The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Hect, E3 ligase catalytic domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
« Back to all FunFams

FunFam 16: E3 ubiquitin-protein ligase HACE1 isoform X1

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 9 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Ubiquitin-protein transferase activity GO:0004842
Catalysis of the transfer of ubiquitin from one protein to another via the reaction X-Ub + Y --> Y-Ub + X, where both X-Ub and Y-Ub are covalent linkages.
8 D3ZBM7 (/ISS) E1C656 (/ISS) F1N6G5 (/ISS) F8W2M1 (/ISS) Q28BK1 (/ISS) Q3U0D9 (/ISS) Q6DCL5 (/ISS) Q6DCL5 (/ISS)
Rab GTPase binding GO:0017137
Interacting selectively and non-covalently with Rab protein, any member of the Rab subfamily of the Ras superfamily of monomeric GTPases.
8 D3ZBM7 (/ISS) E1C656 (/ISS) F1N6G5 (/ISS) F8W2M1 (/ISS) Q28BK1 (/ISS) Q3U0D9 (/ISS) Q6DCL5 (/ISS) Q6DCL5 (/ISS)
Ubiquitin-protein transferase activity GO:0004842
Catalysis of the transfer of ubiquitin from one protein to another via the reaction X-Ub + Y --> Y-Ub + X, where both X-Ub and Y-Ub are covalent linkages.
3 Q8IYU2 (/IDA) Q8IYU2 (/IDA) Q8IYU2 (/IDA)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
3 Q8IYU2 (/IPI) Q8IYU2 (/IPI) Q8IYU2 (/IPI)
Rab GTPase binding GO:0017137
Interacting selectively and non-covalently with Rab protein, any member of the Rab subfamily of the Ras superfamily of monomeric GTPases.
3 Q8IYU2 (/IDA) Q8IYU2 (/IDA) Q8IYU2 (/IDA)
Rac GTPase binding GO:0048365
Interacting selectively and non-covalently with Rac protein, any member of the Rac subfamily of the Ras superfamily of monomeric GTPases.
3 Q8IYU2 (/IPI) Q8IYU2 (/IPI) Q8IYU2 (/IPI)
Ubiquitin-protein transferase activity GO:0004842
Catalysis of the transfer of ubiquitin from one protein to another via the reaction X-Ub + Y --> Y-Ub + X, where both X-Ub and Y-Ub are covalent linkages.
1 Q3U0D9 (/ISO)
Rab GTPase binding GO:0017137
Interacting selectively and non-covalently with Rab protein, any member of the Rab subfamily of the Ras superfamily of monomeric GTPases.
1 Q3U0D9 (/ISO)
Rac GTPase binding GO:0048365
Interacting selectively and non-covalently with Rac protein, any member of the Rac subfamily of the Ras superfamily of monomeric GTPases.
1 Q3U0D9 (/ISO)

There are 24 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Ubiquitin-dependent protein catabolic process GO:0006511
The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the protein.
8 D3ZBM7 (/ISS) E1C656 (/ISS) F1N6G5 (/ISS) F8W2M1 (/ISS) Q28BK1 (/ISS) Q3U0D9 (/ISS) Q6DCL5 (/ISS) Q6DCL5 (/ISS)
Golgi organization GO:0007030
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the Golgi apparatus.
8 D3ZBM7 (/ISS) E1C656 (/ISS) F1N6G5 (/ISS) F8W2M1 (/ISS) Q28BK1 (/ISS) Q3U0D9 (/ISS) Q6DCL5 (/ISS) Q6DCL5 (/ISS)
Protein ubiquitination GO:0016567
The process in which one or more ubiquitin groups are added to a protein.
8 D3ZBM7 (/ISS) E1C656 (/ISS) F1N6G5 (/ISS) F8W2M1 (/ISS) Q28BK1 (/ISS) Q3U0D9 (/ISS) Q6DCL5 (/ISS) Q6DCL5 (/ISS)
Regulation of cell migration GO:0030334
Any process that modulates the frequency, rate or extent of cell migration.
8 D3ZBM7 (/ISS) E1C656 (/ISS) F1N6G5 (/ISS) F8W2M1 (/ISS) Q28BK1 (/ISS) Q3U0D9 (/ISS) Q6DCL5 (/ISS) Q6DCL5 (/ISS)
Membrane fusion GO:0061025
The membrane organization process that joins two lipid bilayers to form a single membrane.
8 D3ZBM7 (/ISS) E1C656 (/ISS) F1N6G5 (/ISS) F8W2M1 (/ISS) Q28BK1 (/ISS) Q3U0D9 (/ISS) Q6DCL5 (/ISS) Q6DCL5 (/ISS)
Protein K48-linked ubiquitination GO:0070936
A protein ubiquitination process in which a polymer of ubiquitin, formed by linkages between lysine residues at position 48 of the ubiquitin monomers, is added to a protein. K48-linked ubiquitination targets the substrate protein for degradation.
8 D3ZBM7 (/ISS) E1C656 (/ISS) F1N6G5 (/ISS) F8W2M1 (/ISS) Q28BK1 (/ISS) Q3U0D9 (/ISS) Q6DCL5 (/ISS) Q6DCL5 (/ISS)
Ubiquitin-dependent protein catabolic process GO:0006511
The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the protein.
3 Q8IYU2 (/IDA) Q8IYU2 (/IDA) Q8IYU2 (/IDA)
Golgi organization GO:0007030
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the Golgi apparatus.
3 Q8IYU2 (/IDA) Q8IYU2 (/IDA) Q8IYU2 (/IDA)
Protein ubiquitination GO:0016567
The process in which one or more ubiquitin groups are added to a protein.
3 Q8IYU2 (/IDA) Q8IYU2 (/IDA) Q8IYU2 (/IDA)
Rac protein signal transduction GO:0016601
A series of molecular signals within the cell that are mediated by a member of the Rac family of proteins switching to a GTP-bound active state.
3 Q8IYU2 (/TAS) Q8IYU2 (/TAS) Q8IYU2 (/TAS)
Regulation of cell migration GO:0030334
Any process that modulates the frequency, rate or extent of cell migration.
3 Q8IYU2 (/IMP) Q8IYU2 (/IMP) Q8IYU2 (/IMP)
Membrane fusion GO:0061025
The membrane organization process that joins two lipid bilayers to form a single membrane.
3 Q8IYU2 (/IMP) Q8IYU2 (/IMP) Q8IYU2 (/IMP)
Protein K48-linked ubiquitination GO:0070936
A protein ubiquitination process in which a polymer of ubiquitin, formed by linkages between lysine residues at position 48 of the ubiquitin monomers, is added to a protein. K48-linked ubiquitination targets the substrate protein for degradation.
3 Q8IYU2 (/IDA) Q8IYU2 (/IDA) Q8IYU2 (/IDA)
Heart looping GO:0001947
The tube morphogenesis process in which the primitive heart tube loops asymmetrically. This looping brings the primitive heart chambers into alignment preceding their future integration. Heart looping begins with dextral-looping and ends when the main regional divisions of the mature heart and primordium of the great arterial trunks become established preceeding septation.
1 F8W2M1 (/IMP)
Atrioventricular valve formation GO:0003190
The developmental process pertaining to the initial formation of the atrioventricular valve from unspecified parts. This process begins with the specific processes that contribute to the appearance of the discrete structure and ends when the structural rudiment is recognizable.
1 F8W2M1 (/IMP)
Cardiac ventricle morphogenesis GO:0003208
The process in which the cardiac ventricle is generated and organized. A cardiac ventricle receives blood from a cardiac atrium and pumps it out of the heart.
1 F8W2M1 (/IMP)
Ubiquitin-dependent protein catabolic process GO:0006511
The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the protein.
1 Q3U0D9 (/ISO)
Golgi organization GO:0007030
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the Golgi apparatus.
1 Q3U0D9 (/ISO)
Protein ubiquitination GO:0016567
The process in which one or more ubiquitin groups are added to a protein.
1 Q3U0D9 (/ISO)
Regulation of cell migration GO:0030334
Any process that modulates the frequency, rate or extent of cell migration.
1 Q3U0D9 (/ISO)
Membrane fusion GO:0061025
The membrane organization process that joins two lipid bilayers to form a single membrane.
1 Q3U0D9 (/ISO)
Protein K48-linked ubiquitination GO:0070936
A protein ubiquitination process in which a polymer of ubiquitin, formed by linkages between lysine residues at position 48 of the ubiquitin monomers, is added to a protein. K48-linked ubiquitination targets the substrate protein for degradation.
1 Q3U0D9 (/ISO)
Negative regulation of reactive oxygen species biosynthetic process GO:1903427
Any process that stops, prevents or reduces the frequency, rate or extent of reactive oxygen species biosynthetic process.
1 F8W2M1 (/IGI)
Negative regulation of reactive oxygen species biosynthetic process GO:1903427
Any process that stops, prevents or reduces the frequency, rate or extent of reactive oxygen species biosynthetic process.
1 F8W2M1 (/IMP)

There are 7 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Golgi membrane GO:0000139
The lipid bilayer surrounding any of the compartments of the Golgi apparatus.
8 D3ZBM7 (/ISS) E1C656 (/ISS) F1N6G5 (/ISS) F8W2M1 (/ISS) Q28BK1 (/ISS) Q3U0D9 (/ISS) Q6DCL5 (/ISS) Q6DCL5 (/ISS)
Golgi membrane GO:0000139
The lipid bilayer surrounding any of the compartments of the Golgi apparatus.
3 Q8IYU2 (/IDA) Q8IYU2 (/IDA) Q8IYU2 (/IDA)
Endoplasmic reticulum GO:0005783
The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).
3 Q8IYU2 (/IDA) Q8IYU2 (/IDA) Q8IYU2 (/IDA)
Nuclear body GO:0016604
Extra-nucleolar nuclear domains usually visualized by confocal microscopy and fluorescent antibodies to specific proteins.
3 Q8IYU2 (/IDA) Q8IYU2 (/IDA) Q8IYU2 (/IDA)
Golgi membrane GO:0000139
The lipid bilayer surrounding any of the compartments of the Golgi apparatus.
1 Q3U0D9 (/ISO)
Endoplasmic reticulum GO:0005783
The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).
1 Q3U0D9 (/ISO)
Nuclear body GO:0016604
Extra-nucleolar nuclear domains usually visualized by confocal microscopy and fluorescent antibodies to specific proteins.
1 Q3U0D9 (/ISO)
CATH-Gene3D is a Global Biodata Core Resource Learn more...