The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:
"SH2 domain
".
FunFam 42: Cytokine-inducible SH2-containing protein b
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 1 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
|
3 | Q62225 (/IPI) Q9NSE2 (/IPI) Q9NSE2 (/IPI) |
There are 13 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Negative regulation of type I interferon-mediated signaling pathway GO:0060339
Any process that decreases the rate, frequency or extent of a type I interferon-mediated signaling pathway. A type I interferon-mediated signaling pathway is the series of molecular events generated as a consequence of a type I interferon binding to a cell surface receptor.
|
3 | A0A060WEW1 (/ISS) A0A060XGY0 (/ISS) D0IN11 (/ISS) |
|
Regulation of cell growth GO:0001558
Any process that modulates the frequency, rate, extent or direction of cell growth.
|
2 | Q9NSE2 (/NAS) Q9NSE2 (/NAS) |
|
Intracellular signal transduction GO:0035556
The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell.
|
2 | Q9NSE2 (/NAS) Q9NSE2 (/NAS) |
|
Interleukin-7-mediated signaling pathway GO:0038111
A series of molecular signals initiated by the binding of interleukin-7 to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription.
|
2 | Q9NSE2 (/TAS) Q9NSE2 (/TAS) |
|
Post-translational protein modification GO:0043687
The process of covalently altering one or more amino acids in a protein after the protein has been completely translated and released from the ribosome.
|
2 | Q9NSE2 (/TAS) Q9NSE2 (/TAS) |
|
Negative regulation of type I interferon-mediated signaling pathway GO:0060339
Any process that decreases the rate, frequency or extent of a type I interferon-mediated signaling pathway. A type I interferon-mediated signaling pathway is the series of molecular events generated as a consequence of a type I interferon binding to a cell surface receptor.
|
2 | B5XCB4 (/IMP) B9EPA9 (/IMP) |
|
Protein kinase C-activating G protein-coupled receptor signaling pathway GO:0007205
The series of molecular signals generated as a consequence of a G protein-coupled receptor binding to its physiological ligand, where the pathway proceeds with activation of protein kinase C (PKC). PKC is activated by second messengers including diacylglycerol (DAG).
|
1 | Q62225 (/IDA) |
|
Cytokine-mediated signaling pathway GO:0019221
A series of molecular signals initiated by the binding of a cytokine to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription.
|
1 | O70512 (/IEP) |
|
Negative regulation of lymphocyte differentiation GO:0045620
Any process that stops, prevents, or reduces the frequency, rate or extent of lymphocyte differentiation.
|
1 | Q08BW5 (/IMP) |
|
Negative regulation of myeloid cell differentiation GO:0045638
Any process that stops, prevents, or reduces the frequency, rate or extent of myeloid cell differentiation.
|
1 | Q08BW5 (/IMP) |
|
Negative regulation of erythrocyte differentiation GO:0045647
Any process that stops, prevents, or reduces the frequency, rate or extent of erythrocyte differentiation.
|
1 | Q08BW5 (/IMP) |
|
Negative regulation of receptor signaling pathway via JAK-STAT GO:0046426
Any process that stops, prevents, or reduces the frequency, rate or extent of a receptor signaling pathway via JAK-STAT.
|
1 | Q08BW5 (/IMP) |
|
Negative regulation of hemopoiesis GO:1903707
Any process that stops, prevents or reduces the frequency, rate or extent of hemopoiesis.
|
1 | Q08BW5 (/IMP) |
There are 2 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
2 | Q9NSE2 (/TAS) Q9NSE2 (/TAS) |
|
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
|
1 | Q62225 (/IDA) |