The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Cyclin-dependent kinase, regulatory subunit
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 2: Cyclin-dependent kinases regulatory subunit

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 7 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
9 P08463 (/IPI) P20486 (/IPI) P20486 (/IPI) P20486 (/IPI) P20486 (/IPI) P20486 (/IPI) P20486 (/IPI) P20486 (/IPI) P20486 (/IPI)
Protein kinase activator activity GO:0030295
Binds to and increases the activity of a protein kinase, an enzyme which phosphorylates a protein.
8 P20486 (/IDA) P20486 (/IDA) P20486 (/IDA) P20486 (/IDA) P20486 (/IDA) P20486 (/IDA) P20486 (/IDA) P20486 (/IDA)
Histone binding GO:0042393
Interacting selectively and non-covalently with a histone, any of a group of water-soluble proteins found in association with the DNA of eukaroytic chromosomes. They are involved in the condensation and coiling of chromosomes during cell division and have also been implicated in nonspecific suppression of gene activity.
8 P20486 (/IDA) P20486 (/IDA) P20486 (/IDA) P20486 (/IDA) P20486 (/IDA) P20486 (/IDA) P20486 (/IDA) P20486 (/IDA)
Ubiquitin binding GO:0043130
Interacting selectively and non-covalently with ubiquitin, a protein that when covalently bound to other cellular proteins marks them for proteolytic degradation.
8 P20486 (/IDA) P20486 (/IDA) P20486 (/IDA) P20486 (/IDA) P20486 (/IDA) P20486 (/IDA) P20486 (/IDA) P20486 (/IDA)
Zinc ion binding GO:0008270
Interacting selectively and non-covalently with zinc (Zn) ions.
1 P08463 (/IDA)
Protein-containing complex binding GO:0044877
Interacting selectively and non-covalently with a macromolecular complex.
1 P08463 (/IDA)
Cyclin-dependent protein serine/threonine kinase activator activity GO:0061575
Binds to and increases the activity of a cyclin-dependent protein serine/threonine kinase.
1 P08463 (/IDA)

There are 7 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Regulation of transcription by RNA polymerase II GO:0006357
Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II.
8 P20486 (/IMP) P20486 (/IMP) P20486 (/IMP) P20486 (/IMP) P20486 (/IMP) P20486 (/IMP) P20486 (/IMP) P20486 (/IMP)
Regulation of mitotic cell cycle GO:0007346
Any process that modulates the rate or extent of progress through the mitotic cell cycle.
8 P20486 (/IMP) P20486 (/IMP) P20486 (/IMP) P20486 (/IMP) P20486 (/IMP) P20486 (/IMP) P20486 (/IMP) P20486 (/IMP)
Positive regulation of transcription by RNA polymerase II GO:0045944
Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
8 P20486 (/IDA) P20486 (/IDA) P20486 (/IDA) P20486 (/IDA) P20486 (/IDA) P20486 (/IDA) P20486 (/IDA) P20486 (/IDA)
Positive regulation of transcription by RNA polymerase II GO:0045944
Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
8 P20486 (/IMP) P20486 (/IMP) P20486 (/IMP) P20486 (/IMP) P20486 (/IMP) P20486 (/IMP) P20486 (/IMP) P20486 (/IMP)
Regulation of nucleosome density GO:0060303
Any process that modulates the number of nucleosomes in a given region of a chromosome.
8 P20486 (/IMP) P20486 (/IMP) P20486 (/IMP) P20486 (/IMP) P20486 (/IMP) P20486 (/IMP) P20486 (/IMP) P20486 (/IMP)
Regulation of G2/M transition of mitotic cell cycle GO:0010389
Any signalling pathway that modulates the activity of a cell cycle cyclin-dependent protein kinase to modulate the switch from G2 phase to M phase of the mitotic cell cycle.
1 P08463 (/IMP)
Signaling GO:0023052
The entirety of a process in which information is transmitted within a biological system. This process begins with an active signal and ends when a cellular response has been triggered.
1 P08463 (/NAS)

There are 4 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Cyclin-dependent protein kinase holoenzyme complex GO:0000307
Cyclin-dependent protein kinases (CDKs) are enzyme complexes that contain a kinase catalytic subunit associated with a regulatory cyclin partner.
9 P08463 (/IDA) P20486 (/IDA) P20486 (/IDA) P20486 (/IDA) P20486 (/IDA) P20486 (/IDA) P20486 (/IDA) P20486 (/IDA) P20486 (/IDA)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
9 P08463 (/HDA) P20486 (/HDA) P20486 (/HDA) P20486 (/HDA) P20486 (/HDA) P20486 (/HDA) P20486 (/HDA) P20486 (/HDA) P20486 (/HDA)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
8 P20486 (/HDA) P20486 (/HDA) P20486 (/HDA) P20486 (/HDA) P20486 (/HDA) P20486 (/HDA) P20486 (/HDA) P20486 (/HDA)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
1 P08463 (/HDA)
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