The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 190: serine/arginine-rich splicing factor 4 isoform X1

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 10 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
7 Q08170 (/IPI) Q13247 (/IPI) Q13247 (/IPI) Q13247 (/IPI) Q13247 (/IPI) Q3TWW8 (/IPI) Q3TWW8 (/IPI)
RNA binding GO:0003723
Interacting selectively and non-covalently with an RNA molecule or a portion thereof.
5 Q08170 (/HDA) Q13247 (/HDA) Q13247 (/HDA) Q13247 (/HDA) Q13247 (/HDA)
RNA binding GO:0003723
Interacting selectively and non-covalently with an RNA molecule or a portion thereof.
5 G3V6S8 (/ISS) G3V6S8 (/ISS) Q3B7L6 (/ISS) Q3TWW8 (/ISS) Q3TWW8 (/ISS)
Pre-mRNA binding GO:0036002
Interacting selectively and non-covalently with pre-messenger RNA (pre-mRNA), an intermediate molecule between DNA and protein that may contain introns and, at least in part, encodes one or more proteins. Introns are removed from pre-mRNA to form a mRNA molecule.
5 G3V6S8 (/ISS) G3V6S8 (/ISS) Q3B7L6 (/ISS) Q3TWW8 (/ISS) Q3TWW8 (/ISS)
RNA binding GO:0003723
Interacting selectively and non-covalently with an RNA molecule or a portion thereof.
4 Q13247 (/IDA) Q13247 (/IDA) Q13247 (/IDA) Q13247 (/IDA)
Pre-mRNA binding GO:0036002
Interacting selectively and non-covalently with pre-messenger RNA (pre-mRNA), an intermediate molecule between DNA and protein that may contain introns and, at least in part, encodes one or more proteins. Introns are removed from pre-mRNA to form a mRNA molecule.
4 Q13247 (/IDA) Q13247 (/IDA) Q13247 (/IDA) Q13247 (/IDA)
RNA binding GO:0003723
Interacting selectively and non-covalently with an RNA molecule or a portion thereof.
2 Q3TWW8 (/ISO) Q3TWW8 (/ISO)
Pre-mRNA binding GO:0036002
Interacting selectively and non-covalently with pre-messenger RNA (pre-mRNA), an intermediate molecule between DNA and protein that may contain introns and, at least in part, encodes one or more proteins. Introns are removed from pre-mRNA to form a mRNA molecule.
2 Q3TWW8 (/ISO) Q3TWW8 (/ISO)
Sequence-specific mRNA binding GO:1990825
Interacting selectively and non-covalently with messenger RNA (mRNA) of a specific nucleotide composition or a specific sequence motif.
1 G3V798 (/IDA)
Sequence-specific mRNA binding GO:1990825
Interacting selectively and non-covalently with messenger RNA (mRNA) of a specific nucleotide composition or a specific sequence motif.
1 Q8VE97 (/ISO)

There are 40 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Alternative mRNA splicing, via spliceosome GO:0000380
The process of generating multiple mRNA molecules from a given set of exons by differential use of exons from the primary transcript(s) to form multiple mature mRNAs that vary in their exon composition.
5 G3V6S8 (/ISS) G3V6S8 (/ISS) Q3B7L6 (/ISS) Q3TWW8 (/ISS) Q3TWW8 (/ISS)
Regulation of alternative mRNA splicing, via spliceosome GO:0000381
Any process that modulates the frequency, rate or extent of alternative splicing of nuclear mRNAs.
5 G3V6S8 (/ISS) G3V6S8 (/ISS) Q3B7L6 (/ISS) Q3TWW8 (/ISS) Q3TWW8 (/ISS)
MRNA splicing, via spliceosome GO:0000398
The joining together of exons from one or more primary transcripts of messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced.
5 Q08170 (/TAS) Q13247 (/TAS) Q13247 (/TAS) Q13247 (/TAS) Q13247 (/TAS)
MRNA splice site selection GO:0006376
Selection of a splice site by components of the assembling spliceosome.
5 G3V6S8 (/ISS) G3V6S8 (/ISS) Q3B7L6 (/ISS) Q3TWW8 (/ISS) Q3TWW8 (/ISS)
RNA export from nucleus GO:0006405
The directed movement of RNA from the nucleus to the cytoplasm.
5 Q08170 (/TAS) Q13247 (/TAS) Q13247 (/TAS) Q13247 (/TAS) Q13247 (/TAS)
MRNA export from nucleus GO:0006406
The directed movement of mRNA from the nucleus to the cytoplasm.
5 Q08170 (/TAS) Q13247 (/TAS) Q13247 (/TAS) Q13247 (/TAS) Q13247 (/TAS)
Regulation of keratinocyte proliferation GO:0010837
Any process that modulates the rate, frequency or extent of keratinocyte proliferation. Keratinocyte proliferation is the multiplication or reproduction of keratinocytes, resulting in the expansion of a cell population.
5 G3V6S8 (/ISS) G3V6S8 (/ISS) Q3B7L6 (/ISS) Q3TWW8 (/ISS) Q3TWW8 (/ISS)
MRNA 3'-end processing GO:0031124
Any process involved in forming the mature 3' end of an mRNA molecule.
5 Q08170 (/TAS) Q13247 (/TAS) Q13247 (/TAS) Q13247 (/TAS) Q13247 (/TAS)
Negative regulation of keratinocyte differentiation GO:0045617
Any process that stops, prevents, or reduces the frequency, rate or extent of keratinocyte differentiation.
5 G3V6S8 (/ISS) G3V6S8 (/ISS) Q3B7L6 (/ISS) Q3TWW8 (/ISS) Q3TWW8 (/ISS)
Negative regulation of mRNA splicing, via spliceosome GO:0048025
Any process that stops, prevents or reduces the rate or extent of mRNA splicing via a spliceosomal mechanism.
5 Q08170 (/IDA) Q13247 (/IDA) Q13247 (/IDA) Q13247 (/IDA) Q13247 (/IDA)
Regulation of wound healing GO:0061041
Any process that modulates the rate, frequency, or extent of the series of events that restore integrity to a damaged tissue, following an injury.
5 G3V6S8 (/ISS) G3V6S8 (/ISS) Q3B7L6 (/ISS) Q3TWW8 (/ISS) Q3TWW8 (/ISS)
Alternative mRNA splicing, via spliceosome GO:0000380
The process of generating multiple mRNA molecules from a given set of exons by differential use of exons from the primary transcript(s) to form multiple mature mRNAs that vary in their exon composition.
4 Q13247 (/IDA) Q13247 (/IDA) Q13247 (/IDA) Q13247 (/IDA)
Regulation of alternative mRNA splicing, via spliceosome GO:0000381
Any process that modulates the frequency, rate or extent of alternative splicing of nuclear mRNAs.
4 Q13247 (/IDA) Q13247 (/IDA) Q13247 (/IDA) Q13247 (/IDA)
Regulation of alternative mRNA splicing, via spliceosome GO:0000381
Any process that modulates the frequency, rate or extent of alternative splicing of nuclear mRNAs.
4 Q13247 (/IMP) Q13247 (/IMP) Q13247 (/IMP) Q13247 (/IMP)
MRNA splice site selection GO:0006376
Selection of a splice site by components of the assembling spliceosome.
4 Q13247 (/IMP) Q13247 (/IMP) Q13247 (/IMP) Q13247 (/IMP)
MRNA splice site selection GO:0006376
Selection of a splice site by components of the assembling spliceosome.
4 Q13247 (/TAS) Q13247 (/TAS) Q13247 (/TAS) Q13247 (/TAS)
Regulation of keratinocyte proliferation GO:0010837
Any process that modulates the rate, frequency or extent of keratinocyte proliferation. Keratinocyte proliferation is the multiplication or reproduction of keratinocytes, resulting in the expansion of a cell population.
4 Q13247 (/IMP) Q13247 (/IMP) Q13247 (/IMP) Q13247 (/IMP)
Negative regulation of keratinocyte differentiation GO:0045617
Any process that stops, prevents, or reduces the frequency, rate or extent of keratinocyte differentiation.
4 Q13247 (/IMP) Q13247 (/IMP) Q13247 (/IMP) Q13247 (/IMP)
Positive regulation of epithelial cell proliferation involved in lung morphogenesis GO:0060501
Any process that increases the rate or frequency of epithelial cell proliferation that results in the lung attaining its shape.
4 Q13247 (/IDA) Q13247 (/IDA) Q13247 (/IDA) Q13247 (/IDA)
Negative regulation of cell death GO:0060548
Any process that decreases the rate or frequency of cell death. Cell death is the specific activation or halting of processes within a cell so that its vital functions markedly cease, rather than simply deteriorating gradually over time, which culminates in cell death.
4 Q13247 (/IDA) Q13247 (/IDA) Q13247 (/IDA) Q13247 (/IDA)
Regulation of wound healing GO:0061041
Any process that modulates the rate, frequency, or extent of the series of events that restore integrity to a damaged tissue, following an injury.
4 Q13247 (/IMP) Q13247 (/IMP) Q13247 (/IMP) Q13247 (/IMP)
Response to insulin GO:0032868
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an insulin stimulus. Insulin is a polypeptide hormone produced by the islets of Langerhans of the pancreas in mammals, and by the homologous organs of other organisms.
3 G3V6S8 (/IEP) G3V6S8 (/IEP) G3V798 (/IEP)
Negative regulation of mRNA splicing, via spliceosome GO:0048025
Any process that stops, prevents or reduces the rate or extent of mRNA splicing via a spliceosomal mechanism.
3 Q3TWW8 (/ISO) Q3TWW8 (/ISO) Q8VE97 (/ISO)
Alternative mRNA splicing, via spliceosome GO:0000380
The process of generating multiple mRNA molecules from a given set of exons by differential use of exons from the primary transcript(s) to form multiple mature mRNAs that vary in their exon composition.
2 Q3TWW8 (/ISO) Q3TWW8 (/ISO)
Regulation of alternative mRNA splicing, via spliceosome GO:0000381
Any process that modulates the frequency, rate or extent of alternative splicing of nuclear mRNAs.
2 Q3TWW8 (/ISO) Q3TWW8 (/ISO)
MRNA splice site selection GO:0006376
Selection of a splice site by components of the assembling spliceosome.
2 Q3TWW8 (/ISO) Q3TWW8 (/ISO)
Negative regulation of gene expression GO:0010629
Any process that decreases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
2 G3V6S8 (/IMP) G3V6S8 (/IMP)
Negative regulation of gene expression GO:0010629
Any process that decreases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
2 Q3TWW8 (/ISO) Q3TWW8 (/ISO)
Regulation of keratinocyte proliferation GO:0010837
Any process that modulates the rate, frequency or extent of keratinocyte proliferation. Keratinocyte proliferation is the multiplication or reproduction of keratinocytes, resulting in the expansion of a cell population.
2 Q3TWW8 (/ISO) Q3TWW8 (/ISO)
Negative regulation of keratinocyte differentiation GO:0045617
Any process that stops, prevents, or reduces the frequency, rate or extent of keratinocyte differentiation.
2 Q3TWW8 (/ISO) Q3TWW8 (/ISO)
Negative regulation of mRNA splicing, via spliceosome GO:0048025
Any process that stops, prevents or reduces the rate or extent of mRNA splicing via a spliceosomal mechanism.
2 Q3B7L6 (/ISS) Q8VE97 (/ISS)
Positive regulation of epithelial cell proliferation involved in lung morphogenesis GO:0060501
Any process that increases the rate or frequency of epithelial cell proliferation that results in the lung attaining its shape.
2 Q3TWW8 (/ISO) Q3TWW8 (/ISO)
Negative regulation of cell death GO:0060548
Any process that decreases the rate or frequency of cell death. Cell death is the specific activation or halting of processes within a cell so that its vital functions markedly cease, rather than simply deteriorating gradually over time, which culminates in cell death.
2 Q3TWW8 (/ISO) Q3TWW8 (/ISO)
Regulation of wound healing GO:0061041
Any process that modulates the rate, frequency, or extent of the series of events that restore integrity to a damaged tissue, following an injury.
2 Q3TWW8 (/ISO) Q3TWW8 (/ISO)
Negative regulation of type B pancreatic cell apoptotic process GO:2000675
Any process that stops, prevents or reduces the frequency, rate or extent of type B pancreatic cell apoptotic process.
2 G3V6S8 (/IMP) G3V6S8 (/IMP)
Negative regulation of type B pancreatic cell apoptotic process GO:2000675
Any process that stops, prevents or reduces the frequency, rate or extent of type B pancreatic cell apoptotic process.
2 Q3TWW8 (/ISO) Q3TWW8 (/ISO)
RNA splicing, via transesterification reactions GO:0000375
Splicing of RNA via a series of two transesterification reactions.
1 Q08170 (/TAS)
Hematopoietic progenitor cell differentiation GO:0002244
The process in which precursor cell type acquires the specialized features of a hematopoietic progenitor cell, a class of cell types including myeloid progenitor cells and lymphoid progenitor cells.
1 Q8VE97 (/IMP)
MRNA processing GO:0006397
Any process involved in the conversion of a primary mRNA transcript into one or more mature mRNA(s) prior to translation into polypeptide.
1 Q08170 (/TAS)
RNA splicing GO:0008380
The process of removing sections of the primary RNA transcript to remove sequences not present in the mature form of the RNA and joining the remaining sections to form the mature form of the RNA.
1 Q08170 (/TAS)

There are 7 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
5 Q08170 (/TAS) Q13247 (/TAS) Q13247 (/TAS) Q13247 (/TAS) Q13247 (/TAS)
Nuclear speck GO:0016607
A discrete extra-nucleolar subnuclear domain, 20-50 in number, in which splicing factors are seen to be localized by immunofluorescence microscopy.
5 Q08170 (/IDA) Q13247 (/IDA) Q13247 (/IDA) Q13247 (/IDA) Q13247 (/IDA)
Nuclear speck GO:0016607
A discrete extra-nucleolar subnuclear domain, 20-50 in number, in which splicing factors are seen to be localized by immunofluorescence microscopy.
5 G3V6S8 (/ISS) G3V6S8 (/ISS) Q3B7L6 (/ISS) Q3TWW8 (/ISS) Q3TWW8 (/ISS)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
3 G3V6S8 (/IDA) G3V6S8 (/IDA) G3V798 (/IDA)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
3 Q3TWW8 (/ISO) Q3TWW8 (/ISO) Q8VE97 (/ISO)
Nuclear speck GO:0016607
A discrete extra-nucleolar subnuclear domain, 20-50 in number, in which splicing factors are seen to be localized by immunofluorescence microscopy.
3 Q3TWW8 (/ISO) Q3TWW8 (/ISO) Q8VE97 (/ISO)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
1 Q08170 (/TAS)
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