The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
« Back to all FunFams

FunFam 4: RNA binding fox-1 homolog 1

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 21 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
MRNA binding GO:0003729
Interacting selectively and non-covalently with messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns.
9 A8JNQ4 (/ISS) A8JNQ5 (/ISS) M9ND74 (/ISS) M9NFQ7 (/ISS) M9PF74 (/ISS) Q7YU08 (/ISS) Q8MSP1 (/ISS) Q9VT98 (/ISS) Q9VT99 (/ISS)
MRNA 3'-UTR binding GO:0003730
Interacting selectively and non-covalently with the 3' untranslated region of an mRNA molecule.
9 A8JNQ4 (/IDA) A8JNQ5 (/IDA) M9ND74 (/IDA) M9NFQ7 (/IDA) M9PF74 (/IDA) Q7YU08 (/IDA) Q8MSP1 (/IDA) Q9VT98 (/IDA) Q9VT99 (/IDA)
Transcription factor binding GO:0008134
Interacting selectively and non-covalently with a transcription factor, a protein required to initiate or regulate transcription.
9 A8JNQ4 (/IPI) A8JNQ5 (/IPI) M9ND74 (/IPI) M9NFQ7 (/IPI) M9PF74 (/IPI) Q7YU08 (/IPI) Q8MSP1 (/IPI) Q9VT98 (/IPI) Q9VT99 (/IPI)
Transcription regulatory region DNA binding GO:0044212
Interacting selectively and non-covalently with a DNA region that regulates the transcription of a region of DNA, which may be a gene, cistron, or operon. Binding may occur as a sequence specific interaction or as an interaction observed only once a factor has been recruited to the DNA by other factors.
9 A8JNQ4 (/IDA) A8JNQ5 (/IDA) M9ND74 (/IDA) M9NFQ7 (/IDA) M9PF74 (/IDA) Q7YU08 (/IDA) Q8MSP1 (/IDA) Q9VT98 (/IDA) Q9VT99 (/IDA)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
6 O43251 (/IPI) Q8BIF2 (/IPI) Q8BP71 (/IPI) Q9NWB1 (/IPI) Q9NWB1 (/IPI) Q9NWB1 (/IPI)
Transcription corepressor activity GO:0003714
A protein or a member of a complex that interacts specifically and non-covalently with a DNA-bound DNA-binding transcription factor to repress the transcription of specific genes. Corepressors often act by altering chromatin structure and modifications. For example, one class of transcription coregulators modifies chromatin structure through covalent modification of histones. A second ATP-dependent class modifies the conformation of chromatin. A third class occludes DNA-binding transcription factor protein-protein interaction domains. A fourth class of corepressors prevents interactions of DNA bound DNA-binding transcription factor with coactivators.
3 A1A5R1 (/ISS) A6QPR6 (/ISS) Q8BP71 (/ISS)
RNA binding GO:0003723
Interacting selectively and non-covalently with an RNA molecule or a portion thereof.
3 O43251 (/IDA) Q7ZT82 (/IDA) Q7ZT82 (/IDA)
RNA binding GO:0003723
Interacting selectively and non-covalently with an RNA molecule or a portion thereof.
3 A1A5R1 (/ISS) A6QPR6 (/ISS) Q8BP71 (/ISS)
RNA binding GO:0003723
Interacting selectively and non-covalently with an RNA molecule or a portion thereof.
3 Q9NWB1 (/NAS) Q9NWB1 (/NAS) Q9NWB1 (/NAS)
Protein C-terminus binding GO:0008022
Interacting selectively and non-covalently with a protein C-terminus, the end of any peptide chain at which the 1-carboxyl function of a constituent amino acid is not attached in peptide linkage to another amino-acid residue.
3 Q9NWB1 (/IPI) Q9NWB1 (/IPI) Q9NWB1 (/IPI)
Transcription factor binding GO:0008134
Interacting selectively and non-covalently with a transcription factor, a protein required to initiate or regulate transcription.
3 A1A5R1 (/ISS) A6QPR6 (/ISS) Q8BP71 (/ISS)
RNA binding GO:0003723
Interacting selectively and non-covalently with an RNA molecule or a portion thereof.
2 Q7ZT82 (/IGI) Q7ZT82 (/IGI)
DNA binding GO:0003677
Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
1 Q8BIF2 (/IDA)
Transcription corepressor activity GO:0003714
A protein or a member of a complex that interacts specifically and non-covalently with a DNA-bound DNA-binding transcription factor to repress the transcription of specific genes. Corepressors often act by altering chromatin structure and modifications. For example, one class of transcription coregulators modifies chromatin structure through covalent modification of histones. A second ATP-dependent class modifies the conformation of chromatin. A third class occludes DNA-binding transcription factor protein-protein interaction domains. A fourth class of corepressors prevents interactions of DNA bound DNA-binding transcription factor with coactivators.
1 O43251 (/IDA)
Transcription corepressor activity GO:0003714
A protein or a member of a complex that interacts specifically and non-covalently with a DNA-bound DNA-binding transcription factor to repress the transcription of specific genes. Corepressors often act by altering chromatin structure and modifications. For example, one class of transcription coregulators modifies chromatin structure through covalent modification of histones. A second ATP-dependent class modifies the conformation of chromatin. A third class occludes DNA-binding transcription factor protein-protein interaction domains. A fourth class of corepressors prevents interactions of DNA bound DNA-binding transcription factor with coactivators.
1 Q8BP71 (/ISO)
RNA binding GO:0003723
Interacting selectively and non-covalently with an RNA molecule or a portion thereof.
1 O43251 (/HDA)
RNA binding GO:0003723
Interacting selectively and non-covalently with an RNA molecule or a portion thereof.
1 Q8BP71 (/ISO)
MRNA binding GO:0003729
Interacting selectively and non-covalently with messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns.
1 Q8BP71 (/IDA)
Protein C-terminus binding GO:0008022
Interacting selectively and non-covalently with a protein C-terminus, the end of any peptide chain at which the 1-carboxyl function of a constituent amino acid is not attached in peptide linkage to another amino-acid residue.
1 Q9JJ43 (/ISO)
Transcription factor binding GO:0008134
Interacting selectively and non-covalently with a transcription factor, a protein required to initiate or regulate transcription.
1 O43251 (/IDA)
Transcription factor binding GO:0008134
Interacting selectively and non-covalently with a transcription factor, a protein required to initiate or regulate transcription.
1 Q8BP71 (/ISO)

There are 34 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Nervous system development GO:0007399
The process whose specific outcome is the progression of nervous tissue over time, from its formation to its mature state.
9 A8JNQ4 (/IMP) A8JNQ5 (/IMP) M9ND74 (/IMP) M9NFQ7 (/IMP) M9PF74 (/IMP) Q7YU08 (/IMP) Q8MSP1 (/IMP) Q9VT98 (/IMP) Q9VT99 (/IMP)
Imaginal disc-derived wing vein specification GO:0007474
The regionalization process in which the area of a imaginal disc-derived wing that will form a wing vein is specified.
9 A8JNQ4 (/IMP) A8JNQ5 (/IMP) M9ND74 (/IMP) M9NFQ7 (/IMP) M9PF74 (/IMP) Q7YU08 (/IMP) Q8MSP1 (/IMP) Q9VT98 (/IMP) Q9VT99 (/IMP)
Memory GO:0007613
The activities involved in the mental information processing system that receives (registers), modifies, stores, and retrieves informational stimuli. The main stages involved in the formation and retrieval of memory are encoding (processing of received information by acquisition), storage (building a permanent record of received information as a result of consolidation) and retrieval (calling back the stored information and use it in a suitable way to execute a given task).
9 A8JNQ4 (/IMP) A8JNQ5 (/IMP) M9ND74 (/IMP) M9NFQ7 (/IMP) M9PF74 (/IMP) Q7YU08 (/IMP) Q8MSP1 (/IMP) Q9VT98 (/IMP) Q9VT99 (/IMP)
Negative regulation of translation GO:0017148
Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA or circRNA.
9 A8JNQ4 (/IDA) A8JNQ5 (/IDA) M9ND74 (/IDA) M9NFQ7 (/IDA) M9PF74 (/IDA) Q7YU08 (/IDA) Q8MSP1 (/IDA) Q9VT98 (/IDA) Q9VT99 (/IDA)
Germarium-derived oocyte differentiation GO:0030706
The process in which one relatively unspecialized immature cystocyte of the germ-line cyst in the germarium acquires the specialized features of an oocyte. An example of this process can be found in Drosophila melanogaster.
9 A8JNQ4 (/IMP) A8JNQ5 (/IMP) M9ND74 (/IMP) M9NFQ7 (/IMP) M9PF74 (/IMP) Q7YU08 (/IMP) Q8MSP1 (/IMP) Q9VT98 (/IMP) Q9VT99 (/IMP)
Positive regulation of transcription, DNA-templated GO:0045893
Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.
9 A8JNQ4 (/IMP) A8JNQ5 (/IMP) M9ND74 (/IMP) M9NFQ7 (/IMP) M9PF74 (/IMP) Q7YU08 (/IMP) Q8MSP1 (/IMP) Q9VT98 (/IMP) Q9VT99 (/IMP)
Oogenesis GO:0048477
The complete process of formation and maturation of an ovum or female gamete from a primordial female germ cell. Examples of this process are found in Mus musculus and Drosophila melanogaster.
9 A8JNQ4 (/IMP) A8JNQ5 (/IMP) M9ND74 (/IMP) M9NFQ7 (/IMP) M9PF74 (/IMP) Q7YU08 (/IMP) Q8MSP1 (/IMP) Q9VT98 (/IMP) Q9VT99 (/IMP)
Regulation of alternative mRNA splicing, via spliceosome GO:0000381
Any process that modulates the frequency, rate or extent of alternative splicing of nuclear mRNAs.
3 Q642J5 (/IMP) Q8BP71 (/IMP) Q9JJ43 (/IMP)
Intracellular estrogen receptor signaling pathway GO:0030520
Any series of molecular signals generated as a consequence of an intracellular estrogen receptor binding to one of its physiological ligands. The pathway begins with receptor-ligand binding, and ends with regulation of a downstream cellular process (e.g. transcription).
3 A1A5R1 (/ISS) A6QPR6 (/ISS) Q8BP71 (/ISS)
Regulation of RNA splicing GO:0043484
Any process that modulates the frequency, rate or extent of RNA splicing, the process of removing sections of the primary RNA transcript to remove sequences not present in the mature form of the RNA and joining the remaining sections to form the mature form of the RNA.
3 Q642J5 (/IMP) Q7ZT82 (/IMP) Q7ZT82 (/IMP)
Negative regulation of transcription, DNA-templated GO:0045892
Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.
3 A1A5R1 (/ISS) A6QPR6 (/ISS) Q8BP71 (/ISS)
RNA transport GO:0050658
The directed movement of RNA, ribonucleic acids, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
3 Q9NWB1 (/NAS) Q9NWB1 (/NAS) Q9NWB1 (/NAS)
Heart process GO:0003015
A circulatory system process carried out by the heart. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood.
2 Q7ZT82 (/IMP) Q7ZT82 (/IMP)
RNA splicing GO:0008380
The process of removing sections of the primary RNA transcript to remove sequences not present in the mature form of the RNA and joining the remaining sections to form the mature form of the RNA.
2 Q7ZT82 (/IDA) Q7ZT82 (/IDA)
Regulation of RNA splicing GO:0043484
Any process that modulates the frequency, rate or extent of RNA splicing, the process of removing sections of the primary RNA transcript to remove sequences not present in the mature form of the RNA and joining the remaining sections to form the mature form of the RNA.
2 Q7ZT82 (/IDA) Q7ZT82 (/IDA)
Regulation of RNA splicing GO:0043484
Any process that modulates the frequency, rate or extent of RNA splicing, the process of removing sections of the primary RNA transcript to remove sequences not present in the mature form of the RNA and joining the remaining sections to form the mature form of the RNA.
2 Q7ZT82 (/IGI) Q7ZT82 (/IGI)
Cardiac muscle fiber development GO:0048739
The process whose specific outcome is the progression of cardiac muscle fiber over time, from its formation to the mature structure.
2 Q7ZT82 (/IGI) Q7ZT82 (/IGI)
Skeletal muscle fiber development GO:0048741
The process whose specific outcome is the progression of the skeletal muscle fiber over time, from its formation to the mature structure. Muscle fibers are formed by the maturation of myotubes. They can be classed as slow, intermediate/fast or fast.
2 Q7ZT82 (/IGI) Q7ZT82 (/IGI)
Neuromuscular process controlling balance GO:0050885
Any process that an organism uses to control its balance, the orientation of the organism (or the head of the organism) in relation to the source of gravity. In humans and animals, balance is perceived through visual cues, the labyrinth system of the inner ears and information from skin pressure receptors and muscle and joint receptors.
2 Q8BP71 (/IGI) Q9JJ43 (/IGI)
Regulation of alternative mRNA splicing, via spliceosome GO:0000381
Any process that modulates the frequency, rate or extent of alternative splicing of nuclear mRNAs.
1 Q8BP71 (/IGI)
Regulation of alternative mRNA splicing, via spliceosome GO:0000381
Any process that modulates the frequency, rate or extent of alternative splicing of nuclear mRNAs.
1 O43251 (/ISS)
Fibroblast growth factor receptor signaling pathway GO:0008543
The series of molecular signals generated as a consequence of a fibroblast growth factor receptor binding to one of its physiological ligands.
1 O43251 (/TAS)
Regulation of definitive erythrocyte differentiation GO:0010724
Any process that modulates the rate, frequency, or extent of definitive erythrocyte differentiation. Definitive erythrocyte differentiation occurs as part of the process of definitive hemopoiesis.
1 Q8BP71 (/IDA)
RNA metabolic process GO:0016070
The cellular chemical reactions and pathways involving RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage.
1 O43251 (/TAS)
Hypothalamus development GO:0021854
The progression of the hypothalamus region of the forebrain, from its initial formation to its mature state.
1 Q642J5 (/IMP)
Radial glia guided migration of Purkinje cell GO:0021942
The migration of postmitotic a Purkinje cell along radial glial cells from the ventricular zone to the Purkinje cell layer.
1 Q8BP71 (/IMP)
Intracellular estrogen receptor signaling pathway GO:0030520
Any series of molecular signals generated as a consequence of an intracellular estrogen receptor binding to one of its physiological ligands. The pathway begins with receptor-ligand binding, and ends with regulation of a downstream cellular process (e.g. transcription).
1 O43251 (/IDA)
Intracellular estrogen receptor signaling pathway GO:0030520
Any series of molecular signals generated as a consequence of an intracellular estrogen receptor binding to one of its physiological ligands. The pathway begins with receptor-ligand binding, and ends with regulation of a downstream cellular process (e.g. transcription).
1 Q8BP71 (/ISO)
Regulation of cell population proliferation GO:0042127
Any process that modulates the frequency, rate or extent of cell proliferation.
1 O43251 (/TAS)
Negative regulation of transcription, DNA-templated GO:0045892
Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.
1 O43251 (/IDA)
Negative regulation of transcription, DNA-templated GO:0045892
Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.
1 Q8BP71 (/ISO)
Dendrite morphogenesis GO:0048813
The process in which the anatomical structures of a dendrite are generated and organized.
1 Q8BP71 (/IMP)
Heart contraction GO:0060047
The multicellular organismal process in which the heart decreases in volume in a characteristic way to propel blood through the body.
1 Q642J5 (/IMP)
Regulation of skeletal muscle cell differentiation GO:2001014
Any process that modulates the frequency, rate or extent of skeletal muscle cell differentiation.
1 Q9JJ43 (/IMP)

There are 15 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
20 A0A0R4IT73 (/IDA) A0A286YA75 (/IDA) A0A2R8Q9N3 (/IDA) A8JNQ4 (/IDA) A8JNQ5 (/IDA) I3ISM5 (/IDA) M9ND74 (/IDA) M9NFQ7 (/IDA) M9PF74 (/IDA) O43251 (/IDA)
(10 more)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
13 A8JNQ4 (/IDA) A8JNQ5 (/IDA) M9ND74 (/IDA) M9NFQ7 (/IDA) M9PF74 (/IDA) Q7YU08 (/IDA) Q8MSP1 (/IDA) Q9JJ43 (/IDA) Q9NWB1 (/IDA) Q9NWB1 (/IDA)
(3 more)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
10 B0QYV1 (/IDA) B0QYV1 (/IDA) B0QYV1 (/IDA) B0QYV1 (/IDA) B0QYV1 (/IDA) B0QYY4 (/IDA) O43251 (/IDA) S4R469 (/IDA) S4R469 (/IDA) S4R469 (/IDA)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
10 B0QYV1 (/IDA) B0QYV1 (/IDA) B0QYV1 (/IDA) B0QYV1 (/IDA) B0QYV1 (/IDA) B0QYY4 (/IDA) O43251 (/IDA) S4R469 (/IDA) S4R469 (/IDA) S4R469 (/IDA)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
9 A8JNQ4 (/HDA) A8JNQ5 (/HDA) M9ND74 (/HDA) M9NFQ7 (/HDA) M9PF74 (/HDA) Q7YU08 (/HDA) Q8MSP1 (/HDA) Q9VT98 (/HDA) Q9VT99 (/HDA)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
3 A1A5R1 (/ISS) A6QPR6 (/ISS) Q8BP71 (/ISS)
Trans-Golgi network GO:0005802
The network of interconnected tubular and cisternal structures located within the Golgi apparatus on the side distal to the endoplasmic reticulum, from which secretory vesicles emerge. The trans-Golgi network is important in the later stages of protein secretion where it is thought to play a key role in the sorting and targeting of secreted proteins to the correct destination.
3 Q9NWB1 (/IDA) Q9NWB1 (/IDA) Q9NWB1 (/IDA)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
2 O43251 (/TAS) Q9JJ43 (/TAS)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
1 Q8BP71 (/ISO)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
1 Q8BP71 (/ISO)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
1 Q9JJ43 (/ISO)
Trans-Golgi network GO:0005802
The network of interconnected tubular and cisternal structures located within the Golgi apparatus on the side distal to the endoplasmic reticulum, from which secretory vesicles emerge. The trans-Golgi network is important in the later stages of protein secretion where it is thought to play a key role in the sorting and targeting of secreted proteins to the correct destination.
1 Q9JJ43 (/ISO)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
1 Q8BP71 (/ISO)
Neuronal cell body GO:0043025
The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites.
1 Q8BIF2 (/IDA)
Perikaryon GO:0043204
The portion of the cell soma (neuronal cell body) that excludes the nucleus.
1 Q8BIF2 (/IDA)
CATH-Gene3D is a Global Biodata Core Resource Learn more...