The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
RNA Cap, Translation Initiation Factor Eif4e
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 10: Eukaryotic translation initiation factor 4E1

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 11 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
RNA cap binding GO:0000339
Interacting selectively and non-covalently with a 7-methylguanosine (m7G) group or derivative located at the 5' end of an RNA molecule.
7 P48598 (/ISS) P48598 (/ISS) Q8MZD6 (/ISS) Q9VRY0 (/ISS) Q9VSB6 (/ISS) Q9VSG1 (/ISS) Q9W5B3 (/ISS)
RNA 7-methylguanosine cap binding GO:0000340
Interacting selectively and non-covalently with the 7-methylguanosine group added cotranscriptionally to the 5' end of RNA molecules transcribed by polymerase II.
7 P48598 (/IDA) P48598 (/IDA) Q8MZD6 (/IDA) Q9VRY0 (/IDA) Q9VSB6 (/IDA) Q9VSG1 (/IDA) Q9W5B3 (/IDA)
Translation initiation factor activity GO:0003743
Functions in the initiation of ribosome-mediated translation of mRNA into a polypeptide.
7 P48598 (/ISS) P48598 (/ISS) Q8MZD6 (/ISS) Q9VRY0 (/ISS) Q9VSB6 (/ISS) Q9VSG1 (/ISS) Q9W5B3 (/ISS)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
7 P48598 (/IPI) P48598 (/IPI) Q8MZD6 (/IPI) Q9VRY0 (/IPI) Q9VSB6 (/IPI) Q9VSG1 (/IPI) Q9W5B3 (/IPI)
Eukaryotic initiation factor 4G binding GO:0031370
Interacting selectively and non-covalently with eukaryotic initiation factor 4G, a polypeptide factor involved in the initiation of ribosome-mediated translation.
7 P48598 (/IPI) P48598 (/IPI) Q8MZD6 (/IPI) Q9VRY0 (/IPI) Q9VSB6 (/IPI) Q9VSG1 (/IPI) Q9W5B3 (/IPI)
Translation initiation factor activity GO:0003743
Functions in the initiation of ribosome-mediated translation of mRNA into a polypeptide.
6 P48598 (/IGI) P48598 (/IGI) Q8MZD6 (/IGI) Q9VRY0 (/IGI) Q9VSB6 (/IGI) Q9W5B3 (/IGI)
RNA cap binding GO:0000339
Interacting selectively and non-covalently with a 7-methylguanosine (m7G) group or derivative located at the 5' end of an RNA molecule.
2 P48598 (/IDA) P48598 (/IDA)
Translation initiation factor activity GO:0003743
Functions in the initiation of ribosome-mediated translation of mRNA into a polypeptide.
2 P48598 (/IDA) P48598 (/IDA)
Translation regulator activity GO:0045182
Any molecular function involved in the initiation, activation, perpetuation, repression or termination of polypeptide synthesis at the ribosome.
2 P48598 (/IDA) P48598 (/IDA)
Translation regulator activity GO:0045182
Any molecular function involved in the initiation, activation, perpetuation, repression or termination of polypeptide synthesis at the ribosome.
2 P48598 (/IMP) P48598 (/IMP)
Translation initiation factor binding GO:0031369
Interacting selectively and non-covalently with a translation initiation factor, any polypeptide factor involved in the initiation of ribosome-mediated translation.
1 Q9VSG1 (/ISS)

There are 23 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Translational initiation GO:0006413
The process preceding formation of the peptide bond between the first two amino acids of a protein. This includes the formation of a complex of the ribosome, mRNA or circRNA, and an initiation complex that contains the first aminoacyl-tRNA.
6 P48598 (/IGI) P48598 (/IGI) Q8MZD6 (/IGI) Q9VRY0 (/IGI) Q9VSB6 (/IGI) Q9W5B3 (/IGI)
Male meiosis chromosome segregation GO:0007060
The cell cycle process in which genetic material, in the form of chromosomes, is organized and then physically separated and apportioned to two or more sets during the meiotic cell cycle in a male.
3 P48598 (/IMP) P48598 (/IMP) Q9VSG1 (/IMP)
Male meiosis cytokinesis GO:0007112
A cell cycle process that occurs as part of the male meiotic cell cycle and results in the division of the cytoplasm of a cell to produce two daughter cells.
3 P48598 (/IMP) P48598 (/IMP) Q9VSG1 (/IMP)
Meiotic chromosome condensation GO:0010032
Compaction of chromatin structure prior to meiosis in eukaryotic cells.
3 P48598 (/IMP) P48598 (/IMP) Q9VSG1 (/IMP)
Spermatocyte division GO:0048137
The meiotic divisions undergone by the primary and secondary spermatocytes to produce haploid spermatids.
3 P48598 (/IMP) P48598 (/IMP) Q9VSG1 (/IMP)
Spermatid differentiation GO:0048515
The process whose specific outcome is the progression of a spermatid over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell.
3 P48598 (/IMP) P48598 (/IMP) Q9VSG1 (/IMP)
Mitotic cell cycle GO:0000278
Progression through the phases of the mitotic cell cycle, the most common eukaryotic cell cycle, which canonically comprises four successive phases called G1, S, G2, and M and includes replication of the genome and the subsequent segregation of chromosomes into daughter cells. In some variant cell cycles nuclear replication or nuclear division may not be followed by cell division, or G1 and G2 phases may be absent.
2 P48598 (/HMP) P48598 (/HMP)
Regulation of cell growth GO:0001558
Any process that modulates the frequency, rate, extent or direction of cell growth.
2 P48598 (/IMP) P48598 (/IMP)
Cap-dependent translational initiation GO:0002191
The process where the \Cap structure\ (composed of a 7- methylguanosine (m7G) group and associated cap-binding proteins) located at the 5' end of an mRNA molecule, which serves as a \molecular tag\ that marks the spot where the 40S ribosomal subunit is recruited and will then scan in a 5' to 3' direction until an AUG codon is encountered in an appropriate sequence context to initiate mRNA translation.
2 P48598 (/IMP) P48598 (/IMP)
Chromatin organization GO:0006325
Any process that results in the specification, formation or maintenance of the physical structure of eukaryotic chromatin.
2 P48598 (/HMP) P48598 (/HMP)
Translation GO:0006412
The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome.
2 P48598 (/IDA) P48598 (/IDA)
Translation GO:0006412
The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome.
2 P48598 (/ISS) P48598 (/ISS)
Translational initiation GO:0006413
The process preceding formation of the peptide bond between the first two amino acids of a protein. This includes the formation of a complex of the ribosome, mRNA or circRNA, and an initiation complex that contains the first aminoacyl-tRNA.
2 P48598 (/IDA) P48598 (/IDA)
Mitotic chromosome condensation GO:0007076
The cell cycle process in which chromatin structure is compacted prior to and during mitosis in eukaryotic cells.
2 P48598 (/HMP) P48598 (/HMP)
RNA metabolic process GO:0016070
The cellular chemical reactions and pathways involving RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage.
2 P48598 (/IDA) P48598 (/IDA)
Female meiosis chromosome segregation GO:0016321
The cell cycle process in which genetic material, in the form of chromosomes, is organized and then physically separated and apportioned to two or more sets during the meiotic cell cycle in a female.
2 P48598 (/HMP) P48598 (/HMP)
Positive regulation of cell growth GO:0030307
Any process that activates or increases the frequency, rate, extent or direction of cell growth.
2 P48598 (/TAS) P48598 (/TAS)
Regulation of embryonic development GO:0045995
Any process that modulates the frequency, rate or extent of embryonic development.
2 P48598 (/IMP) P48598 (/IMP)
Male germ-line cyst formation GO:0048136
Formation of a group of interconnected cells derived from a single male gonial founder cell.
2 P48598 (/IMP) P48598 (/IMP)
Regulation of translation at postsynapse, modulating synaptic transmission GO:0099578
Any process that modulates synaptic transmission by regulating translation occurring at the postsynapse.
2 P48598 (/IDA) P48598 (/IDA)
Regulation of translation at postsynapse, modulating synaptic transmission GO:0099578
Any process that modulates synaptic transmission by regulating translation occurring at the postsynapse.
2 P48598 (/IMP) P48598 (/IMP)
Spermatogenesis GO:0007283
The process of formation of spermatozoa, including spermatocytogenesis and spermiogenesis.
1 Q9VSG1 (/IMP)
Positive regulation of translation GO:0045727
Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA or circRNA.
1 Q9VSG1 (/IMP)

There are 16 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Eukaryotic translation initiation factor 4F complex GO:0016281
The eukaryotic translation initiation factor 4F complex is composed of eIF4E, eIF4A and eIF4G; it is involved in the recognition of the mRNA cap, ATP-dependent unwinding of the 5'-terminal secondary structure and recruitment of the mRNA to the ribosome.
7 P48598 (/IPI) P48598 (/IPI) Q8MZD6 (/IPI) Q9VRY0 (/IPI) Q9VSB6 (/IPI) Q9VSG1 (/IPI) Q9W5B3 (/IPI)
Eukaryotic translation initiation factor 4F complex GO:0016281
The eukaryotic translation initiation factor 4F complex is composed of eIF4E, eIF4A and eIF4G; it is involved in the recognition of the mRNA cap, ATP-dependent unwinding of the 5'-terminal secondary structure and recruitment of the mRNA to the ribosome.
7 P48598 (/ISS) P48598 (/ISS) Q8MZD6 (/ISS) Q9VRY0 (/ISS) Q9VSB6 (/ISS) Q9VSG1 (/ISS) Q9W5B3 (/ISS)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
3 P48598 (/IDA) P48598 (/IDA) Q9VSG1 (/IDA)
P-body GO:0000932
A focus in the cytoplasm where mRNAs may become inactivated by decapping or some other mechanism. Protein and RNA localized to these foci are involved in mRNA degradation, nonsense-mediated mRNA decay (NMD), translational repression, and RNA-mediated gene silencing.
2 P48598 (/IDA) P48598 (/IDA)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
2 P48598 (/HDA) P48598 (/HDA)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
2 P48598 (/ISS) P48598 (/ISS)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
2 P48598 (/TAS) P48598 (/TAS)
MRNA cap binding complex GO:0005845
Any protein complex that binds to an mRNA cap at any time in the lifetime of the mRNA.
2 P48598 (/ISS) P48598 (/ISS)
Eukaryotic translation initiation factor 4F complex GO:0016281
The eukaryotic translation initiation factor 4F complex is composed of eIF4E, eIF4A and eIF4G; it is involved in the recognition of the mRNA cap, ATP-dependent unwinding of the 5'-terminal secondary structure and recruitment of the mRNA to the ribosome.
2 P48598 (/IDA) P48598 (/IDA)
Eukaryotic translation initiation factor 4F complex GO:0016281
The eukaryotic translation initiation factor 4F complex is composed of eIF4E, eIF4A and eIF4G; it is involved in the recognition of the mRNA cap, ATP-dependent unwinding of the 5'-terminal secondary structure and recruitment of the mRNA to the ribosome.
2 P48598 (/NAS) P48598 (/NAS)
Neuromuscular junction GO:0031594
The junction between the axon of a motor neuron and a muscle fiber. In response to the arrival of action potentials, the presynaptic button releases molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane of the muscle fiber, leading to a change in post-synaptic potential.
2 P48598 (/IDA) P48598 (/IDA)
Neuromuscular junction GO:0031594
The junction between the axon of a motor neuron and a muscle fiber. In response to the arrival of action potentials, the presynaptic button releases molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane of the muscle fiber, leading to a change in post-synaptic potential.
2 P48598 (/IMP) P48598 (/IMP)
Neuronal ribonucleoprotein granule GO:0071598
A ribonucleoprotein complex that is found in the cytoplasm of axons and dendrites, and transports translationally silenced mRNAs to dendritic synapses, where they are released and translated in response to specific exogenous stimuli.
2 P48598 (/IDA) P48598 (/IDA)
Muscle cell postsynaptic specialization GO:0097482
A postsynaptic specialization that is part of a neuromuscular junction.
2 P48598 (/IDA) P48598 (/IDA)
Postsynapse GO:0098794
The part of a synapse that is part of the post-synaptic cell.
2 P48598 (/IDA) P48598 (/IDA)
Messenger ribonucleoprotein complex GO:1990124
A ribonucleoprotein complex containing both protein and messenger RNA (mRNA) molecules.
2 P48598 (/IDA) P48598 (/IDA)
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