The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 45: Nucleolysin tiar isoform 1

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 5 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
RNA binding GO:0003723
Interacting selectively and non-covalently with an RNA molecule or a portion thereof.
32 P31483 (/HDA) P31483 (/HDA) P31483 (/HDA) P31483 (/HDA) Q01085 (/HDA) Q01085 (/HDA) Q01085 (/HDA) Q01085 (/HDA) Q01085 (/HDA) Q01085 (/HDA)
(22 more)
RNA binding GO:0003723
Interacting selectively and non-covalently with an RNA molecule or a portion thereof.
28 Q01085 (/TAS) Q01085 (/TAS) Q01085 (/TAS) Q01085 (/TAS) Q01085 (/TAS) Q01085 (/TAS) Q01085 (/TAS) Q01085 (/TAS) Q01085 (/TAS) Q01085 (/TAS)
(18 more)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
9 P31483 (/IPI) P31483 (/IPI) P31483 (/IPI) P31483 (/IPI) P70318 (/IPI) P70318 (/IPI) P70318 (/IPI) P70318 (/IPI) Q80ZW7 (/IPI)
MRNA 3'-UTR AU-rich region binding GO:0035925
Interacting selectively and non-covalently with a region containing frequent adenine and uridine bases within the 3' untranslated region of a mRNA molecule.
6 P52912 (/IDA) P52912 (/IDA) P70318 (/IDA) P70318 (/IDA) P70318 (/IDA) P70318 (/IDA)
Poly(A) binding GO:0008143
Interacting selectively and non-covalently with a sequence of adenylyl residues in an RNA molecule, such as the poly(A) tail, a sequence of adenylyl residues at the 3' end of eukaryotic mRNA.
4 P31483 (/TAS) P31483 (/TAS) P31483 (/TAS) P31483 (/TAS)

There are 15 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Apoptotic process GO:0006915
A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died.
32 P31483 (/TAS) P31483 (/TAS) P31483 (/TAS) P31483 (/TAS) Q01085 (/TAS) Q01085 (/TAS) Q01085 (/TAS) Q01085 (/TAS) Q01085 (/TAS) Q01085 (/TAS)
(22 more)
Fibroblast growth factor receptor signaling pathway GO:0008543
The series of molecular signals generated as a consequence of a fibroblast growth factor receptor binding to one of its physiological ligands.
32 P31483 (/TAS) P31483 (/TAS) P31483 (/TAS) P31483 (/TAS) Q01085 (/TAS) Q01085 (/TAS) Q01085 (/TAS) Q01085 (/TAS) Q01085 (/TAS) Q01085 (/TAS)
(22 more)
Regulation of transcription by RNA polymerase II GO:0006357
Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II.
28 Q01085 (/TAS) Q01085 (/TAS) Q01085 (/TAS) Q01085 (/TAS) Q01085 (/TAS) Q01085 (/TAS) Q01085 (/TAS) Q01085 (/TAS) Q01085 (/TAS) Q01085 (/TAS)
(18 more)
Defense response GO:0006952
Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack.
28 Q01085 (/TAS) Q01085 (/TAS) Q01085 (/TAS) Q01085 (/TAS) Q01085 (/TAS) Q01085 (/TAS) Q01085 (/TAS) Q01085 (/TAS) Q01085 (/TAS) Q01085 (/TAS)
(18 more)
Germ cell development GO:0007281
The process whose specific outcome is the progression of an immature germ cell over time, from its formation to the mature structure (gamete). A germ cell is any reproductive cell in a multicellular organism.
4 P70318 (/IMP) P70318 (/IMP) P70318 (/IMP) P70318 (/IMP)
Positive regulation of cell population proliferation GO:0008284
Any process that activates or increases the rate or extent of cell proliferation.
4 P70318 (/IMP) P70318 (/IMP) P70318 (/IMP) P70318 (/IMP)
Stem cell division GO:0017145
The self-renewing division of a stem cell. A stem cell is an undifferentiated cell, in the embryo or adult, that can undergo unlimited division and give rise to one or several different cell types.
4 P70318 (/IMP) P70318 (/IMP) P70318 (/IMP) P70318 (/IMP)
Regulation of mRNA splicing, via spliceosome GO:0048024
Any process that modulates the frequency, rate or extent of mRNA splicing via a spliceosomal mechanism.
4 P31483 (/IDA) P31483 (/IDA) P31483 (/IDA) P31483 (/IDA)
Protein localization to cytoplasmic stress granule GO:1903608
A process in which a protein is transported to, or maintained in, a location within a cytoplasmic stress granule.
4 P31483 (/IMP) P31483 (/IMP) P31483 (/IMP) P31483 (/IMP)
Negative regulation of translation GO:0017148
Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA or circRNA.
2 P52912 (/IMP) P52912 (/IMP)
Negative regulation of cytokine biosynthetic process GO:0042036
Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of cytokines.
2 P52912 (/IMP) P52912 (/IMP)
Regulation of mRNA splicing, via spliceosome GO:0048024
Any process that modulates the frequency, rate or extent of mRNA splicing via a spliceosomal mechanism.
2 P52912 (/ISO) P52912 (/ISO)
Protein localization to cytoplasmic stress granule GO:1903608
A process in which a protein is transported to, or maintained in, a location within a cytoplasmic stress granule.
2 P52912 (/ISO) P52912 (/ISO)
Positive regulation of epithelial cell apoptotic process GO:1904037
Any process that activates or increases the frequency, rate or extent of epithelial cell apoptotic process.
2 P52912 (/ISO) P52912 (/ISO)
Positive regulation of epithelial cell apoptotic process GO:1904037
Any process that activates or increases the frequency, rate or extent of epithelial cell apoptotic process.
1 Q5PQR7 (/IMP)

There are 19 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
32 P31483 (/TAS) P31483 (/TAS) P31483 (/TAS) P31483 (/TAS) Q01085 (/TAS) Q01085 (/TAS) Q01085 (/TAS) Q01085 (/TAS) Q01085 (/TAS) Q01085 (/TAS)
(22 more)
Cytoplasmic stress granule GO:0010494
A dense aggregation in the cytosol composed of proteins and RNAs that appear when the cell is under stress.
32 P31483 (/ISS) P31483 (/ISS) P31483 (/ISS) P31483 (/ISS) Q01085 (/ISS) Q01085 (/ISS) Q01085 (/ISS) Q01085 (/ISS) Q01085 (/ISS) Q01085 (/ISS)
(22 more)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
28 Q01085 (/ISS) Q01085 (/ISS) Q01085 (/ISS) Q01085 (/ISS) Q01085 (/ISS) Q01085 (/ISS) Q01085 (/ISS) Q01085 (/ISS) Q01085 (/ISS) Q01085 (/ISS)
(18 more)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
28 Q01085 (/ISS) Q01085 (/ISS) Q01085 (/ISS) Q01085 (/ISS) Q01085 (/ISS) Q01085 (/ISS) Q01085 (/ISS) Q01085 (/ISS) Q01085 (/ISS) Q01085 (/ISS)
(18 more)
Lysosome GO:0005764
A small lytic vacuole that has cell cycle-independent morphology and is found in most animal cells and that contains a variety of hydrolases, most of which have their maximal activities in the pH range 5-6. The contained enzymes display latency if properly isolated. About 40 different lysosomal hydrolases are known and lysosomes have a great variety of morphologies and functions.
28 Q01085 (/TAS) Q01085 (/TAS) Q01085 (/TAS) Q01085 (/TAS) Q01085 (/TAS) Q01085 (/TAS) Q01085 (/TAS) Q01085 (/TAS) Q01085 (/TAS) Q01085 (/TAS)
(18 more)
Cytoplasmic stress granule GO:0010494
A dense aggregation in the cytosol composed of proteins and RNAs that appear when the cell is under stress.
15 P31483 (/IDA) P31483 (/IDA) P31483 (/IDA) P31483 (/IDA) P52912 (/IDA) P52912 (/IDA) P70318 (/IDA) P70318 (/IDA) P70318 (/IDA) P70318 (/IDA)
(5 more)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
11 P52912 (/IDA) P52912 (/IDA) P70318 (/IDA) P70318 (/IDA) P70318 (/IDA) P70318 (/IDA) Q5BJN3 (/IDA) Q5BJN3 (/IDA) Q5BJN3 (/IDA) Q5BJN3 (/IDA)
(1 more)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
10 P31483 (/IDA) P31483 (/IDA) P31483 (/IDA) P31483 (/IDA) P52912 (/IDA) P52912 (/IDA) P70318 (/IDA) P70318 (/IDA) P70318 (/IDA) P70318 (/IDA)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
7 F8W8I6 (/IDA) F8W8I6 (/IDA) F8W8I6 (/IDA) P31483 (/IDA) P31483 (/IDA) P31483 (/IDA) P31483 (/IDA)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
7 F8W8I6 (/IDA) F8W8I6 (/IDA) F8W8I6 (/IDA) P31483 (/IDA) P31483 (/IDA) P31483 (/IDA) P31483 (/IDA)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
6 P52912 (/ISO) P52912 (/ISO) P70318 (/ISO) P70318 (/ISO) P70318 (/ISO) P70318 (/ISO)
Cytoplasmic stress granule GO:0010494
A dense aggregation in the cytosol composed of proteins and RNAs that appear when the cell is under stress.
6 P52912 (/ISO) P52912 (/ISO) P70318 (/ISO) P70318 (/ISO) P70318 (/ISO) P70318 (/ISO)
Nuclear stress granule GO:0097165
A dense aggregation in the nucleus composed of proteins and RNAs that appear when the cell is under stress.
6 P31483 (/IDA) P31483 (/IDA) P31483 (/IDA) P31483 (/IDA) P52912 (/IDA) P52912 (/IDA)
Ribonucleoprotein complex GO:1990904
A macromolecular complex containing both protein and RNA molecules.
6 P52912 (/ISO) P52912 (/ISO) P70318 (/ISO) P70318 (/ISO) P70318 (/ISO) P70318 (/ISO)
Ribonucleoprotein complex GO:1990904
A macromolecular complex containing both protein and RNA molecules.
5 Q5BJN3 (/IDA) Q5BJN3 (/IDA) Q5BJN3 (/IDA) Q5BJN3 (/IDA) Q5PQR7 (/IDA)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
2 P52912 (/ISO) P52912 (/ISO)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
2 P52912 (/ISO) P52912 (/ISO)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
2 P52912 (/ISO) P52912 (/ISO)
Nuclear stress granule GO:0097165
A dense aggregation in the nucleus composed of proteins and RNAs that appear when the cell is under stress.
2 P52912 (/ISO) P52912 (/ISO)
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