The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
RNA Cap, Translation Initiation Factor Eif4e
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 2: Eukaryotic translation initiation factor 4E

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 23 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Enzyme binding GO:0019899
Interacting selectively and non-covalently with any enzyme.
279 A0A087QR03 (/ISS) A0A087QR03 (/ISS) A0A087QR03 (/ISS) A0A087QR03 (/ISS) A0A087QR03 (/ISS) A0A087QR03 (/ISS) A0A087QR03 (/ISS) A0A087QR03 (/ISS) A0A087QR03 (/ISS) A0A087QR03 (/ISS)
(269 more)
Repressing transcription factor binding GO:0070491
Interacting selectively and non-covalently with a transcription repressor, any protein whose activity is required to prevent or downregulate transcription.
279 A0A087QR03 (/ISS) A0A087QR03 (/ISS) A0A087QR03 (/ISS) A0A087QR03 (/ISS) A0A087QR03 (/ISS) A0A087QR03 (/ISS) A0A087QR03 (/ISS) A0A087QR03 (/ISS) A0A087QR03 (/ISS) A0A087QR03 (/ISS)
(269 more)
Eukaryotic initiation factor 4G binding GO:0031370
Interacting selectively and non-covalently with eukaryotic initiation factor 4G, a polypeptide factor involved in the initiation of ribosome-mediated translation.
276 A0A087QR03 (/ISS) A0A087QR03 (/ISS) A0A087QR03 (/ISS) A0A087QR03 (/ISS) A0A087QR03 (/ISS) A0A087QR03 (/ISS) A0A087QR03 (/ISS) A0A087QR03 (/ISS) A0A087QR03 (/ISS) A0A087QR03 (/ISS)
(266 more)
Translation initiation factor activity GO:0003743
Functions in the initiation of ribosome-mediated translation of mRNA into a polypeptide.
20 P06730 (/ISS) P06730 (/ISS) P06730 (/ISS) P06730 (/ISS) P06730 (/ISS) P06730 (/ISS) P06730 (/ISS) P06730 (/ISS) P06730 (/ISS) P06730 (/ISS)
(10 more)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
18 P06730 (/IPI) P06730 (/IPI) P06730 (/IPI) P06730 (/IPI) P06730 (/IPI) P06730 (/IPI) P06730 (/IPI) P06730 (/IPI) P06730 (/IPI) P06730 (/IPI)
(8 more)
Translation initiation factor activity GO:0003743
Functions in the initiation of ribosome-mediated translation of mRNA into a polypeptide.
14 P06730 (/IDA) P06730 (/IDA) P06730 (/IDA) P06730 (/IDA) P06730 (/IDA) P06730 (/IDA) P06730 (/IDA) P06730 (/IDA) P06730 (/IDA) P06730 (/IDA)
(4 more)
Translation initiation factor activity GO:0003743
Functions in the initiation of ribosome-mediated translation of mRNA into a polypeptide.
13 P06730 (/TAS) P06730 (/TAS) P06730 (/TAS) P06730 (/TAS) P06730 (/TAS) P06730 (/TAS) P06730 (/TAS) P06730 (/TAS) P06730 (/TAS) P06730 (/TAS)
(3 more)
Enzyme binding GO:0019899
Interacting selectively and non-covalently with any enzyme.
13 D6RBW1 (/IDA) P06730 (/IDA) P06730 (/IDA) P06730 (/IDA) P06730 (/IDA) P06730 (/IDA) P06730 (/IDA) P06730 (/IDA) P06730 (/IDA) P06730 (/IDA)
(3 more)
Eukaryotic initiation factor 4G binding GO:0031370
Interacting selectively and non-covalently with eukaryotic initiation factor 4G, a polypeptide factor involved in the initiation of ribosome-mediated translation.
13 D6RBW1 (/IDA) P06730 (/IDA) P06730 (/IDA) P06730 (/IDA) P06730 (/IDA) P06730 (/IDA) P06730 (/IDA) P06730 (/IDA) P06730 (/IDA) P06730 (/IDA)
(3 more)
Repressing transcription factor binding GO:0070491
Interacting selectively and non-covalently with a transcription repressor, any protein whose activity is required to prevent or downregulate transcription.
13 D6RBW1 (/IDA) P06730 (/IDA) P06730 (/IDA) P06730 (/IDA) P06730 (/IDA) P06730 (/IDA) P06730 (/IDA) P06730 (/IDA) P06730 (/IDA) P06730 (/IDA)
(3 more)
RNA 7-methylguanosine cap binding GO:0000340
Interacting selectively and non-covalently with the 7-methylguanosine group added cotranscriptionally to the 5' end of RNA molecules transcribed by polymerase II.
11 P06730 (/IDA) P06730 (/IDA) P06730 (/IDA) P06730 (/IDA) P06730 (/IDA) P06730 (/IDA) P06730 (/IDA) P06730 (/IDA) P06730 (/IDA) P06730 (/IDA)
(1 more)
RNA cap binding GO:0000339
Interacting selectively and non-covalently with a 7-methylguanosine (m7G) group or derivative located at the 5' end of an RNA molecule.
10 P06730 (/TAS) P06730 (/TAS) P06730 (/TAS) P06730 (/TAS) P06730 (/TAS) P06730 (/TAS) P06730 (/TAS) P06730 (/TAS) P06730 (/TAS) P06730 (/TAS)
RNA binding GO:0003723
Interacting selectively and non-covalently with an RNA molecule or a portion thereof.
10 P06730 (/HDA) P06730 (/HDA) P06730 (/HDA) P06730 (/HDA) P06730 (/HDA) P06730 (/HDA) P06730 (/HDA) P06730 (/HDA) P06730 (/HDA) P06730 (/HDA)
RNA 7-methylguanosine cap binding GO:0000340
Interacting selectively and non-covalently with the 7-methylguanosine group added cotranscriptionally to the 5' end of RNA molecules transcribed by polymerase II.
8 P29338 (/ISS) P63073 (/ISS) P63073 (/ISS) P63073 (/ISS) P63074 (/ISS) P63074 (/ISS) P63074 (/ISS) Q9N0T5 (/ISS)
RNA 7-methylguanosine cap binding GO:0000340
Interacting selectively and non-covalently with the 7-methylguanosine group added cotranscriptionally to the 5' end of RNA molecules transcribed by polymerase II.
3 P63073 (/ISO) P63073 (/ISO) P63073 (/ISO)
Translation initiation factor activity GO:0003743
Functions in the initiation of ribosome-mediated translation of mRNA into a polypeptide.
3 P63073 (/ISO) P63073 (/ISO) P63073 (/ISO)
Enzyme binding GO:0019899
Interacting selectively and non-covalently with any enzyme.
3 P63073 (/ISO) P63073 (/ISO) P63073 (/ISO)
Eukaryotic initiation factor 4G binding GO:0031370
Interacting selectively and non-covalently with eukaryotic initiation factor 4G, a polypeptide factor involved in the initiation of ribosome-mediated translation.
3 P63074 (/IPI) P63074 (/IPI) P63074 (/IPI)
Eukaryotic initiation factor 4G binding GO:0031370
Interacting selectively and non-covalently with eukaryotic initiation factor 4G, a polypeptide factor involved in the initiation of ribosome-mediated translation.
3 P63073 (/ISO) P63073 (/ISO) P63073 (/ISO)
Translation regulator activity GO:0045182
Any molecular function involved in the initiation, activation, perpetuation, repression or termination of polypeptide synthesis at the ribosome.
3 P63073 (/IDA) P63073 (/IDA) P63073 (/IDA)
Translation regulator activity GO:0045182
Any molecular function involved in the initiation, activation, perpetuation, repression or termination of polypeptide synthesis at the ribosome.
3 P63073 (/IMP) P63073 (/IMP) P63073 (/IMP)
Repressing transcription factor binding GO:0070491
Interacting selectively and non-covalently with a transcription repressor, any protein whose activity is required to prevent or downregulate transcription.
3 P63073 (/ISO) P63073 (/ISO) P63073 (/ISO)
Translation initiation factor activity GO:0003743
Functions in the initiation of ribosome-mediated translation of mRNA into a polypeptide.
1 Q9DFS6 (/IMP)

There are 21 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Regulation of translation GO:0006417
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA or circRNA.
11 P29338 (/ISS) P48597 (/ISS) P63073 (/ISS) P63073 (/ISS) P63073 (/ISS) P63074 (/ISS) P63074 (/ISS) P63074 (/ISS) Q9DFS6 (/ISS) Q9N0T5 (/ISS)
(1 more)
G1/S transition of mitotic cell cycle GO:0000082
The mitotic cell cycle transition by which a cell in G1 commits to S phase. The process begins with the build up of G1 cyclin-dependent kinase (G1 CDK), resulting in the activation of transcription of G1 cyclins. The process ends with the positive feedback of the G1 cyclins on the G1 CDK which commits the cell to S phase, in which DNA replication is initiated.
10 P06730 (/IMP) P06730 (/IMP) P06730 (/IMP) P06730 (/IMP) P06730 (/IMP) P06730 (/IMP) P06730 (/IMP) P06730 (/IMP) P06730 (/IMP) P06730 (/IMP)
RNA export from nucleus GO:0006405
The directed movement of RNA from the nucleus to the cytoplasm.
10 P06730 (/TAS) P06730 (/TAS) P06730 (/TAS) P06730 (/TAS) P06730 (/TAS) P06730 (/TAS) P06730 (/TAS) P06730 (/TAS) P06730 (/TAS) P06730 (/TAS)
MRNA export from nucleus GO:0006406
The directed movement of mRNA from the nucleus to the cytoplasm.
10 P06730 (/TAS) P06730 (/TAS) P06730 (/TAS) P06730 (/TAS) P06730 (/TAS) P06730 (/TAS) P06730 (/TAS) P06730 (/TAS) P06730 (/TAS) P06730 (/TAS)
Translational initiation GO:0006413
The process preceding formation of the peptide bond between the first two amino acids of a protein. This includes the formation of a complex of the ribosome, mRNA or circRNA, and an initiation complex that contains the first aminoacyl-tRNA.
10 P06730 (/TAS) P06730 (/TAS) P06730 (/TAS) P06730 (/TAS) P06730 (/TAS) P06730 (/TAS) P06730 (/TAS) P06730 (/TAS) P06730 (/TAS) P06730 (/TAS)
Regulation of translation GO:0006417
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA or circRNA.
10 P06730 (/IDA) P06730 (/IDA) P06730 (/IDA) P06730 (/IDA) P06730 (/IDA) P06730 (/IDA) P06730 (/IDA) P06730 (/IDA) P06730 (/IDA) P06730 (/IDA)
Positive regulation of mitotic cell cycle GO:0045931
Any process that activates or increases the rate or extent of progression through the mitotic cell cycle.
10 P06730 (/IMP) P06730 (/IMP) P06730 (/IMP) P06730 (/IMP) P06730 (/IMP) P06730 (/IMP) P06730 (/IMP) P06730 (/IMP) P06730 (/IMP) P06730 (/IMP)
G1/S transition of mitotic cell cycle GO:0000082
The mitotic cell cycle transition by which a cell in G1 commits to S phase. The process begins with the build up of G1 cyclin-dependent kinase (G1 CDK), resulting in the activation of transcription of G1 cyclins. The process ends with the positive feedback of the G1 cyclins on the G1 CDK which commits the cell to S phase, in which DNA replication is initiated.
3 P63073 (/ISO) P63073 (/ISO) P63073 (/ISO)
Behavioral fear response GO:0001662
An acute behavioral change resulting from a perceived external threat.
3 P63073 (/IGI) P63073 (/IGI) P63073 (/IGI)
Regulation of translation GO:0006417
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA or circRNA.
3 P63073 (/ISO) P63073 (/ISO) P63073 (/ISO)
Negative regulation of translation GO:0017148
Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA or circRNA.
3 P63073 (/IMP) P63073 (/IMP) P63073 (/IMP)
Stem cell population maintenance GO:0019827
The process by which an organism or tissue maintains a population of stem cells of a single type. This can be achieved by a number of mechanisms: stem cell asymmetric division maintains stem cell numbers; stem cell symmetric division increases them; maintenance of a stem cell niche maintains the conditions for commitment to the stem cell fate for some types of stem cell; stem cells may arise de novo from other cell types.
3 P63073 (/IGI) P63073 (/IGI) P63073 (/IGI)
Stem cell population maintenance GO:0019827
The process by which an organism or tissue maintains a population of stem cells of a single type. This can be achieved by a number of mechanisms: stem cell asymmetric division maintains stem cell numbers; stem cell symmetric division increases them; maintenance of a stem cell niche maintains the conditions for commitment to the stem cell fate for some types of stem cell; stem cells may arise de novo from other cell types.
3 P63073 (/IMP) P63073 (/IMP) P63073 (/IMP)
Lung development GO:0030324
The process whose specific outcome is the progression of the lung over time, from its formation to the mature structure. In all air-breathing vertebrates the lungs are developed from the ventral wall of the oesophagus as a pouch which divides into two sacs. In amphibians and many reptiles the lungs retain very nearly this primitive sac-like character, but in the higher forms the connection with the esophagus becomes elongated into the windpipe and the inner walls of the sacs become more and more divided, until, in the mammals, the air spaces become minutely divided into tubes ending in small air cells, in the walls of which the blood circulates in a fine network of capillaries. In mammals the lungs are more or less divided into lobes, and each lung occupies a separate cavity in the thorax.
3 P63074 (/IEP) P63074 (/IEP) P63074 (/IEP)
Negative regulation of neuron differentiation GO:0045665
Any process that stops, prevents, or reduces the frequency, rate or extent of neuron differentiation.
3 P63073 (/IMP) P63073 (/IMP) P63073 (/IMP)
Positive regulation of mitotic cell cycle GO:0045931
Any process that activates or increases the rate or extent of progression through the mitotic cell cycle.
3 P63073 (/ISO) P63073 (/ISO) P63073 (/ISO)
Cellular response to dexamethasone stimulus GO:0071549
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a dexamethasone stimulus.
3 P63073 (/IDA) P63073 (/IDA) P63073 (/IDA)
Regulation of translation at postsynapse, modulating synaptic transmission GO:0099578
Any process that modulates synaptic transmission by regulating translation occurring at the postsynapse.
3 P63073 (/IDA) P63073 (/IDA) P63073 (/IDA)
Regulation of translation at postsynapse, modulating synaptic transmission GO:0099578
Any process that modulates synaptic transmission by regulating translation occurring at the postsynapse.
3 P63073 (/IMP) P63073 (/IMP) P63073 (/IMP)
Translational initiation GO:0006413
The process preceding formation of the peptide bond between the first two amino acids of a protein. This includes the formation of a complex of the ribosome, mRNA or circRNA, and an initiation complex that contains the first aminoacyl-tRNA.
1 Q9DFS6 (/IDA)
Translational initiation GO:0006413
The process preceding formation of the peptide bond between the first two amino acids of a protein. This includes the formation of a complex of the ribosome, mRNA or circRNA, and an initiation complex that contains the first aminoacyl-tRNA.
1 Q9DFS6 (/IMP)

There are 39 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Perinuclear region of cytoplasm GO:0048471
Cytoplasm situated near, or occurring around, the nucleus.
279 A0A087QR03 (/ISS) A0A087QR03 (/ISS) A0A087QR03 (/ISS) A0A087QR03 (/ISS) A0A087QR03 (/ISS) A0A087QR03 (/ISS) A0A087QR03 (/ISS) A0A087QR03 (/ISS) A0A087QR03 (/ISS) A0A087QR03 (/ISS)
(269 more)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
273 A0A087QR03 (/ISS) A0A087QR03 (/ISS) A0A087QR03 (/ISS) A0A087QR03 (/ISS) A0A087QR03 (/ISS) A0A087QR03 (/ISS) A0A087QR03 (/ISS) A0A087QR03 (/ISS) A0A087QR03 (/ISS) A0A087QR03 (/ISS)
(263 more)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
17 D6RBW1 (/IDA) P06730 (/IDA) P06730 (/IDA) P06730 (/IDA) P06730 (/IDA) P06730 (/IDA) P06730 (/IDA) P06730 (/IDA) P06730 (/IDA) P06730 (/IDA)
(7 more)
MRNA cap binding complex GO:0005845
Any protein complex that binds to an mRNA cap at any time in the lifetime of the mRNA.
13 P06730 (/IDA) P06730 (/IDA) P06730 (/IDA) P06730 (/IDA) P06730 (/IDA) P06730 (/IDA) P06730 (/IDA) P06730 (/IDA) P06730 (/IDA) P06730 (/IDA)
(3 more)
Eukaryotic translation initiation factor 4F complex GO:0016281
The eukaryotic translation initiation factor 4F complex is composed of eIF4E, eIF4A and eIF4G; it is involved in the recognition of the mRNA cap, ATP-dependent unwinding of the 5'-terminal secondary structure and recruitment of the mRNA to the ribosome.
13 P06730 (/IDA) P06730 (/IDA) P06730 (/IDA) P06730 (/IDA) P06730 (/IDA) P06730 (/IDA) P06730 (/IDA) P06730 (/IDA) P06730 (/IDA) P06730 (/IDA)
(3 more)
Perinuclear region of cytoplasm GO:0048471
Cytoplasm situated near, or occurring around, the nucleus.
13 D6RBW1 (/IDA) P06730 (/IDA) P06730 (/IDA) P06730 (/IDA) P06730 (/IDA) P06730 (/IDA) P06730 (/IDA) P06730 (/IDA) P06730 (/IDA) P06730 (/IDA)
(3 more)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
12 D6RBW1 (/IDA) P06730 (/IDA) P06730 (/IDA) P06730 (/IDA) P06730 (/IDA) P06730 (/IDA) P06730 (/IDA) P06730 (/IDA) P06730 (/IDA) P06730 (/IDA)
(2 more)
Cytoplasmic ribonucleoprotein granule GO:0036464
A ribonucleoprotein granule located in the cytoplasm.
12 D6RBW1 (/IDA) P06730 (/IDA) P06730 (/IDA) P06730 (/IDA) P06730 (/IDA) P06730 (/IDA) P06730 (/IDA) P06730 (/IDA) P06730 (/IDA) P06730 (/IDA)
(2 more)
P-body GO:0000932
A focus in the cytoplasm where mRNAs may become inactivated by decapping or some other mechanism. Protein and RNA localized to these foci are involved in mRNA degradation, nonsense-mediated mRNA decay (NMD), translational repression, and RNA-mediated gene silencing.
10 P06730 (/IDA) P06730 (/IDA) P06730 (/IDA) P06730 (/IDA) P06730 (/IDA) P06730 (/IDA) P06730 (/IDA) P06730 (/IDA) P06730 (/IDA) P06730 (/IDA)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
10 P06730 (/TAS) P06730 (/TAS) P06730 (/TAS) P06730 (/TAS) P06730 (/TAS) P06730 (/TAS) P06730 (/TAS) P06730 (/TAS) P06730 (/TAS) P06730 (/TAS)
Cytoplasmic stress granule GO:0010494
A dense aggregation in the cytosol composed of proteins and RNAs that appear when the cell is under stress.
10 P06730 (/IDA) P06730 (/IDA) P06730 (/IDA) P06730 (/IDA) P06730 (/IDA) P06730 (/IDA) P06730 (/IDA) P06730 (/IDA) P06730 (/IDA) P06730 (/IDA)
Eukaryotic translation initiation factor 4F complex GO:0016281
The eukaryotic translation initiation factor 4F complex is composed of eIF4E, eIF4A and eIF4G; it is involved in the recognition of the mRNA cap, ATP-dependent unwinding of the 5'-terminal secondary structure and recruitment of the mRNA to the ribosome.
10 P06730 (/TAS) P06730 (/TAS) P06730 (/TAS) P06730 (/TAS) P06730 (/TAS) P06730 (/TAS) P06730 (/TAS) P06730 (/TAS) P06730 (/TAS) P06730 (/TAS)
RISC complex GO:0016442
A ribonucleoprotein complex that contains members of the Argonaute family of proteins, small interfering RNAs (siRNAs) or microRNAs (miRNAs), and miRNA or siRNA-complementary mRNAs, in addition to a number of accessory factors. The RISC complex is involved in posttranscriptional repression of gene expression through downregulation of translation or induction of mRNA degradation.
10 P06730 (/IDA) P06730 (/IDA) P06730 (/IDA) P06730 (/IDA) P06730 (/IDA) P06730 (/IDA) P06730 (/IDA) P06730 (/IDA) P06730 (/IDA) P06730 (/IDA)
Extracellular exosome GO:0070062
A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
10 P06730 (/HDA) P06730 (/HDA) P06730 (/HDA) P06730 (/HDA) P06730 (/HDA) P06730 (/HDA) P06730 (/HDA) P06730 (/HDA) P06730 (/HDA) P06730 (/HDA)
MRNA cap binding complex GO:0005845
Any protein complex that binds to an mRNA cap at any time in the lifetime of the mRNA.
9 A6NMX2 (/ISS) P29338 (/ISS) P48597 (/ISS) P63074 (/ISS) P63074 (/ISS) P63074 (/ISS) Q9DFS6 (/ISS) Q9N0T5 (/ISS) Q9PW28 (/ISS)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
8 P29338 (/ISS) P63073 (/ISS) P63073 (/ISS) P63073 (/ISS) P63074 (/ISS) P63074 (/ISS) P63074 (/ISS) Q9N0T5 (/ISS)
Cytoplasmic stress granule GO:0010494
A dense aggregation in the cytosol composed of proteins and RNAs that appear when the cell is under stress.
8 P29338 (/ISS) P63073 (/ISS) P63073 (/ISS) P63073 (/ISS) P63074 (/ISS) P63074 (/ISS) P63074 (/ISS) Q9N0T5 (/ISS)
Eukaryotic translation initiation factor 4F complex GO:0016281
The eukaryotic translation initiation factor 4F complex is composed of eIF4E, eIF4A and eIF4G; it is involved in the recognition of the mRNA cap, ATP-dependent unwinding of the 5'-terminal secondary structure and recruitment of the mRNA to the ribosome.
8 P29338 (/ISS) P48597 (/ISS) P63073 (/ISS) P63073 (/ISS) P63073 (/ISS) Q9DFS6 (/ISS) Q9N0T5 (/ISS) Q9PW28 (/ISS)
Glutamatergic synapse GO:0098978
A synapse that uses glutamate as a neurotransmitter.
6 P63073 (/IDA) P63073 (/IDA) P63073 (/IDA) P63074 (/IDA) P63074 (/IDA) P63074 (/IDA)
P-body GO:0000932
A focus in the cytoplasm where mRNAs may become inactivated by decapping or some other mechanism. Protein and RNA localized to these foci are involved in mRNA degradation, nonsense-mediated mRNA decay (NMD), translational repression, and RNA-mediated gene silencing.
3 P63073 (/ISO) P63073 (/ISO) P63073 (/ISO)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
3 P63073 (/ISO) P63073 (/ISO) P63073 (/ISO)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
3 P63073 (/ISO) P63073 (/ISO) P63073 (/ISO)
MRNA cap binding complex GO:0005845
Any protein complex that binds to an mRNA cap at any time in the lifetime of the mRNA.
3 P63073 (/ISO) P63073 (/ISO) P63073 (/ISO)
Cytoplasmic stress granule GO:0010494
A dense aggregation in the cytosol composed of proteins and RNAs that appear when the cell is under stress.
3 P63073 (/ISO) P63073 (/ISO) P63073 (/ISO)
Eukaryotic translation initiation factor 4F complex GO:0016281
The eukaryotic translation initiation factor 4F complex is composed of eIF4E, eIF4A and eIF4G; it is involved in the recognition of the mRNA cap, ATP-dependent unwinding of the 5'-terminal secondary structure and recruitment of the mRNA to the ribosome.
3 P63073 (/ISO) P63073 (/ISO) P63073 (/ISO)
RISC complex GO:0016442
A ribonucleoprotein complex that contains members of the Argonaute family of proteins, small interfering RNAs (siRNAs) or microRNAs (miRNAs), and miRNA or siRNA-complementary mRNAs, in addition to a number of accessory factors. The RISC complex is involved in posttranscriptional repression of gene expression through downregulation of translation or induction of mRNA degradation.
3 P63073 (/ISO) P63073 (/ISO) P63073 (/ISO)
Protein-containing complex GO:0032991
A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together.
3 P63074 (/IDA) P63074 (/IDA) P63074 (/IDA)
Protein-containing complex GO:0032991
A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together.
3 P63073 (/ISO) P63073 (/ISO) P63073 (/ISO)
Chromatoid body GO:0033391
A ribonucleoprotein complex found in the cytoplasm of male germ cells, composed of exceedingly thin filaments that are consolidated into a compact mass or into dense strands of varying thickness that branch to form an irregular network. Contains mRNAs, miRNAs, and protein components involved in miRNA processing (such as Argonaute proteins and the endonuclease Dicer) and in RNA decay (such as the decapping enzyme DCP1a and GW182).
3 P63073 (/IDA) P63073 (/IDA) P63073 (/IDA)
Cytoplasmic ribonucleoprotein granule GO:0036464
A ribonucleoprotein granule located in the cytoplasm.
3 P63073 (/ISO) P63073 (/ISO) P63073 (/ISO)
Perinuclear region of cytoplasm GO:0048471
Cytoplasm situated near, or occurring around, the nucleus.
3 P63073 (/ISO) P63073 (/ISO) P63073 (/ISO)
Postsynapse GO:0098794
The part of a synapse that is part of the post-synaptic cell.
3 P63074 (/IDA) P63074 (/IDA) P63074 (/IDA)
Postsynapse GO:0098794
The part of a synapse that is part of the post-synaptic cell.
3 P63073 (/ISO) P63073 (/ISO) P63073 (/ISO)
Glutamatergic synapse GO:0098978
A synapse that uses glutamate as a neurotransmitter.
3 P63073 (/IMP) P63073 (/IMP) P63073 (/IMP)
Glutamatergic synapse GO:0098978
A synapse that uses glutamate as a neurotransmitter.
3 P63073 (/ISO) P63073 (/ISO) P63073 (/ISO)
Postsynaptic cytosol GO:0099524
The region of the cytosol consisting of all cytosol that is part of the postsynapse.
3 P63074 (/IDA) P63074 (/IDA) P63074 (/IDA)
Postsynaptic cytosol GO:0099524
The region of the cytosol consisting of all cytosol that is part of the postsynapse.
3 P63073 (/ISO) P63073 (/ISO) P63073 (/ISO)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
1 Q9DFS6 (/IDA)
Protein-containing complex GO:0032991
A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together.
1 P48597 (/IPI)
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