The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:
"Hect, E3 ligase catalytic domain
".
FunFam 14: E3 ubiquitin-protein ligase SMURF1
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 15 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
|
5 | A0A0G2K612 (/IPI) D3ZCF5 (/IPI) Q9CUN6 (/IPI) Q9HCE7 (/IPI) Q9HCE7 (/IPI) |
|
Ubiquitin-protein transferase activity GO:0004842
Catalysis of the transfer of ubiquitin from one protein to another via the reaction X-Ub + Y --> Y-Ub + X, where both X-Ub and Y-Ub are covalent linkages.
|
3 | Q9HCE7 (/IDA) Q9HCE7 (/IDA) Q9PUN2 (/IDA) |
|
Ubiquitin protein ligase activity GO:0061630
Catalysis of the transfer of ubiquitin to a substrate protein via the reaction X-ubiquitin + S -> X + S-ubiquitin, where X is either an E2 or E3 enzyme, the X-ubiquitin linkage is a thioester bond, and the S-ubiquitin linkage is an amide bond: an isopeptide bond between the C-terminal glycine of ubiquitin and the epsilon-amino group of lysine residues in the substrate or, in the linear extension of ubiquitin chains, a peptide bond the between the C-terminal glycine and N-terminal methionine of ubiquitin residues.
|
3 | Q9CUN6 (/TAS) Q9HCE7 (/TAS) Q9HCE7 (/TAS) |
|
Ubiquitin-protein transferase activity GO:0004842
Catalysis of the transfer of ubiquitin from one protein to another via the reaction X-Ub + Y --> Y-Ub + X, where both X-Ub and Y-Ub are covalent linkages.
|
2 | Q9CUN6 (/ISS) Q9PUN2 (/ISS) |
|
Phospholipid binding GO:0005543
Interacting selectively and non-covalently with phospholipids, a class of lipids containing phosphoric acid as a mono- or diester.
|
2 | Q9HCE7 (/TAS) Q9HCE7 (/TAS) |
|
Activin binding GO:0048185
Interacting selectively and non-covalently with activin, a dimer of inhibin-beta subunits.
|
2 | Q9HCE7 (/NAS) Q9HCE7 (/NAS) |
|
Ubiquitin protein ligase activity GO:0061630
Catalysis of the transfer of ubiquitin to a substrate protein via the reaction X-ubiquitin + S -> X + S-ubiquitin, where X is either an E2 or E3 enzyme, the X-ubiquitin linkage is a thioester bond, and the S-ubiquitin linkage is an amide bond: an isopeptide bond between the C-terminal glycine of ubiquitin and the epsilon-amino group of lysine residues in the substrate or, in the linear extension of ubiquitin chains, a peptide bond the between the C-terminal glycine and N-terminal methionine of ubiquitin residues.
|
2 | Q9HCE7 (/IDA) Q9HCE7 (/IDA) |
|
I-SMAD binding GO:0070411
Interacting selectively and non-covalently with an inhibitory SMAD signaling protein.
|
2 | Q9HCE7 (/IPI) Q9HCE7 (/IPI) |
|
R-SMAD binding GO:0070412
Interacting selectively and non-covalently with a receptor-regulated SMAD signaling protein.
|
2 | Q9HCE7 (/IPI) Q9HCE7 (/IPI) |
|
Ubiquitin-protein transferase activity GO:0004842
Catalysis of the transfer of ubiquitin from one protein to another via the reaction X-Ub + Y --> Y-Ub + X, where both X-Ub and Y-Ub are covalent linkages.
|
1 | Q9CUN6 (/ISO) |
|
Transforming growth factor beta receptor binding GO:0005160
Interacting selectively and non-covalently with the transforming growth factor beta receptor.
|
1 | F1M3F2 (/IPI) |
|
SMAD binding GO:0046332
Interacting selectively and non-covalently with a SMAD signaling protein.
|
1 | F1M3F2 (/IPI) |
|
Ubiquitin protein ligase activity GO:0061630
Catalysis of the transfer of ubiquitin to a substrate protein via the reaction X-ubiquitin + S -> X + S-ubiquitin, where X is either an E2 or E3 enzyme, the X-ubiquitin linkage is a thioester bond, and the S-ubiquitin linkage is an amide bond: an isopeptide bond between the C-terminal glycine of ubiquitin and the epsilon-amino group of lysine residues in the substrate or, in the linear extension of ubiquitin chains, a peptide bond the between the C-terminal glycine and N-terminal methionine of ubiquitin residues.
|
1 | Q9CUN6 (/ISO) |
|
I-SMAD binding GO:0070411
Interacting selectively and non-covalently with an inhibitory SMAD signaling protein.
|
1 | Q9CUN6 (/ISO) |
|
R-SMAD binding GO:0070412
Interacting selectively and non-covalently with a receptor-regulated SMAD signaling protein.
|
1 | Q9CUN6 (/ISO) |
There are 48 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Ectoderm development GO:0007398
The process whose specific outcome is the progression of the ectoderm over time, from its formation to the mature structure. In animal embryos, the ectoderm is the outer germ layer of the embryo, formed during gastrulation.
|
3 | Q9HCE7 (/TAS) Q9HCE7 (/TAS) Q9PUN2 (/TAS) |
|
Cell differentiation GO:0030154
The process in which relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state.
|
3 | Q9HCE7 (/IDA) Q9HCE7 (/IDA) Q9PUN2 (/IDA) |
|
Negative regulation of BMP signaling pathway GO:0030514
Any process that stops, prevents, or reduces the frequency, rate or extent of the BMP signaling pathway.
|
3 | Q9HCE7 (/TAS) Q9HCE7 (/TAS) Q9PUN2 (/TAS) |
|
Protein polyubiquitination GO:0000209
Addition of multiple ubiquitin groups to a protein, forming a ubiquitin chain.
|
2 | Q9HCE7 (/IDA) Q9HCE7 (/IDA) |
|
Protein polyubiquitination GO:0000209
Addition of multiple ubiquitin groups to a protein, forming a ubiquitin chain.
|
2 | Q9CUN6 (/ISS) Q9PUN2 (/ISS) |
|
Ubiquitin-dependent protein catabolic process GO:0006511
The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the protein.
|
2 | Q9HCE7 (/IDA) Q9HCE7 (/IDA) |
|
Ubiquitin-dependent protein catabolic process GO:0006511
The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the protein.
|
2 | Q9CUN6 (/ISS) Q9PUN2 (/ISS) |
|
Protein export from nucleus GO:0006611
The directed movement of a protein from the nucleus into the cytoplasm.
|
2 | Q9HCE7 (/IDA) Q9HCE7 (/IDA) |
|
Transforming growth factor beta receptor signaling pathway GO:0007179
A series of molecular signals initiated by the binding of an extracellular ligand to a transforming growth factor beta receptor on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription.
|
2 | Q9HCE7 (/TAS) Q9HCE7 (/TAS) |
|
Protein ubiquitination GO:0016567
The process in which one or more ubiquitin groups are added to a protein.
|
2 | Q9HCE7 (/IDA) Q9HCE7 (/IDA) |
|
BMP signaling pathway GO:0030509
A series of molecular signals initiated by the binding of a member of the BMP (bone morphogenetic protein) family to a receptor on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription.
|
2 | Q9HCE7 (/IDA) Q9HCE7 (/IDA) |
|
BMP signaling pathway GO:0030509
A series of molecular signals initiated by the binding of a member of the BMP (bone morphogenetic protein) family to a receptor on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription.
|
2 | Q9CUN6 (/ISS) Q9PUN2 (/ISS) |
|
BMP signaling pathway GO:0030509
A series of molecular signals initiated by the binding of a member of the BMP (bone morphogenetic protein) family to a receptor on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription.
|
2 | Q9HCE7 (/TAS) Q9HCE7 (/TAS) |
|
Negative regulation of transforming growth factor beta receptor signaling pathway GO:0030512
Any process that stops, prevents, or reduces the frequency, rate or extent of any TGF-beta receptor signaling pathway.
|
2 | Q9HCE7 (/IDA) Q9HCE7 (/IDA) |
|
Negative regulation of BMP signaling pathway GO:0030514
Any process that stops, prevents, or reduces the frequency, rate or extent of the BMP signaling pathway.
|
2 | Q9HCE7 (/IDA) Q9HCE7 (/IDA) |
|
Ubiquitin-dependent SMAD protein catabolic process GO:0030579
The chemical reactions and pathways resulting in the breakdown of SMAD signaling proteins by ubiquitination and targeting to the proteasome.
|
2 | Q9HCE7 (/IDA) Q9HCE7 (/IDA) |
|
Receptor catabolic process GO:0032801
The chemical reactions and pathways resulting in the breakdown of a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function.
|
2 | Q9HCE7 (/IDA) Q9HCE7 (/IDA) |
|
Protein localization to cell surface GO:0034394
A process in which a protein is transported to, or maintained in, a location within the external part of the cell wall and/or plasma membrane.
|
2 | Q9HCE7 (/IDA) Q9HCE7 (/IDA) |
|
Proteasome-mediated ubiquitin-dependent protein catabolic process GO:0043161
The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome.
|
2 | Q9HCE7 (/IDA) Q9HCE7 (/IDA) |
|
Wnt signaling pathway, planar cell polarity pathway GO:0060071
The series of molecular signals initiated by binding of a Wnt protein to a receptor on the surface of the target cell where activated receptors signal via downstream effectors including C-Jun N-terminal kinase (JNK) to modulate cytoskeletal elements and control cell polarity.
|
2 | Q9HCE7 (/TAS) Q9HCE7 (/TAS) |
|
Engulfment of target by autophagosome GO:0061736
The membrane invagination process by which an autophagosomal membrane surrounds an object that will be degraded by macroautophagy.
|
2 | Q9HCE7 (/IMP) Q9HCE7 (/IMP) |
|
Substrate localization to autophagosome GO:0061753
The localization process by which an autophagic substrate is delivered to a forming autophagosome.
|
2 | Q9HCE7 (/IMP) Q9HCE7 (/IMP) |
|
Protein targeting to vacuole involved in autophagy GO:0071211
The process of directing proteins towards the vacuole using signals contained within the protein, occurring as part of autophagy, the process in which cells digest parts of their own cytoplasm.
|
2 | Q9HCE7 (/IMP) Q9HCE7 (/IMP) |
|
Protein localization to plasma membrane GO:0072659
A process in which a protein is transported to, or maintained in, a specific location in the plasma membrane.
|
2 | Q9HCE7 (/TAS) Q9HCE7 (/TAS) |
|
Positive regulation of dendrite extension GO:1903861
Any process that activates or increases the frequency, rate or extent of dendrite extension.
|
2 | Q9HCE7 (/IDA) Q9HCE7 (/IDA) |
|
Positive regulation of ubiquitin-dependent protein catabolic process GO:2000060
Any process that activates or increases the frequency, rate or extent of ubiquitin-dependent protein catabolic process.
|
2 | Q9HCE7 (/IMP) Q9HCE7 (/IMP) |
|
Protein polyubiquitination GO:0000209
Addition of multiple ubiquitin groups to a protein, forming a ubiquitin chain.
|
1 | Q9CUN6 (/ISO) |
|
Cellular protein modification process GO:0006464
The covalent alteration of one or more amino acids occurring in proteins, peptides and nascent polypeptides (co-translational, post-translational modifications) occurring at the level of an individual cell. Includes the modification of charged tRNAs that are destined to occur in a protein (pre-translation modification).
|
1 | Q9PUN2 (/TAS) |
|
Ubiquitin-dependent protein catabolic process GO:0006511
The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the protein.
|
1 | Q9CUN6 (/ISO) |
|
Protein export from nucleus GO:0006611
The directed movement of a protein from the nucleus into the cytoplasm.
|
1 | Q9CUN6 (/ISO) |
|
Protein ubiquitination GO:0016567
The process in which one or more ubiquitin groups are added to a protein.
|
1 | Q9CUN6 (/IMP) |
|
Protein ubiquitination GO:0016567
The process in which one or more ubiquitin groups are added to a protein.
|
1 | Q9CUN6 (/ISO) |
|
Cell differentiation GO:0030154
The process in which relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state.
|
1 | Q9CUN6 (/ISO) |
|
Cell differentiation GO:0030154
The process in which relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state.
|
1 | Q9CUN6 (/ISS) |
|
Negative regulation of ossification GO:0030279
Any process that stops, prevents, or reduces the frequency, rate or extent of ossification, the formation of bone or of a bony substance or the conversion of fibrous tissue or of cartilage into bone or a bony substance.
|
1 | Q9CUN6 (/IMP) |
|
BMP signaling pathway GO:0030509
A series of molecular signals initiated by the binding of a member of the BMP (bone morphogenetic protein) family to a receptor on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription.
|
1 | Q9CUN6 (/ISO) |
|
Negative regulation of transforming growth factor beta receptor signaling pathway GO:0030512
Any process that stops, prevents, or reduces the frequency, rate or extent of any TGF-beta receptor signaling pathway.
|
1 | Q9CUN6 (/ISO) |
|
Negative regulation of BMP signaling pathway GO:0030514
Any process that stops, prevents, or reduces the frequency, rate or extent of the BMP signaling pathway.
|
1 | Q9CUN6 (/ISO) |
|
Ubiquitin-dependent SMAD protein catabolic process GO:0030579
The chemical reactions and pathways resulting in the breakdown of SMAD signaling proteins by ubiquitination and targeting to the proteasome.
|
1 | Q9CUN6 (/ISO) |
|
Receptor catabolic process GO:0032801
The chemical reactions and pathways resulting in the breakdown of a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function.
|
1 | Q9CUN6 (/ISO) |
|
Protein localization to cell surface GO:0034394
A process in which a protein is transported to, or maintained in, a location within the external part of the cell wall and/or plasma membrane.
|
1 | Q9CUN6 (/ISO) |
|
Proteasome-mediated ubiquitin-dependent protein catabolic process GO:0043161
The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome.
|
1 | Q9CUN6 (/ISO) |
|
Parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization GO:0061734
A positive regulation of the macromitophagy pathway that is triggered by mitochondrial depolarization and requires the function of a parkin-family molecule.
|
1 | Q9CUN6 (/IMP) |
|
Engulfment of target by autophagosome GO:0061736
The membrane invagination process by which an autophagosomal membrane surrounds an object that will be degraded by macroautophagy.
|
1 | Q9CUN6 (/ISO) |
|
Substrate localization to autophagosome GO:0061753
The localization process by which an autophagic substrate is delivered to a forming autophagosome.
|
1 | Q9CUN6 (/ISO) |
|
Protein targeting to vacuole involved in autophagy GO:0071211
The process of directing proteins towards the vacuole using signals contained within the protein, occurring as part of autophagy, the process in which cells digest parts of their own cytoplasm.
|
1 | Q9CUN6 (/ISO) |
|
Positive regulation of dendrite extension GO:1903861
Any process that activates or increases the frequency, rate or extent of dendrite extension.
|
1 | Q9CUN6 (/ISO) |
|
Positive regulation of ubiquitin-dependent protein catabolic process GO:2000060
Any process that activates or increases the frequency, rate or extent of ubiquitin-dependent protein catabolic process.
|
1 | Q9CUN6 (/ISO) |
There are 12 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
3 | Q9CUN6 (/TAS) Q9HCE7 (/TAS) Q9HCE7 (/TAS) |
|
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
|
2 | Q9HCE7 (/TAS) Q9HCE7 (/TAS) |
|
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
|
2 | Q9HCE7 (/IDA) Q9HCE7 (/IDA) |
|
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
|
2 | Q9CUN6 (/ISS) Q9PUN2 (/ISS) |
|
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
|
2 | Q9HCE7 (/IDA) Q9HCE7 (/IDA) |
|
Axon GO:0030424
The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter.
|
2 | A0A0G2K612 (/IDA) D3ZCF5 (/IDA) |
|
Neuronal cell body GO:0043025
The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites.
|
2 | A0A0G2K612 (/IDA) D3ZCF5 (/IDA) |
|
Extracellular exosome GO:0070062
A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
|
2 | Q9HCE7 (/HDA) Q9HCE7 (/HDA) |
|
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
|
1 | Q9CUN6 (/ISO) |
|
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
|
1 | Q9CUN6 (/ISO) |
|
Axon GO:0030424
The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter.
|
1 | Q9CUN6 (/ISO) |
|
Neuronal cell body GO:0043025
The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites.
|
1 | Q9CUN6 (/ISO) |