The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:
"Macrophage Migration Inhibitory Factor
".
FunFam 3: D-dopachrome decarboxylase
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 6 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Dopachrome isomerase activity GO:0004167
Catalysis of the reaction: L-dopachrome = 5,6-dihydroxyindole-2-carboxylate.
|
5 | P30046 (/TAS) P30046 (/TAS) P30046 (/TAS) P80254 (/TAS) P80254 (/TAS) |
|
Cytokine receptor binding GO:0005126
Interacting selectively and non-covalently with a cytokine receptor.
|
3 | P30046 (/IDA) P30046 (/IDA) P30046 (/IDA) |
|
Phenylpyruvate tautomerase activity GO:0050178
Catalysis of the reaction: keto-phenylpyruvate = enol-phenylpyruvate.
|
3 | P30046 (/IDA) P30046 (/IDA) P30046 (/IDA) |
|
Protease binding GO:0002020
Interacting selectively and non-covalently with any protease or peptidase.
|
2 | O35215 (/IPI) O35215 (/IPI) |
|
Cytokine receptor binding GO:0005126
Interacting selectively and non-covalently with a cytokine receptor.
|
2 | O35215 (/ISO) O35215 (/ISO) |
|
Phenylpyruvate tautomerase activity GO:0050178
Catalysis of the reaction: keto-phenylpyruvate = enol-phenylpyruvate.
|
2 | O35215 (/ISO) O35215 (/ISO) |
There are 11 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Negative regulation of macrophage chemotaxis GO:0010760
Any process that decreases the rate, frequency or extent of macrophage chemotaxis. Macrophage chemotaxis is the movement of a macrophage in response to an external stimulus.
|
3 | P30046 (/IDA) P30046 (/IDA) P30046 (/IDA) |
|
Positive regulation of tumor necrosis factor production GO:0032760
Any process that activates or increases the frequency, rate, or extent of tumor necrosis factor production.
|
3 | P30046 (/IDA) P30046 (/IDA) P30046 (/IDA) |
|
Positive regulation of inflammatory response GO:0050729
Any process that activates or increases the frequency, rate or extent of the inflammatory response.
|
3 | P30046 (/IC) P30046 (/IC) P30046 (/IC) |
|
Positive regulation of ERK1 and ERK2 cascade GO:0070374
Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the ERK1 and ERK2 cascade.
|
3 | P30046 (/IGI) P30046 (/IGI) P30046 (/IGI) |
|
Inflammatory response GO:0006954
The immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. The process is characterized by local vasodilation, extravasation of plasma into intercellular spaces and accumulation of white blood cells and macrophages.
|
2 | P80254 (/NAS) P80254 (/NAS) |
|
Negative regulation of macrophage chemotaxis GO:0010760
Any process that decreases the rate, frequency or extent of macrophage chemotaxis. Macrophage chemotaxis is the movement of a macrophage in response to an external stimulus.
|
2 | O35215 (/ISO) O35215 (/ISO) |
|
Positive regulation of tumor necrosis factor production GO:0032760
Any process that activates or increases the frequency, rate, or extent of tumor necrosis factor production.
|
2 | O35215 (/ISO) O35215 (/ISO) |
|
Negative regulation of apoptotic process GO:0043066
Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process.
|
2 | F1QJV7 (/IGI) Q6IQL4 (/IGI) |
|
Inner ear development GO:0048839
The process whose specific outcome is the progression of the inner ear over time, from its formation to the mature structure.
|
2 | F1QJV7 (/IGI) Q6IQL4 (/IGI) |
|
Positive regulation of inflammatory response GO:0050729
Any process that activates or increases the frequency, rate or extent of the inflammatory response.
|
2 | O35215 (/IMP) O35215 (/IMP) |
|
Positive regulation of ERK1 and ERK2 cascade GO:0070374
Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the ERK1 and ERK2 cascade.
|
2 | O35215 (/ISO) O35215 (/ISO) |
There are 3 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Extracellular exosome GO:0070062
A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
|
6 | A6NHG4 (/HDA) A6NHG4 (/HDA) A6NHG4 (/HDA) P30046 (/HDA) P30046 (/HDA) P30046 (/HDA) |
|
Extracellular space GO:0005615
That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
|
5 | O35215 (/IDA) O35215 (/IDA) P30046 (/IDA) P30046 (/IDA) P30046 (/IDA) |
|
Extracellular space GO:0005615
That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
|
2 | O35215 (/ISO) O35215 (/ISO) |