The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:
"SH2 domain
".
FunFam 30: Transcription elongation factor spt6
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 8 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
RNA polymerase II complex binding GO:0000993
Interacting selectively and non-covalently with RNA polymerase II core enzyme, a multisubunit eukaryotic nuclear RNA polymerase typically composed of twelve subunits.
|
2 | Q9W420 (/IDA) Q9W420 (/IDA) |
|
Chromatin binding GO:0003682
Interacting selectively and non-covalently with chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase.
|
2 | Q9W420 (/IDA) Q9W420 (/IDA) |
|
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
|
2 | Q62383 (/IPI) Q7KZ85 (/IPI) |
|
Histone binding GO:0042393
Interacting selectively and non-covalently with a histone, any of a group of water-soluble proteins found in association with the DNA of eukaroytic chromosomes. They are involved in the condensation and coiling of chromosomes during cell division and have also been implicated in nonspecific suppression of gene activity.
|
2 | Q62383 (/ISS) Q8UVK2 (/ISS) |
|
DNA-binding transcription factor activity GO:0003700
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
|
1 | Q7KZ85 (/TAS) |
|
RNA binding GO:0003723
Interacting selectively and non-covalently with an RNA molecule or a portion thereof.
|
1 | Q7KZ85 (/HDA) |
|
Histone binding GO:0042393
Interacting selectively and non-covalently with a histone, any of a group of water-soluble proteins found in association with the DNA of eukaroytic chromosomes. They are involved in the condensation and coiling of chromosomes during cell division and have also been implicated in nonspecific suppression of gene activity.
|
1 | Q7KZ85 (/IDA) |
|
Histone binding GO:0042393
Interacting selectively and non-covalently with a histone, any of a group of water-soluble proteins found in association with the DNA of eukaroytic chromosomes. They are involved in the condensation and coiling of chromosomes during cell division and have also been implicated in nonspecific suppression of gene activity.
|
1 | Q62383 (/ISO) |
There are 25 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Positive regulation of transcription elongation from RNA polymerase II promoter GO:0032968
Any process that activates or increases the frequency, rate or extent of transcription elongation, the extension of an RNA molecule after transcription initiation and promoter clearance by the addition of ribonucleotides, catalyzed by RNA polymerase II.
|
4 | Q62383 (/IMP) Q7KZ85 (/IMP) Q9W420 (/IMP) Q9W420 (/IMP) |
|
Negative regulation of histone H3-K27 methylation GO:0061086
Any process that decreases the rate, frequency, or extent of histone H3-K27 methylation. Histone H3-K27 methylation is the modification of histone H3 by addition of a methyl group to lysine at position 27 of the histone.
|
3 | Q62383 (/IMP) Q7KZ85 (/IMP) Q8UVK2 (/IMP) |
|
Transcription by RNA polymerase II GO:0006366
The synthesis of RNA from a DNA template by RNA polymerase II (RNAP II), originating at an RNA polymerase II promoter. Includes transcription of messenger RNA (mRNA) and certain small nuclear RNAs (snRNAs).
|
2 | Q9W420 (/IEP) Q9W420 (/IEP) |
|
Positive regulation of antibacterial peptide biosynthetic process GO:0006963
Any process that activates or increases the frequency, rate, or extent of antibacterial peptide biosynthesis.
|
2 | Q9W420 (/IMP) Q9W420 (/IMP) |
|
Ovarian follicle cell development GO:0030707
The process that occurs during oogenesis involving the ovarian follicle cells, somatic cells which surround the germ cells of an ovary. An example of this is found in Drosophila melanogaster.
|
2 | Q9W420 (/IMP) Q9W420 (/IMP) |
|
Somitogenesis GO:0001756
The formation of mesodermal clusters that are arranged segmentally along the anterior posterior axis of an embryo.
|
1 | Q8UVK2 (/IMP) |
|
Blastocyst formation GO:0001825
The initial formation of a blastocyst from a solid ball of cells known as a morula.
|
1 | Q62383 (/IMP) |
|
Chromatin remodeling GO:0006338
Dynamic structural changes to eukaryotic chromatin occurring throughout the cell division cycle. These changes range from the local changes necessary for transcriptional regulation to global changes necessary for chromosome segregation.
|
1 | Q7KZ85 (/NAS) |
|
Regulation of transcription, DNA-templated GO:0006355
Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
|
1 | Q7KZ85 (/NAS) |
|
Transcription by RNA polymerase II GO:0006366
The synthesis of RNA from a DNA template by RNA polymerase II (RNAP II), originating at an RNA polymerase II promoter. Includes transcription of messenger RNA (mRNA) and certain small nuclear RNAs (snRNAs).
|
1 | Q7KZ85 (/TAS) |
|
Transcription elongation from RNA polymerase II promoter GO:0006368
The extension of an RNA molecule after transcription initiation and promoter clearance at an RNA polymerase II promoter by the addition of ribonucleotides catalyzed by RNA polymerase II.
|
1 | Q7KZ85 (/TAS) |
|
Heart development GO:0007507
The process whose specific outcome is the progression of the heart over time, from its formation to the mature structure. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood.
|
1 | Q8UVK2 (/IMP) |
|
Regulation of mRNA export from nucleus GO:0010793
Any process that modulates the frequency, rate or extent of the directed movement of mRNA from the nucleus to the cytoplasm.
|
1 | Q62383 (/IMP) |
|
Regulation of mRNA export from nucleus GO:0010793
Any process that modulates the frequency, rate or extent of the directed movement of mRNA from the nucleus to the cytoplasm.
|
1 | Q7KZ85 (/ISS) |
|
Positive regulation of transcription elongation from RNA polymerase II promoter GO:0032968
Any process that activates or increases the frequency, rate or extent of transcription elongation, the extension of an RNA molecule after transcription initiation and promoter clearance by the addition of ribonucleotides, catalyzed by RNA polymerase II.
|
1 | Q62383 (/ISO) |
|
Positive regulation of transcription elongation from RNA polymerase II promoter GO:0032968
Any process that activates or increases the frequency, rate or extent of transcription elongation, the extension of an RNA molecule after transcription initiation and promoter clearance by the addition of ribonucleotides, catalyzed by RNA polymerase II.
|
1 | Q8UVK2 (/ISS) |
|
Embryonic heart tube development GO:0035050
The process whose specific outcome is the progression of the embryonic heart tube over time, from its formation to the mature structure. The heart tube forms as the heart rudiment from the heart field.
|
1 | Q8UVK2 (/IMP) |
|
Regulation of isotype switching GO:0045191
Any process that modulates the frequency, rate or extent of isotype switching.
|
1 | Q62383 (/IMP) |
|
Regulation of isotype switching GO:0045191
Any process that modulates the frequency, rate or extent of isotype switching.
|
1 | Q7KZ85 (/ISS) |
|
Regulation of mRNA processing GO:0050684
Any process that modulates the frequency, rate or extent of mRNA processing, those processes involved in the conversion of a primary mRNA transcript into a mature mRNA prior to its translation into polypeptide.
|
1 | Q62383 (/IMP) |
|
Regulation of mRNA processing GO:0050684
Any process that modulates the frequency, rate or extent of mRNA processing, those processes involved in the conversion of a primary mRNA transcript into a mature mRNA prior to its translation into polypeptide.
|
1 | Q7KZ85 (/ISS) |
|
Regulation of muscle cell differentiation GO:0051147
Any process that modulates the frequency, rate or extent of muscle cell differentiation.
|
1 | Q62383 (/IMP) |
|
Regulation of muscle cell differentiation GO:0051147
Any process that modulates the frequency, rate or extent of muscle cell differentiation.
|
1 | Q7KZ85 (/ISS) |
|
Negative regulation of histone H3-K27 methylation GO:0061086
Any process that decreases the rate, frequency, or extent of histone H3-K27 methylation. Histone H3-K27 methylation is the modification of histone H3 by addition of a methyl group to lysine at position 27 of the histone.
|
1 | Q62383 (/ISO) |
|
Otic vesicle development GO:0071599
The process whose specific outcome is the progression of the otic vesicle over time, from its formation to the mature structure. The otic vesicle is a transient embryonic structure formed during development of the vertebrate inner ear.
|
1 | Q8UVK2 (/IMP) |
There are 8 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
2 | Q9W420 (/IDA) Q9W420 (/IDA) |
|
Polytene chromosome puff GO:0005703
A swelling at a site along the length of a polytene chromosome, thought to be the site of active transcription.
|
2 | Q9W420 (/IDA) Q9W420 (/IDA) |
|
Polytene chromosome interband GO:0005705
A stretch of less tightly packed chromatin along the polytene chromosome, found between bands.
|
2 | Q9W420 (/IDA) Q9W420 (/IDA) |
|
Transcription elongation factor complex GO:0008023
Any protein complex that interacts with RNA polymerase II to increase (positive transcription elongation factor) or reduce (negative transcription elongation factor) the rate of transcription elongation.
|
2 | Q9W420 (/IPI) Q9W420 (/IPI) |
|
Transcriptionally active chromatin GO:0035327
The ordered and organized complex of DNA and protein that forms regions of the chromosome that are being actively transcribed.
|
2 | Q9W420 (/IDA) Q9W420 (/IDA) |
|
Histone locus body GO:0035363
A nuclear body associated with the histone gene locus that is thought to contain all of the factors necessary for histone mRNA transcription and pre-mRNA processing. In Drosophila, U7 snRNP is located in the histone locus body rather than the distinct Cajal body.
|
2 | Q9W420 (/IDA) Q9W420 (/IDA) |
|
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
1 | Q7KZ85 (/NAS) |
|
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
|
1 | Q7KZ85 (/TAS) |
