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CATH Superfamily 3.40.30.10

Glutaredoxin

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Glutaredoxin
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 239: Iodothyronine deiodinase

There are 1 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Thyroxine 5-deiodinase. [EC: 1.21.99.3]
3,3',5'-triiodo-L-thyronine + iodide + acceptor + H(+) = L-thyroxine + reduced acceptor.
  • The enzyme activity has only been demonstrated in the direction of 5-deiodination.
  • This removal of the 5-iodine, i.e. from the inner ring, largely inactivates the hormone thyroxine.
  • Formerly EC 1.97.1.11.
 7 O42412 P49897 P55073 Q5I3B1 Q6DN07 Q6QN11 Q91ZI8