The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was: waiting to be named.
FunFam 55: Splicing factor U2AF 35 kDa subunit
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 6 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
|
33 |
Q01081 (/IPI)
Q01081 (/IPI)
Q01081 (/IPI)
Q01081 (/IPI)
Q01081 (/IPI)
Q01081 (/IPI)
Q01081 (/IPI)
Q01081 (/IPI)
Q01081 (/IPI)
Q01081 (/IPI)
(23 more) |
RNA binding GO:0003723
Interacting selectively and non-covalently with an RNA molecule or a portion thereof.
|
21 |
Q01081 (/HDA)
Q01081 (/HDA)
Q01081 (/HDA)
Q01081 (/HDA)
Q01081 (/HDA)
Q01081 (/HDA)
Q01081 (/HDA)
Q01081 (/HDA)
Q01081 (/HDA)
Q01081 (/HDA)
(11 more) |
RS domain binding GO:0050733
Interacting selectively and non-covalently with an RS domain of a protein; RS domains are usually highly phosphorylated and characterized by the presence of arginine (R)/serine (S) dipeptides. The RS domain promotes protein-protein interactions and directs subcellular localization and, in certain situations, nucleocytoplasmic shuttling of individual SR proteins. They also play a role in splicing.
|
6 | Q9D883 (/IPI) Q9D883 (/IPI) Q9D883 (/IPI) Q9D883 (/IPI) Q9D883 (/IPI) Q9D883 (/IPI) |
MRNA binding GO:0003729
Interacting selectively and non-covalently with messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns.
|
3 | Q94535 (/ISS) Q94535 (/ISS) Q94535 (/ISS) |
Poly-pyrimidine tract binding GO:0008187
Interacting selectively and non-covalently with any stretch of pyrimidines (cytosine or uracil) in an RNA molecule.
|
3 | Q94535 (/IDA) Q94535 (/IDA) Q94535 (/IDA) |
Pre-mRNA 3'-splice site binding GO:0030628
Interacting selectively and non-covalently with the pre-mRNA 3' splice site sequence.
|
1 | Q9U2U0 (/IDA) |
There are 11 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
MRNA splicing, via spliceosome GO:0000398
The joining together of exons from one or more primary transcripts of messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced.
|
24 |
Q01081 (/IC)
Q01081 (/IC)
Q01081 (/IC)
Q01081 (/IC)
Q01081 (/IC)
Q01081 (/IC)
Q01081 (/IC)
Q01081 (/IC)
Q01081 (/IC)
Q01081 (/IC)
(14 more) |
MRNA splicing, via spliceosome GO:0000398
The joining together of exons from one or more primary transcripts of messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced.
|
22 |
Q01081 (/TAS)
Q01081 (/TAS)
Q01081 (/TAS)
Q01081 (/TAS)
Q01081 (/TAS)
Q01081 (/TAS)
Q01081 (/TAS)
Q01081 (/TAS)
Q01081 (/TAS)
Q01081 (/TAS)
(12 more) |
RNA export from nucleus GO:0006405
The directed movement of RNA from the nucleus to the cytoplasm.
|
22 |
Q01081 (/TAS)
Q01081 (/TAS)
Q01081 (/TAS)
Q01081 (/TAS)
Q01081 (/TAS)
Q01081 (/TAS)
Q01081 (/TAS)
Q01081 (/TAS)
Q01081 (/TAS)
Q01081 (/TAS)
(12 more) |
MRNA export from nucleus GO:0006406
The directed movement of mRNA from the nucleus to the cytoplasm.
|
22 |
Q01081 (/TAS)
Q01081 (/TAS)
Q01081 (/TAS)
Q01081 (/TAS)
Q01081 (/TAS)
Q01081 (/TAS)
Q01081 (/TAS)
Q01081 (/TAS)
Q01081 (/TAS)
Q01081 (/TAS)
(12 more) |
MRNA 3'-end processing GO:0031124
Any process involved in forming the mature 3' end of an mRNA molecule.
|
22 |
Q01081 (/TAS)
Q01081 (/TAS)
Q01081 (/TAS)
Q01081 (/TAS)
Q01081 (/TAS)
Q01081 (/TAS)
Q01081 (/TAS)
Q01081 (/TAS)
Q01081 (/TAS)
Q01081 (/TAS)
(12 more) |
MRNA processing GO:0006397
Any process involved in the conversion of a primary mRNA transcript into one or more mature mRNA(s) prior to translation into polypeptide.
|
21 |
Q01081 (/TAS)
Q01081 (/TAS)
Q01081 (/TAS)
Q01081 (/TAS)
Q01081 (/TAS)
Q01081 (/TAS)
Q01081 (/TAS)
Q01081 (/TAS)
Q01081 (/TAS)
Q01081 (/TAS)
(11 more) |
RNA splicing GO:0008380
The process of removing sections of the primary RNA transcript to remove sequences not present in the mature form of the RNA and joining the remaining sections to form the mature form of the RNA.
|
21 |
Q01081 (/TAS)
Q01081 (/TAS)
Q01081 (/TAS)
Q01081 (/TAS)
Q01081 (/TAS)
Q01081 (/TAS)
Q01081 (/TAS)
Q01081 (/TAS)
Q01081 (/TAS)
Q01081 (/TAS)
(11 more) |
Regulation of alternative mRNA splicing, via spliceosome GO:0000381
Any process that modulates the frequency, rate or extent of alternative splicing of nuclear mRNAs.
|
3 | Q94535 (/HMP) Q94535 (/HMP) Q94535 (/HMP) |
Regulation of alternative mRNA splicing, via spliceosome GO:0000381
Any process that modulates the frequency, rate or extent of alternative splicing of nuclear mRNAs.
|
3 | Q94535 (/IMP) Q94535 (/IMP) Q94535 (/IMP) |
MRNA splicing, via spliceosome GO:0000398
The joining together of exons from one or more primary transcripts of messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced.
|
3 | Q94535 (/IMP) Q94535 (/IMP) Q94535 (/IMP) |
RNA splicing GO:0008380
The process of removing sections of the primary RNA transcript to remove sequences not present in the mature form of the RNA and joining the remaining sections to form the mature form of the RNA.
|
3 | Q94535 (/IMP) Q94535 (/IMP) Q94535 (/IMP) |
There are 10 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
|
42 |
P0DN76 (/IDA)
P0DN76 (/IDA)
P0DN76 (/IDA)
P0DN76 (/IDA)
P0DN76 (/IDA)
P0DN76 (/IDA)
P0DN76 (/IDA)
P0DN76 (/IDA)
P0DN76 (/IDA)
P0DN76 (/IDA)
(32 more) |
Nuclear speck GO:0016607
A discrete extra-nucleolar subnuclear domain, 20-50 in number, in which splicing factors are seen to be localized by immunofluorescence microscopy.
|
27 |
A1A4K8 (/ISS)
A1A4K8 (/ISS)
A1A4K8 (/ISS)
A1A4K8 (/ISS)
A1A4K8 (/ISS)
A1A4K8 (/ISS)
Q01081 (/ISS)
Q01081 (/ISS)
Q01081 (/ISS)
Q01081 (/ISS)
(17 more) |
U2AF GO:0089701
A heterodimeric protein complex consisting of conserved large and small U2AF subunits that contributes to spliceosomal RNA splicing by binding to consensus sequences at the 3' splice site. U2AF is required to stabilize the association of the U2 snRNP with the branch point.
|
24 |
Q01081 (/IDA)
Q01081 (/IDA)
Q01081 (/IDA)
Q01081 (/IDA)
Q01081 (/IDA)
Q01081 (/IDA)
Q01081 (/IDA)
Q01081 (/IDA)
Q01081 (/IDA)
Q01081 (/IDA)
(14 more) |
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
|
22 |
Q01081 (/TAS)
Q01081 (/TAS)
Q01081 (/TAS)
Q01081 (/TAS)
Q01081 (/TAS)
Q01081 (/TAS)
Q01081 (/TAS)
Q01081 (/TAS)
Q01081 (/TAS)
Q01081 (/TAS)
(12 more) |
Spliceosomal complex GO:0005681
Any of a series of ribonucleoprotein complexes that contain snRNA(s) and small nuclear ribonucleoproteins (snRNPs), and are formed sequentially during the spliceosomal splicing of one or more substrate RNAs, and which also contain the RNA substrate(s) from the initial target RNAs of splicing, the splicing intermediate RNA(s), to the final RNA products. During cis-splicing, the initial target RNA is a single, contiguous RNA transcript, whether mRNA, snoRNA, etc., and the released products are a spliced RNA and an excised intron, generally as a lariat structure. During trans-splicing, there are two initial substrate RNAs, the spliced leader RNA and a pre-mRNA.
|
21 |
Q01081 (/IDA)
Q01081 (/IDA)
Q01081 (/IDA)
Q01081 (/IDA)
Q01081 (/IDA)
Q01081 (/IDA)
Q01081 (/IDA)
Q01081 (/IDA)
Q01081 (/IDA)
Q01081 (/IDA)
(11 more) |
Cajal body GO:0015030
A class of nuclear body, first seen after silver staining by Ramon y Cajal in 1903, enriched in small nuclear ribonucleoproteins, and certain general RNA polymerase II transcription factors; ultrastructurally, they appear as a tangle of coiled, electron-dense threads roughly 0.5 micrometers in diameter; involved in aspects of snRNP biogenesis; the protein coilin serves as a marker for Cajal bodies. Some argue that Cajal bodies are the sites for preassembly of transcriptosomes, unitary particles involved in transcription and processing of RNA.
|
21 |
Q01081 (/TAS)
Q01081 (/TAS)
Q01081 (/TAS)
Q01081 (/TAS)
Q01081 (/TAS)
Q01081 (/TAS)
Q01081 (/TAS)
Q01081 (/TAS)
Q01081 (/TAS)
Q01081 (/TAS)
(11 more) |
Catalytic step 2 spliceosome GO:0071013
A spliceosomal complex that contains three snRNPs, including U5, bound to a splicing intermediate in which the first catalytic cleavage of the 5' splice site has occurred. The precise subunit composition differs significantly from that of the catalytic step 1, or activated, spliceosome, and includes many proteins in addition to those found in the associated snRNPs.
|
21 |
Q01081 (/IDA)
Q01081 (/IDA)
Q01081 (/IDA)
Q01081 (/IDA)
Q01081 (/IDA)
Q01081 (/IDA)
Q01081 (/IDA)
Q01081 (/IDA)
Q01081 (/IDA)
Q01081 (/IDA)
(11 more) |
Nuclear speck GO:0016607
A discrete extra-nucleolar subnuclear domain, 20-50 in number, in which splicing factors are seen to be localized by immunofluorescence microscopy.
|
6 | Q9D883 (/IDA) Q9D883 (/IDA) Q9D883 (/IDA) Q9D883 (/IDA) Q9D883 (/IDA) Q9D883 (/IDA) |
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
3 | Q94535 (/IC) Q94535 (/IC) Q94535 (/IC) |
Precatalytic spliceosome GO:0071011
A spliceosomal complex that is formed by the recruitment of a preassembled U5-containing tri-snRNP to the prespliceosome. Although all 5 snRNPs are present, the precatalytic spliceosome is catalytically inactive. The precatalytic spliceosome includes many proteins in addition to those found in the associated snRNPs.
|
3 | Q94535 (/HDA) Q94535 (/HDA) Q94535 (/HDA) |