The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Potassium Channel Kv1.1; Chain A
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 13: BTB/POZ domain-containing adapter for CUL3-mediate...

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 11 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
23 Q13829 (/IPI) Q13829 (/IPI) Q13829 (/IPI) Q13829 (/IPI) Q13829 (/IPI) Q13829 (/IPI) Q13829 (/IPI) Q13829 (/IPI) Q13829 (/IPI) Q13829 (/IPI)
(13 more)
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
18 Q13829 (/IPI) Q13829 (/IPI) Q13829 (/IPI) Q13829 (/IPI) Q13829 (/IPI) Q13829 (/IPI) Q13829 (/IPI) Q13829 (/IPI) Q13829 (/IPI) Q13829 (/IPI)
(8 more)
GTP-Rho binding GO:0017049
Interacting selectively and non-covalently with the GTP-bound form of the Rho protein.
16 Q13829 (/IDA) Q13829 (/IDA) Q13829 (/IDA) Q13829 (/IDA) Q13829 (/IDA) Q13829 (/IDA) Q13829 (/IDA) Q13829 (/IDA) Q13829 (/IDA) Q13829 (/IDA)
(6 more)
GTP-Rho binding GO:0017049
Interacting selectively and non-covalently with the GTP-bound form of the Rho protein.
9 O70479 (/ISS) Q28DC9 (/ISS) Q2T9W0 (/ISS) Q5EAX2 (/ISS) Q5F3E8 (/ISS) Q5RBH4 (/ISS) Q5RBH4 (/ISS) Q7TNY1 (/ISS) Q8BGV7 (/ISS)
Notch binding GO:0005112
Interacting selectively and non-covalently with the Notch (N) protein, a surface receptor.
3 Q9H3F6 (/IPI) Q9H3F6 (/IPI) Q9H3F6 (/IPI)
GTP-Rho binding GO:0017049
Interacting selectively and non-covalently with the GTP-bound form of the Rho protein.
2 O70479 (/ISO) Q8BGV7 (/ISO)
Protein domain specific binding GO:0019904
Interacting selectively and non-covalently with a specific domain of a protein.
2 Q7TNY1 (/IPI) Q7TQ24 (/IPI)
Protein domain specific binding GO:0019904
Interacting selectively and non-covalently with a specific domain of a protein.
2 O70479 (/ISO) Q8BGV7 (/ISO)
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
2 O70479 (/ISO) Q8BGV7 (/ISO)
Transcription corepressor activity GO:0003714
A protein or a member of a complex that interacts specifically and non-covalently with a DNA-bound DNA-binding transcription factor to repress the transcription of specific genes. Corepressors often act by altering chromatin structure and modifications. For example, one class of transcription coregulators modifies chromatin structure through covalent modification of histones. A second ATP-dependent class modifies the conformation of chromatin. A third class occludes DNA-binding transcription factor protein-protein interaction domains. A fourth class of corepressors prevents interactions of DNA bound DNA-binding transcription factor with coactivators.
1 Q6P7X5 (/IPI)
Notch binding GO:0005112
Interacting selectively and non-covalently with the Notch (N) protein, a surface receptor.
1 Q922M3 (/ISO)

There are 44 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
DNA replication GO:0006260
The cellular metabolic process in which a cell duplicates one or more molecules of DNA. DNA replication begins when specific sequences, known as origins of replication, are recognized and bound by initiation proteins, and ends when the original DNA molecule has been completely duplicated and the copies topologically separated. The unit of replication usually corresponds to the genome of the cell, an organelle, or a virus. The template for replication can either be an existing DNA molecule or RNA.
22 O70479 (/ISS) Q13829 (/ISS) Q13829 (/ISS) Q13829 (/ISS) Q13829 (/ISS) Q13829 (/ISS) Q13829 (/ISS) Q13829 (/ISS) Q13829 (/ISS) Q13829 (/ISS)
(12 more)
Negative regulation of Rho protein signal transduction GO:0035024
Any process that stops, prevents, or reduces the frequency, rate or extent of Rho protein signal transduction.
17 Q13829 (/IMP) Q13829 (/IMP) Q13829 (/IMP) Q13829 (/IMP) Q13829 (/IMP) Q13829 (/IMP) Q13829 (/IMP) Q13829 (/IMP) Q13829 (/IMP) Q13829 (/IMP)
(7 more)
Cell migration GO:0016477
The controlled self-propelled movement of a cell from one site to a destination guided by molecular cues. Cell migration is a central process in the development and maintenance of multicellular organisms.
16 Q13829 (/IMP) Q13829 (/IMP) Q13829 (/IMP) Q13829 (/IMP) Q13829 (/IMP) Q13829 (/IMP) Q13829 (/IMP) Q13829 (/IMP) Q13829 (/IMP) Q13829 (/IMP)
(6 more)
Protein ubiquitination GO:0016567
The process in which one or more ubiquitin groups are added to a protein.
16 Q13829 (/IDA) Q13829 (/IDA) Q13829 (/IDA) Q13829 (/IDA) Q13829 (/IDA) Q13829 (/IDA) Q13829 (/IDA) Q13829 (/IDA) Q13829 (/IDA) Q13829 (/IDA)
(6 more)
Stress fiber assembly GO:0043149
The aggregation, arrangement and bonding together of a set of components to form a stress fiber. A stress fiber is a contractile actin filament bundle that consists of short actin filaments with alternating polarity.
16 Q13829 (/IMP) Q13829 (/IMP) Q13829 (/IMP) Q13829 (/IMP) Q13829 (/IMP) Q13829 (/IMP) Q13829 (/IMP) Q13829 (/IMP) Q13829 (/IMP) Q13829 (/IMP)
(6 more)
Proteasome-mediated ubiquitin-dependent protein catabolic process GO:0043161
The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome.
16 Q13829 (/IDA) Q13829 (/IDA) Q13829 (/IDA) Q13829 (/IDA) Q13829 (/IDA) Q13829 (/IDA) Q13829 (/IDA) Q13829 (/IDA) Q13829 (/IDA) Q13829 (/IDA)
(6 more)
Protein ubiquitination GO:0016567
The process in which one or more ubiquitin groups are added to a protein.
14 O70479 (/ISS) Q28DC9 (/ISS) Q2T9W0 (/ISS) Q5EAX2 (/ISS) Q5F3E8 (/ISS) Q5RBH4 (/ISS) Q5RBH4 (/ISS) Q7TNY1 (/ISS) Q7TPL3 (/ISS) Q8BGV7 (/ISS)
(4 more)
Proteasome-mediated ubiquitin-dependent protein catabolic process GO:0043161
The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome.
14 O70479 (/ISS) Q28DC9 (/ISS) Q2T9W0 (/ISS) Q5EAX2 (/ISS) Q5F3E8 (/ISS) Q5RBH4 (/ISS) Q5RBH4 (/ISS) Q7TNY1 (/ISS) Q7TPL3 (/ISS) Q8BGV7 (/ISS)
(4 more)
Apoptotic process GO:0006915
A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died.
13 Q13829 (/TAS) Q13829 (/TAS) Q13829 (/TAS) Q13829 (/TAS) Q13829 (/TAS) Q13829 (/TAS) Q13829 (/TAS) Q13829 (/TAS) Q13829 (/TAS) Q13829 (/TAS)
(3 more)
Immune response GO:0006955
Any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat.
13 Q13829 (/IEP) Q13829 (/IEP) Q13829 (/IEP) Q13829 (/IEP) Q13829 (/IEP) Q13829 (/IEP) Q13829 (/IEP) Q13829 (/IEP) Q13829 (/IEP) Q13829 (/IEP)
(3 more)
Negative regulation of Rho protein signal transduction GO:0035024
Any process that stops, prevents, or reduces the frequency, rate or extent of Rho protein signal transduction.
12 O70479 (/ISS) Q28DC9 (/ISS) Q2T9W0 (/ISS) Q5EAX2 (/ISS) Q5F3E8 (/ISS) Q5RBH4 (/ISS) Q5RBH4 (/ISS) Q7TNY1 (/ISS) Q8BGV7 (/ISS) Q8WZ19 (/ISS)
(2 more)
Cell migration GO:0016477
The controlled self-propelled movement of a cell from one site to a destination guided by molecular cues. Cell migration is a central process in the development and maintenance of multicellular organisms.
9 O70479 (/ISS) Q28DC9 (/ISS) Q2T9W0 (/ISS) Q5EAX2 (/ISS) Q5F3E8 (/ISS) Q5RBH4 (/ISS) Q5RBH4 (/ISS) Q7TNY1 (/ISS) Q8BGV7 (/ISS)
Stress fiber assembly GO:0043149
The aggregation, arrangement and bonding together of a set of components to form a stress fiber. A stress fiber is a contractile actin filament bundle that consists of short actin filaments with alternating polarity.
9 O70479 (/ISS) Q28DC9 (/ISS) Q2T9W0 (/ISS) Q5EAX2 (/ISS) Q5F3E8 (/ISS) Q5RBH4 (/ISS) Q5RBH4 (/ISS) Q7TNY1 (/ISS) Q8BGV7 (/ISS)
Immune response GO:0006955
Any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat.
7 O70479 (/ISS) Q28DC9 (/ISS) Q5EAX2 (/ISS) Q5F3E8 (/ISS) Q5RBH4 (/ISS) Q5RBH4 (/ISS) Q7TNY1 (/ISS)
Positive regulation of synaptic transmission GO:0050806
Any process that activates or increases the frequency, rate or extent of synaptic transmission, the process of communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse.
4 Q2T9W0 (/ISS) Q8WZ19 (/ISS) Q8WZ19 (/ISS) Q8WZ19 (/ISS)
Ubiquitin-dependent protein catabolic process GO:0006511
The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the protein.
3 Q9H3F6 (/IDA) Q9H3F6 (/IDA) Q9H3F6 (/IDA)
DNA replication GO:0006260
The cellular metabolic process in which a cell duplicates one or more molecules of DNA. DNA replication begins when specific sequences, known as origins of replication, are recognized and bound by initiation proteins, and ends when the original DNA molecule has been completely duplicated and the copies topologically separated. The unit of replication usually corresponds to the genome of the cell, an organelle, or a virus. The template for replication can either be an existing DNA molecule or RNA.
2 Q7TNY1 (/IDA) Q7TQ24 (/IDA)
DNA replication GO:0006260
The cellular metabolic process in which a cell duplicates one or more molecules of DNA. DNA replication begins when specific sequences, known as origins of replication, are recognized and bound by initiation proteins, and ends when the original DNA molecule has been completely duplicated and the copies topologically separated. The unit of replication usually corresponds to the genome of the cell, an organelle, or a virus. The template for replication can either be an existing DNA molecule or RNA.
2 O70479 (/ISO) Q8BGV7 (/ISO)
DNA repair GO:0006281
The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway.
2 Q7TNY1 (/TAS) Q7TQ24 (/TAS)
Regulation of transcription, DNA-templated GO:0006355
Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
2 Q7TNY1 (/TAS) Q7TQ24 (/TAS)
Heart development GO:0007507
The process whose specific outcome is the progression of the heart over time, from its formation to the mature structure. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood.
2 Q6P7X5 (/IMP) Q922M3 (/IMP)
Cell migration GO:0016477
The controlled self-propelled movement of a cell from one site to a destination guided by molecular cues. Cell migration is a central process in the development and maintenance of multicellular organisms.
2 O70479 (/ISO) Q8BGV7 (/ISO)
Protein ubiquitination GO:0016567
The process in which one or more ubiquitin groups are added to a protein.
2 O70479 (/ISO) Q8BGV7 (/ISO)
Actin cytoskeleton organization GO:0030036
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins.
2 Q7TNY1 (/TAS) Q7TQ24 (/TAS)
Negative regulation of Rho protein signal transduction GO:0035024
Any process that stops, prevents, or reduces the frequency, rate or extent of Rho protein signal transduction.
2 O70479 (/ISO) Q8BGV7 (/ISO)
Stress fiber assembly GO:0043149
The aggregation, arrangement and bonding together of a set of components to form a stress fiber. A stress fiber is a contractile actin filament bundle that consists of short actin filaments with alternating polarity.
2 O70479 (/ISO) Q8BGV7 (/ISO)
Proteasome-mediated ubiquitin-dependent protein catabolic process GO:0043161
The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome.
2 O70479 (/ISO) Q8BGV7 (/ISO)
Positive regulation of DNA replication GO:0045740
Any process that activates or increases the frequency, rate or extent of DNA replication.
2 Q7TNY1 (/IDA) Q7TQ24 (/IDA)
Positive regulation of DNA replication GO:0045740
Any process that activates or increases the frequency, rate or extent of DNA replication.
2 O70479 (/ISO) Q8BGV7 (/ISO)
Protein homooligomerization GO:0051260
The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of identical component monomers. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer.
2 Q7TNY1 (/TAS) Q7TQ24 (/TAS)
Protein heterooligomerization GO:0051291
The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of component monomers that are not all identical. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer.
2 Q7TNY1 (/TAS) Q7TQ24 (/TAS)
Angiogenesis GO:0001525
Blood vessel formation when new vessels emerge from the proliferation of pre-existing blood vessels.
1 Q922M3 (/IMP)
Heart looping GO:0001947
The tube morphogenesis process in which the primitive heart tube loops asymmetrically. This looping brings the primitive heart chambers into alignment preceding their future integration. Heart looping begins with dextral-looping and ends when the main regional divisions of the mature heart and primordium of the great arterial trunks become established preceeding septation.
1 Q6P7X5 (/IGI)
Heart looping GO:0001947
The tube morphogenesis process in which the primitive heart tube loops asymmetrically. This looping brings the primitive heart chambers into alignment preceding their future integration. Heart looping begins with dextral-looping and ends when the main regional divisions of the mature heart and primordium of the great arterial trunks become established preceeding septation.
1 Q6P7X5 (/IMP)
Sprouting angiogenesis GO:0002040
The extension of new blood vessels from existing vessels into avascular tissues, this process includes the specialization of endothelial cells into leading tip and stalk cells, proliferation and migration of the endothelial cells and cell adhesion resulting in angiogenic sprout fusion or lumen formation.
1 Q6P7X5 (/IMP)
Endocardium development GO:0003157
The process whose specific outcome is the progression of the endocardium over time, from its formation to the mature structure. The endocardium is an anatomical structure comprised of an endothelium and an extracellular matrix that forms the innermost layer of tissue of the heart, and lines the heart chambers.
1 Q6P7X5 (/IMP)
Ubiquitin-dependent protein catabolic process GO:0006511
The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the protein.
1 Q922M3 (/ISO)
Pectoral fin development GO:0033339
The process whose specific outcome is the progression of the pectoral fin over time, from its formation to the mature structure.
1 Q6P7X5 (/IMP)
Atrioventricular canal development GO:0036302
The progression of the atrioventricular canal over time, from its formation to the mature structure. The atrioventricular canal is the part of the heart connecting the atrium to the cardiac ventricle.
1 Q6P7X5 (/IGI)
Atrioventricular canal development GO:0036302
The progression of the atrioventricular canal over time, from its formation to the mature structure. The atrioventricular canal is the part of the heart connecting the atrium to the cardiac ventricle.
1 Q6P7X5 (/IMP)
Negative regulation of DNA-binding transcription factor activity GO:0043433
Any process that stops, prevents, or reduces the frequency, rate or extent of the activity of a transcription factor, any factor involved in the initiation or regulation of transcription.
1 Q6P7X5 (/IDA)
Negative regulation of Notch signaling pathway GO:0045746
Any process that stops, prevents, or reduces the frequency, rate or extent of the Notch signaling pathway.
1 Q922M3 (/IMP)
Positive regulation of synaptic transmission GO:0050806
Any process that activates or increases the frequency, rate or extent of synaptic transmission, the process of communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse.
1 Q8BGV7 (/IMP)
Regulation of hyaluronan biosynthetic process GO:1900125
Any process that modulates the frequency, rate or extent of hyaluronan biosynthetic process.
1 Q6P7X5 (/IMP)

There are 21 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Cul3-RING ubiquitin ligase complex GO:0031463
A ubiquitin ligase complex in which a cullin from the Cul3 subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by a BTB-domain-containing protein.
16 Q13829 (/IDA) Q13829 (/IDA) Q13829 (/IDA) Q13829 (/IDA) Q13829 (/IDA) Q13829 (/IDA) Q13829 (/IDA) Q13829 (/IDA) Q13829 (/IDA) Q13829 (/IDA)
(6 more)
Cul3-RING ubiquitin ligase complex GO:0031463
A ubiquitin ligase complex in which a cullin from the Cul3 subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by a BTB-domain-containing protein.
14 O70479 (/ISS) Q28DC9 (/ISS) Q2T9W0 (/ISS) Q5EAX2 (/ISS) Q5F3E8 (/ISS) Q5RBH4 (/ISS) Q5RBH4 (/ISS) Q7TNY1 (/ISS) Q7TPL3 (/ISS) Q8BGV7 (/ISS)
(4 more)
Nucleolus GO:0005730
A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.
13 Q13829 (/IDA) Q13829 (/IDA) Q13829 (/IDA) Q13829 (/IDA) Q13829 (/IDA) Q13829 (/IDA) Q13829 (/IDA) Q13829 (/IDA) Q13829 (/IDA) Q13829 (/IDA)
(3 more)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
13 Q13829 (/IDA) Q13829 (/IDA) Q13829 (/IDA) Q13829 (/IDA) Q13829 (/IDA) Q13829 (/IDA) Q13829 (/IDA) Q13829 (/IDA) Q13829 (/IDA) Q13829 (/IDA)
(3 more)
Endosome GO:0005768
A vacuole to which materials ingested by endocytosis are delivered.
13 Q13829 (/IDA) Q13829 (/IDA) Q13829 (/IDA) Q13829 (/IDA) Q13829 (/IDA) Q13829 (/IDA) Q13829 (/IDA) Q13829 (/IDA) Q13829 (/IDA) Q13829 (/IDA)
(3 more)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
7 A0A024RBJ2 (/IDA) A0A024RBJ2 (/IDA) A0A024RBJ2 (/IDA) F5GWA4 (/IDA) Q9H3F6 (/IDA) Q9H3F6 (/IDA) Q9H3F6 (/IDA)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
7 O70479 (/ISS) Q28DC9 (/ISS) Q5EAX2 (/ISS) Q5F3E8 (/ISS) Q5RBH4 (/ISS) Q5RBH4 (/ISS) Q7TNY1 (/ISS)
Endosome GO:0005768
A vacuole to which materials ingested by endocytosis are delivered.
7 O70479 (/ISS) Q28DC9 (/ISS) Q5EAX2 (/ISS) Q5F3E8 (/ISS) Q5RBH4 (/ISS) Q5RBH4 (/ISS) Q7TNY1 (/ISS)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
7 A0A024RBJ2 (/IDA) A0A024RBJ2 (/IDA) A0A024RBJ2 (/IDA) F5GWA4 (/IDA) Q9H3F6 (/IDA) Q9H3F6 (/IDA) Q9H3F6 (/IDA)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
3 Q8WZ19 (/IDA) Q8WZ19 (/IDA) Q8WZ19 (/IDA)
Nuclear body GO:0016604
Extra-nucleolar nuclear domains usually visualized by confocal microscopy and fluorescent antibodies to specific proteins.
3 Q8WZ19 (/IDA) Q8WZ19 (/IDA) Q8WZ19 (/IDA)
Cul3-RING ubiquitin ligase complex GO:0031463
A ubiquitin ligase complex in which a cullin from the Cul3 subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by a BTB-domain-containing protein.
2 O70479 (/ISO) Q8BGV7 (/ISO)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
1 Q8BGV7 (/ISO)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
1 Q922M3 (/ISO)
Nucleolus GO:0005730
A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.
1 O70479 (/ISO)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
1 O70479 (/ISO)
Endosome GO:0005768
A vacuole to which materials ingested by endocytosis are delivered.
1 O70479 (/ISO)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
1 Q922M3 (/ISO)
Nuclear body GO:0016604
Extra-nucleolar nuclear domains usually visualized by confocal microscopy and fluorescent antibodies to specific proteins.
1 Q8BGV7 (/ISO)
MKS complex GO:0036038
A protein complex that is located at the ciliary transition zone and consists of several proteins some of which are membrane bound. Acts as an organiser of transition zone inner structure, specifically the Y-shaped links, in conjunction with the NPHP complex. The MKS complex also acts as part of the selective barrier that prevents diffusion of proteins between the ciliary cytoplasm and cellular cytoplasm as well as between the ciliary membrane and plasma membrane.
1 Q922M3 (/IDA)
MKS complex GO:0036038
A protein complex that is located at the ciliary transition zone and consists of several proteins some of which are membrane bound. Acts as an organiser of transition zone inner structure, specifically the Y-shaped links, in conjunction with the NPHP complex. The MKS complex also acts as part of the selective barrier that prevents diffusion of proteins between the ciliary cytoplasm and cellular cytoplasm as well as between the ciliary membrane and plasma membrane.
1 Q922M3 (/TAS)
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