The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was: waiting to be named.
FunFam 487: Poly [ADP-ribose] polymerase
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 25 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
|
3 | Q2EMV9 (/IPI) Q460N5 (/IPI) Q8TDB6 (/IPI) |
Enzyme binding GO:0019899
Interacting selectively and non-covalently with any enzyme.
|
2 | Q460N5 (/IPI) Q8TDB6 (/IPI) |
Enzyme binding GO:0019899
Interacting selectively and non-covalently with any enzyme.
|
2 | Q2EMV9 (/ISO) Q3UIR3 (/ISO) |
NAD+ ADP-ribosyltransferase activity GO:0003950
Catalysis of the reaction: NAD+ + (ADP-D-ribosyl)(n)-acceptor = nicotinamide + (ADP-D-ribosyl)(n+1)-acceptor.
|
1 | Q460N5 (/IDA) |
NAD+ ADP-ribosyltransferase activity GO:0003950
Catalysis of the reaction: NAD+ + (ADP-D-ribosyl)(n)-acceptor = nicotinamide + (ADP-D-ribosyl)(n+1)-acceptor.
|
1 | Q2EMV9 (/ISO) |
Ubiquitin-protein transferase activity GO:0004842
Catalysis of the transfer of ubiquitin from one protein to another via the reaction X-Ub + Y --> Y-Ub + X, where both X-Ub and Y-Ub are covalent linkages.
|
1 | Q8TDB6 (/IDA) |
Ubiquitin-protein transferase activity GO:0004842
Catalysis of the transfer of ubiquitin from one protein to another via the reaction X-Ub + Y --> Y-Ub + X, where both X-Ub and Y-Ub are covalent linkages.
|
1 | Q8TDB6 (/IMP) |
Ubiquitin-protein transferase activity GO:0004842
Catalysis of the transfer of ubiquitin from one protein to another via the reaction X-Ub + Y --> Y-Ub + X, where both X-Ub and Y-Ub are covalent linkages.
|
1 | Q3UIR3 (/ISO) |
Ubiquitin-protein transferase activity GO:0004842
Catalysis of the transfer of ubiquitin from one protein to another via the reaction X-Ub + Y --> Y-Ub + X, where both X-Ub and Y-Ub are covalent linkages.
|
1 | Q3UIR3 (/ISS) |
Enzyme inhibitor activity GO:0004857
Binds to and stops, prevents or reduces the activity of an enzyme.
|
1 | Q8TDB6 (/IMP) |
Enzyme inhibitor activity GO:0004857
Binds to and stops, prevents or reduces the activity of an enzyme.
|
1 | Q3UIR3 (/ISO) |
Enzyme activator activity GO:0008047
Binds to and increases the activity of an enzyme.
|
1 | Q8TDB6 (/IDA) |
Enzyme activator activity GO:0008047
Binds to and increases the activity of an enzyme.
|
1 | Q3UIR3 (/ISO) |
Histone binding GO:0042393
Interacting selectively and non-covalently with a histone, any of a group of water-soluble proteins found in association with the DNA of eukaroytic chromosomes. They are involved in the condensation and coiling of chromosomes during cell division and have also been implicated in nonspecific suppression of gene activity.
|
1 | Q8TDB6 (/IDA) |
Histone binding GO:0042393
Interacting selectively and non-covalently with a histone, any of a group of water-soluble proteins found in association with the DNA of eukaroytic chromosomes. They are involved in the condensation and coiling of chromosomes during cell division and have also been implicated in nonspecific suppression of gene activity.
|
1 | Q8TDB6 (/IPI) |
Histone binding GO:0042393
Interacting selectively and non-covalently with a histone, any of a group of water-soluble proteins found in association with the DNA of eukaroytic chromosomes. They are involved in the condensation and coiling of chromosomes during cell division and have also been implicated in nonspecific suppression of gene activity.
|
1 | Q3UIR3 (/ISO) |
Histone binding GO:0042393
Interacting selectively and non-covalently with a histone, any of a group of water-soluble proteins found in association with the DNA of eukaroytic chromosomes. They are involved in the condensation and coiling of chromosomes during cell division and have also been implicated in nonspecific suppression of gene activity.
|
1 | Q3UIR3 (/ISS) |
Ubiquitin-like protein ligase binding GO:0044389
Interacting selectively and non-covalently with a ubiquitin-like protein ligase, such as ubiquitin-ligase.
|
1 | Q8TDB6 (/IPI) |
Ubiquitin-like protein ligase binding GO:0044389
Interacting selectively and non-covalently with a ubiquitin-like protein ligase, such as ubiquitin-ligase.
|
1 | Q3UIR3 (/ISO) |
NAD+ binding GO:0070403
Interacting selectively and non-covalently with the oxidized form, NAD, of nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions.
|
1 | Q2EMV9 (/ISO) |
STAT family protein binding GO:0097677
Interacting selectively and non-covalently with any member of the signal transducers and activators of transcription (STAT) protein family. STATs are, as the name indicates, both signal transducers and transcription factors. STATs are activated by cytokines and some growth factors and thus control important biological processes including cell growth, cell differentiation, apoptosis and immune responses.
|
1 | Q8TDB6 (/IPI) |
STAT family protein binding GO:0097677
Interacting selectively and non-covalently with any member of the signal transducers and activators of transcription (STAT) protein family. STATs are, as the name indicates, both signal transducers and transcription factors. STATs are activated by cytokines and some growth factors and thus control important biological processes including cell growth, cell differentiation, apoptosis and immune responses.
|
1 | Q3UIR3 (/ISO) |
Protein ADP-ribosylase activity GO:1990404
The transfer, from NAD, of ADP-ribose to a protein amino acid residue.
|
1 | Q460N5 (/IDA) |
Protein ADP-ribosylase activity GO:1990404
The transfer, from NAD, of ADP-ribose to a protein amino acid residue.
|
1 | Q2EMV9 (/ISO) |
Protein ADP-ribosylase activity GO:1990404
The transfer, from NAD, of ADP-ribose to a protein amino acid residue.
|
1 | Q2EMV9 (/ISS) |
There are 58 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Negative regulation of interferon-gamma-mediated signaling pathway GO:0060336
Any process that decreases the rate, frequency or extent of the series of molecular events generated as a consequence of interferon-gamma binding to a cell surface receptor.
|
2 | Q2EMV9 (/IMP) Q460N5 (/IMP) |
Positive regulation of interleukin-4-mediated signaling pathway GO:1902216
Any process that activates or increases the frequency, rate or extent of interleukin-4-mediated signaling pathway.
|
2 | Q2EMV9 (/IMP) Q460N5 (/IMP) |
Protein polyubiquitination GO:0000209
Addition of multiple ubiquitin groups to a protein, forming a ubiquitin chain.
|
1 | Q8TDB6 (/TAS) |
Positive regulation of defense response to virus by host GO:0002230
Any host process that results in the promotion of antiviral immune response mechanisms, thereby limiting viral replication.
|
1 | Q8TDB6 (/IGI) |
Positive regulation of defense response to virus by host GO:0002230
Any host process that results in the promotion of antiviral immune response mechanisms, thereby limiting viral replication.
|
1 | Q3UIR3 (/ISO) |
Double-strand break repair GO:0006302
The repair of double-strand breaks in DNA via homologous and nonhomologous mechanisms to reform a continuous DNA helix.
|
1 | Q8TDB6 (/IMP) |
Double-strand break repair GO:0006302
The repair of double-strand breaks in DNA via homologous and nonhomologous mechanisms to reform a continuous DNA helix.
|
1 | Q3UIR3 (/ISO) |
Double-strand break repair GO:0006302
The repair of double-strand breaks in DNA via homologous and nonhomologous mechanisms to reform a continuous DNA helix.
|
1 | Q3UIR3 (/ISS) |
Protein ADP-ribosylation GO:0006471
The transfer, from NAD, of ADP-ribose to protein amino acids.
|
1 | Q460N5 (/IDA) |
Protein ADP-ribosylation GO:0006471
The transfer, from NAD, of ADP-ribose to protein amino acids.
|
1 | Q2EMV9 (/ISO) |
Ubiquitin-dependent protein catabolic process GO:0006511
The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the protein.
|
1 | Q8TDB6 (/IMP) |
Ubiquitin-dependent protein catabolic process GO:0006511
The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the protein.
|
1 | Q3UIR3 (/ISO) |
Cellular response to DNA damage stimulus GO:0006974
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism.
|
1 | Q8TDB6 (/IMP) |
Cellular response to DNA damage stimulus GO:0006974
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism.
|
1 | Q3UIR3 (/ISO) |
Cellular response to DNA damage stimulus GO:0006974
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism.
|
1 | Q3UIR3 (/ISS) |
Endosome to lysosome transport GO:0008333
The directed movement of substances from endosomes to lysosomes.
|
1 | Q8TDB6 (/IMP) |
Endosome to lysosome transport GO:0008333
The directed movement of substances from endosomes to lysosomes.
|
1 | Q3UIR3 (/ISO) |
Histone monoubiquitination GO:0010390
The modification of histones by addition of a single ubiquitin group.
|
1 | Q8TDB6 (/IDA) |
Histone monoubiquitination GO:0010390
The modification of histones by addition of a single ubiquitin group.
|
1 | Q3UIR3 (/ISO) |
Histone monoubiquitination GO:0010390
The modification of histones by addition of a single ubiquitin group.
|
1 | Q3UIR3 (/ISS) |
Negative regulation of gene expression GO:0010629
Any process that decreases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
|
1 | Q460N5 (/IMP) |
Negative regulation of gene expression GO:0010629
Any process that decreases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
|
1 | Q2EMV9 (/ISO) |
Positive regulation of protein binding GO:0032092
Any process that activates or increases the frequency, rate or extent of protein binding.
|
1 | Q8TDB6 (/IMP) |
Positive regulation of protein binding GO:0032092
Any process that activates or increases the frequency, rate or extent of protein binding.
|
1 | Q3UIR3 (/ISO) |
Histone H2A ubiquitination GO:0033522
The modification of histone H2A by addition of one or more ubiquitin groups.
|
1 | Q8TDB6 (/IMP) |
Histone H2A ubiquitination GO:0033522
The modification of histone H2A by addition of one or more ubiquitin groups.
|
1 | Q3UIR3 (/ISO) |
Histone H2B ubiquitination GO:0033523
The modification of histone H2B by addition of ubiquitin groups.
|
1 | Q8TDB6 (/IMP) |
Histone H2B ubiquitination GO:0033523
The modification of histone H2B by addition of ubiquitin groups.
|
1 | Q3UIR3 (/ISO) |
Positive regulation of chromatin binding GO:0035563
Any process that increases the frequency, rate or extent of chromatin binding. Chromatin binding is the selective interaction with chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase.
|
1 | Q8TDB6 (/IGI) |
Positive regulation of chromatin binding GO:0035563
Any process that increases the frequency, rate or extent of chromatin binding. Chromatin binding is the selective interaction with chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase.
|
1 | Q3UIR3 (/ISO) |
Positive regulation of tyrosine phosphorylation of STAT protein GO:0042531
Any process that activates or increases the frequency, rate or extent of the introduction of a phosphate group to a tyrosine residue of a STAT (Signal Transducer and Activator of Transcription) protein.
|
1 | Q460N5 (/IMP) |
Positive regulation of tyrosine phosphorylation of STAT protein GO:0042531
Any process that activates or increases the frequency, rate or extent of the introduction of a phosphate group to a tyrosine residue of a STAT (Signal Transducer and Activator of Transcription) protein.
|
1 | Q2EMV9 (/ISO) |
Negative regulation of tyrosine phosphorylation of STAT protein GO:0042532
Any process that stops, prevents, or reduces the frequency, rate or extent of the introduction of a phosphate group to a tyrosine residue of a STAT (Signal Transducer and Activator of Transcription) protein.
|
1 | Q460N5 (/IMP) |
Negative regulation of tyrosine phosphorylation of STAT protein GO:0042532
Any process that stops, prevents, or reduces the frequency, rate or extent of the introduction of a phosphate group to a tyrosine residue of a STAT (Signal Transducer and Activator of Transcription) protein.
|
1 | Q2EMV9 (/ISO) |
Positive regulation of transcription, DNA-templated GO:0045893
Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.
|
1 | Q8TDB6 (/IGI) |
Positive regulation of transcription, DNA-templated GO:0045893
Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.
|
1 | Q3UIR3 (/ISO) |
Negative regulation of ubiquitin-protein transferase activity GO:0051444
Any process that stops, prevents, or reduces the frequency, rate or extent of ubiquitin transferase activity.
|
1 | Q8TDB6 (/IMP) |
Negative regulation of ubiquitin-protein transferase activity GO:0051444
Any process that stops, prevents, or reduces the frequency, rate or extent of ubiquitin transferase activity.
|
1 | Q3UIR3 (/ISO) |
Protein autoubiquitination GO:0051865
The ubiquitination by a protein of one or more of its own amino acid residues, or residues on an identical protein. Ubiquitination occurs on the lysine residue by formation of an isopeptide crosslink.
|
1 | Q8TDB6 (/IMP) |
Protein autoubiquitination GO:0051865
The ubiquitination by a protein of one or more of its own amino acid residues, or residues on an identical protein. Ubiquitination occurs on the lysine residue by formation of an isopeptide crosslink.
|
1 | Q3UIR3 (/ISO) |
Negative regulation of interferon-gamma-mediated signaling pathway GO:0060336
Any process that decreases the rate, frequency or extent of the series of molecular events generated as a consequence of interferon-gamma binding to a cell surface receptor.
|
1 | Q2EMV9 (/ISO) |
Protein poly-ADP-ribosylation GO:0070212
The transfer of multiple ADP-ribose residues from NAD to a protein amino acid, forming a poly(ADP-ribose) chain.
|
1 | Q2EMV9 (/ISO) |
Protein K48-linked ubiquitination GO:0070936
A protein ubiquitination process in which a polymer of ubiquitin, formed by linkages between lysine residues at position 48 of the ubiquitin monomers, is added to a protein. K48-linked ubiquitination targets the substrate protein for degradation.
|
1 | Q8TDB6 (/IDA) |
Protein K48-linked ubiquitination GO:0070936
A protein ubiquitination process in which a polymer of ubiquitin, formed by linkages between lysine residues at position 48 of the ubiquitin monomers, is added to a protein. K48-linked ubiquitination targets the substrate protein for degradation.
|
1 | Q3UIR3 (/ISO) |
Protein mono-ADP-ribosylation GO:0140289
The transfer, from NAD, of a single (mono) ADP-ribose molecule to protein amino acids.
|
1 | Q460N5 (/IDA) |
Protein mono-ADP-ribosylation GO:0140289
The transfer, from NAD, of a single (mono) ADP-ribose molecule to protein amino acids.
|
1 | Q2EMV9 (/ISO) |
Protein mono-ADP-ribosylation GO:0140289
The transfer, from NAD, of a single (mono) ADP-ribose molecule to protein amino acids.
|
1 | Q2EMV9 (/ISS) |
Positive regulation of protein localization to nucleus GO:1900182
Any process that activates or increases the frequency, rate or extent of protein localization to nucleus.
|
1 | Q8TDB6 (/IGI) |
Positive regulation of protein localization to nucleus GO:1900182
Any process that activates or increases the frequency, rate or extent of protein localization to nucleus.
|
1 | Q3UIR3 (/ISO) |
Positive regulation of NAD+ ADP-ribosyltransferase activity GO:1901666
Any process that activates or increases the frequency, rate or extent of NAD+ ADP-ribosyltransferase activity.
|
1 | Q8TDB6 (/IDA) |
Positive regulation of NAD+ ADP-ribosyltransferase activity GO:1901666
Any process that activates or increases the frequency, rate or extent of NAD+ ADP-ribosyltransferase activity.
|
1 | Q3UIR3 (/ISO) |
Positive regulation of interleukin-4-mediated signaling pathway GO:1902216
Any process that activates or increases the frequency, rate or extent of interleukin-4-mediated signaling pathway.
|
1 | Q2EMV9 (/ISO) |
Positive regulation of protein localization to early endosome GO:1902966
Any process that activates or increases the frequency, rate or extent of protein localization to early endosome.
|
1 | Q8TDB6 (/IMP) |
Positive regulation of protein localization to early endosome GO:1902966
Any process that activates or increases the frequency, rate or extent of protein localization to early endosome.
|
1 | Q3UIR3 (/ISO) |
Positive regulation of receptor catabolic process GO:2000646
Any process that activates or increases the frequency, rate or extent of receptor catabolic process.
|
1 | Q8TDB6 (/IMP) |
Positive regulation of receptor catabolic process GO:2000646
Any process that activates or increases the frequency, rate or extent of receptor catabolic process.
|
1 | Q3UIR3 (/ISO) |
Positive regulation of double-strand break repair via nonhomologous end joining GO:2001034
Any process that activates or increases the frequency, rate or extent of double-strand break repair via nonhomologous end joining.
|
1 | Q8TDB6 (/IMP) |
Positive regulation of double-strand break repair via nonhomologous end joining GO:2001034
Any process that activates or increases the frequency, rate or extent of double-strand break repair via nonhomologous end joining.
|
1 | Q3UIR3 (/ISO) |
There are 16 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
|
3 | Q2EMV9 (/IDA) Q460N5 (/IDA) Q8TDB6 (/IDA) |
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
|
2 | Q2EMV9 (/ISO) Q3UIR3 (/ISO) |
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
2 | Q460N5 (/IDA) Q8TDB6 (/IDA) |
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
2 | Q2EMV9 (/ISO) Q3UIR3 (/ISO) |
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
1 | Q8TDB6 (/IDA) |
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
1 | Q3UIR3 (/ISO) |
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
1 | Q3UIR3 (/ISS) |
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
|
1 | Q8TDB6 (/IDA) |
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
|
1 | Q3UIR3 (/ISO) |
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
|
1 | Q3UIR3 (/ISS) |
Lysosome GO:0005764
A small lytic vacuole that has cell cycle-independent morphology and is found in most animal cells and that contains a variety of hydrolases, most of which have their maximal activities in the pH range 5-6. The contained enzymes display latency if properly isolated. About 40 different lysosomal hydrolases are known and lysosomes have a great variety of morphologies and functions.
|
1 | Q8TDB6 (/IDA) |
Lysosome GO:0005764
A small lytic vacuole that has cell cycle-independent morphology and is found in most animal cells and that contains a variety of hydrolases, most of which have their maximal activities in the pH range 5-6. The contained enzymes display latency if properly isolated. About 40 different lysosomal hydrolases are known and lysosomes have a great variety of morphologies and functions.
|
1 | Q3UIR3 (/ISO) |
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
1 | Q8TDB6 (/TAS) |
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
|
1 | Q460N5 (/HDA) |
Protein-containing complex GO:0032991
A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together.
|
1 | Q8TDB6 (/IDA) |
Protein-containing complex GO:0032991
A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together.
|
1 | Q3UIR3 (/ISO) |