The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:
"2-Layer Sandwich
".
FunFam 1: 1-phosphatidylinositol 3-phosphate 5-kinase FAB1
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 19 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
1-phosphatidylinositol-3-phosphate 5-kinase activity GO:0000285
Catalysis of the reaction: a 1-phosphatidyl-1D-myo-inositol 3-phosphate + ATP = a 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate + ADP + 2 H(+).
|
3 | O59722 (/IDA) P34756 (/IDA) Q9SSJ8 (/IDA) |
1-phosphatidylinositol-3-phosphate 5-kinase activity GO:0000285
Catalysis of the reaction: a 1-phosphatidyl-1D-myo-inositol 3-phosphate + ATP = a 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate + ADP + 2 H(+).
|
3 | O96838 (/IMP) O96838 (/IMP) P34756 (/IMP) |
1-phosphatidylinositol-3-phosphate 5-kinase activity GO:0000285
Catalysis of the reaction: a 1-phosphatidyl-1D-myo-inositol 3-phosphate + ATP = a 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate + ADP + 2 H(+).
|
3 | B0G126 (/ISS) Q0WUR5 (/ISS) Q9LUM0 (/ISS) |
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
|
3 | P34756 (/IPI) Q9Y2I7 (/IPI) Q9Z1T6 (/IPI) |
1-phosphatidylinositol-3-phosphate 5-kinase activity GO:0000285
Catalysis of the reaction: a 1-phosphatidyl-1D-myo-inositol 3-phosphate + ATP = a 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate + ADP + 2 H(+).
|
2 | Q0WUR5 (/IGI) Q9LUM0 (/IGI) |
Zinc ion binding GO:0008270
Interacting selectively and non-covalently with zinc (Zn) ions.
|
2 | O96838 (/ISS) O96838 (/ISS) |
1-phosphatidylinositol-4-phosphate 5-kinase activity GO:0016308
Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 4-phosphate + ATP = 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + ADP + 2 H(+).
|
2 | O96838 (/ISS) O96838 (/ISS) |
1-phosphatidylinositol-3-phosphate 5-kinase activity GO:0000285
Catalysis of the reaction: a 1-phosphatidyl-1D-myo-inositol 3-phosphate + ATP = a 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate + ADP + 2 H(+).
|
1 | Q9Z1T6 (/TAS) |
ATP binding GO:0005524
Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
|
1 | O59722 (/ISM) |
Zinc ion binding GO:0008270
Interacting selectively and non-covalently with zinc (Zn) ions.
|
1 | Q9Z1T6 (/IDA) |
Zinc ion binding GO:0008270
Interacting selectively and non-covalently with zinc (Zn) ions.
|
1 | Q387A6 (/ISM) |
1-phosphatidylinositol-4-phosphate 5-kinase activity GO:0016308
Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 4-phosphate + ATP = 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + ADP + 2 H(+).
|
1 | Q9Z1T6 (/IDA) |
1-phosphatidylinositol-4-phosphate 5-kinase activity GO:0016308
Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 4-phosphate + ATP = 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + ADP + 2 H(+).
|
1 | Q387A6 (/ISM) |
1-phosphatidylinositol-4-phosphate 5-kinase activity GO:0016308
Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 4-phosphate + ATP = 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + ADP + 2 H(+).
|
1 | Q9Y2I7 (/TAS) |
Phosphatidylinositol-3-phosphate binding GO:0032266
Interacting selectively and non-covalently with phosphatidylinositol-3-phosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 3' position.
|
1 | P34756 (/IDA) |
Phosphatidylinositol-3-phosphate binding GO:0032266
Interacting selectively and non-covalently with phosphatidylinositol-3-phosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 3' position.
|
1 | O59722 (/ISO) |
Phosphatidylinositol-3-phosphate binding GO:0032266
Interacting selectively and non-covalently with phosphatidylinositol-3-phosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 3' position.
|
1 | G5ED98 (/ISS) |
Phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity GO:0043813
Catalysis of the reaction: phosphatidylinositol-3,5-bisphosphate + H2O = phosphatidylinositol-3-phosphate + orthophosphate.
|
1 | Q9Y2I7 (/TAS) |
1-phosphatidylinositol-5-kinase activity GO:0052810
Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol + ATP = a 1-phosphatidyl-1D-myo-inositol 5-phosphate + ADP + 2 H(+).
|
1 | Q9Z1T6 (/TAS) |
There are 29 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Phosphatidylinositol phosphorylation GO:0046854
The process of introducing one or more phosphate groups into a phosphatidylinositol, any glycerophosphoinositol having one phosphatidyl group esterified to one of the hydroxy groups of inositol.
|
3 | O96838 (/IMP) O96838 (/IMP) P34756 (/IMP) |
Vacuole organization GO:0007033
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a vacuole.
|
2 | Q0WUR5 (/IGI) Q9LUM0 (/IGI) |
Endosome to lysosome transport GO:0008333
The directed movement of substances from endosomes to lysosomes.
|
2 | O96838 (/IMP) O96838 (/IMP) |
Pollen development GO:0009555
The process whose specific outcome is the progression of the pollen grain over time, from its formation to the mature structure. The process begins with the meiosis of the microsporocyte to form four haploid microspores. The nucleus of each microspore then divides by mitosis to form a two-celled organism, the pollen grain, that contains a tube cell as well as a smaller generative cell. The pollen grain is surrounded by an elaborate cell wall. In some species, the generative cell immediately divides again to give a pair of sperm cells. In most flowering plants, however this division takes place later, in the tube that develops when a pollen grain germinates.
|
2 | Q0WUR5 (/IGI) Q9LUM0 (/IGI) |
Endomembrane system organization GO:0010256
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the endomembrane system.
|
2 | Q0WUR5 (/IGI) Q9LUM0 (/IGI) |
Intracellular signal transduction GO:0035556
The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell.
|
2 | O96838 (/ISS) O96838 (/ISS) |
Stomatal closure GO:0090332
The process of closing of stomata, pores in the epidermis of leaves and stems bordered by two guard cells and serving in gas exchange.
|
2 | Q9LUM0 (/IMP) Q9SSJ8 (/IMP) |
Autophagosome maturation GO:0097352
Removal of PI3P and Atg8/LC3 after the closure of the phagophore and before the fusion with the endosome/lysosome (e.g. mammals and insects) or vacuole (yeast), and that very likely destabilizes other Atg proteins and thus enables their efficient dissociation and recycling.
|
2 | O96838 (/IMP) O96838 (/IMP) |
Vacuole inheritance GO:0000011
The distribution of vacuoles into daughter cells after mitosis or meiosis, mediated by interactions between vacuoles and the cytoskeleton.
|
1 | A0A1D8PGH4 (/IMP) |
Pheromone-dependent signal transduction involved in conjugation with cellular fusion GO:0000750
A signal transduction process resulting in the relay, amplification or dampening of a signal generated in response to pheromone exposure in organisms that undergo conjugation with cellular fusion. An example of this process is found in Saccharomyces cerevisiae.
|
1 | O59722 (/IMP) |
Phospholipid metabolic process GO:0006644
The chemical reactions and pathways involving phospholipids, any lipid containing phosphoric acid as a mono- or diester.
|
1 | B0G126 (/ISS) |
Phosphatidylinositol biosynthetic process GO:0006661
The chemical reactions and pathways resulting in the formation of phosphatidylinositol, any glycophospholipid in which the sn-glycerol 3-phosphate residue is esterified to the 1-hydroxyl group of 1D-myo-inositol.
|
1 | Q9Y2I7 (/TAS) |
Vacuole organization GO:0007033
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a vacuole.
|
1 | A0A1D8PGH4 (/IMP) |
Vacuolar acidification GO:0007035
Any process that reduces the pH of the vacuole, measured by the concentration of the hydrogen ion.
|
1 | A0A1D8PGH4 (/IMP) |
Cellular response to starvation GO:0009267
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of nourishment.
|
1 | A0A1D8PGH4 (/IMP) |
Filamentous growth GO:0030447
The process in which a multicellular organism, a unicellular organism or a group of unicellular organisms grow in a threadlike, filamentous shape.
|
1 | A0A1D8PGH4 (/IMP) |
Myelin assembly GO:0032288
The process in which the wraps of cell membrane that constitute myelin are laid down around an axon in the central or peripheral nervous system.
|
1 | Q9Z1T6 (/IGI) |
Protein localization to nucleus GO:0034504
A process in which a protein transports or maintains the localization of another protein to the nucleus.
|
1 | Q9Y2I7 (/IMP) |
Protein localization to nucleus GO:0034504
A process in which a protein transports or maintains the localization of another protein to the nucleus.
|
1 | Q9Z1T6 (/ISO) |
Intracellular signal transduction GO:0035556
The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell.
|
1 | Q9Z1T6 (/IDA) |
Filamentous growth of a population of unicellular organisms in response to starvation GO:0036170
The process in which a group of unicellular organisms grow in a threadlike, filamentous shape in response to deprivation of nourishment.
|
1 | A0A1D8PGH4 (/IMP) |
Filamentous growth of a population of unicellular organisms in response to biotic stimulus GO:0036180
The process in which a group of unicellular organisms grow in a threadlike, filamentous shape in response to a biotic (living) stimulus.
|
1 | A0A1D8PGH4 (/IMP) |
Retrograde transport, endosome to Golgi GO:0042147
The directed movement of membrane-bounded vesicles from endosomes back to the trans-Golgi network where they are recycled for further rounds of transport.
|
1 | Q9Y2I7 (/IMP) |
Retrograde transport, endosome to Golgi GO:0042147
The directed movement of membrane-bounded vesicles from endosomes back to the trans-Golgi network where they are recycled for further rounds of transport.
|
1 | Q9Z1T6 (/ISO) |
Phosphatidylinositol phosphorylation GO:0046854
The process of introducing one or more phosphate groups into a phosphatidylinositol, any glycerophosphoinositol having one phosphatidyl group esterified to one of the hydroxy groups of inositol.
|
1 | P34756 (/IDA) |
Protein modification by small protein conjugation or removal GO:0070647
A protein modification process in which one or more groups of a small protein, such as ubiquitin or a ubiquitin-like protein, are covalently attached to or removed from a target protein.
|
1 | O59722 (/IC) |
Phosphatidylinositol 5-phosphate metabolic process GO:1904562
The chemical reactions and pathways involving phosphatidylinositol 5-phosphate.
|
1 | Q9Y2I7 (/IC) |
Regulation of autophagosome assembly GO:2000785
Any process that modulates the frequency, rate or extent of autophagosome assembly.
|
1 | Q9Y2I7 (/IMP) |
Regulation of autophagosome assembly GO:2000785
Any process that modulates the frequency, rate or extent of autophagosome assembly.
|
1 | Q9Z1T6 (/ISO) |
There are 27 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Perinuclear region of cytoplasm GO:0048471
Cytoplasm situated near, or occurring around, the nucleus.
|
8 | A0A2R8QAJ5 (/IDA) A0A2R8RNV7 (/IDA) B2KTE1 (/IDA) B2KTE2 (/IDA) B2KTE3 (/IDA) B2KTE4 (/IDA) Q7SZQ5 (/IDA) Q9Z1T6 (/IDA) |
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
|
7 | A0A2R8QAJ5 (/IDA) A0A2R8RNV7 (/IDA) B2KTE1 (/IDA) B2KTE2 (/IDA) B2KTE3 (/IDA) B2KTE4 (/IDA) Q7SZQ5 (/IDA) |
Endosome GO:0005768
A vacuole to which materials ingested by endocytosis are delivered.
|
4 | O96838 (/IDA) O96838 (/IDA) Q0WUR5 (/IDA) Q9LUM0 (/IDA) |
Golgi membrane GO:0000139
The lipid bilayer surrounding any of the compartments of the Golgi apparatus.
|
2 | Q9Y2I7 (/TAS) Q9Z1T6 (/TAS) |
Endosome membrane GO:0010008
The lipid bilayer surrounding an endosome.
|
2 | P34756 (/IDA) Q9Y2I7 (/IDA) |
Vesicle membrane GO:0012506
The lipid bilayer surrounding any membrane-bounded vesicle in the cell.
|
2 | O96838 (/ISS) O96838 (/ISS) |
Early endosome membrane GO:0031901
The lipid bilayer surrounding an early endosome.
|
2 | Q9Y2I7 (/TAS) Q9Z1T6 (/TAS) |
Late endosome membrane GO:0031902
The lipid bilayer surrounding a late endosome.
|
2 | Q9Y2I7 (/TAS) Q9Z1T6 (/TAS) |
Fungal-type vacuole membrane GO:0000329
The lipid bilayer surrounding a vacuole, the shape of which correlates with cell cycle phase. The membrane separates its contents from the cytoplasm of the cell. An example of this structure is found in Saccharomyces cerevisiae.
|
1 | P34756 (/IDA) |
Fungal-type vacuole membrane GO:0000329
The lipid bilayer surrounding a vacuole, the shape of which correlates with cell cycle phase. The membrane separates its contents from the cytoplasm of the cell. An example of this structure is found in Saccharomyces cerevisiae.
|
1 | O59722 (/ISO) |
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
|
1 | G5ED98 (/IDA) |
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
|
1 | P34756 (/HDA) |
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
|
1 | Q9LUM0 (/IDA) |
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
1 | Q9Z1T6 (/IDA) |
Cell-cell junction GO:0005911
A cell junction that forms a connection between two or more cells in a multicellular organism; excludes direct cytoplasmic junctions such as ring canals.
|
1 | Q9Z1T6 (/IDA) |
Endosome membrane GO:0010008
The lipid bilayer surrounding an endosome.
|
1 | Q9Z1T6 (/ISO) |
Vesicle membrane GO:0012506
The lipid bilayer surrounding any membrane-bounded vesicle in the cell.
|
1 | Q9Z1T6 (/IDA) |
Axon GO:0030424
The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter.
|
1 | G5ED98 (/IDA) |
Cytoplasmic vesicle GO:0031410
A vesicle found in the cytoplasm of a cell.
|
1 | Q9Z1T6 (/IDA) |
Early endosome membrane GO:0031901
The lipid bilayer surrounding an early endosome.
|
1 | Q9Y2I7 (/IDA) |
Early endosome membrane GO:0031901
The lipid bilayer surrounding an early endosome.
|
1 | Q9Z1T6 (/ISO) |
Neuronal cell body GO:0043025
The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites.
|
1 | G5ED98 (/IDA) |
Membrane raft GO:0045121
Any of the small (10-200 nm), heterogeneous, highly dynamic, sterol- and sphingolipid-enriched membrane domains that compartmentalize cellular processes. Small rafts can sometimes be stabilized to form larger platforms through protein-protein and protein-lipid interactions.
|
1 | Q9Y2I7 (/IDA) |
Membrane raft GO:0045121
Any of the small (10-200 nm), heterogeneous, highly dynamic, sterol- and sphingolipid-enriched membrane domains that compartmentalize cellular processes. Small rafts can sometimes be stabilized to form larger platforms through protein-protein and protein-lipid interactions.
|
1 | Q9Z1T6 (/ISO) |
PAS complex GO:0070772
A class III phosphatidylinositol 3-kinase complex that contains a phosphatidylinositol-3-phosphate 5-kinase subunit (Fab1p in yeast; PIKfyve in mammals), a kinase activator, and a phosphatase, and may also contain additional proteins; it is involved in regulating the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate. In mammals the complex is composed of PIKFYVE, FIG4 and VAC14. In yeast it is composed of Atg18p, Fig4p, Fab1p, Vac14p and Vac7p.
|
1 | P34756 (/IDA) |
PAS complex GO:0070772
A class III phosphatidylinositol 3-kinase complex that contains a phosphatidylinositol-3-phosphate 5-kinase subunit (Fab1p in yeast; PIKfyve in mammals), a kinase activator, and a phosphatase, and may also contain additional proteins; it is involved in regulating the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate. In mammals the complex is composed of PIKFYVE, FIG4 and VAC14. In yeast it is composed of Atg18p, Fig4p, Fab1p, Vac14p and Vac7p.
|
1 | P34756 (/IPI) |
PAS complex GO:0070772
A class III phosphatidylinositol 3-kinase complex that contains a phosphatidylinositol-3-phosphate 5-kinase subunit (Fab1p in yeast; PIKfyve in mammals), a kinase activator, and a phosphatase, and may also contain additional proteins; it is involved in regulating the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate. In mammals the complex is composed of PIKFYVE, FIG4 and VAC14. In yeast it is composed of Atg18p, Fig4p, Fab1p, Vac14p and Vac7p.
|
1 | O59722 (/ISO) |