene silencing by miRNA.
1 Q9NDJ2 (/IMP)

There are 20 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
6 A0A087WNL7 (/ISO) A0A087WNX7 (/ISO) A0A087WQ44 (/ISO) A0A087WQY5 (/ISO) E9Q9V7 (/ISO) Q3U4M6 (/ISO)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
6 A0A087WNL7 (/ISO) A0A087WNX7 (/ISO) A0A087WQ44 (/ISO) A0A087WQY5 (/ISO) E9Q9V7 (/ISO) Q3U4M6 (/ISO)
Golgi apparatus GO:0005794
A compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack. The Golgi apparatus differs from the endoplasmic reticulum in often having slightly thicker membranes, appearing in sections as a characteristic shallow semicircle so that the convex side (cis or entry face) abuts the endoplasmic reticulum, secretory vesicles emerging from the concave side (trans or exit face). In vertebrate cells there is usually one such organelle, while in invertebrates and plants, where they are known usually as dictyosomes, there may be several scattered in the cytoplasm. The Golgi apparatus processes proteins produced on the ribosomes of the rough endoplasmic reticulum; such processing includes modification of the core oligosaccharides of glycoproteins, and the sorting and packaging of proteins for transport to a variety of cellular locations. Three different regions of the Golgi are now recognized both in terms of structure and function: cis, in the vicinity of the cis face, trans, in the vicinity of the trans face, and medial, lying between the cis and trans regions.
6 A0A087WNL7 (/ISO) A0A087WNX7 (/ISO) A0A087WQ44 (/ISO) A0A087WQY5 (/ISO) E9Q9V7 (/ISO) Q3U4M6 (/ISO)
Nuclear body GO:0016604
Extra-nucleolar nuclear domains usually visualized by confocal microscopy and fluorescent antibodies to specific proteins.
6 A0A087WNL7 (/ISO) A0A087WNX7 (/ISO) A0A087WQ44 (/ISO) A0A087WQY5 (/ISO) E9Q9V7 (/ISO) Q3U4M6 (/ISO)
Protein-containing complex GO:0032991
A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together.
6 A0A087WNL7 (/ISO) A0A087WNX7 (/ISO) A0A087WQ44 (/ISO) A0A087WQY5 (/ISO) E9Q9V7 (/ISO) Q3U4M6 (/ISO)
Perinuclear region of cytoplasm GO:0048471
Cytoplasm situated near, or occurring around, the nucleus.
6 A0A087WNL7 (/ISO) A0A087WNX7 (/ISO) A0A087WQ44 (/ISO) A0A087WQY5 (/ISO) E9Q9V7 (/ISO) Q3U4M6 (/ISO)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
4 Q05471 (/IDA) Q05471 (/IDA) Q6ZRS2 (/IDA) Q9NDJ2 (/IDA)
Swr1 complex GO:0000812
A multisubunit protein complex that is involved in chromatin remodeling. It is required for the incorporation of the histone variant H2AZ into chromatin. In S. cerevisiae, the complex contains Swr1p, a Swi2/Snf2-related ATPase, and 12 additional subunits.
3 O13682 (/IDA) Q05471 (/IDA) Q05471 (/IDA)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
3 O13682 (/HDA) Q05471 (/HDA) Q05471 (/HDA)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
2 A0A0A0MS59 (/IDA) Q6ZRS2 (/IDA)
Golgi apparatus GO:0005794
A compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack. The Golgi apparatus differs from the endoplasmic reticulum in often having slightly thicker membranes, appearing in sections as a characteristic shallow semicircle so that the convex side (cis or entry face) abuts the endoplasmic reticulum, secretory vesicles emerging from the concave side (trans or exit face). In vertebrate cells there is usually one such organelle, while in invertebrates and plants, where they are known usually as dictyosomes, there may be several scattered in the cytoplasm. The Golgi apparatus processes proteins produced on the ribosomes of the rough endoplasmic reticulum; such processing includes modification of the core oligosaccharides of glycoproteins, and the sorting and packaging of proteins for transport to a variety of cellular locations. Three different regions of the Golgi are now recognized both in terms of structure and function: cis, in the vicinity of the cis face, trans, in the vicinity of the trans face, and medial, lying between the cis and trans regions.
2 A0A0A0MS59 (/IDA) Q6ZRS2 (/IDA)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
2 Q05471 (/IDA) Q05471 (/IDA)
Nuclear body GO:0016604
Extra-nucleolar nuclear domains usually visualized by confocal microscopy and fluorescent antibodies to specific proteins.
2 A0A0A0MS59 (/IDA) Q6ZRS2 (/IDA)
Histone acetyltransferase complex GO:0000123
A protein complex that possesses histone acetyltransferase activity.
1 Q9NDJ2 (/IPI)
Cell wall GO:0005618
The rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal, most prokaryotic cells and some protozoan parasites, maintaining their shape and protecting them from osmotic lysis. In plants it is made of cellulose and, often, lignin; in fungi it is composed largely of polysaccharides; in bacteria it is composed of peptidoglycan; in protozoan parasites such as Giardia species, it's made of carbohydrates and proteins.
1 Q7X9V2 (/IDA)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
1 Q9NDJ2 (/IC)
SWI/SNF complex GO:0016514
A SWI/SNF-type complex that contains 8 to 14 proteins, including both conserved (core) and nonconserved components; contains the ATPase product of the yeast SNF2 or mammalian SMARCA4/BAF190A/BRG1 gene, or an ortholog thereof.
1 Q7X9V2 (/ISS)
Protein-containing complex GO:0032991
A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together.
1 Q6ZRS2 (/IDA)
NuA4 histone acetyltransferase complex GO:0035267
A complex having histone acetylase activity on chromatin, as well as ATPase, DNA helicase and structural DNA binding activities. The complex is thought to be involved in double-strand DNA break repair. Subunits of the human complex include HTATIP/TIP60, TRRAP, RUVBL1, BUVBL2, beta-actin and BAF53/ACTL6A. In yeast, the complex has 13 subunits, including the catalytic subunit Esa1 (homologous to human Tip60).
1 Q9NDJ2 (/IDA)
Perinuclear region of cytoplasm GO:0048471
Cytoplasm situated near, or occurring around, the nucleus.
1 Q6ZRS2 (/IDA)