The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 71: heterogeneous nuclear ribonucleoprotein H isoform ...

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 16 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
58 O35737 (/IPI) O35737 (/IPI) O35737 (/IPI) O35737 (/IPI) P31943 (/IPI) P31943 (/IPI) P31943 (/IPI) P31943 (/IPI) P31943 (/IPI) P31943 (/IPI)
(48 more)
RNA binding GO:0003723
Interacting selectively and non-covalently with an RNA molecule or a portion thereof.
54 P31943 (/HDA) P31943 (/HDA) P31943 (/HDA) P31943 (/HDA) P31943 (/HDA) P31943 (/HDA) P31943 (/HDA) P31943 (/HDA) P31943 (/HDA) P31943 (/HDA)
(44 more)
RNA binding GO:0003723
Interacting selectively and non-covalently with an RNA molecule or a portion thereof.
38 P31943 (/IDA) P31943 (/IDA) P31943 (/IDA) P31943 (/IDA) P31943 (/IDA) P31943 (/IDA) P31943 (/IDA) P31943 (/IDA) P31943 (/IDA) P31943 (/IDA)
(28 more)
Poly(U) RNA binding GO:0008266
Interacting selectively and non-covalently with a sequence of uracil residues in an RNA molecule.
38 P31943 (/TAS) P31943 (/TAS) P31943 (/TAS) P31943 (/TAS) P31943 (/TAS) P31943 (/TAS) P31943 (/TAS) P31943 (/TAS) P31943 (/TAS) P31943 (/TAS)
(28 more)
RNA binding GO:0003723
Interacting selectively and non-covalently with an RNA molecule or a portion thereof.
16 P52597 (/TAS) P52597 (/TAS) P52597 (/TAS) P52597 (/TAS) P52597 (/TAS) P52597 (/TAS) P52597 (/TAS) P52597 (/TAS) P55795 (/TAS) P55795 (/TAS)
(6 more)
Single-stranded RNA binding GO:0003727
Interacting selectively and non-covalently with single-stranded RNA.
12 Q5E9J1 (/ISS) Q5E9J1 (/ISS) Q5E9J1 (/ISS) Q60HC3 (/ISS) Q794E4 (/ISS) Q794E4 (/ISS) Q794E4 (/ISS) Q794E4 (/ISS) Q9Z2X1 (/ISS) Q9Z2X1 (/ISS)
(2 more)
Single-stranded RNA binding GO:0003727
Interacting selectively and non-covalently with single-stranded RNA.
8 P52597 (/IDA) P52597 (/IDA) P52597 (/IDA) P52597 (/IDA) P52597 (/IDA) P52597 (/IDA) P52597 (/IDA) P52597 (/IDA)
RNA binding GO:0003723
Interacting selectively and non-covalently with an RNA molecule or a portion thereof.
5 O35737 (/ISS) O35737 (/ISS) O35737 (/ISS) O35737 (/ISS) Q8VHV7 (/ISS)
RNA binding GO:0003723
Interacting selectively and non-covalently with an RNA molecule or a portion thereof.
4 O35737 (/ISO) O35737 (/ISO) O35737 (/ISO) O35737 (/ISO)
Single-stranded RNA binding GO:0003727
Interacting selectively and non-covalently with single-stranded RNA.
4 Q9Z2X1 (/ISO) Q9Z2X1 (/ISO) Q9Z2X1 (/ISO) Q9Z2X1 (/ISO)
Transcription factor binding GO:0008134
Interacting selectively and non-covalently with a transcription factor, a protein required to initiate or regulate transcription.
4 Q794E4 (/IPI) Q794E4 (/IPI) Q794E4 (/IPI) Q794E4 (/IPI)
Transcription factor binding GO:0008134
Interacting selectively and non-covalently with a transcription factor, a protein required to initiate or regulate transcription.
4 Q9Z2X1 (/ISO) Q9Z2X1 (/ISO) Q9Z2X1 (/ISO) Q9Z2X1 (/ISO)
TBP-class protein binding GO:0017025
Interacting selectively and non-covalently with a member of the class of TATA-binding proteins (TBP), including any of the TBP-related factors (TRFs).
4 Q794E4 (/IPI) Q794E4 (/IPI) Q794E4 (/IPI) Q794E4 (/IPI)
TBP-class protein binding GO:0017025
Interacting selectively and non-covalently with a member of the class of TATA-binding proteins (TBP), including any of the TBP-related factors (TRFs).
4 Q9Z2X1 (/ISO) Q9Z2X1 (/ISO) Q9Z2X1 (/ISO) Q9Z2X1 (/ISO)
MRNA binding GO:0003729
Interacting selectively and non-covalently with messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns.
1 Q12849 (/TAS)
Enzyme binding GO:0019899
Interacting selectively and non-covalently with any enzyme.
1 Q8VHV7 (/IPI)

There are 15 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
MRNA splicing, via spliceosome GO:0000398
The joining together of exons from one or more primary transcripts of messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced.
53 P31943 (/TAS) P31943 (/TAS) P31943 (/TAS) P31943 (/TAS) P31943 (/TAS) P31943 (/TAS) P31943 (/TAS) P31943 (/TAS) P31943 (/TAS) P31943 (/TAS)
(43 more)
RNA metabolic process GO:0016070
The cellular chemical reactions and pathways involving RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage.
53 P31943 (/TAS) P31943 (/TAS) P31943 (/TAS) P31943 (/TAS) P31943 (/TAS) P31943 (/TAS) P31943 (/TAS) P31943 (/TAS) P31943 (/TAS) P31943 (/TAS)
(43 more)
RNA processing GO:0006396
Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules.
47 P31943 (/TAS) P31943 (/TAS) P31943 (/TAS) P31943 (/TAS) P31943 (/TAS) P31943 (/TAS) P31943 (/TAS) P31943 (/TAS) P31943 (/TAS) P31943 (/TAS)
(37 more)
MRNA splicing, via spliceosome GO:0000398
The joining together of exons from one or more primary transcripts of messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced.
46 P31943 (/IC) P31943 (/IC) P31943 (/IC) P31943 (/IC) P31943 (/IC) P31943 (/IC) P31943 (/IC) P31943 (/IC) P31943 (/IC) P31943 (/IC)
(36 more)
Fibroblast growth factor receptor signaling pathway GO:0008543
The series of molecular signals generated as a consequence of a fibroblast growth factor receptor binding to one of its physiological ligands.
46 P31943 (/TAS) P31943 (/TAS) P31943 (/TAS) P31943 (/TAS) P31943 (/TAS) P31943 (/TAS) P31943 (/TAS) P31943 (/TAS) P31943 (/TAS) P31943 (/TAS)
(36 more)
Regulation of RNA splicing GO:0043484
Any process that modulates the frequency, rate or extent of RNA splicing, the process of removing sections of the primary RNA transcript to remove sequences not present in the mature form of the RNA and joining the remaining sections to form the mature form of the RNA.
46 P31943 (/IDA) P31943 (/IDA) P31943 (/IDA) P31943 (/IDA) P31943 (/IDA) P31943 (/IDA) P31943 (/IDA) P31943 (/IDA) P31943 (/IDA) P31943 (/IDA)
(36 more)
Regulation of RNA splicing GO:0043484
Any process that modulates the frequency, rate or extent of RNA splicing, the process of removing sections of the primary RNA transcript to remove sequences not present in the mature form of the RNA and joining the remaining sections to form the mature form of the RNA.
17 O35737 (/ISS) O35737 (/ISS) O35737 (/ISS) O35737 (/ISS) Q5E9J1 (/ISS) Q5E9J1 (/ISS) Q5E9J1 (/ISS) Q60HC3 (/ISS) Q794E4 (/ISS) Q794E4 (/ISS)
(7 more)
Interleukin-12-mediated signaling pathway GO:0035722
A series of molecular signals initiated by the binding of interleukin-12 to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription.
8 P52597 (/TAS) P52597 (/TAS) P52597 (/TAS) P52597 (/TAS) P52597 (/TAS) P52597 (/TAS) P52597 (/TAS) P52597 (/TAS)
Regulation of RNA splicing GO:0043484
Any process that modulates the frequency, rate or extent of RNA splicing, the process of removing sections of the primary RNA transcript to remove sequences not present in the mature form of the RNA and joining the remaining sections to form the mature form of the RNA.
8 P52597 (/IMP) P52597 (/IMP) P52597 (/IMP) P52597 (/IMP) P52597 (/IMP) P52597 (/IMP) P52597 (/IMP) P52597 (/IMP)
Regulation of RNA splicing GO:0043484
Any process that modulates the frequency, rate or extent of RNA splicing, the process of removing sections of the primary RNA transcript to remove sequences not present in the mature form of the RNA and joining the remaining sections to form the mature form of the RNA.
8 O35737 (/ISO) O35737 (/ISO) O35737 (/ISO) O35737 (/ISO) Q9Z2X1 (/ISO) Q9Z2X1 (/ISO) Q9Z2X1 (/ISO) Q9Z2X1 (/ISO)
Cellular response to interleukin-7 GO:0098761
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-7 stimulus.
4 O35737 (/IDA) O35737 (/IDA) O35737 (/IDA) O35737 (/IDA)
MRNA polyadenylation GO:0006378
The enzymatic addition of a sequence of 40-200 adenylyl residues at the 3' end of a eukaryotic mRNA primary transcript.
1 Q12849 (/TAS)
Anterior/posterior pattern specification GO:0009952
The regionalization process in which specific areas of cell differentiation are determined along the anterior-posterior axis. The anterior-posterior axis is defined by a line that runs from the head or mouth of an organism to the tail or opposite end of the organism.
1 Q8C5Q4 (/IMP)
Morphogenesis of embryonic epithelium GO:0016331
The process in which the anatomical structures of embryonic epithelia are generated and organized.
1 Q8C5Q4 (/IMP)
Cellular response to peptide GO:1901653
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a peptide stimulus.
1 Q8VHV7 (/IEP)

There are 28 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
92 A0A024R7T3 (/IDA) A0A024R7T3 (/IDA) A0A024R7T3 (/IDA) A0A024R7T3 (/IDA) A0A024R7T3 (/IDA) A0A024R7T3 (/IDA) A0A024R7T3 (/IDA) A0A024R7T3 (/IDA) D6RBM0 (/IDA) D6RBM0 (/IDA)
(82 more)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
91 A0A024R7T3 (/IDA) A0A024R7T3 (/IDA) A0A024R7T3 (/IDA) A0A024R7T3 (/IDA) A0A024R7T3 (/IDA) A0A024R7T3 (/IDA) A0A024R7T3 (/IDA) A0A024R7T3 (/IDA) D6RBM0 (/IDA) D6RBM0 (/IDA)
(81 more)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
53 P31943 (/TAS) P31943 (/TAS) P31943 (/TAS) P31943 (/TAS) P31943 (/TAS) P31943 (/TAS) P31943 (/TAS) P31943 (/TAS) P31943 (/TAS) P31943 (/TAS)
(43 more)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
53 P31943 (/TAS) P31943 (/TAS) P31943 (/TAS) P31943 (/TAS) P31943 (/TAS) P31943 (/TAS) P31943 (/TAS) P31943 (/TAS) P31943 (/TAS) P31943 (/TAS)
(43 more)
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
53 P31943 (/HDA) P31943 (/HDA) P31943 (/HDA) P31943 (/HDA) P31943 (/HDA) P31943 (/HDA) P31943 (/HDA) P31943 (/HDA) P31943 (/HDA) P31943 (/HDA)
(43 more)
Catalytic step 2 spliceosome GO:0071013
A spliceosomal complex that contains three snRNPs, including U5, bound to a splicing intermediate in which the first catalytic cleavage of the 5' splice site has occurred. The precise subunit composition differs significantly from that of the catalytic step 1, or activated, spliceosome, and includes many proteins in addition to those found in the associated snRNPs.
46 P31943 (/IDA) P31943 (/IDA) P31943 (/IDA) P31943 (/IDA) P31943 (/IDA) P31943 (/IDA) P31943 (/IDA) P31943 (/IDA) P31943 (/IDA) P31943 (/IDA)
(36 more)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
43 P31943 (/IDA) P31943 (/IDA) P31943 (/IDA) P31943 (/IDA) P31943 (/IDA) P31943 (/IDA) P31943 (/IDA) P31943 (/IDA) P31943 (/IDA) P31943 (/IDA)
(33 more)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
11 O35737 (/ISO) O35737 (/ISO) O35737 (/ISO) O35737 (/ISO) P70333 (/ISO) P70333 (/ISO) P70333 (/ISO) Q9Z2X1 (/ISO) Q9Z2X1 (/ISO) Q9Z2X1 (/ISO)
(1 more)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
11 O35737 (/ISO) O35737 (/ISO) O35737 (/ISO) O35737 (/ISO) P70333 (/ISO) P70333 (/ISO) P70333 (/ISO) Q9Z2X1 (/ISO) Q9Z2X1 (/ISO) Q9Z2X1 (/ISO)
(1 more)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
8 O35737 (/ISO) O35737 (/ISO) O35737 (/ISO) O35737 (/ISO) Q9Z2X1 (/ISO) Q9Z2X1 (/ISO) Q9Z2X1 (/ISO) Q9Z2X1 (/ISO)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
8 P52597 (/TAS) P52597 (/TAS) P52597 (/TAS) P52597 (/TAS) P52597 (/TAS) P52597 (/TAS) P52597 (/TAS) P52597 (/TAS)
Catalytic step 2 spliceosome GO:0071013
A spliceosomal complex that contains three snRNPs, including U5, bound to a splicing intermediate in which the first catalytic cleavage of the 5' splice site has occurred. The precise subunit composition differs significantly from that of the catalytic step 1, or activated, spliceosome, and includes many proteins in addition to those found in the associated snRNPs.
8 O35737 (/ISO) O35737 (/ISO) O35737 (/ISO) O35737 (/ISO) Q9Z2X1 (/ISO) Q9Z2X1 (/ISO) Q9Z2X1 (/ISO) Q9Z2X1 (/ISO)
Ribonucleoprotein complex GO:1990904
A macromolecular complex containing both protein and RNA molecules.
7 P55795 (/IDA) P55795 (/IDA) P55795 (/IDA) P55795 (/IDA) P55795 (/IDA) P55795 (/IDA) P55795 (/IDA)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
6 A0A024RD99 (/IDA) A0A024RD99 (/IDA) F5H5I6 (/IDA) H0Y8R1 (/IDA) H0YAK1 (/IDA) Q12849 (/IDA)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
4 O35737 (/ISS) O35737 (/ISS) O35737 (/ISS) O35737 (/ISS)
Postsynaptic density GO:0014069
An electron dense network of proteins within and adjacent to the postsynaptic membrane of an asymmetric, neuron-neuron synapse. Its major components include neurotransmitter receptors and the proteins that spatially and functionally organize them such as anchoring and scaffolding molecules, signaling enzymes and cytoskeletal components.
3 P70333 (/ISO) P70333 (/ISO) P70333 (/ISO)
Ribonucleoprotein complex GO:1990904
A macromolecular complex containing both protein and RNA molecules.
3 P70333 (/ISO) P70333 (/ISO) P70333 (/ISO)
Postsynaptic density GO:0014069
An electron dense network of proteins within and adjacent to the postsynaptic membrane of an asymmetric, neuron-neuron synapse. Its major components include neurotransmitter receptors and the proteins that spatially and functionally organize them such as anchoring and scaffolding molecules, signaling enzymes and cytoskeletal components.
2 Q6AY09 (/EXP) Q8VHV7 (/EXP)
Postsynaptic density GO:0014069
An electron dense network of proteins within and adjacent to the postsynaptic membrane of an asymmetric, neuron-neuron synapse. Its major components include neurotransmitter receptors and the proteins that spatially and functionally organize them such as anchoring and scaffolding molecules, signaling enzymes and cytoskeletal components.
2 Q6AY09 (/IDA) Q8VHV7 (/IDA)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
1 Q12849 (/TAS)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
1 Q8C5Q4 (/HDA)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
1 Q8C5Q4 (/ISO)
Ribonucleoprotein granule GO:0035770
A non-membranous macromolecular complex containing proteins and translationally silenced mRNAs. RNA granules contain proteins that control the localization, stability, and translation of their RNA cargo. Different types of RNA granules (RGs) exist, depending on the cell type and cellular conditions.
1 Q12849 (/IDA)
Ribonucleoprotein granule GO:0035770
A non-membranous macromolecular complex containing proteins and translationally silenced mRNAs. RNA granules contain proteins that control the localization, stability, and translation of their RNA cargo. Different types of RNA granules (RGs) exist, depending on the cell type and cellular conditions.
1 Q8C5Q4 (/ISO)
Ribonucleoprotein granule GO:0035770
A non-membranous macromolecular complex containing proteins and translationally silenced mRNAs. RNA granules contain proteins that control the localization, stability, and translation of their RNA cargo. Different types of RNA granules (RGs) exist, depending on the cell type and cellular conditions.
1 Q8C5Q4 (/ISS)
Mitochondrial nucleoid GO:0042645
The region of a mitochondrion to which the DNA is confined.
1 Q12849 (/IDA)
Mitochondrial nucleoid GO:0042645
The region of a mitochondrion to which the DNA is confined.
1 Q8C5Q4 (/ISO)
Mitochondrial nucleoid GO:0042645
The region of a mitochondrion to which the DNA is confined.
1 Q8C5Q4 (/ISS)
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