The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Zinc/RING finger domain, C3HC4 (zinc finger)
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 126: metal-response element-binding transcription facto...

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 6 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Methylated histone binding GO:0035064
Interacting selectively and non-covalently with a histone in which a residue has been modified by methylation. Histones are any of a group of water-soluble proteins found in association with the DNA of eukaroytic chromosomes.
6 Q02395 (/IDA) Q9Y483 (/IDA) Q9Y483 (/IDA) Q9Y483 (/IDA) Q9Y483 (/IDA) Q9Y483 (/IDA)
Methylated histone binding GO:0035064
Interacting selectively and non-covalently with a histone in which a residue has been modified by methylation. Histones are any of a group of water-soluble proteins found in association with the DNA of eukaroytic chromosomes.
5 Q5R7T9 (/ISS) Q5R7T9 (/ISS) Q5R7T9 (/ISS) Q5R7T9 (/ISS) Q5R7T9 (/ISS)
RNA polymerase II regulatory region sequence-specific DNA binding GO:0000977
Interacting selectively and non-covalently with a specific sequence of DNA that is part of a regulatory region that controls the transcription of a gene or cistron by RNA polymerase II.
1 Q02395 (/IDA)
DNA-binding transcription repressor activity, RNA polymerase II-specific GO:0001227
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to repress or decrease transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
1 Q02395 (/IC)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
1 Q02395 (/IPI)
Methylated histone binding GO:0035064
Interacting selectively and non-covalently with a histone in which a residue has been modified by methylation. Histones are any of a group of water-soluble proteins found in association with the DNA of eukaroytic chromosomes.
1 Q02395 (/ISO)

There are 16 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Negative regulation of transcription by RNA polymerase II GO:0000122
Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.
10 Q5R7T9 (/ISS) Q5R7T9 (/ISS) Q5R7T9 (/ISS) Q5R7T9 (/ISS) Q5R7T9 (/ISS) Q9Y483 (/ISS) Q9Y483 (/ISS) Q9Y483 (/ISS) Q9Y483 (/ISS) Q9Y483 (/ISS)
Segment specification GO:0007379
The process in which segments assume individual identities; exemplified in insects by the actions of the products of the homeotic genes.
10 Q5R7T9 (/ISS) Q5R7T9 (/ISS) Q5R7T9 (/ISS) Q5R7T9 (/ISS) Q5R7T9 (/ISS) Q9Y483 (/ISS) Q9Y483 (/ISS) Q9Y483 (/ISS) Q9Y483 (/ISS) Q9Y483 (/ISS)
Stem cell population maintenance GO:0019827
The process by which an organism or tissue maintains a population of stem cells of a single type. This can be achieved by a number of mechanisms: stem cell asymmetric division maintains stem cell numbers; stem cell symmetric division increases them; maintenance of a stem cell niche maintains the conditions for commitment to the stem cell fate for some types of stem cell; stem cells may arise de novo from other cell types.
10 Q5R7T9 (/ISS) Q5R7T9 (/ISS) Q5R7T9 (/ISS) Q5R7T9 (/ISS) Q5R7T9 (/ISS) Q9Y483 (/ISS) Q9Y483 (/ISS) Q9Y483 (/ISS) Q9Y483 (/ISS) Q9Y483 (/ISS)
Positive regulation of transcription by RNA polymerase II GO:0045944
Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
10 Q5R7T9 (/ISS) Q5R7T9 (/ISS) Q5R7T9 (/ISS) Q5R7T9 (/ISS) Q5R7T9 (/ISS) Q9Y483 (/ISS) Q9Y483 (/ISS) Q9Y483 (/ISS) Q9Y483 (/ISS) Q9Y483 (/ISS)
Stem cell differentiation GO:0048863
The process in which a relatively unspecialized cell acquires specialized features of a stem cell. A stem cell is a cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into specialized cells.
10 Q5R7T9 (/ISS) Q5R7T9 (/ISS) Q5R7T9 (/ISS) Q5R7T9 (/ISS) Q5R7T9 (/ISS) Q9Y483 (/ISS) Q9Y483 (/ISS) Q9Y483 (/ISS) Q9Y483 (/ISS) Q9Y483 (/ISS)
Negative regulation of histone H3-K27 methylation GO:0061086
Any process that decreases the rate, frequency, or extent of histone H3-K27 methylation. Histone H3-K27 methylation is the modification of histone H3 by addition of a methyl group to lysine at position 27 of the histone.
10 Q5R7T9 (/ISS) Q5R7T9 (/ISS) Q5R7T9 (/ISS) Q5R7T9 (/ISS) Q5R7T9 (/ISS) Q9Y483 (/ISS) Q9Y483 (/ISS) Q9Y483 (/ISS) Q9Y483 (/ISS) Q9Y483 (/ISS)
Positive regulation of histone H3-K27 methylation GO:0061087
Any process that increases the rate, frequency, or extent of histone H3-K27 methylation. Histone H3-K27 methylation is the modification of histone H3 by addition of a methyl group to lysine at position 27 of the histone.
10 Q5R7T9 (/ISS) Q5R7T9 (/ISS) Q5R7T9 (/ISS) Q5R7T9 (/ISS) Q5R7T9 (/ISS) Q9Y483 (/ISS) Q9Y483 (/ISS) Q9Y483 (/ISS) Q9Y483 (/ISS) Q9Y483 (/ISS)
Negative regulation of gene expression, epigenetic GO:0045814
Any epigenetic process that stops, prevents or reduces the rate of gene expression.
5 Q9Y483 (/TAS) Q9Y483 (/TAS) Q9Y483 (/TAS) Q9Y483 (/TAS) Q9Y483 (/TAS)
Negative regulation of transcription by RNA polymerase II GO:0000122
Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.
1 Q02395 (/IMP)
Segment specification GO:0007379
The process in which segments assume individual identities; exemplified in insects by the actions of the products of the homeotic genes.
1 Q02395 (/IMP)
Stem cell population maintenance GO:0019827
The process by which an organism or tissue maintains a population of stem cells of a single type. This can be achieved by a number of mechanisms: stem cell asymmetric division maintains stem cell numbers; stem cell symmetric division increases them; maintenance of a stem cell niche maintains the conditions for commitment to the stem cell fate for some types of stem cell; stem cells may arise de novo from other cell types.
1 Q02395 (/IMP)
Positive regulation of transcription by RNA polymerase II GO:0045944
Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
1 Q02395 (/IMP)
Stem cell differentiation GO:0048863
The process in which a relatively unspecialized cell acquires specialized features of a stem cell. A stem cell is a cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into specialized cells.
1 Q02395 (/IMP)
Negative regulation of histone H3-K27 methylation GO:0061086
Any process that decreases the rate, frequency, or extent of histone H3-K27 methylation. Histone H3-K27 methylation is the modification of histone H3 by addition of a methyl group to lysine at position 27 of the histone.
1 Q02395 (/IMP)
Positive regulation of histone H3-K27 methylation GO:0061087
Any process that increases the rate, frequency, or extent of histone H3-K27 methylation. Histone H3-K27 methylation is the modification of histone H3 by addition of a methyl group to lysine at position 27 of the histone.
1 Q02395 (/IMP)
Cellular response to leukemia inhibitory factor GO:1990830
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a leukemia inhibitory factor stimulus.
1 Q02395 (/IEP)

There are 9 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
8 B4DZG1 (/IDA) B4DZG1 (/IDA) B4DZG1 (/IDA) Q9Y483 (/IDA) Q9Y483 (/IDA) Q9Y483 (/IDA) Q9Y483 (/IDA) Q9Y483 (/IDA)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
8 B4DZG1 (/IDA) B4DZG1 (/IDA) B4DZG1 (/IDA) Q9Y483 (/IDA) Q9Y483 (/IDA) Q9Y483 (/IDA) Q9Y483 (/IDA) Q9Y483 (/IDA)
Focal adhesion GO:0005925
Small region on the surface of a cell that anchors the cell to the extracellular matrix and that forms a point of termination of actin filaments.
8 B4DZG1 (/IDA) B4DZG1 (/IDA) B4DZG1 (/IDA) Q9Y483 (/IDA) Q9Y483 (/IDA) Q9Y483 (/IDA) Q9Y483 (/IDA) Q9Y483 (/IDA)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
5 Q9Y483 (/TAS) Q9Y483 (/TAS) Q9Y483 (/TAS) Q9Y483 (/TAS) Q9Y483 (/TAS)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
5 Q9Y483 (/IDA) Q9Y483 (/IDA) Q9Y483 (/IDA) Q9Y483 (/IDA) Q9Y483 (/IDA)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
1 Q02395 (/ISO)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
1 Q02395 (/ISO)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
1 Q02395 (/ISO)
Focal adhesion GO:0005925
Small region on the surface of a cell that anchors the cell to the extracellular matrix and that forms a point of termination of actin filaments.
1 Q02395 (/ISO)
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