The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Endonuclease Chain A
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 4: protein FAM83H isoform X2

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 20 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein kinase binding GO:0019901
Interacting selectively and non-covalently with a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate.
6 Q2M2I3 (/IPI) Q5T0W9 (/IPI) Q6ZRV2 (/IPI) Q86UY5 (/IPI) Q9BQN1 (/IPI) Q9H4H8 (/IPI)
Protein kinase binding GO:0019901
Interacting selectively and non-covalently with a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate.
6 A2ARK0 (/ISO) Q0VBM2 (/ISO) Q148V8 (/ISO) Q80XS7 (/ISO) Q8K2P2 (/ISO) Q9D7I8 (/ISO)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
3 A6ND36 (/IPI) Q86UY5 (/IPI) Q9H4H8 (/IPI)
Microtubule binding GO:0008017
Interacting selectively and non-covalently with microtubules, filaments composed of tubulin monomers.
2 A3KN19 (/ISS) Q9D7I8 (/ISS)
Protein kinase binding GO:0019901
Interacting selectively and non-covalently with a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate.
2 Q5T0W9 (/IDA) Q86UY5 (/IDA)
Protein kinase binding GO:0019901
Interacting selectively and non-covalently with a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate.
2 Q0VBM2 (/ISS) Q8K2P2 (/ISS)
Phosphatidylinositol 3-kinase regulatory subunit binding GO:0036312
Interacting selectively and non-covalently with a regulatory subunit of phosphatidylinositol 3-kinase. The regulatory subunit associates with the catalytic subunit to regulate both its activity and subcellular location.
2 Q0VBM2 (/ISO) Q8K2P2 (/ISO)
Epidermal growth factor receptor binding GO:0005154
Interacting selectively and non-covalently with the epidermal growth factor receptor.
1 Q5T0W9 (/IPI)
Epidermal growth factor receptor binding GO:0005154
Interacting selectively and non-covalently with the epidermal growth factor receptor.
1 Q0VBM2 (/ISO)
Microtubule binding GO:0008017
Interacting selectively and non-covalently with microtubules, filaments composed of tubulin monomers.
1 Q9H4H8 (/IDA)
Microtubule binding GO:0008017
Interacting selectively and non-covalently with microtubules, filaments composed of tubulin monomers.
1 Q9D7I8 (/ISO)
Kinesin binding GO:0019894
Interacting selectively and non-covalently and stoichiometrically with kinesin, a member of a superfamily of microtubule-based motor proteins that perform force-generating tasks such as organelle transport and chromosome segregation.
1 Q9H4H8 (/IPI)
Kinesin binding GO:0019894
Interacting selectively and non-covalently and stoichiometrically with kinesin, a member of a superfamily of microtubule-based motor proteins that perform force-generating tasks such as organelle transport and chromosome segregation.
1 Q9D7I8 (/ISO)
Phosphatidylinositol 3-kinase regulatory subunit binding GO:0036312
Interacting selectively and non-covalently with a regulatory subunit of phosphatidylinositol 3-kinase. The regulatory subunit associates with the catalytic subunit to regulate both its activity and subcellular location.
1 Q86UY5 (/IDA)
Phosphatidylinositol 3-kinase regulatory subunit binding GO:0036312
Interacting selectively and non-covalently with a regulatory subunit of phosphatidylinositol 3-kinase. The regulatory subunit associates with the catalytic subunit to regulate both its activity and subcellular location.
1 Q5T0W9 (/IPI)
Phosphatidylinositol 3-kinase catalytic subunit binding GO:0036313
Interacting selectively and non-covalently with the catalytic subunit of a phosphatidylinositol 3-kinase. The catalytic subunit catalyzes the addition of a phosphate group to an inositol lipid at the 3' position of the inositol ring.
1 Q5T0W9 (/IPI)
Phosphatidylinositol 3-kinase catalytic subunit binding GO:0036313
Interacting selectively and non-covalently with the catalytic subunit of a phosphatidylinositol 3-kinase. The catalytic subunit catalyzes the addition of a phosphate group to an inositol lipid at the 3' position of the inositol ring.
1 Q0VBM2 (/ISO)
Keratin filament binding GO:1990254
Interacting selectively and non-covalently with a keratin filament, an intermediate filament composed of acidic and basic keratins (types I and II), typically expressed in epithelial cells.
1 Q6ZRV2 (/IDA)
Keratin filament binding GO:1990254
Interacting selectively and non-covalently with a keratin filament, an intermediate filament composed of acidic and basic keratins (types I and II), typically expressed in epithelial cells.
1 Q148V8 (/ISO)
Keratin filament binding GO:1990254
Interacting selectively and non-covalently with a keratin filament, an intermediate filament composed of acidic and basic keratins (types I and II), typically expressed in epithelial cells.
1 Q148V8 (/ISS)

There are 44 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Cell population proliferation GO:0008283
The multiplication or reproduction of cells, resulting in the expansion of a cell population.
11 A1L1G9 (/ISS) A1L1G9 (/ISS) A3KN19 (/ISS) A4QP72 (/ISS) Q0VBM2 (/ISS) Q5XGY0 (/ISS) Q66JF7 (/ISS) Q6PF42 (/ISS) Q6PF42 (/ISS) Q8K2P2 (/ISS)
(1 more)
Metaphase plate congression GO:0051310
The alignment of chromosomes at the metaphase plate (spindle equator), a plane halfway between the poles of the spindle.
6 A1L1G9 (/ISS) A1L1G9 (/ISS) A3KN19 (/ISS) A4QP72 (/ISS) Q5XGY0 (/ISS) Q9D7I8 (/ISS)
Regulation of ERK1 and ERK2 cascade GO:0070372
Any process that modulates the frequency, rate or extent of signal transduction mediated by the ERK1 and ERK2 cascade.
6 A1L1G9 (/ISS) A1L1G9 (/ISS) A3KN19 (/ISS) A4QP72 (/ISS) Q5XGY0 (/ISS) Q9D7I8 (/ISS)
Epidermal growth factor receptor signaling pathway GO:0007173
A series of molecular signals initiated by binding of a ligand to the tyrosine kinase receptor EGFR (ERBB1) on the surface of a cell. The pathway ends with regulation of a downstream cellular process, e.g. transcription.
5 Q0VBM2 (/ISS) Q66JF7 (/ISS) Q6PF42 (/ISS) Q6PF42 (/ISS) Q8K2P2 (/ISS)
Cell population proliferation GO:0008283
The multiplication or reproduction of cells, resulting in the expansion of a cell population.
3 Q0VBM2 (/ISO) Q8K2P2 (/ISO) Q9D7I8 (/ISO)
Intermediate filament cytoskeleton organization GO:0045104
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising intermediate filaments and their associated proteins.
3 A9JRM0 (/ISS) Q148V8 (/ISS) Q1LVV0 (/ISS)
Epithelial to mesenchymal transition GO:0001837
A transition where an epithelial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell.
2 A3KN19 (/ISS) Q9D7I8 (/ISS)
Epidermal growth factor receptor signaling pathway GO:0007173
A series of molecular signals initiated by binding of a ligand to the tyrosine kinase receptor EGFR (ERBB1) on the surface of a cell. The pathway ends with regulation of a downstream cellular process, e.g. transcription.
2 Q5T0W9 (/IDA) Q86UY5 (/IDA)
Epidermal growth factor receptor signaling pathway GO:0007173
A series of molecular signals initiated by binding of a ligand to the tyrosine kinase receptor EGFR (ERBB1) on the surface of a cell. The pathway ends with regulation of a downstream cellular process, e.g. transcription.
2 Q0VBM2 (/ISO) Q8K2P2 (/ISO)
Cell population proliferation GO:0008283
The multiplication or reproduction of cells, resulting in the expansion of a cell population.
2 Q5T0W9 (/IMP) Q86UY5 (/IMP)
Cell migration GO:0016477
The controlled self-propelled movement of a cell from one site to a destination guided by molecular cues. Cell migration is a central process in the development and maintenance of multicellular organisms.
2 A3KN19 (/ISS) Q9D7I8 (/ISS)
Regulation of TOR signaling GO:0032006
Any process that modulates the frequency, rate or extent of TOR signaling.
2 A3KN19 (/ISS) Q9D7I8 (/ISS)
Regulation of protein catabolic process GO:0042176
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds.
2 A3KN19 (/ISS) Q9D7I8 (/ISS)
Protein localization to mitotic spindle GO:1902480
A process in which a protein is transported to, or maintained in, a location within a mitotic spindle.
2 A3KN19 (/ISS) Q9D7I8 (/ISS)
Positive regulation of cell cycle G1/S phase transition GO:1902808
Any signalling pathway that activates or increases the activity of a cell cycle cyclin-dependent protein kinase to modulate the switch from G1 phase to S phase of the cell cycle.
2 A3KN19 (/ISS) Q9D7I8 (/ISS)
Epithelial to mesenchymal transition GO:0001837
A transition where an epithelial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell.
1 Q9H4H8 (/IDA)
Epithelial to mesenchymal transition GO:0001837
A transition where an epithelial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell.
1 Q9D7I8 (/ISO)
Epidermal growth factor receptor signaling pathway GO:0007173
A series of molecular signals initiated by binding of a ligand to the tyrosine kinase receptor EGFR (ERBB1) on the surface of a cell. The pathway ends with regulation of a downstream cellular process, e.g. transcription.
1 Q5T0W9 (/IMP)
Cell population proliferation GO:0008283
The multiplication or reproduction of cells, resulting in the expansion of a cell population.
1 Q9H4H8 (/IDA)
Cell migration GO:0016477
The controlled self-propelled movement of a cell from one site to a destination guided by molecular cues. Cell migration is a central process in the development and maintenance of multicellular organisms.
1 Q9H4H8 (/IDA)
Cell migration GO:0016477
The controlled self-propelled movement of a cell from one site to a destination guided by molecular cues. Cell migration is a central process in the development and maintenance of multicellular organisms.
1 Q9D7I8 (/ISO)
Positive regulation of cell migration GO:0030335
Any process that activates or increases the frequency, rate or extent of cell migration.
1 Q6ZRV2 (/IMP)
Positive regulation of cell migration GO:0030335
Any process that activates or increases the frequency, rate or extent of cell migration.
1 Q148V8 (/ISO)
Positive regulation of cell migration GO:0030335
Any process that activates or increases the frequency, rate or extent of cell migration.
1 Q148V8 (/ISS)
BMP signaling pathway GO:0030509
A series of molecular signals initiated by the binding of a member of the BMP (bone morphogenetic protein) family to a receptor on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription.
1 A6ND36 (/IDA)
BMP signaling pathway GO:0030509
A series of molecular signals initiated by the binding of a member of the BMP (bone morphogenetic protein) family to a receptor on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription.
1 Q5SWY7 (/ISO)
BMP signaling pathway GO:0030509
A series of molecular signals initiated by the binding of a member of the BMP (bone morphogenetic protein) family to a receptor on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription.
1 Q5SWY7 (/ISS)
Regulation of TOR signaling GO:0032006
Any process that modulates the frequency, rate or extent of TOR signaling.
1 Q9H4H8 (/IDA)
Regulation of TOR signaling GO:0032006
Any process that modulates the frequency, rate or extent of TOR signaling.
1 Q9D7I8 (/ISO)
Regulation of protein catabolic process GO:0042176
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds.
1 Q9H4H8 (/IDA)
Regulation of protein catabolic process GO:0042176
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds.
1 Q9D7I8 (/ISO)
Protein localization to cytoskeleton GO:0044380
A process in which a protein is transported to, or maintained in, a location within the cytoskeleton.
1 Q6ZRV2 (/IMP)
Protein localization to cytoskeleton GO:0044380
A process in which a protein is transported to, or maintained in, a location within the cytoskeleton.
1 Q148V8 (/ISO)
Protein localization to cytoskeleton GO:0044380
A process in which a protein is transported to, or maintained in, a location within the cytoskeleton.
1 Q148V8 (/ISS)
Intermediate filament cytoskeleton organization GO:0045104
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising intermediate filaments and their associated proteins.
1 Q6ZRV2 (/IMP)
Intermediate filament cytoskeleton organization GO:0045104
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising intermediate filaments and their associated proteins.
1 Q148V8 (/ISO)
Metaphase plate congression GO:0051310
The alignment of chromosomes at the metaphase plate (spindle equator), a plane halfway between the poles of the spindle.
1 Q9H4H8 (/IMP)
Metaphase plate congression GO:0051310
The alignment of chromosomes at the metaphase plate (spindle equator), a plane halfway between the poles of the spindle.
1 Q9D7I8 (/ISO)
Regulation of ERK1 and ERK2 cascade GO:0070372
Any process that modulates the frequency, rate or extent of signal transduction mediated by the ERK1 and ERK2 cascade.
1 Q9H4H8 (/IMP)
Regulation of ERK1 and ERK2 cascade GO:0070372
Any process that modulates the frequency, rate or extent of signal transduction mediated by the ERK1 and ERK2 cascade.
1 Q9D7I8 (/ISO)
Protein localization to mitotic spindle GO:1902480
A process in which a protein is transported to, or maintained in, a location within a mitotic spindle.
1 Q9H4H8 (/IMP)
Protein localization to mitotic spindle GO:1902480
A process in which a protein is transported to, or maintained in, a location within a mitotic spindle.
1 Q9D7I8 (/ISO)
Positive regulation of cell cycle G1/S phase transition GO:1902808
Any signalling pathway that activates or increases the activity of a cell cycle cyclin-dependent protein kinase to modulate the switch from G1 phase to S phase of the cell cycle.
1 Q9H4H8 (/IMP)
Positive regulation of cell cycle G1/S phase transition GO:1902808
Any signalling pathway that activates or increases the activity of a cell cycle cyclin-dependent protein kinase to modulate the switch from G1 phase to S phase of the cell cycle.
1 Q9D7I8 (/ISO)

There are 16 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
7 A1L1G9 (/ISS) A1L1G9 (/ISS) A3KN19 (/ISS) A4QP72 (/ISS) Q0VBM2 (/ISS) Q5XGY0 (/ISS) Q9D7I8 (/ISS)
Mitotic spindle pole GO:0097431
Either of the ends of a mitotic spindle, a spindle that forms as part of mitosis, where spindle microtubules are organized; usually contains a microtubule organizing center and accessory molecules, spindle microtubules and astral microtubules.
6 A1L1G9 (/ISS) A1L1G9 (/ISS) A3KN19 (/ISS) A4QP72 (/ISS) Q5XGY0 (/ISS) Q9D7I8 (/ISS)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
2 Q5T0W9 (/IDA) Q9H4H8 (/IDA)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
2 Q0VBM2 (/ISO) Q9D7I8 (/ISO)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
1 A6ND36 (/IDA)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
1 Q5SWY7 (/ISO)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
1 Q5SWY7 (/ISS)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
1 Q9H4H8 (/IC)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
1 A6ND36 (/IDA)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
1 Q5SWY7 (/ISO)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
1 Q5SWY7 (/ISS)
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
1 Q5T0W9 (/IDA)
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
1 Q0VBM2 (/ISO)
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
1 Q0VBM2 (/ISS)
Mitotic spindle pole GO:0097431
Either of the ends of a mitotic spindle, a spindle that forms as part of mitosis, where spindle microtubules are organized; usually contains a microtubule organizing center and accessory molecules, spindle microtubules and astral microtubules.
1 Q9H4H8 (/IDA)
Mitotic spindle pole GO:0097431
Either of the ends of a mitotic spindle, a spindle that forms as part of mitosis, where spindle microtubules are organized; usually contains a microtubule organizing center and accessory molecules, spindle microtubules and astral microtubules.
1 Q9D7I8 (/ISO)
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