The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Nucleotide cyclase
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.

Browse Functional Families

ID Function Family (FunFam) Name Total Sequences Enzyme? Structure? Structural Representative PDB Sites? Alignment Diversity (0-100)
1
1049 - - 86.8
2
867
3D
3maaA00 - 74.6
3
623
3D
3maaB00 - 78.1
4
380 - - 85.9
5
274
3D
4ni2B00 - 86.7
6
269 - - 80.8
7
265
3D
4ni2A00 - 89.2
8
253 - - 87.7
9
252 - - 73.9
10
236 - - 37.8
11
232 - - 56.3
12
227 - - 50.0
13
217 - - 79.8
14
216 - - 84.6
15
199 - - 88.0
17
160
3D
5iv4A02 - 97.2
16
154 - - 95.0
18
118 - - 70.5
21
115
3D
5iv4A01 - 96.1
19
99 - - 75.4
20
98 - - 48.9
22
79
3D
1fx2A00 - 94.1
23
77 - - 73.6
24
74 - - 87.1
25
67
3D
3r5gB00 - 56.2
33
65
3D
4p2xB00 - 91.0
26
56 - - 83.6
27
53 - - 82.2
28
52 - - 82.6
29
47 - - 30.5
30
47 - - 90.5
32
46 - - 86.2
31
46 - - 59.5
34
36 - - 21.4
35
34 - - 81.0
36
33 - - 86.1
39
32 - - 47.0
37
32 - - 41.4
38
32 - - 72.5
40
Ca
2+
31 - - 45.5
41
28 - - 73.9
43
24 - - 38.6
44
24 - - 65.5
42
24 - - 81.3
46
23 - - 24.9
45
23 - - 83.7
47
20 - - 0.0
48
19 - - 71.6
49
19 - - 0.6
50
19 - - 87.7
70
19
3D
1ybuD00 - 12.9
51
18 - - 8.6
53
18 - - 68.5
52
18 - - 0.6
54
18 - - 35.3
55
17 - - 92.3
56
15 - - 83.3
58
15 - - 67.4
57
15 - - 71.1
59
15 - - 89.1
60
13 - - 31.7
76
13
3D
1y11A02 - 9.1
62
13 - - 89.2
61
13 - - 56.5
65
12 - - 60.4
67
12 - - 4.5
68
12 - - 23.3
63
12 - - 12.2
64
12 - - 62.5
66
12 - - 76.6
69
11 - - 32.5
71
ATP pyrophosphate-lyase
11 - - 13.3
72
10 - - 1.2
73
10 - - 58.3
74
9 - - 34.6
75
9 - - 45.8
78
8 - - 20.7
80
8 - - 39.7
82
8 - - 77.6
84
8 - - 32.7
81
8 - - 73.5
77
8 - - 16.5
79
8 - - 16.9
83
8 - - 46.1
89
7 - - 14.9
90
7 - - 66.3
85
7 - - 15.4
87
7 - - 72.0
91
7 - - 68.5
86
7 - - 74.4
88
7 - - 74.8
92
6 - - 10.9
96
6 - - 78.8
94
6 - - 66.1
93
6 - - 0.0
95
6 - - 70.2
105
5 - - 45.3
99
5 - - 11.6
103
5 - - 10.4
98
5 - - 7.3
102
5 - - 16.3
100
5 - - 10.2
101
5 - - 52.4
106
5 - - 21.4
104
5 - - 12.4
97
5 - - 54.8
112
4 - - 8.2
119
4 - - 36.2
110
4 - - 1.1
117
4 - - 67.3
109
4 - - 3.6
107
4 - - 84.6
115
4 - - 67.5
111
4 - - 25.9
113
4 - - 10.9
118
4 - - 65.5
116
4 - - 62.7
108
4 - - 20.0
114
brain
4 - - 50.6
129
3 - - 0.6
124
3 - - 0.0
131
3 - - 4.4
126
3 - - 5.0
133
3 - - 57.6
121
3 - - 7.0
130
3 - - 7.0
123
ATP pyrophosphate-lyase Adenylyl cyclase
3 - - 0.0
128
3 - - 0.6
132
3 - - 52.4
125
3 - - 31.7
134
3 - - 73.3
127
3 - - 0.0
120
3 - - 29.9
122
3 - - 6.6
170
2 - - 0.0
184
2 - - 0.0
181
2 - - 0.0
165
2 - - 0.0
168
2 - - 6.0
192
2 - - 0.0
199
2 - - 18.2
148
2 - - 0.0
157
2 - - 33.7
179
2 - - 0.0
141
2 - - 0.0
193
2 - - 0.0
205
2 - - 40.4
163
2 - - 0.0
186
2 - - 8.4
176
2 - - 0.0
143
2 - - 0.0
180
2 - - 1.7
137
2 - - 44.7
187
2 - - 0.0
175
2 - - 0.0
202
2 - - 33.8
154
2 - - 1.1
147
2 - - 11.3
135
2 - - 35.6
145
2 - - 31.7
152
2 - - 0.0
200
2 - - 28.7
160
2 - - 39.0
189
2 - - 0.0
182
2 - - 0.0
167
2 - - 0.0
140
Ca
2+
2 - - 10.8
206
2 - - 27.1
197
2 - - 0.0
150
2 - - 0.0
159
2 - - 41.4
162
2 - - 0.0
169
2 - - 0.0
190
2 - - 0.0
172
2 - - 0.0
191
2 - - 0.8
142
2 - - 1.8
158
2 - - 38.0
149
2 - - 0.0
139
2 - - 19.7
178
2 - - 0.7
183
2 - - 0.0
204
2 - - 40.5
144
2 - - 12.0
177
2 - - 0.0
156
2 - - 20.2
196
2 - - 2.8
194
2 - - 0.0
171
2 - - 0.0
166
2 - - 0.0
185
2 - - 0.0
153
2 - - 7.2
136
2 - - 44.6
155
2 - - 0.0
198
2 - - 0.0
161
2 - - 0.0
195
2 - - 11.6
174
2 - - 0.0
188
2 - - 0.0
203
2 - - 36.4
146
2 - - 41.4
164
2 - - 0.0
151
2 - - 7.9
138
2 - - 20.2
173
2 - - 0.0
201
2 - - 31.4
232
1 - - 0.0
207
1 - - 0.0
281
1 - - 0.0
252
1 - - 0.0
224
1 - - 0.0
279
1 - - 0.0
263
1 - - 0.0
273
1 - - 0.0
258
1 - - 0.0
248
1 - - 0.0
234
1 - - 0.0
264
1 - - 0.0
283
1 - - 0.0
226
1 - - 0.0
237
1 - - 0.0
256
1 - - 0.0
215
1 - - 0.0
270
1 - - 0.0
261
1 - - 0.0
285
1 - - 0.0
212
1 - - 0.0
257
1 - - 0.0
247
1 - - 0.0
242
1 - - 0.0
254
1 - - 0.0
228
1 - - 0.0
211
1 - - 0.0
218
1 - - 0.0
221
1 - - 0.0
274
1 - - 0.0
250
1 - - 0.0
276
1 - - 0.0
240
1 - - 0.0
230
1 - - 0.0
239
1 - - 0.0
269
1 - - 0.0
245
1 - - 0.0
266
1 - - 0.0
223
1 - - 0.0
216
1 - - 0.0
272
1 - - 0.0
262
1 - - 0.0
225
1 - - 0.0
278
1 - - 0.0
222
1 - - 0.0
217
1 - - 0.0
209
1 - - 0.0
267
1 - - 0.0
233
1 - - 0.0
280
1 - - 0.0
253
1 - - 0.0
236
1 - - 0.0
260
1 - - 0.0
227
1 - - 0.0
259
1 - - 0.0
249
1 - - 0.0
214
1 - - 0.0
244
1 - - 0.0
235
1 - - 0.0
265
1 - - 0.0
282
1 - - 0.0
246
1 - - 0.0
229
1 - - 0.0
284
1 - - 0.0
210
1 - - 0.0
271
1 - - 0.0
213
1 - - 0.0
243
1 - - 0.0
268
1 - - 0.0
238
1 - - 0.0
255
1 - - 0.0
219
1 - - 0.0
220
1 - - 0.0
286
1 - - 0.0
275
1 - - 0.0
251
1 - - 0.0
208
1 - - 0.0
241
1 - - 0.0
231
1 - - 0.0
277
1 - - 0.0