The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:
"MHC class I-like antigen recognition-like
".
FunFam 3: IgG receptor FcRn large subunit p51
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 9 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
|
7 | P13599 (/IPI) Q29983 (/IPI) Q8HWA4 (/IPI) Q8HWA5 (/IPI) Q8HWE5 (/IPI) Q8HWE6 (/IPI) Q8HWE7 (/IPI) |
IgG binding GO:0019864
Interacting selectively and non-covalently with an immunoglobulin of an IgG isotype.
|
3 | P55899 (/IDA) P55899 (/IDA) P55899 (/IDA) |
Natural killer cell lectin-like receptor binding GO:0046703
Interacting selectively and non-covalently with a lectin-like natural killer cell receptor.
|
2 | Q29980 (/IDA) Q29983 (/IDA) |
Natural killer cell lectin-like receptor binding GO:0046703
Interacting selectively and non-covalently with a lectin-like natural killer cell receptor.
|
2 | Q8HWE5 (/ISO) Q8HWE6 (/ISO) |
IgG receptor activity GO:0019770
Combining with an immunoglobulin of an IgG isotype via the Fc region, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.
|
1 | P13599 (/TAS) |
IgG binding GO:0019864
Interacting selectively and non-covalently with an immunoglobulin of an IgG isotype.
|
1 | Q61559 (/ISO) |
Beta-2-microglobulin binding GO:0030881
Interacting selectively and non-covalently with beta-2-microglobulin.
|
1 | P13599 (/IDA) |
Beta-2-microglobulin binding GO:0030881
Interacting selectively and non-covalently with beta-2-microglobulin.
|
1 | Q61559 (/ISO) |
Natural killer cell lectin-like receptor binding GO:0046703
Interacting selectively and non-covalently with a lectin-like natural killer cell receptor.
|
1 | Q29983 (/IPI) |
There are 23 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
IgG immunoglobulin transcytosis in epithelial cells mediated by FcRn immunoglobulin receptor GO:0002416
The process of transporting IgG immunoglobulin, via transcytosis using the FcRn (also known as the neonatal Fc receptor; gene name FCGRT), from apical surface of an epithelial cell to the basolateral surface or vice versa depending on the location. This process is used for uptake of IgG from the milk in the gut in rodents, for transplacental transport of IgG from mother to embryo in humans, and for maintenance of a steady-state distribution of IgG across epithelial boundaries in general in adult mammals.
|
3 | P55899 (/NAS) P55899 (/NAS) P55899 (/NAS) |
Immune response-activating cell surface receptor signaling pathway GO:0002429
A series of molecular signals initiated by the binding of an extracellular ligand to a receptor on the surface of a cell capable of activating or perpetuating an immune response.
|
2 | Q8HWE5 (/ISO) Q8HWE6 (/ISO) |
Response to oxidative stress GO:0006979
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals.
|
2 | Q8HWE5 (/ISO) Q8HWE6 (/ISO) |
Response to heat GO:0009408
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a heat stimulus, a temperature stimulus above the optimal temperature for that organism.
|
2 | Q29980 (/IDA) Q29983 (/IDA) |
Response to heat GO:0009408
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a heat stimulus, a temperature stimulus above the optimal temperature for that organism.
|
2 | Q8HWE5 (/ISO) Q8HWE6 (/ISO) |
Response to retinoic acid GO:0032526
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a retinoic acid stimulus.
|
2 | Q8HWE5 (/ISO) Q8HWE6 (/ISO) |
Gamma-delta T cell activation GO:0046629
The change in morphology and behavior of a gamma-delta T cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific.
|
2 | Q29980 (/IDA) Q29983 (/IDA) |
Gamma-delta T cell activation GO:0046629
The change in morphology and behavior of a gamma-delta T cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific.
|
2 | Q8HWE5 (/ISO) Q8HWE6 (/ISO) |
Negative regulation of defense response to virus by host GO:0050689
Any host process that results in the inhibition of antiviral immune response mechanisms, thereby facilitating viral replication. The host is defined as the larger of the organisms involved in a symbiotic interaction.
|
2 | Q8HWE5 (/ISO) Q8HWE6 (/ISO) |
Regulation of immune response GO:0050776
Any process that modulates the frequency, rate or extent of the immune response, the immunological reaction of an organism to an immunogenic stimulus.
|
2 | Q29980 (/TAS) Q29983 (/TAS) |
T cell mediated cytotoxicity GO:0001913
The directed killing of a target cell by a T cell through the release of granules containing cytotoxic mediators or through the engagement of death receptors.
|
1 | Q29983 (/IDA) |
Immune response to tumor cell GO:0002418
An immune system process that functions in the response of an organism to a tumor cell.
|
1 | Q29983 (/IDA) |
Immune response-activating cell surface receptor signaling pathway GO:0002429
A series of molecular signals initiated by the binding of an extracellular ligand to a receptor on the surface of a cell capable of activating or perpetuating an immune response.
|
1 | Q29980 (/IDA) |
Humoral immune response GO:0006959
An immune response mediated through a body fluid.
|
1 | P13599 (/TAS) |
Cellular response to DNA damage stimulus GO:0006974
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism.
|
1 | Q29983 (/IDA) |
Response to oxidative stress GO:0006979
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals.
|
1 | Q29980 (/IDA) |
Response to retinoic acid GO:0032526
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a retinoic acid stimulus.
|
1 | Q29980 (/IDA) |
Negative regulation of natural killer cell activation GO:0032815
Any process that stops, prevents, or reduces the frequency, rate or extent of natural killer cell activation.
|
1 | Q29983 (/IDA) |
Natural killer cell mediated cytotoxicity GO:0042267
The directed killing of a target cell by a natural killer cell through the release of granules containing cytotoxic mediators or through the engagement of death receptors.
|
1 | Q29983 (/IDA) |
Defense response to bacterium GO:0042742
Reactions triggered in response to the presence of a bacterium that act to protect the cell or organism.
|
1 | Q29983 (/IDA) |
Negative regulation of natural killer cell mediated cytotoxicity GO:0045953
Any process that stops, prevents, or reduces the rate of natural killer mediated cytotoxicity.
|
1 | Q29983 (/IMP) |
Negative regulation of defense response to virus by host GO:0050689
Any host process that results in the inhibition of antiviral immune response mechanisms, thereby facilitating viral replication. The host is defined as the larger of the organisms involved in a symbiotic interaction.
|
1 | Q29980 (/IDA) |
Defense response to virus GO:0051607
Reactions triggered in response to the presence of a virus that act to protect the cell or organism.
|
1 | Q29983 (/IDA) |
There are 6 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Anchored component of external side of plasma membrane GO:0031362
The component of the plasma membrane consisting of the gene products that are tethered to the external side of the membrane only by a covalently attached anchor, such as a lipid group embedded in the membrane. Gene products with peptide sequences that are embedded in the membrane are excluded from this grouping.
|
5 | Q8HWA4 (/IDA) Q8HWA5 (/IDA) Q8HWE5 (/IDA) Q8HWE6 (/IDA) Q8HWE7 (/IDA) |
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
|
2 | Q29980 (/TAS) Q29983 (/TAS) |
Extracellular space GO:0005615
That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
|
1 | Q29983 (/IDA) |
Integral component of plasma membrane GO:0005887
The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
|
1 | Q29983 (/IDA) |
Cell surface GO:0009986
The external part of the cell wall and/or plasma membrane.
|
1 | Q29983 (/IDA) |
Cell surface GO:0009986
The external part of the cell wall and/or plasma membrane.
|
1 | Q29980 (/ISS) |