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CATH Superfamily 3.40.309.10

Aldehyde Dehydrogenase; Chain A, domain 2

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Aldehyde Dehydrogenase; Chain A, domain 2
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 9: Aldehyde dehydrogenase A

There are 9 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Succinate-semialdehyde dehydrogenase (NADP(+)). [EC: 1.2.1.79]
Succinate semialdehyde + NADP(+) + H(2)O = succinate + NADPH.
  • This enzyme participates in the degradation of glutamate and 4-aminobutyrate.
  • It is similar to EC 1.2.1.24 and EC 1.2.1.16 but is specific for NADP(+).
  • The enzyme from Escherichia coli is 20-fold more active with NADP(+) than NAD(+).
 74 A0A045JTD4 A0A045JTD4 A0A045JTD4 A0A045JTD4 A0A045JTD4 A0A045JTD4 A0A045JTD4 A0A045JTD4 A0A0H3LGA9 A0A0H3LGA9
(64 more...)
Lactaldehyde dehydrogenase. [EC: 1.2.1.22]
(S)-lactaldehyde + NAD(+) + H(2)O = (S)-lactate + NADH.
    		 72 A0A024L3U1 A0A024L3U1 A0A024L3U1 A0A024L3U1 A0A024L3U1 A0A024L3U1 A0A024L3U1 A0A024L3U1 A0A069XL70 A0A069XL70
    (62 more...)
    Glycolaldehyde dehydrogenase. [EC: 1.2.1.21]
    Glycolaldehyde + NAD(+) + H(2)O = glycolate + NADH.
      		 72 A0A024L3U1 A0A024L3U1 A0A024L3U1 A0A024L3U1 A0A024L3U1 A0A024L3U1 A0A024L3U1 A0A024L3U1 A0A069XL70 A0A069XL70
      (62 more...)
      2,5-dioxovalerate dehydrogenase. [EC: 1.2.1.26]
      2,5-dioxopentanoate + NADP(+) + H(2)O = 2-oxoglutarate + NADPH.
        		 9 A0A0B2BDQ2 A0A0B2BDQ2 A0A0B2BDQ2 A0A1E3FT19 A0A1E3FT19 A0A1E3FT19 Q1JUP4 Q1JUP4 Q1JUP4
        Succinate-semialdehyde dehydrogenase (NAD(+)). [EC: 1.2.1.24]
        Succinate semialdehyde + NAD(+) + H(2)O = succinate + NADH.
        • This enzyme participates in the degradation of glutamate and 4-aminobutyrate.
        • It is similar to EC 1.2.1.79 and EC 1.2.1.16 but is specific for NAD(+).
        		 9 A0A0B2BDQ2 A0A0B2BDQ2 A0A0B2BDQ2 A0A1E3FT19 A0A1E3FT19 A0A1E3FT19 Q1JUP4 Q1JUP4 Q1JUP4
        Geranial dehydrogenase. [EC: 1.2.1.86]
        Geranial + H(2)O + NAD(+) = geranate + NADH.
        • Does not act on neral.
        • Formerly EC 1.2.1.n3.
        		 4 H1ZV37 H1ZV37 W8X5L1 W8X5L1
        4-hydroxybenzaldehyde dehydrogenase (NADP(+)). [EC: 1.2.1.96]
        4-hydroxybenzaldehyde + NADP(+) + H(2)O = 4-hydroxybenzoate + NADPH.
        • Involved in the aerobic pathway for degradation of toluene, 4-methylphenol, and 2,4-xylenol by several Pseudomonas strains.
        • The enzyme is also active with 4-hydroxy-3-methylbenzaldehyde.
        • Cf. EC 1.2.1.64.
        		 4 A0A077FA43 A0A077FA43 Q59702 Q59702
        D-glyceraldehyde dehydrogenase (NADP(+)). [EC: 1.2.1.89]
        D-glyceraldehyde + NADP(+) + H(2)O = D-glycerate + NADPH.
        • The enzyme from the archaea Thermoplasma acidophilum and Picrophilus torridus is involved in the non-phosphorylative Entner-Doudoroff pathway, cf. EC 1.2.99.8.
        		 2 Q6L285 Q9HK01
        3-succinoylsemialdehyde-pyridine dehydrogenase. [EC: 1.2.1.83]
        4-oxo-4-(pyridin-3-yl)butanal + NADP(+) + H(2)O = 4-oxo-4-(pyridin-3- yl)butanoate + NADPH.
        • The enzyme has been characterized from the soil bacterium Pseudomonas sp. HZN6.
        • It participates in the nicotine degradation pathway.
        		 1 H8ZPX2