The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
RNA Cap, Translation Initiation Factor Eif4e
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 14: Eukaryotic translation initiation factor 4E-4

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 3 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
RNA 7-methylguanosine cap binding GO:0000340
Interacting selectively and non-covalently with the 7-methylguanosine group added cotranscriptionally to the 5' end of RNA molecules transcribed by polymerase II.
5 A0A0B4JDB9 (/IDA) C1C3I0 (/IDA) E1JIV5 (/IDA) Q22888 (/IDA) Q8T3K5 (/IDA)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
4 A0A0B4JDB9 (/IPI) C1C3I0 (/IPI) E1JIV5 (/IPI) Q8T3K5 (/IPI)
Translation repressor activity GO:0030371
Antagonizes ribosome-mediated translation of mRNA into a polypeptide.
4 A0A0B4JDB9 (/IGI) C1C3I0 (/IGI) E1JIV5 (/IGI) Q8T3K5 (/IGI)

There are 2 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Negative regulation of translation GO:0017148
Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA or circRNA.
4 A0A0B4JDB9 (/IGI) C1C3I0 (/IGI) E1JIV5 (/IGI) Q8T3K5 (/IGI)
Positive regulation of ecdysteroid biosynthetic process GO:0045998
Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of ecdysteroids.
4 A0A0B4JDB9 (/IMP) C1C3I0 (/IMP) E1JIV5 (/IMP) Q8T3K5 (/IMP)

There are 0 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
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