The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:
"Zinc/RING finger domain, C3HC4 (zinc finger)
".
FunFam 78: E3 ubiquitin-protein ligase MYCBP2 isoform X1
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 16 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
|
5 | F1RD40 (/IPI) O75592 (/IPI) Q7TPH6 (/IPI) Q9NB71 (/IPI) Q9NB71 (/IPI) |
Ubiquitin-protein transferase activity GO:0004842
Catalysis of the transfer of ubiquitin from one protein to another via the reaction X-Ub + Y --> Y-Ub + X, where both X-Ub and Y-Ub are covalent linkages.
|
2 | Q9NB71 (/ISS) Q9NB71 (/ISS) |
Guanyl-nucleotide exchange factor activity GO:0005085
Stimulates the exchange of guanyl nucleotides associated with a GTPase. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase.
|
2 | F1RD40 (/ISS) Q7TPH6 (/ISS) |
Zinc ion binding GO:0008270
Interacting selectively and non-covalently with zinc (Zn) ions.
|
2 | Q9NB71 (/ISM) Q9NB71 (/ISM) |
Ran GTPase binding GO:0008536
Interacting selectively and non-covalently with Ran, a conserved Ras-like GTP-binding protein, implicated in nucleocytoplasmic transport, cell cycle progression, spindle assembly, nuclear organization and nuclear envelope (NE) assembly.
|
2 | F1RD40 (/ISS) Q7TPH6 (/ISS) |
Ubiquitin protein ligase activity GO:0061630
Catalysis of the transfer of ubiquitin to a substrate protein via the reaction X-ubiquitin + S -> X + S-ubiquitin, where X is either an E2 or E3 enzyme, the X-ubiquitin linkage is a thioester bond, and the S-ubiquitin linkage is an amide bond: an isopeptide bond between the C-terminal glycine of ubiquitin and the epsilon-amino group of lysine residues in the substrate or, in the linear extension of ubiquitin chains, a peptide bond the between the C-terminal glycine and N-terminal methionine of ubiquitin residues.
|
2 | F1RD40 (/ISS) Q7TPH6 (/ISS) |
Ubiquitin-protein transferase activity GO:0004842
Catalysis of the transfer of ubiquitin from one protein to another via the reaction X-Ub + Y --> Y-Ub + X, where both X-Ub and Y-Ub are covalent linkages.
|
1 | F1RD40 (/IDA) |
Guanyl-nucleotide exchange factor activity GO:0005085
Stimulates the exchange of guanyl nucleotides associated with a GTPase. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase.
|
1 | O75592 (/IDA) |
Guanyl-nucleotide exchange factor activity GO:0005085
Stimulates the exchange of guanyl nucleotides associated with a GTPase. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase.
|
1 | Q7TPH6 (/ISO) |
Zinc ion binding GO:0008270
Interacting selectively and non-covalently with zinc (Zn) ions.
|
1 | O75592 (/IDA) |
Zinc ion binding GO:0008270
Interacting selectively and non-covalently with zinc (Zn) ions.
|
1 | Q7TPH6 (/ISO) |
Ran GTPase binding GO:0008536
Interacting selectively and non-covalently with Ran, a conserved Ras-like GTP-binding protein, implicated in nucleocytoplasmic transport, cell cycle progression, spindle assembly, nuclear organization and nuclear envelope (NE) assembly.
|
1 | O75592 (/IDA) |
Ran GTPase binding GO:0008536
Interacting selectively and non-covalently with Ran, a conserved Ras-like GTP-binding protein, implicated in nucleocytoplasmic transport, cell cycle progression, spindle assembly, nuclear organization and nuclear envelope (NE) assembly.
|
1 | Q7TPH6 (/ISO) |
Protein homodimerization activity GO:0042803
Interacting selectively and non-covalently with an identical protein to form a homodimer.
|
1 | Q7TPH6 (/IPI) |
Ubiquitin protein ligase activity GO:0061630
Catalysis of the transfer of ubiquitin to a substrate protein via the reaction X-ubiquitin + S -> X + S-ubiquitin, where X is either an E2 or E3 enzyme, the X-ubiquitin linkage is a thioester bond, and the S-ubiquitin linkage is an amide bond: an isopeptide bond between the C-terminal glycine of ubiquitin and the epsilon-amino group of lysine residues in the substrate or, in the linear extension of ubiquitin chains, a peptide bond the between the C-terminal glycine and N-terminal methionine of ubiquitin residues.
|
1 | O75592 (/IDA) |
Ubiquitin protein ligase activity GO:0061630
Catalysis of the transfer of ubiquitin to a substrate protein via the reaction X-ubiquitin + S -> X + S-ubiquitin, where X is either an E2 or E3 enzyme, the X-ubiquitin linkage is a thioester bond, and the S-ubiquitin linkage is an amide bond: an isopeptide bond between the C-terminal glycine of ubiquitin and the epsilon-amino group of lysine residues in the substrate or, in the linear extension of ubiquitin chains, a peptide bond the between the C-terminal glycine and N-terminal methionine of ubiquitin residues.
|
1 | Q7TPH6 (/ISO) |
There are 39 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Protein ubiquitination GO:0016567
The process in which one or more ubiquitin groups are added to a protein.
|
3 | Q7TPH6 (/ISS) Q9NB71 (/ISS) Q9NB71 (/ISS) |
Autophagy GO:0006914
The cellular catabolic process in which cells digest parts of their own cytoplasm; allows for both recycling of macromolecular constituents under conditions of cellular stress and remodeling the intracellular structure for cell differentiation.
|
2 | Q9NB71 (/IDA) Q9NB71 (/IDA) |
Long-term memory GO:0007616
The memory process that deals with the storage, retrieval and modification of information a long time (typically weeks, months or years) after receiving that information. This type of memory is typically dependent on gene transcription regulated by second messenger activation.
|
2 | Q9NB71 (/IMP) Q9NB71 (/IMP) |
Adult walking behavior GO:0007628
The behavior of an adult relating to the progression of that organism along the ground by the process of lifting and setting down each leg.
|
2 | Q9NB71 (/NAS) Q9NB71 (/NAS) |
Regulation of synaptic growth at neuromuscular junction GO:0008582
Any process that modulates the frequency, rate or extent of synaptic growth at neuromuscular junctions.
|
2 | Q9NB71 (/IMP) Q9NB71 (/IMP) |
Regulation of synaptic growth at neuromuscular junction GO:0008582
Any process that modulates the frequency, rate or extent of synaptic growth at neuromuscular junctions.
|
2 | Q9NB71 (/TAS) Q9NB71 (/TAS) |
Negative regulation of gene expression GO:0010629
Any process that decreases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
|
2 | Q9NB71 (/IMP) Q9NB71 (/IMP) |
Central nervous system projection neuron axonogenesis GO:0021952
Generation of a long process of a CNS neuron, that carries efferent (outgoing) action potentials from the cell body towards target cells in a different central nervous system region.
|
2 | F1RD40 (/ISS) O75592 (/ISS) |
Negative regulation of BMP signaling pathway GO:0030514
Any process that stops, prevents, or reduces the frequency, rate or extent of the BMP signaling pathway.
|
2 | Q9NB71 (/IGI) Q9NB71 (/IGI) |
Positive regulation of protein ubiquitination GO:0031398
Any process that activates or increases the frequency, rate or extent of the addition of ubiquitin groups to a protein.
|
2 | O75592 (/IDA) Q7TPH6 (/IDA) |
Circadian regulation of gene expression GO:0032922
Any process that modulates the frequency, rate or extent of gene expression such that an expression pattern recurs with a regularity of approximately 24 hours.
|
2 | O75592 (/IMP) Q7TPH6 (/IMP) |
Locomotion GO:0040011
Self-propelled movement of a cell or organism from one location to another.
|
2 | Q9NB71 (/NAS) Q9NB71 (/NAS) |
Negative regulation of synaptic growth at neuromuscular junction GO:0045886
Any process that stops, prevents, or reduces the frequency, rate or extent of synaptic growth at neuromuscular junction.
|
2 | Q9NB71 (/IGI) Q9NB71 (/IGI) |
Negative regulation of synaptic growth at neuromuscular junction GO:0045886
Any process that stops, prevents, or reduces the frequency, rate or extent of synaptic growth at neuromuscular junction.
|
2 | Q9NB71 (/IMP) Q9NB71 (/IMP) |
Response to axon injury GO:0048678
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an axon injury stimulus.
|
2 | Q9NB71 (/IMP) Q9NB71 (/IMP) |
Synapse organization GO:0050808
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a synapse, the junction between a neuron and a target (neuron, muscle, or secretory cell).
|
2 | Q9NB71 (/IDA) Q9NB71 (/IDA) |
Neuromuscular process GO:0050905
Any process pertaining to the functions of the nervous and muscular systems of an organism.
|
2 | F1RD40 (/ISS) O75592 (/ISS) |
Regulation of axon guidance GO:1902667
Any process that modulates the frequency, rate or extent of axon guidance.
|
2 | F1RD40 (/ISS) O75592 (/ISS) |
Regulation of terminal button organization GO:2000331
Any process that modulates the frequency, rate or extent of terminal button organization.
|
2 | Q9NB71 (/IMP) Q9NB71 (/IMP) |
Axon guidance GO:0007411
The chemotaxis process that directs the migration of an axon growth cone to a specific target site in response to a combination of attractive and repulsive cues.
|
1 | F1RD40 (/IMP) |
Motor neuron axon guidance GO:0008045
The process in which the migration of an axon growth cone of a motor neuron is directed to a specific target site in response to a combination of attractive and repulsive cues.
|
1 | Q7TPH6 (/IMP) |
Axon choice point recognition GO:0016198
The recognition of molecules at a choice point by an axon growth cone; at a choice point the growth cone determines the direction of its future growth.
|
1 | F1RD40 (/IMP) |
Protein ubiquitination GO:0016567
The process in which one or more ubiquitin groups are added to a protein.
|
1 | O75592 (/IDA) |
Protein ubiquitination GO:0016567
The process in which one or more ubiquitin groups are added to a protein.
|
1 | Q7TPH6 (/ISO) |
Branchiomotor neuron axon guidance GO:0021785
The process in which a branchiomotor neuron growth cone is directed to a specific target site. Branchiomotor neurons are located in the hindbrain and innervate branchial arch-derived muscles that control jaw movements, facial expression, the larynx, and the pharynx.
|
1 | Q7TPH6 (/IMP) |
Central nervous system projection neuron axonogenesis GO:0021952
Generation of a long process of a CNS neuron, that carries efferent (outgoing) action potentials from the cell body towards target cells in a different central nervous system region.
|
1 | Q7TPH6 (/IMP) |
Habenula development GO:0021986
The progression of the habenula over time from its initial formation until its mature state. The habenula is the group of nuclei that makes up the stalk of the pineal gland.
|
1 | F1RD40 (/IMP) |
Retinal ganglion cell axon guidance GO:0031290
The process in which the migration of an axon growth cone of a retinal ganglion cell (RGC) is directed to its target in the brain in response to a combination of attractive and repulsive cues.
|
1 | F1RD40 (/IMP) |
Positive regulation of protein ubiquitination GO:0031398
Any process that activates or increases the frequency, rate or extent of the addition of ubiquitin groups to a protein.
|
1 | Q7TPH6 (/ISO) |
Regulation of protein localization GO:0032880
Any process that modulates the frequency, rate or extent of any process in which a protein is transported to, or maintained in, a specific location.
|
1 | Q7TPH6 (/IMP) |
Circadian regulation of gene expression GO:0032922
Any process that modulates the frequency, rate or extent of gene expression such that an expression pattern recurs with a regularity of approximately 24 hours.
|
1 | Q7TPH6 (/ISO) |
Circadian regulation of gene expression GO:0032922
Any process that modulates the frequency, rate or extent of gene expression such that an expression pattern recurs with a regularity of approximately 24 hours.
|
1 | F1RD40 (/ISS) |
Regulation of pteridine metabolic process GO:0042068
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving pteridine.
|
1 | F1RD40 (/IMP) |
Negative regulation of protein catabolic process GO:0042177
Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds.
|
1 | Q7TPH6 (/IDA) |
Developmental pigmentation GO:0048066
The developmental process that results in the deposition of coloring matter in an organism, tissue or cell.
|
1 | F1RD40 (/IMP) |
Cell morphogenesis involved in neuron differentiation GO:0048667
The process in which the structures of a neuron are generated and organized. This process occurs while the initially relatively unspecialized cell is acquiring the specialized features of a neuron.
|
1 | Q7TPH6 (/IMP) |
Neuromuscular process GO:0050905
Any process pertaining to the functions of the nervous and muscular systems of an organism.
|
1 | Q7TPH6 (/IMP) |
Regulation of cytoskeleton organization GO:0051493
Any process that modulates the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures.
|
1 | Q7TPH6 (/IMP) |
Regulation of axon guidance GO:1902667
Any process that modulates the frequency, rate or extent of axon guidance.
|
1 | Q7TPH6 (/IMP) |
There are 11 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
2 | F1RD40 (/ISS) Q7TPH6 (/ISS) |
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
|
2 | Q9NB71 (/IDA) Q9NB71 (/IDA) |
Cytoplasmic vesicle GO:0031410
A vesicle found in the cytoplasm of a cell.
|
2 | Q9NB71 (/IDA) Q9NB71 (/IDA) |
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
1 | O75592 (/IDA) |
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
1 | Q7TPH6 (/ISO) |
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
|
1 | F1RD40 (/IDA) |
Microtubule cytoskeleton GO:0015630
The part of the cytoskeleton (the internal framework of a cell) composed of microtubules and associated proteins.
|
1 | Q7TPH6 (/IDA) |
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
|
1 | O75592 (/HDA) |
Axon GO:0030424
The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter.
|
1 | Q7TPH6 (/IDA) |
Intracellular membrane-bounded organelle GO:0043231
Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.
|
1 | O75592 (/IDA) |
Intracellular membrane-bounded organelle GO:0043231
Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.
|
1 | Q7TPH6 (/ISO) |