The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Metalloenzyme, LuxS/M16 peptidase-like
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 12: Protease 3

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 7 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Metalloendopeptidase activity GO:0004222
Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions.
13 P05458 (/IDA) P05458 (/IDA) P05458 (/IDA) P05458 (/IDA) P05458 (/IDA) P05458 (/IDA) P05458 (/IDA) P05458 (/IDA) P05458 (/IDA) P05458 (/IDA)
(3 more)
Zinc ion binding GO:0008270
Interacting selectively and non-covalently with zinc (Zn) ions.
13 P05458 (/IDA) P05458 (/IDA) P05458 (/IDA) P05458 (/IDA) P05458 (/IDA) P05458 (/IDA) P05458 (/IDA) P05458 (/IDA) P05458 (/IDA) P05458 (/IDA)
(3 more)
Metalloendopeptidase activity GO:0004222
Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions.
5 P40851 (/IMP) P40851 (/IMP) P40851 (/IMP) P40851 (/IMP) P40851 (/IMP)
Metalloendopeptidase activity GO:0004222
Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions.
5 P40851 (/ISS) P40851 (/ISS) P40851 (/ISS) P40851 (/ISS) P40851 (/ISS)
Peptidase activity GO:0008233
Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid.
5 Q9KQC8 (/ISS) Q9KQC8 (/ISS) Q9KQC8 (/ISS) Q9KQC8 (/ISS) Q9KQC8 (/ISS)
Metalloendopeptidase activity GO:0004222
Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions.
2 Q57YQ9 (/ISM) Q57YQ9 (/ISM)
Protein folding chaperone GO:0044183
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules) that contributes to the process of protein folding.
1 Q9VYT3 (/IDA)

There are 8 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Proteolysis GO:0006508
The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds.
13 P05458 (/IDA) P05458 (/IDA) P05458 (/IDA) P05458 (/IDA) P05458 (/IDA) P05458 (/IDA) P05458 (/IDA) P05458 (/IDA) P05458 (/IDA) P05458 (/IDA)
(3 more)
Cytogamy GO:0000755
During conjugation with cellular fusion, the process resulting in creating a single cell from complementary mating types. The localized remodeling and dissolution of external protective structures allow the fusion of the plasma membranes and cytoplasmic mixing. An example of this process is found in Saccharomyces cerevisiae.
5 P40851 (/IMP) P40851 (/IMP) P40851 (/IMP) P40851 (/IMP) P40851 (/IMP)
Proteolysis GO:0006508
The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds.
5 Q9KQC8 (/ISS) Q9KQC8 (/ISS) Q9KQC8 (/ISS) Q9KQC8 (/ISS) Q9KQC8 (/ISS)
Axial cellular bud site selection GO:0007120
The process of defining the next site of bud emergence adjacent to the last site of bud emergence on a budding cell.
5 P40851 (/IMP) P40851 (/IMP) P40851 (/IMP) P40851 (/IMP) P40851 (/IMP)
Peptide mating pheromone maturation involved in positive regulation of conjugation with cellular fusion GO:0071432
The formation of a mature peptide mating pheromone by proteolysis and/or modification of a peptide precursor, occurring in the context of conjugation with cellular fusion.
5 P40851 (/IGI) P40851 (/IGI) P40851 (/IGI) P40851 (/IGI) P40851 (/IGI)
Peptide mating pheromone maturation involved in positive regulation of conjugation with cellular fusion GO:0071432
The formation of a mature peptide mating pheromone by proteolysis and/or modification of a peptide precursor, occurring in the context of conjugation with cellular fusion.
5 P40851 (/IMP) P40851 (/IMP) P40851 (/IMP) P40851 (/IMP) P40851 (/IMP)
Proteolysis GO:0006508
The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds.
2 Q57YQ9 (/ISM) Q57YQ9 (/ISM)
Chaperone-mediated protein folding GO:0061077
The process of inhibiting aggregation and assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure that is dependent on interaction with a chaperone.
1 Q9VYT3 (/IDA)

There are 10 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
15 P05458 (/IDA) P05458 (/IDA) P05458 (/IDA) P05458 (/IDA) P05458 (/IDA) P05458 (/IDA) P05458 (/IDA) P05458 (/IDA) P05458 (/IDA) P05458 (/IDA)
(5 more)
Outer membrane-bounded periplasmic space GO:0030288
The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin peptidoglycan layer (PGL), also referred to as a thin cell wall.
13 P05458 (/IDA) P05458 (/IDA) P05458 (/IDA) P05458 (/IDA) P05458 (/IDA) P05458 (/IDA) P05458 (/IDA) P05458 (/IDA) P05458 (/IDA) P05458 (/IDA)
(3 more)
Cellular bud neck GO:0005935
The constriction between the mother cell and daughter cell (bud) in an organism that reproduces by budding.
5 P40851 (/IDA) P40851 (/IDA) P40851 (/IDA) P40851 (/IDA) P40851 (/IDA)
Mating projection tip GO:0043332
The apex of the mating projection in unicellular fungi exposed to mating pheromone; site of polarized growth.
5 P40851 (/IDA) P40851 (/IDA) P40851 (/IDA) P40851 (/IDA) P40851 (/IDA)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
2 F4HNU6 (/IDA) F4HNU6 (/IDA)
Ciliary plasm GO:0097014
All of the contents of a cilium, excluding the plasma membrane surrounding the cilium.
2 Q57YQ9 (/IDA) Q57YQ9 (/IDA)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
1 Q4Q5U8 (/ISO)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
1 Q9VYT3 (/IDA)
Ciliary plasm GO:0097014
All of the contents of a cilium, excluding the plasma membrane surrounding the cilium.
1 Q4Q5U8 (/ISO)
Chaperone complex GO:0101031
A protein complex required for the non-covalent folding or unfolding, maturation, stabilization or assembly or disassembly of macromolecular structures. Usually active during or immediately after completion of translation. Many chaperone complexes contain heat shock proteins.
1 Q9VYT3 (/IDA)