The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Uracil-DNA glycosylase-like domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 12: Type-5 uracil-DNA glycosylase

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 3 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Uracil DNA N-glycosylase activity GO:0004844
Catalysis of the cleavage of the N-C1' glycosidic bond between the damaged DNA base and the deoxyribose sugar, releasing a free base and leaving an apyrimidinic (AP) site. Enzymes with this activity recognize and remove uracil bases in DNA that result from the deamination of cytosine or the misincorporation of dUTP opposite an adenine.
3 P9WM53 (/IDA) P9WM53 (/IDA) P9WM53 (/IDA)
DNA-deoxyinosine glycosylase activity GO:0033958
Catalysis of the hydrolysis of DNA and polynucleotides, releasing free hypoxanthine.
3 P9WM53 (/IDA) P9WM53 (/IDA) P9WM53 (/IDA)
Iron-sulfur cluster binding GO:0051536
Interacting selectively and non-covalently with an iron-sulfur cluster, a combination of iron and sulfur atoms.
3 P9WM53 (/IDA) P9WM53 (/IDA) P9WM53 (/IDA)

There are 1 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Base-excision repair GO:0006284
In base excision repair, an altered base is removed by a DNA glycosylase enzyme, followed by excision of the resulting sugar phosphate. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase.
3 P9WM53 (/IDA) P9WM53 (/IDA) P9WM53 (/IDA)

There are 0 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.