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CATH Superfamily 3.30.420.40

ATPase, nucleotide binding domain

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 60: Bifunctional UDP-N-acetylglucosamine 2-epimerase/N...

There are 2 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
N-acylmannosamine kinase. [EC: 2.7.1.60]
ATP + N-acyl-D-mannosamine = ADP + N-acyl-D-mannosamine 6-phosphate.
  • Acts on the acetyl and glycolyl derivatives.
 55 A0A2J8QRQ4 A0A2J8QRQ4 A0A2J8QRQ4 A0A2J8QRQ4 A0A2J8QRQ4 A0A2J8QRQ4 A0A2J8QRQ4 A0A2J8T082 A0A2J8T082 A0A2J8T082
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UDP-N-acetylglucosamine 2-epimerase (hydrolyzing). [EC: 3.2.1.183]
UDP-N-acetyl-alpha-D-glucosamine + H(2)O = N-acetyl-D-mannosamine + UDP.
  • The enzyme is found in mammalian liver, as well as in some pathogenic bacteria including Neisseria meningitidis and Staphylococcus aureus.
  • It catalyzes the first step of sialic acid (N-acetylneuraminic acid) biosynthesis.
  • The initial product formed is the alpha anomer, which rapidly mutarotates to a mixture of anomers.
  • The mammalian enzyme is bifunctional and also catalyzes EC 2.7.1.60.
  • Cf. EC 5.1.3.14.
 55 A0A2J8QRQ4 A0A2J8QRQ4 A0A2J8QRQ4 A0A2J8QRQ4 A0A2J8QRQ4 A0A2J8QRQ4 A0A2J8QRQ4 A0A2J8T082 A0A2J8T082 A0A2J8T082
(45 more...)