The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
SH2 domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 88: Tyrosine-protein kinase

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 3 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Non-membrane spanning protein tyrosine kinase activity GO:0004715
Catalysis of the reaction: ATP + protein L-tyrosine = ADP + protein L-tyrosine phosphate by a non-membrane spanning protein.
5 P00528 (/IDA) P00528 (/IDA) P00528 (/IDA) P00528 (/IDA) P00528 (/IDA)
Signaling receptor binding GO:0005102
Interacting selectively and non-covalently with one or more specific sites on a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function.
5 P00528 (/IPI) P00528 (/IPI) P00528 (/IPI) P00528 (/IPI) P00528 (/IPI)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
5 P00528 (/IPI) P00528 (/IPI) P00528 (/IPI) P00528 (/IPI) P00528 (/IPI)

There are 29 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Activation of MAPKKK activity GO:0000185
Any process that initiates the activity of the inactive enzyme MAP kinase kinase kinase (MAPKKK).
5 P00528 (/IDA) P00528 (/IDA) P00528 (/IDA) P00528 (/IDA) P00528 (/IDA)
Germarium-derived egg chamber formation GO:0007293
Construction of a stage-1 egg chamber in the anterior part of the germarium, from the progeny of germ-line and somatic stem cells. An example of this is found in Drosophila melanogaster.
5 P00528 (/IMP) P00528 (/IMP) P00528 (/IMP) P00528 (/IMP) P00528 (/IMP)
Ovarian nurse cell to oocyte transport GO:0007300
Transfer of constituents synthesized in the ovarian nurse cells to the oocyte, through the ring canals, as the egg chamber is growing. An example of this is found in Drosophila melanogaster.
5 P00528 (/IMP) P00528 (/IMP) P00528 (/IMP) P00528 (/IMP) P00528 (/IMP)
Female germline ring canal formation GO:0007301
Assembly of the intercellular bridges that connect the germ-line cells of a female cyst.
5 P00528 (/IMP) P00528 (/IMP) P00528 (/IMP) P00528 (/IMP) P00528 (/IMP)
Cellularization GO:0007349
The separation of a multi-nucleate cell or syncytium into individual cells. An example of this is found in Drosophila melanogaster embryo development.
5 P00528 (/IMP) P00528 (/IMP) P00528 (/IMP) P00528 (/IMP) P00528 (/IMP)
Axon guidance GO:0007411
The chemotaxis process that directs the migration of an axon growth cone to a specific target site in response to a combination of attractive and repulsive cues.
5 P00528 (/IMP) P00528 (/IMP) P00528 (/IMP) P00528 (/IMP) P00528 (/IMP)
Open tracheal system development GO:0007424
The process whose specific outcome is the progression of an open tracheal system over time, from its formation to the mature structure. An open tracheal system is a respiratory system, a branched network of epithelial tubes that supplies oxygen to target tissues via spiracles. An example of this is found in Drosophila melanogaster.
5 P00528 (/IMP) P00528 (/IMP) P00528 (/IMP) P00528 (/IMP) P00528 (/IMP)
Salivary gland morphogenesis GO:0007435
The process in which the anatomical structures of the salivary gland are generated and organized.
5 P00528 (/IMP) P00528 (/IMP) P00528 (/IMP) P00528 (/IMP) P00528 (/IMP)
Long-term memory GO:0007616
The memory process that deals with the storage, retrieval and modification of information a long time (typically weeks, months or years) after receiving that information. This type of memory is typically dependent on gene transcription regulated by second messenger activation.
5 P00528 (/IMP) P00528 (/IMP) P00528 (/IMP) P00528 (/IMP) P00528 (/IMP)
Regulation of actin polymerization or depolymerization GO:0008064
Any process that modulates the frequency, rate or extent of the assembly or disassembly of actin filaments by the addition or removal of actin monomers from a filament.
5 P00528 (/IMP) P00528 (/IMP) P00528 (/IMP) P00528 (/IMP) P00528 (/IMP)
Female germline ring canal formation, actin assembly GO:0008302
Recruitment and organization of actin filaments in female germline ring canals.
5 P00528 (/IMP) P00528 (/IMP) P00528 (/IMP) P00528 (/IMP) P00528 (/IMP)
Female germline ring canal stabilization GO:0008335
Maintenance of the structural integrity of the ring canals connecting the female germline cyst.
5 P00528 (/IMP) P00528 (/IMP) P00528 (/IMP) P00528 (/IMP) P00528 (/IMP)
Mushroom body development GO:0016319
The process whose specific outcome is the progression of the mushroom body over time, from its formation to the mature structure. The mushroom body is composed of the prominent neuropil structures of the insect central brain, thought to be crucial for olfactory associated learning. These consist mainly of a bulbous calyx and tightly packaged arrays of thin parallel fibers of the Kenyon cells.
5 P00528 (/IMP) P00528 (/IMP) P00528 (/IMP) P00528 (/IMP) P00528 (/IMP)
Peptidyl-tyrosine phosphorylation GO:0018108
The phosphorylation of peptidyl-tyrosine to form peptidyl-O4'-phospho-L-tyrosine.
5 P00528 (/IGI) P00528 (/IGI) P00528 (/IGI) P00528 (/IGI) P00528 (/IGI)
Actin cytoskeleton organization GO:0030036
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins.
5 P00528 (/IMP) P00528 (/IMP) P00528 (/IMP) P00528 (/IMP) P00528 (/IMP)
Parallel actin filament bundle assembly GO:0030046
Assembly of actin filament bundles in which the filaments are tightly packed (approximately 10-20 nm apart) and oriented with the same polarity.
5 P00528 (/IMP) P00528 (/IMP) P00528 (/IMP) P00528 (/IMP) P00528 (/IMP)
Germarium-derived female germ-line cyst encapsulation GO:0030708
Formation of a single follicular epithelium around the germ-line derived cells of a cyst formed in the germarium. An example of this process is found in Drosophila melanogaster.
5 P00528 (/IMP) P00528 (/IMP) P00528 (/IMP) P00528 (/IMP) P00528 (/IMP)
Oocyte karyosome formation GO:0030717
The chromosome organization process in which meiotic chromosomes in the oocyte nucleus cluster together to form a compact spherical structure called the karyosome.
5 P00528 (/IMP) P00528 (/IMP) P00528 (/IMP) P00528 (/IMP) P00528 (/IMP)
Ovarian fusome organization GO:0030723
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the fusome of ovarian cells, an organelle derived from the spectrosome. It anchors the mitotic spindle pole to provide orientation during cystoblast cell divisions.
5 P00528 (/IMP) P00528 (/IMP) P00528 (/IMP) P00528 (/IMP) P00528 (/IMP)
Adherens junction organization GO:0034332
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an adherens junction. An adherens junction is a cell junction at which the cytoplasmic face of the plasma membrane is attached to actin filaments.
5 P00528 (/IMP) P00528 (/IMP) P00528 (/IMP) P00528 (/IMP) P00528 (/IMP)
Filtration diaphragm assembly GO:0036058
The aggregation, arrangement and bonding together of a set of components to form a filtration diaphragm, a specialized cell-cell junction found between the cells of the excretory system, which provides a barrier for filtration of blood or hemolymph.
5 P00528 (/IMP) P00528 (/IMP) P00528 (/IMP) P00528 (/IMP) P00528 (/IMP)
Positive regulation of epidermal growth factor receptor signaling pathway GO:0045742
Any process that activates or increases the frequency, rate or extent of epidermal growth factor receptor signaling pathway activity.
5 P00528 (/IGI) P00528 (/IGI) P00528 (/IGI) P00528 (/IGI) P00528 (/IGI)
Positive regulation of fibroblast growth factor receptor signaling pathway GO:0045743
Any process that activates or increases the frequency, rate or extent of fibroblast growth factor receptor signaling pathway activity.
5 P00528 (/IMP) P00528 (/IMP) P00528 (/IMP) P00528 (/IMP) P00528 (/IMP)
Positive regulation of sevenless signaling pathway GO:0045874
Any process that activates or increases the frequency, rate or extent of the sevenless signaling pathway.
5 P00528 (/IGI) P00528 (/IGI) P00528 (/IGI) P00528 (/IGI) P00528 (/IGI)
Negative regulation of synaptic growth at neuromuscular junction GO:0045886
Any process that stops, prevents, or reduces the frequency, rate or extent of synaptic growth at neuromuscular junction.
5 P00528 (/IGI) P00528 (/IGI) P00528 (/IGI) P00528 (/IGI) P00528 (/IGI)
Regulation of synaptic plasticity GO:0048167
A process that modulates synaptic plasticity, the ability of synapses to change as circumstances require. They may alter function, such as increasing or decreasing their sensitivity, or they may increase or decrease in actual numbers.
5 P00528 (/IGI) P00528 (/IGI) P00528 (/IGI) P00528 (/IGI) P00528 (/IGI)
Oogenesis GO:0048477
The complete process of formation and maturation of an ovum or female gamete from a primordial female germ cell. Examples of this process are found in Mus musculus and Drosophila melanogaster.
5 P00528 (/IMP) P00528 (/IMP) P00528 (/IMP) P00528 (/IMP) P00528 (/IMP)
Epithelial cell-cell adhesion GO:0090136
The attachment of an epithelial cell to another epithelial cell via adhesion molecules.
5 P00528 (/IMP) P00528 (/IMP) P00528 (/IMP) P00528 (/IMP) P00528 (/IMP)
Positive regulation of torso signaling pathway GO:0120176
Any process that activates or increases the frequency, rate or extent of the torso signaling pathway.
5 P00528 (/IGI) P00528 (/IGI) P00528 (/IGI) P00528 (/IGI) P00528 (/IGI)

There are 3 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
5 P00528 (/HDA) P00528 (/HDA) P00528 (/HDA) P00528 (/HDA) P00528 (/HDA)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
5 P00528 (/HDA) P00528 (/HDA) P00528 (/HDA) P00528 (/HDA) P00528 (/HDA)
Germline ring canal GO:0045172
Germline specific intercellular bridge. During cyst formation in insects, ring canals interconnect the cells of the cyst, facilitating the passage of cytoplasmic components between cells.
5 P00528 (/IDA) P00528 (/IDA) P00528 (/IDA) P00528 (/IDA) P00528 (/IDA)
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