The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:
"Malic enzyme, N-terminal domain
".
FunFam 1: NAD-dependent malic enzyme
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 11 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Malate dehydrogenase (decarboxylating) (NAD+) activity GO:0004471
Catalysis of the reaction: (S)-malate + NAD+ = pyruvate + CO2 + NADH + H+.
|
18 |
P26616 (/IDA)
P26616 (/IDA)
P26616 (/IDA)
P26616 (/IDA)
P26616 (/IDA)
P26616 (/IDA)
P26616 (/IDA)
P26616 (/IDA)
P26616 (/IDA)
P26616 (/IDA)
(8 more) |
|
Malate dehydrogenase activity GO:0016615
Catalysis of the reversible conversion of pyruvate or oxaloacetate to malate.
|
9 | Q81S70 (/ISS) Q81S70 (/ISS) Q87Y79 (/ISS) Q87Y79 (/ISS) Q8EAP2 (/ISS) Q9KSR8 (/ISS) Q9KSR8 (/ISS) Q9KSR8 (/ISS) Q9KSR8 (/ISS) |
|
Carboxy-lyase activity GO:0016831
Catalysis of the nonhydrolytic addition or removal of a carboxyl group to or from a compound.
|
5 | A0A095AMW7 (/IDA) F9UMS6 (/IDA) Q48796 (/IDA) Q48796 (/IDA) Q48796 (/IDA) |
|
Manganese ion binding GO:0030145
Interacting selectively and non-covalently with manganese (Mn) ions.
|
5 | A0A095AMW7 (/IDA) F9UMS6 (/IDA) Q48796 (/IDA) Q48796 (/IDA) Q48796 (/IDA) |
|
NAD binding GO:0051287
Interacting selectively and non-covalently with nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD+, or the reduced form, NADH.
|
5 | A0A095AMW7 (/IDA) F9UMS6 (/IDA) Q48796 (/IDA) Q48796 (/IDA) Q48796 (/IDA) |
|
Carboxy-lyase activity GO:0016831
Catalysis of the nonhydrolytic addition or removal of a carboxyl group to or from a compound.
|
3 | Q48662 (/ISS) Q48662 (/ISS) Q48662 (/ISS) |
|
Manganese ion binding GO:0030145
Interacting selectively and non-covalently with manganese (Mn) ions.
|
3 | Q48662 (/ISS) Q48662 (/ISS) Q48662 (/ISS) |
|
NAD binding GO:0051287
Interacting selectively and non-covalently with nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD+, or the reduced form, NADH.
|
3 | Q48662 (/ISS) Q48662 (/ISS) Q48662 (/ISS) |
|
Malic enzyme activity GO:0004470
Catalysis of the oxidative decarboxylation of malate with the concomitant production of pyruvate.
|
1 | P36013 (/IDA) |
|
Malic enzyme activity GO:0004470
Catalysis of the oxidative decarboxylation of malate with the concomitant production of pyruvate.
|
1 | Q5A4M2 (/NAS) |
|
Malate dehydrogenase (decarboxylating) (NAD+) activity GO:0004471
Catalysis of the reaction: (S)-malate + NAD+ = pyruvate + CO2 + NADH + H+.
|
1 | Q607C5 (/ISS) |
There are 6 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Gluconeogenesis GO:0006094
The formation of glucose from noncarbohydrate precursors, such as pyruvate, amino acids and glycerol.
|
18 |
P26616 (/IMP)
P26616 (/IMP)
P26616 (/IMP)
P26616 (/IMP)
P26616 (/IMP)
P26616 (/IMP)
P26616 (/IMP)
P26616 (/IMP)
P26616 (/IMP)
P26616 (/IMP)
(8 more) |
|
Malate metabolic process GO:0006108
The chemical reactions and pathways involving malate, the anion of hydroxybutanedioic acid, a chiral hydroxydicarboxylic acid. The (+) enantiomer is an important intermediate in metabolism as a component of both the TCA cycle and the glyoxylate cycle.
|
10 | Q607C5 (/ISS) Q81S70 (/ISS) Q81S70 (/ISS) Q87Y79 (/ISS) Q87Y79 (/ISS) Q8EAP2 (/ISS) Q9KSR8 (/ISS) Q9KSR8 (/ISS) Q9KSR8 (/ISS) Q9KSR8 (/ISS) |
|
Malolactic fermentation GO:0043464
The anaerobic enzymatic conversion of L-malate to L-lactate and carbon dioxide, yielding energy in the form of ATP.
|
5 | A0A095AMW7 (/IDA) F9UMS6 (/IDA) Q48796 (/IDA) Q48796 (/IDA) Q48796 (/IDA) |
|
Malolactic fermentation GO:0043464
The anaerobic enzymatic conversion of L-malate to L-lactate and carbon dioxide, yielding energy in the form of ATP.
|
3 | Q48662 (/ISS) Q48662 (/ISS) Q48662 (/ISS) |
|
Pyruvate metabolic process GO:0006090
The chemical reactions and pathways involving pyruvate, 2-oxopropanoate.
|
1 | P36013 (/IMP) |
|
Cellular amino acid metabolic process GO:0006520
The chemical reactions and pathways involving amino acids, carboxylic acids containing one or more amino groups, as carried out by individual cells.
|
1 | P36013 (/IMP) |
There are 4 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
18 |
P26616 (/IDA)
P26616 (/IDA)
P26616 (/IDA)
P26616 (/IDA)
P26616 (/IDA)
P26616 (/IDA)
P26616 (/IDA)
P26616 (/IDA)
P26616 (/IDA)
P26616 (/IDA)
(8 more) |
|
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
6 | P9WK25 (/HDA) P9WK25 (/HDA) P9WK25 (/HDA) P9WK25 (/HDA) P9WK25 (/HDA) P9WK25 (/HDA) |
|
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
|
1 | P36013 (/HDA) |
|
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
|
1 | P36013 (/IDA) |
