The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
2-Layer Sandwich
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 8: MSS4p Phosphatidylinositol-4-phosphate 5-kinase

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 7 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
1-phosphatidylinositol-4-phosphate 5-kinase activity GO:0016308
Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 4-phosphate + ATP = 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + ADP + 2 H(+).
3 P38994 (/IDA) P38994 (/IDA) Q55GN6 (/IDA)
1-phosphatidylinositol-4-phosphate 5-kinase activity GO:0016308
Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 4-phosphate + ATP = 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + ADP + 2 H(+).
2 A0A1D8PJ31 (/IGI) O13853 (/IGI)
Phosphatidylinositol-3-phosphate binding GO:0032266
Interacting selectively and non-covalently with phosphatidylinositol-3-phosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 3' position.
2 P38994 (/IDA) P38994 (/IDA)
Phosphatidylinositol-4-phosphate binding GO:0070273
Interacting selectively and non-covalently with phosphatidylinositol-4-phosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 4' position.
2 P38994 (/IDA) P38994 (/IDA)
Phosphatidylinositol phosphate kinase activity GO:0016307
Catalysis of the reaction: ATP + a phosphatidylinositol phosphate = ADP + a phosphatidylinositol bisphosphate.
1 Q55GN6 (/ISS)
1-phosphatidylinositol-3-phosphate 4-kinase activity GO:0052811
Catalysis of the reaction: a 1-phosphatidyl-1D-myo-inositol 4-phosphate + ATP = a 1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate + ADP + 2 H(+).
1 O13853 (/IMP)
Phosphatidylinositol-3,4-bisphosphate 5-kinase activity GO:0052812
Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate + ATP = a 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate + ADP + 2 H(+).
1 O13853 (/IMP)

There are 12 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Cortical actin cytoskeleton organization GO:0030866
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of actin-based cytoskeletal structures in the cell cortex, i.e. just beneath the plasma membrane.
2 P38994 (/IMP) P38994 (/IMP)
Ascospore-type prospore assembly GO:0031321
During ascospore formation, the process in which each haploid nucleus becomes encapsulated by a double membrane.
2 P38994 (/IGI) P38994 (/IGI)
Phosphatidylinositol phosphorylation GO:0046854
The process of introducing one or more phosphate groups into a phosphatidylinositol, any glycerophosphoinositol having one phosphatidyl group esterified to one of the hydroxy groups of inositol.
2 P38994 (/IDA) P38994 (/IDA)
Signal transduction GO:0007165
The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell.
1 A0A1D8PJ31 (/IGI)
Actin cytoskeleton organization GO:0030036
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins.
1 A0A1D8PJ31 (/IGI)
Dynein-driven meiotic oscillatory nuclear movement GO:0030989
Oscillatory movement of the nucleus involved in meiosis I. This oscillatory movement is led by an astral microtubule array emanating from the spindle pole body, and driven by the microtubule motor cytoplasmic dynein.
1 O13853 (/EXP)
Activation of protein kinase activity GO:0032147
Any process that initiates the activity of an inactive protein kinase.
1 Q55GN6 (/IMP)
Invasive filamentous growth GO:0036267
The growth of colonies in filamentous chains of cells into a substrate.
1 A0A1D8PJ31 (/IMP)
Chemotaxis to cAMP GO:0043327
The directed movement of a motile cell or organism in response to the presence of 3',5'-cAMP.
1 Q55GN6 (/IMP)
Regulation of Ras protein signal transduction GO:0046578
Any process that modulates the frequency, rate or extent of Ras protein signal transduction.
1 Q55GN6 (/IMP)
Phosphatidylinositol phosphorylation GO:0046854
The process of introducing one or more phosphate groups into a phosphatidylinositol, any glycerophosphoinositol having one phosphatidyl group esterified to one of the hydroxy groups of inositol.
1 O13853 (/IMP)
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthetic process GO:1902635
The chemical reactions and pathways resulting in the formation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate.
1 Q55GN6 (/IMP)

There are 5 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
4 A0A1D8PJ31 (/IDA) O13853 (/IDA) P38994 (/IDA) P38994 (/IDA)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
2 P38994 (/IDA) P38994 (/IDA)
Division septum GO:0000935
A cell septum which forms as part of the division site and functions in the compartmentalization of a cell into two daughter cells at division. A division septum spans a cell and does not allow exchange of organelles or cytoplasm between compartments.
1 O13853 (/IDA)
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
1 A0A1D8PJ31 (/IDA)
Site of polarized growth GO:0030427
Any part of a cell where non-isotropic growth takes place.
1 A0A1D8PJ31 (/IDA)
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