The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:
"Phosphorylase Kinase; domain 1
".
FunFam 41: Vascular endothelial growth factor receptor 2
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 40 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
|
13 |
F1MWF1 (/IPI)
O08775 (/IPI)
P17948 (/IPI)
P17948 (/IPI)
P35916 (/IPI)
P35917 (/IPI)
P35917 (/IPI)
P35918 (/IPI)
P35968 (/IPI)
P35968 (/IPI)
(3 more) |
Growth factor binding GO:0019838
Interacting selectively and non-covalently with any growth factor, proteins or polypeptides that stimulate a cell or organism to grow or proliferate.
|
8 | O08775 (/IPI) P17948 (/IPI) P17948 (/IPI) P35916 (/IPI) P35918 (/IPI) P35968 (/IPI) P35968 (/IPI) P53767 (/IPI) |
Vascular endothelial growth factor-activated receptor activity GO:0005021
Combining with a vascular endothelial growth factor (VEGF) and transmitting the signal across the plasma membrane to initiate a change in cell activity.
|
7 | P17948 (/IDA) P17948 (/IDA) P35916 (/IDA) P35918 (/IDA) P35968 (/IDA) P35968 (/IDA) P35969 (/IDA) |
Vascular endothelial growth factor-activated receptor activity GO:0005021
Combining with a vascular endothelial growth factor (VEGF) and transmitting the signal across the plasma membrane to initiate a change in cell activity.
|
6 | O08775 (/IMP) P17948 (/IMP) P17948 (/IMP) P35916 (/IMP) P53767 (/IMP) Q91ZT1 (/IMP) |
VEGF-C-activated receptor activity GO:0036328
Combining with vascular endothelial growth factor C (VEGF-C) and transmitting the signal across the plasma membrane to initiate a change in cell activity.
|
6 | P35917 (/ISS) P35917 (/ISS) P35969 (/ISS) P79701 (/ISS) Q5MD89 (/ISS) Q91ZT1 (/ISS) |
Transmembrane receptor protein tyrosine kinase activity GO:0004714
Combining with a signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP + a protein-L-tyrosine = ADP + a protein-L-tyrosine phosphate.
|
5 | P17948 (/TAS) P17948 (/TAS) P35916 (/TAS) P35968 (/TAS) P35968 (/TAS) |
Protein homodimerization activity GO:0042803
Interacting selectively and non-covalently with an identical protein to form a homodimer.
|
5 | P35917 (/ISS) P35917 (/ISS) P35969 (/ISS) P79701 (/ISS) Q91ZT1 (/ISS) |
Vascular endothelial growth factor-activated receptor activity GO:0005021
Combining with a vascular endothelial growth factor (VEGF) and transmitting the signal across the plasma membrane to initiate a change in cell activity.
|
4 | P35917 (/ISO) P35917 (/ISO) P35918 (/ISO) P35969 (/ISO) |
Growth factor binding GO:0019838
Interacting selectively and non-covalently with any growth factor, proteins or polypeptides that stimulate a cell or organism to grow or proliferate.
|
4 | P35917 (/ISO) P35917 (/ISO) P35918 (/ISO) P35969 (/ISO) |
Protein tyrosine kinase activity GO:0004713
Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate.
|
3 | P35968 (/IDA) P35968 (/IDA) Q8AXB3 (/IDA) |
Showing 1 to 10 of 40 entries
There are 236 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Protein autophosphorylation GO:0046777
The phosphorylation by a protein of one or more of its own amino acid residues (cis-autophosphorylation), or residues on an identical protein (trans-autophosphorylation).
|
9 | P35917 (/ISS) P35917 (/ISS) P35918 (/ISS) P35969 (/ISS) P52583 (/ISS) P53767 (/ISS) P79701 (/ISS) Q5MD89 (/ISS) Q91ZT1 (/ISS) |
Vascular endothelial growth factor receptor signaling pathway GO:0048010
Any series of molecular signals initiated by the binding of an extracellular ligand to a vascular endothelial growth factor receptor (VEGFR) located on the surface of the receiving cell, and ending with regulation of a downstream cellular process, e.g. transcription.
|
8 | O08775 (/IMP) P17948 (/IMP) P17948 (/IMP) P35916 (/IMP) P35968 (/IMP) P35968 (/IMP) P35969 (/IMP) Q91ZT1 (/IMP) |
Angiogenesis GO:0001525
Blood vessel formation when new vessels emerge from the proliferation of pre-existing blood vessels.
|
7 | B3DKP1 (/IMP) P35969 (/IMP) Q4JDD5 (/IMP) Q5GIT3 (/IMP) Q5GIT4 (/IMP) Q5MD89 (/IMP) Q8AXB3 (/IMP) |
Angiogenesis GO:0001525
Blood vessel formation when new vessels emerge from the proliferation of pre-existing blood vessels.
|
6 | B3DKP1 (/IGI) Q4JDD5 (/IGI) Q5GIT3 (/IGI) Q5GIT4 (/IGI) Q5MD89 (/IGI) Q8AXB3 (/IGI) |
Sprouting angiogenesis GO:0002040
The extension of new blood vessels from existing vessels into avascular tissues, this process includes the specialization of endothelial cells into leading tip and stalk cells, proliferation and migration of the endothelial cells and cell adhesion resulting in angiogenic sprout fusion or lumen formation.
|
6 | B3DKP1 (/IMP) P35917 (/IMP) P35917 (/IMP) P35969 (/IMP) Q4JDD5 (/IMP) Q5GIT3 (/IMP) |
Peptidyl-tyrosine phosphorylation GO:0018108
The phosphorylation of peptidyl-tyrosine to form peptidyl-O4'-phospho-L-tyrosine.
|
6 | P17948 (/IDA) P17948 (/IDA) P35916 (/IDA) P35968 (/IDA) P35968 (/IDA) Q8AXB3 (/IDA) |
Protein autophosphorylation GO:0046777
The phosphorylation by a protein of one or more of its own amino acid residues (cis-autophosphorylation), or residues on an identical protein (trans-autophosphorylation).
|
6 | O08775 (/IDA) P17948 (/IDA) P17948 (/IDA) P35916 (/IDA) P35968 (/IDA) P35968 (/IDA) |
Vascular endothelial growth factor receptor signaling pathway GO:0048010
Any series of molecular signals initiated by the binding of an extracellular ligand to a vascular endothelial growth factor receptor (VEGFR) located on the surface of the receiving cell, and ending with regulation of a downstream cellular process, e.g. transcription.
|
6 | P17948 (/IDA) P17948 (/IDA) P35916 (/IDA) P35918 (/IDA) P35968 (/IDA) P35968 (/IDA) |
Sprouting angiogenesis GO:0002040
The extension of new blood vessels from existing vessels into avascular tissues, this process includes the specialization of endothelial cells into leading tip and stalk cells, proliferation and migration of the endothelial cells and cell adhesion resulting in angiogenic sprout fusion or lumen formation.
|
5 | B3DKP1 (/IGI) Q4JDD5 (/IGI) Q5GIT3 (/IGI) Q5MD89 (/IGI) Q8AXB3 (/IGI) |
Transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169
A series of molecular signals initiated by the binding of an extracellular ligand to a receptor on the surface of the target cell where the receptor possesses tyrosine kinase activity, and ending with regulation of a downstream cellular process, e.g. transcription.
|
5 | P17948 (/TAS) P17948 (/TAS) P35916 (/TAS) P35968 (/TAS) P35968 (/TAS) |
Showing 1 to 10 of 236 entries
There are 42 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
|
11 |
E9PD35 (/IDA)
L7RSL3 (/IDA)
L7RSL3 (/IDA)
O08775 (/IDA)
P17948 (/IDA)
P17948 (/IDA)
P35916 (/IDA)
P35918 (/IDA)
P35968 (/IDA)
P35968 (/IDA)
(1 more) |
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
|
6 | P17948 (/TAS) P17948 (/TAS) P35916 (/TAS) P35918 (/TAS) P35968 (/TAS) P35968 (/TAS) |
Integral component of plasma membrane GO:0005887
The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
|
5 | P17948 (/TAS) P17948 (/TAS) P35916 (/TAS) P35968 (/TAS) P35968 (/TAS) |
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
|
4 | F1NW21 (/IDA) O08775 (/IDA) P35918 (/IDA) Q677M1 (/IDA) |
Endoplasmic reticulum GO:0005783
The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).
|
4 | O08775 (/ISS) P35918 (/ISS) P52583 (/ISS) Q5GIT4 (/ISS) |
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
|
4 | P35917 (/ISO) P35917 (/ISO) P35918 (/ISO) P35969 (/ISO) |
Integral component of plasma membrane GO:0005887
The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
|
4 | P17948 (/IDA) P17948 (/IDA) P35968 (/IDA) P35968 (/IDA) |
Integral component of plasma membrane GO:0005887
The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
|
4 | O08775 (/ISS) P35918 (/ISS) P35969 (/ISS) P53767 (/ISS) |
Actin cytoskeleton GO:0015629
The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes.
|
4 | L7RSL3 (/IDA) L7RSL3 (/IDA) P17948 (/IDA) P17948 (/IDA) |
Cell junction GO:0030054
A cellular component that forms a specialized region of connection between two or more cells or between a cell and the extracellular matrix. At a cell junction, anchoring proteins extend through the plasma membrane to link cytoskeletal proteins in one cell to cytoskeletal proteins in neighboring cells or to proteins in the extracellular matrix.
|
3 | O08775 (/ISS) P35968 (/ISS) P35968 (/ISS) |
Showing 1 to 10 of 42 entries