CATH Superfamily 3.30.1600.10

FunFam 3: NAD-dependent histone deacetylase sirtuin-1

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 60 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

GO Term	Annotations	Evidence
Protein binding GO:0005515 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).	7	A7LKB1 (/IPI) B3FK65 (/IPI) Q54GV7 (/IPI) Q923E4 (/IPI) Q923E4 (/IPI) Q96EB6 (/IPI) Q96EB6 (/IPI)
NAD-dependent histone deacetylase activity GO:0017136 Catalysis of the reaction: histone N6-acetyl-L-lysine + H2O = histone L-lysine + acetate. This reaction requires the presence of NAD, and represents the removal of an acetyl group from a histone.	6	A0A0G2JZ79 (/IDA) Q923E4 (/IDA) Q923E4 (/IDA) Q96EB6 (/IDA) Q96EB6 (/IDA) Q9VK34 (/IDA)
Enzyme binding GO:0019899 Interacting selectively and non-covalently with any enzyme.	5	A0A0G2JZ79 (/IPI) Q923E4 (/IPI) Q923E4 (/IPI) Q96EB6 (/IPI) Q96EB6 (/IPI)
Protein deacetylase activity GO:0033558 Catalysis of the hydrolysis of an acetyl group or groups from a protein substrate.	5	Q923E4 (/IMP) Q923E4 (/IMP) Q96EB6 (/IMP) Q96EB6 (/IMP) Q9VK34 (/IMP)
P53 binding GO:0002039 Interacting selectively and non-covalently with one of the p53 family of proteins.	4	Q923E4 (/IPI) Q923E4 (/IPI) Q96EB6 (/IPI) Q96EB6 (/IPI)
Histone deacetylase activity GO:0004407 Catalysis of the reaction: histone N6-acetyl-L-lysine + H2O = histone L-lysine + acetate. This reaction represents the removal of an acetyl group from a histone, a class of proteins complexed to DNA in chromatin and chromosomes.	4	O94640 (/IDA) Q96EB6 (/IDA) Q96EB6 (/IDA) Q9VK34 (/IDA)
Protein deacetylase activity GO:0033558 Catalysis of the hydrolysis of an acetyl group or groups from a protein substrate.	4	Q923E4 (/IDA) Q923E4 (/IDA) Q96EB6 (/IDA) Q96EB6 (/IDA)
NAD-dependent protein deacetylase activity GO:0034979 Catalysis of the removal of one or more acetyl groups from a protein, requiring NAD.	4	Q923E4 (/IDA) Q923E4 (/IDA) Q96EB6 (/IDA) Q96EB6 (/IDA)
Transcription factor binding GO:0008134 Interacting selectively and non-covalently with a transcription factor, a protein required to initiate or regulate transcription.	3	Q96EB6 (/IPI) Q96EB6 (/IPI) Q9VK34 (/IPI)
NAD-dependent histone deacetylase activity (H3-K9 specific) GO:0046969 Catalysis of the reaction: histone H3 N6-acetyl-L-lysine (position 9) + H2O = histone H3 L-lysine (position 9) + acetate. This reaction requires the presence of NAD, and represents the removal of an acetyl group from lysine at position 9 of the histone H3 protein.	3	O94640 (/IDA) Q923E4 (/IDA) Q923E4 (/IDA)
RNA polymerase II distal enhancer sequence-specific DNA binding GO:0000980 Interacting selectively and non-covalently with a RNA polymerase II (Pol II) distal enhancer. In mammalian cells, enhancers are distal sequences that increase the utilization of some promoters, and can function in either orientation and in any location (upstream or downstream) relative to the core promoter.	2	Q923E4 (/IDA) Q923E4 (/IDA)
DNA-binding transcription activator activity, RNA polymerase II-specific GO:0001228 A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to activate or increase transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.	2	Q923E4 (/IDA) Q923E4 (/IDA)
P53 binding GO:0002039 Interacting selectively and non-covalently with one of the p53 family of proteins.	2	Q923E4 (/ISO) Q923E4 (/ISO)
Transcription corepressor activity GO:0003714 A protein or a member of a complex that interacts specifically and non-covalently with a DNA-bound DNA-binding transcription factor to repress the transcription of specific genes. Corepressors often act by altering chromatin structure and modifications. For example, one class of transcription coregulators modifies chromatin structure through covalent modification of histones. A second ATP-dependent class modifies the conformation of chromatin. A third class occludes DNA-binding transcription factor protein-protein interaction domains. A fourth class of corepressors prevents interactions of DNA bound DNA-binding transcription factor with coactivators.	2	Q96EB6 (/IDA) Q96EB6 (/IDA)
Transcription corepressor activity GO:0003714 A protein or a member of a complex that interacts specifically and non-covalently with a DNA-bound DNA-binding transcription factor to repress the transcription of specific genes. Corepressors often act by altering chromatin structure and modifications. For example, one class of transcription coregulators modifies chromatin structure through covalent modification of histones. A second ATP-dependent class modifies the conformation of chromatin. A third class occludes DNA-binding transcription factor protein-protein interaction domains. A fourth class of corepressors prevents interactions of DNA bound DNA-binding transcription factor with coactivators.	2	Q923E4 (/IMP) Q923E4 (/IMP)
Transcription corepressor activity GO:0003714 A protein or a member of a complex that interacts specifically and non-covalently with a DNA-bound DNA-binding transcription factor to repress the transcription of specific genes. Corepressors often act by altering chromatin structure and modifications. For example, one class of transcription coregulators modifies chromatin structure through covalent modification of histones. A second ATP-dependent class modifies the conformation of chromatin. A third class occludes DNA-binding transcription factor protein-protein interaction domains. A fourth class of corepressors prevents interactions of DNA bound DNA-binding transcription factor with coactivators.	2	Q923E4 (/ISO) Q923E4 (/ISO)
Transcription corepressor activity GO:0003714 A protein or a member of a complex that interacts specifically and non-covalently with a DNA-bound DNA-binding transcription factor to repress the transcription of specific genes. Corepressors often act by altering chromatin structure and modifications. For example, one class of transcription coregulators modifies chromatin structure through covalent modification of histones. A second ATP-dependent class modifies the conformation of chromatin. A third class occludes DNA-binding transcription factor protein-protein interaction domains. A fourth class of corepressors prevents interactions of DNA bound DNA-binding transcription factor with coactivators.	2	Q96EB6 (/ISS) Q96EB6 (/ISS)
Histone deacetylase activity GO:0004407 Catalysis of the reaction: histone N6-acetyl-L-lysine + H2O = histone L-lysine + acetate. This reaction represents the removal of an acetyl group from a histone, a class of proteins complexed to DNA in chromatin and chromosomes.	2	Q96EB6 (/EXP) Q96EB6 (/EXP)
Histone deacetylase activity GO:0004407 Catalysis of the reaction: histone N6-acetyl-L-lysine + H2O = histone L-lysine + acetate. This reaction represents the removal of an acetyl group from a histone, a class of proteins complexed to DNA in chromatin and chromosomes.	2	Q923E4 (/ISO) Q923E4 (/ISO)
Protein C-terminus binding GO:0008022 Interacting selectively and non-covalently with a protein C-terminus, the end of any peptide chain at which the 1-carboxyl function of a constituent amino acid is not attached in peptide linkage to another amino-acid residue.	2	Q96EB6 (/IPI) Q96EB6 (/IPI)
Protein C-terminus binding GO:0008022 Interacting selectively and non-covalently with a protein C-terminus, the end of any peptide chain at which the 1-carboxyl function of a constituent amino acid is not attached in peptide linkage to another amino-acid residue.	2	Q923E4 (/ISO) Q923E4 (/ISO)
Transcription factor binding GO:0008134 Interacting selectively and non-covalently with a transcription factor, a protein required to initiate or regulate transcription.	2	Q923E4 (/ISO) Q923E4 (/ISO)
NAD-dependent histone deacetylase activity GO:0017136 Catalysis of the reaction: histone N6-acetyl-L-lysine + H2O = histone L-lysine + acetate. This reaction requires the presence of NAD, and represents the removal of an acetyl group from a histone.	2	Q923E4 (/ISO) Q923E4 (/ISO)
Deacetylase activity GO:0019213 Catalysis of the hydrolysis of an acetyl group or groups from a substrate molecule.	2	Q96EB6 (/IDA) Q96EB6 (/IDA)
Deacetylase activity GO:0019213 Catalysis of the hydrolysis of an acetyl group or groups from a substrate molecule.	2	Q923E4 (/IMP) Q923E4 (/IMP)
Deacetylase activity GO:0019213 Catalysis of the hydrolysis of an acetyl group or groups from a substrate molecule.	2	Q923E4 (/ISO) Q923E4 (/ISO)
Enzyme binding GO:0019899 Interacting selectively and non-covalently with any enzyme.	2	Q923E4 (/ISO) Q923E4 (/ISO)
Protein domain specific binding GO:0019904 Interacting selectively and non-covalently with a specific domain of a protein.	2	Q923E4 (/IPI) Q923E4 (/IPI)
Protein deacetylase activity GO:0033558 Catalysis of the hydrolysis of an acetyl group or groups from a protein substrate.	2	Q923E4 (/ISO) Q923E4 (/ISO)
NAD-dependent protein deacetylase activity GO:0034979 Catalysis of the removal of one or more acetyl groups from a protein, requiring NAD.	2	Q923E4 (/EXP) Q923E4 (/EXP)
NAD-dependent protein deacetylase activity GO:0034979 Catalysis of the removal of one or more acetyl groups from a protein, requiring NAD.	2	Q96EB6 (/IMP) Q96EB6 (/IMP)
NAD-dependent protein deacetylase activity GO:0034979 Catalysis of the removal of one or more acetyl groups from a protein, requiring NAD.	2	Q923E4 (/ISO) Q923E4 (/ISO)
NAD-dependent protein deacetylase activity GO:0034979 Catalysis of the removal of one or more acetyl groups from a protein, requiring NAD.	2	Q96EB6 (/TAS) Q96EB6 (/TAS)
Nuclear hormone receptor binding GO:0035257 Interacting selectively and non-covalently with a nuclear hormone receptor, a ligand-dependent receptor found in the nucleus of the cell.	2	Q96EB6 (/IPI) Q96EB6 (/IPI)
Nuclear hormone receptor binding GO:0035257 Interacting selectively and non-covalently with a nuclear hormone receptor, a ligand-dependent receptor found in the nucleus of the cell.	2	Q923E4 (/ISO) Q923E4 (/ISO)
Histone binding GO:0042393 Interacting selectively and non-covalently with a histone, any of a group of water-soluble proteins found in association with the DNA of eukaroytic chromosomes. They are involved in the condensation and coiling of chromosomes during cell division and have also been implicated in nonspecific suppression of gene activity.	2	Q96EB6 (/IPI) Q96EB6 (/IPI)
Histone binding GO:0042393 Interacting selectively and non-covalently with a histone, any of a group of water-soluble proteins found in association with the DNA of eukaroytic chromosomes. They are involved in the condensation and coiling of chromosomes during cell division and have also been implicated in nonspecific suppression of gene activity.	2	Q923E4 (/ISO) Q923E4 (/ISO)
Identical protein binding GO:0042802 Interacting selectively and non-covalently with an identical protein or proteins.	2	Q96EB6 (/IPI) Q96EB6 (/IPI)
Identical protein binding GO:0042802 Interacting selectively and non-covalently with an identical protein or proteins.	2	Q923E4 (/ISO) Q923E4 (/ISO)
HLH domain binding GO:0043398 Interacting selectively and non-covalently with Helix Loop Helix, a domain of 40-50 residues that occurs in specific DNA-binding proteins that act as transcription factors. The domain is formed of two amphipathic helices joined by a variable length linker region that can form a loop and it mediates protein dimerization.	2	Q96EB6 (/IPI) Q96EB6 (/IPI)
HLH domain binding GO:0043398 Interacting selectively and non-covalently with Helix Loop Helix, a domain of 40-50 residues that occurs in specific DNA-binding proteins that act as transcription factors. The domain is formed of two amphipathic helices joined by a variable length linker region that can form a loop and it mediates protein dimerization.	2	Q923E4 (/ISO) Q923E4 (/ISO)
Protein kinase B binding GO:0043422 Interacting selectively and non-covalently with protein kinase B, an intracellular kinase that is important in regulating glucose metabolism.	2	Q923E4 (/ISO) Q923E4 (/ISO)
BHLH transcription factor binding GO:0043425 Interacting selectively and non-covalently with any of the basic Helix-Loop-Helix (bHLH) superfamily of transcription factors, important regulatory components in transcriptional networks of many developmental pathways.	2	Q96EB6 (/IPI) Q96EB6 (/IPI)
BHLH transcription factor binding GO:0043425 Interacting selectively and non-covalently with any of the basic Helix-Loop-Helix (bHLH) superfamily of transcription factors, important regulatory components in transcriptional networks of many developmental pathways.	2	Q923E4 (/ISO) Q923E4 (/ISO)
BHLH transcription factor binding GO:0043425 Interacting selectively and non-covalently with any of the basic Helix-Loop-Helix (bHLH) superfamily of transcription factors, important regulatory components in transcriptional networks of many developmental pathways.	2	Q923E4 (/ISS) Q923E4 (/ISS)
NAD-dependent histone deacetylase activity (H3-K9 specific) GO:0046969 Catalysis of the reaction: histone H3 N6-acetyl-L-lysine (position 9) + H2O = histone H3 L-lysine (position 9) + acetate. This reaction requires the presence of NAD, and represents the removal of an acetyl group from lysine at position 9 of the histone H3 protein.	2	Q96EB6 (/ISS) Q96EB6 (/ISS)
Mitogen-activated protein kinase binding GO:0051019 Interacting selectively and non-covalently with a mitogen-activated protein kinase.	2	Q96EB6 (/IPI) Q96EB6 (/IPI)
Mitogen-activated protein kinase binding GO:0051019 Interacting selectively and non-covalently with a mitogen-activated protein kinase.	2	Q923E4 (/ISO) Q923E4 (/ISO)
Caspase binding GO:0089720 Interacting selectively and non-covalently with a caspase family protein.	2	A7LKB1 (/IPI) B3FK65 (/IPI)
Keratin filament binding GO:1990254 Interacting selectively and non-covalently with a keratin filament, an intermediate filament composed of acidic and basic keratins (types I and II), typically expressed in epithelial cells.	2	Q96EB6 (/IPI) Q96EB6 (/IPI)
Keratin filament binding GO:1990254 Interacting selectively and non-covalently with a keratin filament, an intermediate filament composed of acidic and basic keratins (types I and II), typically expressed in epithelial cells.	2	Q923E4 (/ISO) Q923E4 (/ISO)
Histone deacetylase activity GO:0004407 Catalysis of the reaction: histone N6-acetyl-L-lysine + H2O = histone L-lysine + acetate. This reaction represents the removal of an acetyl group from a histone, a class of proteins complexed to DNA in chromatin and chromosomes.	1	Q9VK34 (/IMP)
Histone deacetylase activity (H3-K14 specific) GO:0031078 Catalysis of the reaction: histone H3 N6-acetyl-L-lysine (position 14) + H2O = histone H3 L-lysine (position 14) + acetate. This reaction represents the removal of an acetyl group from lysine at position 14 of the histone H3 protein.	1	O94640 (/IDA)
Histone deacetylase activity (H3-K9 specific) GO:0032129 Catalysis of the reaction: histone H3 N6-acetyl-L-lysine (position 9) + H2O = histone H3 L-lysine (position 9) + acetate. This reaction represents the removal of an acetyl group from lysine at position 9 of the histone H3 protein.	1	O94640 (/IDA)
Histone deacetylase activity (H4-K16 specific) GO:0034739 Catalysis of the reaction: histone H4 N6-acetyl-L-lysine (position 16) + H2O = histone H4 L-lysine (position 16) + acetate. This reaction represents the removal of an acetyl group from lysine at position 16 of the histone H4 protein.	1	O94640 (/IDA)
Protein kinase B binding GO:0043422 Interacting selectively and non-covalently with protein kinase B, an intracellular kinase that is important in regulating glucose metabolism.	1	A0A0G2JZ79 (/IDA)
NAD-dependent histone deacetylase activity (H4-K16 specific) GO:0046970 Catalysis of the reaction: histone H4 N6-acetyl-L-lysine (position 16) + H2O = histone H4 L-lysine (position 16) + acetate. This reaction requires the presence of NAD, and represents the removal of an acetyl group from lysine at position 16 of the histone H4 protein.	1	O94640 (/IDA)
NAD-dependent histone deacetylase activity (H4-K16 specific) GO:0046970 Catalysis of the reaction: histone H4 N6-acetyl-L-lysine (position 16) + H2O = histone H4 L-lysine (position 16) + acetate. This reaction requires the presence of NAD, and represents the removal of an acetyl group from lysine at position 16 of the histone H4 protein.	1	C8V3W5 (/IMP)
NAD+ binding GO:0070403 Interacting selectively and non-covalently with the oxidized form, NAD, of nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions.	1	O94640 (/IDA)
Histone deacetylase activity (H3-K4 specific) GO:1990162 Catalysis of the reaction: histone H3 N6-acetyl-L-lysine (position 4) + H2O = histone H3 L-lysine (position 4) + acetate. This reaction represents the removal of an acetyl group from lysine at position 4 of the histone H3 protein.	1	O94640 (/IDA)

There are 344 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

GO Term	Annotations	Evidence
Histone deacetylation GO:0016575 The modification of histones by removal of acetyl groups.	6	O94640 (/IDA) Q923E4 (/IDA) Q923E4 (/IDA) Q96EB6 (/IDA) Q96EB6 (/IDA) Q9VK34 (/IDA)
Protein deacetylation GO:0006476 The removal of an acetyl group from a protein amino acid. An acetyl group is CH3CO-, derived from acetic	5	A0A0G2JZ79 (/IDA) Q923E4 (/IDA) Q923E4 (/IDA) Q96EB6 (/IDA) Q96EB6 (/IDA)
Protein deacetylation GO:0006476 The removal of an acetyl group from a protein amino acid. An acetyl group is CH3CO-, derived from acetic	5	Q923E4 (/IMP) Q923E4 (/IMP) Q96EB6 (/IMP) Q96EB6 (/IMP) Q9VK34 (/IMP)
Negative regulation of gene expression GO:0010629 Any process that decreases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.	5	A7LKB1 (/IMP) B3FK65 (/IMP) Q54GV7 (/IMP) Q96EB6 (/IMP) Q96EB6 (/IMP)
Negative regulation of protein acetylation GO:1901984 Any process that stops, prevents or reduces the frequency, rate or extent of protein acetylation.	5	A0A0G2JZ79 (/IMP) A7LKB1 (/IMP) B3FK65 (/IMP) Q96EB6 (/IMP) Q96EB6 (/IMP)
Negative regulation of transcription by RNA polymerase II GO:0000122 Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.	4	Q923E4 (/IDA) Q923E4 (/IDA) Q96EB6 (/IDA) Q96EB6 (/IDA)
Negative regulation of transcription by RNA polymerase II GO:0000122 Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.	4	Q923E4 (/IMP) Q923E4 (/IMP) Q96EB6 (/IMP) Q96EB6 (/IMP)
Pyrimidine dimer repair by nucleotide-excision repair GO:0000720 The repair of UV-induced T-T, C-T, and C-C dimers by the recognition and removal of the damaged DNA strand from the DNA helix as an oligonucleotide. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase.	4	Q923E4 (/IMP) Q923E4 (/IMP) Q96EB6 (/IMP) Q96EB6 (/IMP)
Positive regulation of macroautophagy GO:0016239 Any process, such as recognition of nutrient depletion, that activates or increases the rate of macroautophagy to bring cytosolic macromolecules to the vacuole/lysosome for degradation.	4	Q923E4 (/IDA) Q923E4 (/IDA) Q96EB6 (/IDA) Q96EB6 (/IDA)
Protein destabilization GO:0031648 Any process that decreases the stability of a protein, making it more vulnerable to degradative processes or aggregation.	4	Q923E4 (/IDA) Q923E4 (/IDA) Q96EB6 (/IDA) Q96EB6 (/IDA)
Negative regulation of TOR signaling GO:0032007 Any process that stops, prevents, or reduces the frequency, rate or extent of TOR signaling.	4	Q923E4 (/IMP) Q923E4 (/IMP) Q96EB6 (/IMP) Q96EB6 (/IMP)
Circadian regulation of gene expression GO:0032922 Any process that modulates the frequency, rate or extent of gene expression such that an expression pattern recurs with a regularity of approximately 24 hours.	4	Q923E4 (/IMP) Q923E4 (/IMP) Q96EB6 (/IMP) Q96EB6 (/IMP)
Negative regulation of phosphorylation GO:0042326 Any process that stops, prevents or decreases the rate of addition of phosphate groups to a molecule.	4	Q923E4 (/IMP) Q923E4 (/IMP) Q96EB6 (/IMP) Q96EB6 (/IMP)
Positive regulation of apoptotic process GO:0043065 Any process that activates or increases the frequency, rate or extent of cell death by apoptotic process.	4	Q923E4 (/IMP) Q923E4 (/IMP) Q96EB6 (/IMP) Q96EB6 (/IMP)
Negative regulation of apoptotic process GO:0043066 Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process.	4	A7LKB1 (/IMP) B3FK65 (/IMP) Q96EB6 (/IMP) Q96EB6 (/IMP)
Negative regulation of DNA-binding transcription factor activity GO:0043433 Any process that stops, prevents, or reduces the frequency, rate or extent of the activity of a transcription factor, any factor involved in the initiation or regulation of transcription.	4	Q923E4 (/IMP) Q923E4 (/IMP) Q96EB6 (/IMP) Q96EB6 (/IMP)
Negative regulation of transcription, DNA-templated GO:0045892 Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.	4	Q923E4 (/IDA) Q923E4 (/IDA) Q96EB6 (/IDA) Q96EB6 (/IDA)
Positive regulation of transcription by RNA polymerase II GO:0045944 Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.	4	Q923E4 (/IDA) Q923E4 (/IDA) Q96EB6 (/IDA) Q96EB6 (/IDA)
Negative regulation of protein kinase B signaling GO:0051898 Any process that stops, prevents, or reduces the frequency, rate or extent of protein kinase B signaling, a series of reactions mediated by the intracellular serine/threonine kinase protein kinase B.	4	Q923E4 (/IMP) Q923E4 (/IMP) Q96EB6 (/IMP) Q96EB6 (/IMP)
Negative regulation of cellular senescence GO:2000773 Any process that stops, prevents or reduces the frequency, rate or extent of cellular senescence.	4	A7LKB1 (/IMP) B3FK65 (/IMP) Q96EB6 (/IMP) Q96EB6 (/IMP)
Positive regulation of gene expression GO:0010628 Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.	3	A7LKB1 (/IMP) B3FK65 (/IMP) Q54GV7 (/IMP)
Regulation of apoptotic process GO:0042981 Any process that modulates the occurrence or rate of cell death by apoptotic process.	3	Q96EB6 (/IMP) Q96EB6 (/IMP) Q9VK34 (/IMP)
Positive regulation of angiogenesis GO:0045766 Any process that activates or increases angiogenesis.	3	E7F8W3 (/IMP) Q96EB6 (/IMP) Q96EB6 (/IMP)
Histone H3 deacetylation GO:0070932 The modification of histone H3 by the removal of one or more acetyl groups.	3	A0A0G2JZ79 (/IMP) Q96EB6 (/IMP) Q96EB6 (/IMP)
Single strand break repair GO:0000012 The repair of single strand breaks in DNA. Repair of such breaks is mediated by the same enzyme systems as are used in base excision repair.	2	Q96EB6 (/IMP) Q96EB6 (/IMP)
Single strand break repair GO:0000012 The repair of single strand breaks in DNA. Repair of such breaks is mediated by the same enzyme systems as are used in base excision repair.	2	Q923E4 (/ISO) Q923E4 (/ISO)
Single strand break repair GO:0000012 The repair of single strand breaks in DNA. Repair of such breaks is mediated by the same enzyme systems as are used in base excision repair.	2	Q923E4 (/ISS) Q923E4 (/ISS)
Negative regulation of transcription by RNA polymerase II GO:0000122 Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.	2	Q923E4 (/ISO) Q923E4 (/ISO)
Negative regulation of transcription by RNA polymerase II GO:0000122 Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.	2	Q923E4 (/ISS) Q923E4 (/ISS)
Chromatin silencing at rDNA GO:0000183 Repression of transcription of ribosomal DNA by altering the structure of chromatin.	2	Q96EB6 (/IDA) Q96EB6 (/IDA)
Chromatin silencing at rDNA GO:0000183 Repression of transcription of ribosomal DNA by altering the structure of chromatin.	2	Q923E4 (/ISO) Q923E4 (/ISO)
Chromatin silencing at rDNA GO:0000183 Repression of transcription of ribosomal DNA by altering the structure of chromatin.	2	Q96EB6 (/TAS) Q96EB6 (/TAS)
Pyrimidine dimer repair by nucleotide-excision repair GO:0000720 The repair of UV-induced T-T, C-T, and C-C dimers by the recognition and removal of the damaged DNA strand from the DNA helix as an oligonucleotide. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase.	2	Q923E4 (/ISO) Q923E4 (/ISO)
DNA synthesis involved in DNA repair GO:0000731 Synthesis of DNA that proceeds from the broken 3' single-strand DNA end and uses the homologous intact duplex as the template.	2	Q923E4 (/IMP) Q923E4 (/IMP)
DNA synthesis involved in DNA repair GO:0000731 Synthesis of DNA that proceeds from the broken 3' single-strand DNA end and uses the homologous intact duplex as the template.	2	Q96EB6 (/ISS) Q96EB6 (/ISS)
Angiogenesis GO:0001525 Blood vessel formation when new vessels emerge from the proliferation of pre-existing blood vessels.	2	Q96EB6 (/IDA) Q96EB6 (/IDA)
Angiogenesis GO:0001525 Blood vessel formation when new vessels emerge from the proliferation of pre-existing blood vessels.	2	Q923E4 (/IMP) Q923E4 (/IMP)
Angiogenesis GO:0001525 Blood vessel formation when new vessels emerge from the proliferation of pre-existing blood vessels.	2	Q923E4 (/ISO) Q923E4 (/ISO)
Angiogenesis GO:0001525 Blood vessel formation when new vessels emerge from the proliferation of pre-existing blood vessels.	2	Q923E4 (/ISS) Q923E4 (/ISS)
Ovulation from ovarian follicle GO:0001542 The process leading to the rupture of the follicle, releasing the centrally located oocyte into the oviduct. An example of this is found in Mus musculus.	2	Q923E4 (/IMP) Q923E4 (/IMP)
Cellular glucose homeostasis GO:0001678 A cellular homeostatic process involved in the maintenance of an internal steady state of glucose within a cell or between a cell and its external environment.	2	Q923E4 (/IMP) Q923E4 (/IMP)
Cellular glucose homeostasis GO:0001678 A cellular homeostatic process involved in the maintenance of an internal steady state of glucose within a cell or between a cell and its external environment.	2	Q96EB6 (/ISS) Q96EB6 (/ISS)
Positive regulation of protein phosphorylation GO:0001934 Any process that activates or increases the frequency, rate or extent of addition of phosphate groups to amino acids within a protein.	2	Q923E4 (/IMP) Q923E4 (/IMP)
Positive regulation of protein phosphorylation GO:0001934 Any process that activates or increases the frequency, rate or extent of addition of phosphate groups to amino acids within a protein.	2	Q96EB6 (/ISS) Q96EB6 (/ISS)
Positive regulation of endothelial cell proliferation GO:0001938 Any process that activates or increases the rate or extent of endothelial cell proliferation.	2	Q96EB6 (/IMP) Q96EB6 (/IMP)
Positive regulation of endothelial cell proliferation GO:0001938 Any process that activates or increases the rate or extent of endothelial cell proliferation.	2	Q923E4 (/ISO) Q923E4 (/ISO)
Positive regulation of adaptive immune response GO:0002821 Any process that activates or increases the frequency, rate, or extent of an adaptive immune response.	2	Q96EB6 (/IDA) Q96EB6 (/IDA)
Positive regulation of adaptive immune response GO:0002821 Any process that activates or increases the frequency, rate, or extent of an adaptive immune response.	2	Q923E4 (/ISO) Q923E4 (/ISO)
Positive regulation of adaptive immune response GO:0002821 Any process that activates or increases the frequency, rate, or extent of an adaptive immune response.	2	Q923E4 (/ISS) Q923E4 (/ISS)
Chromatin organization GO:0006325 Any process that results in the specification, formation or maintenance of the physical structure of eukaryotic chromatin.	2	Q96EB6 (/IMP) Q96EB6 (/IMP)
Chromatin organization GO:0006325 Any process that results in the specification, formation or maintenance of the physical structure of eukaryotic chromatin.	2	Q923E4 (/ISO) Q923E4 (/ISO)
Chromatin silencing GO:0006342 Repression of transcription by altering the structure of chromatin, e.g. by conversion of large regions of DNA into an inaccessible state often called heterochromatin.	2	O94640 (/IMP) Q9VK34 (/IMP)
Chromatin silencing GO:0006342 Repression of transcription by altering the structure of chromatin, e.g. by conversion of large regions of DNA into an inaccessible state often called heterochromatin.	2	Q96EB6 (/TAS) Q96EB6 (/TAS)
Establishment of chromatin silencing GO:0006343 The initial formation of a transcriptionally silent chromatin structure such as heterochromatin.	2	Q96EB6 (/IDA) Q96EB6 (/IDA)
Establishment of chromatin silencing GO:0006343 The initial formation of a transcriptionally silent chromatin structure such as heterochromatin.	2	Q923E4 (/ISO) Q923E4 (/ISO)
Maintenance of chromatin silencing GO:0006344 The maintenance of chromatin in a transcriptionally silent state such as heterochromatin.	2	Q96EB6 (/IMP) Q96EB6 (/IMP)
Maintenance of chromatin silencing GO:0006344 The maintenance of chromatin in a transcriptionally silent state such as heterochromatin.	2	Q923E4 (/ISO) Q923E4 (/ISO)
Methylation-dependent chromatin silencing GO:0006346 Repression of transcription by methylation of DNA, leading to the formation of heterochromatin.	2	Q96EB6 (/TAS) Q96EB6 (/TAS)
Protein deacetylation GO:0006476 The removal of an acetyl group from a protein amino acid. An acetyl group is CH3CO-, derived from acetic	2	Q923E4 (/ISO) Q923E4 (/ISO)
Protein deacetylation GO:0006476 The removal of an acetyl group from a protein amino acid. An acetyl group is CH3CO-, derived from acetic	2	Q96EB6 (/TAS) Q96EB6 (/TAS)
Triglyceride mobilization GO:0006642 The release of triglycerides, any triester of glycerol, from storage within cells or tissues, making them available for metabolism.	2	Q923E4 (/IMP) Q923E4 (/IMP)
Triglyceride mobilization GO:0006642 The release of triglycerides, any triester of glycerol, from storage within cells or tissues, making them available for metabolism.	2	Q96EB6 (/ISS) Q96EB6 (/ISS)
Cellular response to DNA damage stimulus GO:0006974 Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism.	2	Q96EB6 (/IDA) Q96EB6 (/IDA)
Cellular response to DNA damage stimulus GO:0006974 Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism.	2	Q923E4 (/ISO) Q923E4 (/ISO)
Response to oxidative stress GO:0006979 Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals.	2	Q96EB6 (/IDA) Q96EB6 (/IDA)
Response to oxidative stress GO:0006979 Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals.	2	Q923E4 (/ISO) Q923E4 (/ISO)
Mitochondrion organization GO:0007005 A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a mitochondrion; includes mitochondrial morphogenesis and distribution, and replication of the mitochondrial genome as well as synthesis of new mitochondrial components.	2	A7LKB1 (/IMP) B3FK65 (/IMP)
Transforming growth factor beta receptor signaling pathway GO:0007179 A series of molecular signals initiated by the binding of an extracellular ligand to a transforming growth factor beta receptor on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription.	2	Q96EB6 (/IDA) Q96EB6 (/IDA)
Transforming growth factor beta receptor signaling pathway GO:0007179 A series of molecular signals initiated by the binding of an extracellular ligand to a transforming growth factor beta receptor on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription.	2	Q923E4 (/ISO) Q923E4 (/ISO)
Spermatogenesis GO:0007283 The process of formation of spermatozoa, including spermatocytogenesis and spermiogenesis.	2	Q923E4 (/IMP) Q923E4 (/IMP)
Regulation of mitotic cell cycle GO:0007346 Any process that modulates the rate or extent of progress through the mitotic cell cycle.	2	Q96EB6 (/IDA) Q96EB6 (/IDA)
Regulation of mitotic cell cycle GO:0007346 Any process that modulates the rate or extent of progress through the mitotic cell cycle.	2	Q923E4 (/ISO) Q923E4 (/ISO)
Regulation of mitotic cell cycle GO:0007346 Any process that modulates the rate or extent of progress through the mitotic cell cycle.	2	Q923E4 (/ISS) Q923E4 (/ISS)
Cell aging GO:0007569 An aging process that has as participant a cell after a cell has stopped dividing. Cell aging may occur when a cell has temporarily stopped dividing through cell cycle arrest (GO:0007050) or when a cell has permanently stopped dividing, in which case it is undergoing cellular senescence (GO:0090398). May precede cell death (GO:0008219) and succeed cell maturation (GO:0048469).	2	Q96EB6 (/TAS) Q96EB6 (/TAS)
Circadian rhythm GO:0007623 Any biological process in an organism that recurs with a regularity of approximately 24 hours.	2	Q923E4 (/IEP) Q923E4 (/IEP)
Positive regulation of cell population proliferation GO:0008284 Any process that activates or increases the rate or extent of cell proliferation.	2	Q96EB6 (/IMP) Q96EB6 (/IMP)
Positive regulation of cell population proliferation GO:0008284 Any process that activates or increases the rate or extent of cell proliferation.	2	Q923E4 (/ISO) Q923E4 (/ISO)
Positive regulation of cell population proliferation GO:0008284 Any process that activates or increases the rate or extent of cell proliferation.	2	Q923E4 (/ISS) Q923E4 (/ISS)
Intrinsic apoptotic signaling pathway in response to DNA damage GO:0008630 A series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway is induced by the detection of DNA damage, and ends when the execution phase of apoptosis is triggered.	2	Q923E4 (/IDA) Q923E4 (/IDA)
Cellular response to starvation GO:0009267 Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of nourishment.	2	Q923E4 (/IMP) Q923E4 (/IMP)
Cellular response to starvation GO:0009267 Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of nourishment.	2	Q96EB6 (/ISS) Q96EB6 (/ISS)
Positive regulation of heart rate GO:0010460 Any process that activates or increases the frequency or rate of heart contraction.	2	Q923E4 (/ISO) Q923E4 (/ISO)
Negative regulation of gene expression GO:0010629 Any process that decreases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.	2	Q923E4 (/ISO) Q923E4 (/ISO)
Negative regulation of cardiac muscle cell apoptotic process GO:0010667 Any process that decreases the rate or extent of cardiac cell apoptotic process, a form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases whose actions dismantle a cardiac muscle cell and result in its death.	2	Q923E4 (/ISO) Q923E4 (/ISO)
Positive regulation of cholesterol efflux GO:0010875 Any process that increases the frequency, rate or extent of cholesterol efflux. Cholesterol efflux is the directed movement of cholesterol, cholest-5-en-3-beta-ol, out of a cell or organelle.	2	Q923E4 (/IMP) Q923E4 (/IMP)
Positive regulation of cholesterol efflux GO:0010875 Any process that increases the frequency, rate or extent of cholesterol efflux. Cholesterol efflux is the directed movement of cholesterol, cholest-5-en-3-beta-ol, out of a cell or organelle.	2	Q96EB6 (/ISS) Q96EB6 (/ISS)
Regulation of lipid storage GO:0010883 Any process that modulates the rate, frequency or extent of lipid storage. Lipid storage is the accumulation and maintenance in cells or tissues of lipids, compounds soluble in organic solvents but insoluble or sparingly soluble in aqueous solvents. Lipid reserves can be accumulated during early developmental stages for mobilization and utilization at later stages of development.	2	Q923E4 (/IMP) Q923E4 (/IMP)
Regulation of lipid storage GO:0010883 Any process that modulates the rate, frequency or extent of lipid storage. Lipid storage is the accumulation and maintenance in cells or tissues of lipids, compounds soluble in organic solvents but insoluble or sparingly soluble in aqueous solvents. Lipid reserves can be accumulated during early developmental stages for mobilization and utilization at later stages of development.	2	Q96EB6 (/ISS) Q96EB6 (/ISS)
Positive regulation of triglyceride catabolic process GO:0010898 Any process that increases the frequency, rate, or extent of the chemical reactions and pathways resulting in the breakdown of triglyceride.	2	A7LKB1 (/IMP) B3FK65 (/IMP)
Regulation of glucose metabolic process GO:0010906 Any process that modulates the rate, frequency or extent of glucose metabolism. Glucose metabolic processes are the chemical reactions and pathways involving glucose, the aldohexose gluco-hexose.	2	Q923E4 (/IMP) Q923E4 (/IMP)
Regulation of glucose metabolic process GO:0010906 Any process that modulates the rate, frequency or extent of glucose metabolism. Glucose metabolic processes are the chemical reactions and pathways involving glucose, the aldohexose gluco-hexose.	2	Q96EB6 (/ISS) Q96EB6 (/ISS)
Positive regulation of mitochondrial membrane potential GO:0010918 Any process that activates or increases the frequency, rate or extent of establishment or extent of a mitochondrial membrane potential, the electric potential existing across any mitochondrial membrane arising from charges in the membrane itself and from the charges present in the media on either side of the membrane.	2	A7LKB1 (/IMP) B3FK65 (/IMP)
Macrophage cytokine production GO:0010934 The appearance of a macrophage cytokine due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.	2	Q923E4 (/IMP) Q923E4 (/IMP)
Macrophage cytokine production GO:0010934 The appearance of a macrophage cytokine due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.	2	Q96EB6 (/ISS) Q96EB6 (/ISS)
Positive regulation of neuron projection development GO:0010976 Any process that increases the rate, frequency or extent of neuron projection development. Neuron projection development is the process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites).	2	Q923E4 (/ISO) Q923E4 (/ISO)
Positive regulation of phosphatidylinositol 3-kinase signaling GO:0014068 Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the phosphatidylinositol 3-kinase cascade.	2	Q923E4 (/IMP) Q923E4 (/IMP)
Positive regulation of phosphatidylinositol 3-kinase signaling GO:0014068 Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the phosphatidylinositol 3-kinase cascade.	2	Q96EB6 (/ISS) Q96EB6 (/ISS)
Positive regulation of skeletal muscle cell proliferation GO:0014858 Any process that activates or increases the frequency, rate or extent of skeletal muscle cell proliferation.	2	Q923E4 (/ISO) Q923E4 (/ISO)
Positive regulation of macroautophagy GO:0016239 Any process, such as recognition of nutrient depletion, that activates or increases the rate of macroautophagy to bring cytosolic macromolecules to the vacuole/lysosome for degradation.	2	Q923E4 (/ISO) Q923E4 (/ISO)
Protein ubiquitination GO:0016567 The process in which one or more ubiquitin groups are added to a protein.	2	Q96EB6 (/IDA) Q96EB6 (/IDA)
Protein ubiquitination GO:0016567 The process in which one or more ubiquitin groups are added to a protein.	2	Q96EB6 (/IMP) Q96EB6 (/IMP)
Protein ubiquitination GO:0016567 The process in which one or more ubiquitin groups are added to a protein.	2	Q923E4 (/ISO) Q923E4 (/ISO)
Protein ubiquitination GO:0016567 The process in which one or more ubiquitin groups are added to a protein.	2	Q923E4 (/ISS) Q923E4 (/ISS)
Histone deacetylation GO:0016575 The modification of histones by removal of acetyl groups.	2	Q923E4 (/IGI) Q923E4 (/IGI)
Histone deacetylation GO:0016575 The modification of histones by removal of acetyl groups.	2	Q923E4 (/ISO) Q923E4 (/ISO)
Histone deacetylation GO:0016575 The modification of histones by removal of acetyl groups.	2	Q923E4 (/ISS) Q923E4 (/ISS)
Peptidyl-lysine acetylation GO:0018394 The acetylation of peptidyl-lysine.	2	Q96EB6 (/IMP) Q96EB6 (/IMP)
Peptidyl-lysine acetylation GO:0018394 The acetylation of peptidyl-lysine.	2	Q923E4 (/ISO) Q923E4 (/ISO)
Macrophage differentiation GO:0030225 The process in which a relatively unspecialized monocyte acquires the specialized features of a macrophage.	2	Q923E4 (/IMP) Q923E4 (/IMP)
Macrophage differentiation GO:0030225 The process in which a relatively unspecialized monocyte acquires the specialized features of a macrophage.	2	Q96EB6 (/ISS) Q96EB6 (/ISS)
Negative regulation of cell growth GO:0030308 Any process that stops, prevents, or reduces the frequency, rate, extent or direction of cell growth.	2	Q96EB6 (/IMP) Q96EB6 (/IMP)
Negative regulation of cell growth GO:0030308 Any process that stops, prevents, or reduces the frequency, rate, extent or direction of cell growth.	2	Q923E4 (/ISO) Q923E4 (/ISO)
Negative regulation of transforming growth factor beta receptor signaling pathway GO:0030512 Any process that stops, prevents, or reduces the frequency, rate or extent of any TGF-beta receptor signaling pathway.	2	Q923E4 (/IDA) Q923E4 (/IDA)
Negative regulation of transforming growth factor beta receptor signaling pathway GO:0030512 Any process that stops, prevents, or reduces the frequency, rate or extent of any TGF-beta receptor signaling pathway.	2	Q96EB6 (/ISS) Q96EB6 (/ISS)
Negative regulation of prostaglandin biosynthetic process GO:0031393 Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of prostaglandin.	2	Q923E4 (/IMP) Q923E4 (/IMP)
Negative regulation of prostaglandin biosynthetic process GO:0031393 Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of prostaglandin.	2	Q96EB6 (/ISS) Q96EB6 (/ISS)
Protein destabilization GO:0031648 Any process that decreases the stability of a protein, making it more vulnerable to degradative processes or aggregation.	2	Q923E4 (/ISO) Q923E4 (/ISO)
Protein destabilization GO:0031648 Any process that decreases the stability of a protein, making it more vulnerable to degradative processes or aggregation.	2	Q96EB6 (/ISS) Q96EB6 (/ISS)
Positive regulation of chromatin silencing GO:0031937 Any process that activates or increases the frequency, rate or extent of chromatin silencing.	2	Q96EB6 (/IMP) Q96EB6 (/IMP)
Positive regulation of chromatin silencing GO:0031937 Any process that activates or increases the frequency, rate or extent of chromatin silencing.	2	Q923E4 (/ISO) Q923E4 (/ISO)
Negative regulation of TOR signaling GO:0032007 Any process that stops, prevents, or reduces the frequency, rate or extent of TOR signaling.	2	Q923E4 (/ISO) Q923E4 (/ISO)
Regulation of endodeoxyribonuclease activity GO:0032071 Any process that modulates the frequency, rate or extent of endodeoxyribonuclease activity, the hydrolysis of ester linkages within deoxyribonucleic acid by creating internal breaks.	2	Q96EB6 (/IMP) Q96EB6 (/IMP)
Regulation of endodeoxyribonuclease activity GO:0032071 Any process that modulates the frequency, rate or extent of endodeoxyribonuclease activity, the hydrolysis of ester linkages within deoxyribonucleic acid by creating internal breaks.	2	Q923E4 (/ISO) Q923E4 (/ISO)
Regulation of endodeoxyribonuclease activity GO:0032071 Any process that modulates the frequency, rate or extent of endodeoxyribonuclease activity, the hydrolysis of ester linkages within deoxyribonucleic acid by creating internal breaks.	2	Q923E4 (/ISS) Q923E4 (/ISS)
Negative regulation of NF-kappaB transcription factor activity GO:0032088 Any process that stops, prevents, or reduces the frequency, rate or extent of the activity of the transcription factor NF-kappaB.	2	Q96EB6 (/IDA) Q96EB6 (/IDA)
Negative regulation of NF-kappaB transcription factor activity GO:0032088 Any process that stops, prevents, or reduces the frequency, rate or extent of the activity of the transcription factor NF-kappaB.	2	Q923E4 (/ISO) Q923E4 (/ISO)
Negative regulation of NF-kappaB transcription factor activity GO:0032088 Any process that stops, prevents, or reduces the frequency, rate or extent of the activity of the transcription factor NF-kappaB.	2	Q923E4 (/ISS) Q923E4 (/ISS)
Negative regulation of tumor necrosis factor production GO:0032720 Any process that stops, prevents, or reduces the frequency, rate, or extent of tumor necrosis factor production.	2	Q923E4 (/ISO) Q923E4 (/ISO)
Response to insulin GO:0032868 Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an insulin stimulus. Insulin is a polypeptide hormone produced by the islets of Langerhans of the pancreas in mammals, and by the homologous organs of other organisms.	2	Q923E4 (/IDA) Q923E4 (/IDA)
Response to insulin GO:0032868 Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an insulin stimulus. Insulin is a polypeptide hormone produced by the islets of Langerhans of the pancreas in mammals, and by the homologous organs of other organisms.	2	Q96EB6 (/ISS) Q96EB6 (/ISS)
Circadian regulation of gene expression GO:0032922 Any process that modulates the frequency, rate or extent of gene expression such that an expression pattern recurs with a regularity of approximately 24 hours.	2	Q923E4 (/ISO) Q923E4 (/ISO)
Circadian regulation of gene expression GO:0032922 Any process that modulates the frequency, rate or extent of gene expression such that an expression pattern recurs with a regularity of approximately 24 hours.	2	Q96EB6 (/ISS) Q96EB6 (/ISS)
Leptin-mediated signaling pathway GO:0033210 A series of molecular signals initiated by the binding of leptin to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription. Leptin is a hormone manufactured primarily in the adipocytes of white adipose tissue, and the level of circulating leptin is directly proportional to the total amount of fat in the body.	2	Q923E4 (/IMP) Q923E4 (/IMP)
Leptin-mediated signaling pathway GO:0033210 A series of molecular signals initiated by the binding of leptin to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription. Leptin is a hormone manufactured primarily in the adipocytes of white adipose tissue, and the level of circulating leptin is directly proportional to the total amount of fat in the body.	2	Q96EB6 (/ISS) Q96EB6 (/ISS)
Regulation of smooth muscle cell apoptotic process GO:0034391 Any process that modulates the frequency, rate, or extent of smooth muscle cell apoptotic process.	2	Q923E4 (/IDA) Q923E4 (/IDA)
Regulation of smooth muscle cell apoptotic process GO:0034391 Any process that modulates the frequency, rate, or extent of smooth muscle cell apoptotic process.	2	Q96EB6 (/ISS) Q96EB6 (/ISS)
Peptidyl-lysine deacetylation GO:0034983 The removal of an acetyl group from an acetylated lysine residue in a peptide or protein.	2	Q96EB6 (/IDA) Q96EB6 (/IDA)
Peptidyl-lysine deacetylation GO:0034983 The removal of an acetyl group from an acetylated lysine residue in a peptide or protein.	2	Q923E4 (/ISO) Q923E4 (/ISO)
Cellular triglyceride homeostasis GO:0035356 Any process involved in the maintenance of an internal steady state of triglyceride within a cell or between a cell and its external environment.	2	Q923E4 (/IMP) Q923E4 (/IMP)
Cellular triglyceride homeostasis GO:0035356 Any process involved in the maintenance of an internal steady state of triglyceride within a cell or between a cell and its external environment.	2	Q96EB6 (/ISS) Q96EB6 (/ISS)
Regulation of peroxisome proliferator activated receptor signaling pathway GO:0035358 Any process that modulates the frequency, rate or extent of the peroxisome proliferator activated receptor signaling pathway.	2	Q923E4 (/IMP) Q923E4 (/IMP)
Regulation of peroxisome proliferator activated receptor signaling pathway GO:0035358 Any process that modulates the frequency, rate or extent of the peroxisome proliferator activated receptor signaling pathway.	2	Q96EB6 (/ISS) Q96EB6 (/ISS)
Positive regulation of insulin secretion involved in cellular response to glucose stimulus GO:0035774 Any process that increases the frequency, rate or extent of the regulated release of insulin that contributes to the response of a cell to glucose.	2	Q923E4 (/ISO) Q923E4 (/ISO)
Regulation of cell population proliferation GO:0042127 Any process that modulates the frequency, rate or extent of cell proliferation.	2	Q96EB6 (/IMP) Q96EB6 (/IMP)
Regulation of cell population proliferation GO:0042127 Any process that modulates the frequency, rate or extent of cell proliferation.	2	Q923E4 (/ISO) Q923E4 (/ISO)
Negative regulation of phosphorylation GO:0042326 Any process that stops, prevents or decreases the rate of addition of phosphate groups to a molecule.	2	Q923E4 (/ISO) Q923E4 (/ISO)
Response to hydrogen peroxide GO:0042542 Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hydrogen peroxide (H2O2) stimulus.	2	Q96EB6 (/IDA) Q96EB6 (/IDA)
Response to hydrogen peroxide GO:0042542 Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hydrogen peroxide (H2O2) stimulus.	2	Q923E4 (/ISO) Q923E4 (/ISO)
Response to hydrogen peroxide GO:0042542 Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hydrogen peroxide (H2O2) stimulus.	2	Q923E4 (/ISS) Q923E4 (/ISS)
Behavioral response to starvation GO:0042595 Any process that results in a change in the behavior of an organism as a result of deprivation of nourishment.	2	Q923E4 (/IMP) Q923E4 (/IMP)
Cholesterol homeostasis GO:0042632 Any process involved in the maintenance of an internal steady state of cholesterol within an organism or cell.	2	Q923E4 (/IMP) Q923E4 (/IMP)
Cholesterol homeostasis GO:0042632 Any process involved in the maintenance of an internal steady state of cholesterol within an organism or cell.	2	Q96EB6 (/ISS) Q96EB6 (/ISS)
Intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator GO:0042771 A series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway is induced by the cell cycle regulator phosphoprotein p53, or an equivalent protein, in response to the detection of DNA damage, and ends when the execution phase of apoptosis is triggered.	2	Q96EB6 (/IMP) Q96EB6 (/IMP)
Intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator GO:0042771 A series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway is induced by the cell cycle regulator phosphoprotein p53, or an equivalent protein, in response to the detection of DNA damage, and ends when the execution phase of apoptosis is triggered.	2	Q923E4 (/ISO) Q923E4 (/ISO)
Intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator GO:0042771 A series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway is induced by the cell cycle regulator phosphoprotein p53, or an equivalent protein, in response to the detection of DNA damage, and ends when the execution phase of apoptosis is triggered.	2	Q923E4 (/ISS) Q923E4 (/ISS)
Regulation of apoptotic process GO:0042981 Any process that modulates the occurrence or rate of cell death by apoptotic process.	2	Q923E4 (/ISO) Q923E4 (/ISO)
Regulation of apoptotic process GO:0042981 Any process that modulates the occurrence or rate of cell death by apoptotic process.	2	Q923E4 (/ISS) Q923E4 (/ISS)
Positive regulation of apoptotic process GO:0043065 Any process that activates or increases the frequency, rate or extent of cell death by apoptotic process.	2	Q96EB6 (/IDA) Q96EB6 (/IDA)
Positive regulation of apoptotic process GO:0043065 Any process that activates or increases the frequency, rate or extent of cell death by apoptotic process.	2	Q923E4 (/ISO) Q923E4 (/ISO)
Positive regulation of apoptotic process GO:0043065 Any process that activates or increases the frequency, rate or extent of cell death by apoptotic process.	2	Q923E4 (/ISS) Q923E4 (/ISS)
Negative regulation of apoptotic process GO:0043066 Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process.	2	Q923E4 (/ISO) Q923E4 (/ISO)
Negative regulation of apoptotic process GO:0043066 Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process.	2	Q923E4 (/ISS) Q923E4 (/ISS)
Negative regulation of I-kappaB kinase/NF-kappaB signaling GO:0043124 Any process that stops, prevents, or reduces the frequency, rate or extent of -kappaB kinase/NF-kappaB signaling.	2	Q96EB6 (/IDA) Q96EB6 (/IDA)
Negative regulation of I-kappaB kinase/NF-kappaB signaling GO:0043124 Any process that stops, prevents, or reduces the frequency, rate or extent of -kappaB kinase/NF-kappaB signaling.	2	Q923E4 (/ISO) Q923E4 (/ISO)
Negative regulation of I-kappaB kinase/NF-kappaB signaling GO:0043124 Any process that stops, prevents, or reduces the frequency, rate or extent of -kappaB kinase/NF-kappaB signaling.	2	Q923E4 (/ISS) Q923E4 (/ISS)
Proteasome-mediated ubiquitin-dependent protein catabolic process GO:0043161 The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome.	2	Q96EB6 (/IMP) Q96EB6 (/IMP)
Proteasome-mediated ubiquitin-dependent protein catabolic process GO:0043161 The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome.	2	Q923E4 (/ISO) Q923E4 (/ISO)
Proteasome-mediated ubiquitin-dependent protein catabolic process GO:0043161 The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome.	2	Q923E4 (/ISS) Q923E4 (/ISS)
Positive regulation of cysteine-type endopeptidase activity involved in apoptotic process GO:0043280 Any process that activates or increases the activity of a cysteine-type endopeptidase involved in the apoptotic process.	2	Q96EB6 (/IMP) Q96EB6 (/IMP)
Positive regulation of cysteine-type endopeptidase activity involved in apoptotic process GO:0043280 Any process that activates or increases the activity of a cysteine-type endopeptidase involved in the apoptotic process.	2	Q923E4 (/ISO) Q923E4 (/ISO)
Negative regulation of DNA binding GO:0043392 Any process that stops or reduces the frequency, rate or extent of DNA binding. DNA binding is any process in which a gene product interacts selectively with DNA (deoxyribonucleic acid).	2	Q923E4 (/ISO) Q923E4 (/ISO)
Negative regulation of DNA-binding transcription factor activity GO:0043433 Any process that stops, prevents, or reduces the frequency, rate or extent of the activity of a transcription factor, any factor involved in the initiation or regulation of transcription.	2	Q96EB6 (/IDA) Q96EB6 (/IDA)
Negative regulation of DNA-binding transcription factor activity GO:0043433 Any process that stops, prevents, or reduces the frequency, rate or extent of the activity of a transcription factor, any factor involved in the initiation or regulation of transcription.	2	Q923E4 (/ISO) Q923E4 (/ISO)
Negative regulation of DNA damage response, signal transduction by p53 class mediator GO:0043518 Any process that stops, prevents, or reduces the frequency, rate or extent of the cascade of processes induced by the cell cycle regulator phosphoprotein p53, or an equivalent protein, in response to the detection of DNA damage.	2	Q96EB6 (/IDA) Q96EB6 (/IDA)
Negative regulation of DNA damage response, signal transduction by p53 class mediator GO:0043518 Any process that stops, prevents, or reduces the frequency, rate or extent of the cascade of processes induced by the cell cycle regulator phosphoprotein p53, or an equivalent protein, in response to the detection of DNA damage.	2	Q923E4 (/ISO) Q923E4 (/ISO)
Negative regulation of neuron apoptotic process GO:0043524 Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process in neurons.	2	Q923E4 (/ISO) Q923E4 (/ISO)
Positive regulation of blood vessel endothelial cell migration GO:0043536 Any process that activates or increases the frequency, rate or extent of the migration of the endothelial cells of blood vessels.	2	Q96EB6 (/IDA) Q96EB6 (/IDA)
Positive regulation of blood vessel endothelial cell migration GO:0043536 Any process that activates or increases the frequency, rate or extent of the migration of the endothelial cells of blood vessels.	2	Q923E4 (/ISO) Q923E4 (/ISO)
Response to leptin GO:0044321 Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a leptin stimulus. Leptin is a hormone manufactured primarily in the adipocytes of white adipose tissue, and the level of circulating leptin is directly proportional to the total amount of fat in the body. It plays a key role in regulating energy intake and energy expenditure, including appetite and metabolism].	2	Q923E4 (/IMP) Q923E4 (/IMP)
Response to leptin GO:0044321 Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a leptin stimulus. Leptin is a hormone manufactured primarily in the adipocytes of white adipose tissue, and the level of circulating leptin is directly proportional to the total amount of fat in the body. It plays a key role in regulating energy intake and energy expenditure, including appetite and metabolism].	2	Q96EB6 (/ISS) Q96EB6 (/ISS)
Positive regulation of MHC class II biosynthetic process GO:0045348 Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of MHC class II.	2	Q96EB6 (/IDA) Q96EB6 (/IDA)
Positive regulation of MHC class II biosynthetic process GO:0045348 Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of MHC class II.	2	Q923E4 (/ISO) Q923E4 (/ISO)
Response to ethanol GO:0045471 Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ethanol stimulus.	2	Q923E4 (/ISO) Q923E4 (/ISO)
Negative regulation of fat cell differentiation GO:0045599 Any process that stops, prevents, or reduces the frequency, rate or extent of adipocyte differentiation.	2	Q923E4 (/IMP) Q923E4 (/IMP)
Negative regulation of fat cell differentiation GO:0045599 Any process that stops, prevents, or reduces the frequency, rate or extent of adipocyte differentiation.	2	Q96EB6 (/ISS) Q96EB6 (/ISS)
Positive regulation of gluconeogenesis GO:0045722 Any process that activates or increases the frequency, rate or extent of gluconeogenesis.	2	Q96EB6 (/IDA) Q96EB6 (/IDA)
Positive regulation of gluconeogenesis GO:0045722 Any process that activates or increases the frequency, rate or extent of gluconeogenesis.	2	Q923E4 (/ISO) Q923E4 (/ISO)
Positive regulation of DNA repair GO:0045739 Any process that activates or increases the frequency, rate or extent of DNA repair.	2	Q96EB6 (/IMP) Q96EB6 (/IMP)
Positive regulation of DNA repair GO:0045739 Any process that activates or increases the frequency, rate or extent of DNA repair.	2	Q923E4 (/ISO) Q923E4 (/ISO)
Positive regulation of DNA repair GO:0045739 Any process that activates or increases the frequency, rate or extent of DNA repair.	2	Q923E4 (/ISS) Q923E4 (/ISS)
Positive regulation of angiogenesis GO:0045766 Any process that activates or increases angiogenesis.	2	Q96EB6 (/IDA) Q96EB6 (/IDA)
Positive regulation of angiogenesis GO:0045766 Any process that activates or increases angiogenesis.	2	Q923E4 (/ISO) Q923E4 (/ISO)
Negative regulation of transcription, DNA-templated GO:0045892 Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.	2	Q923E4 (/ISO) Q923E4 (/ISO)
Positive regulation of transcription by RNA polymerase II GO:0045944 Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.	2	Q923E4 (/ISO) Q923E4 (/ISO)
Positive regulation of transcription by RNA polymerase II GO:0045944 Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.	2	Q923E4 (/ISS) Q923E4 (/ISS)
Positive regulation of insulin receptor signaling pathway GO:0046628 Any process that increases the frequency, rate or extent of insulin receptor signaling.	2	Q96EB6 (/IDA) Q96EB6 (/IDA)
Positive regulation of insulin receptor signaling pathway GO:0046628 Any process that increases the frequency, rate or extent of insulin receptor signaling.	2	Q923E4 (/ISO) Q923E4 (/ISO)
Positive regulation of insulin receptor signaling pathway GO:0046628 Any process that increases the frequency, rate or extent of insulin receptor signaling.	2	Q923E4 (/ISS) Q923E4 (/ISS)
White fat cell differentiation GO:0050872 The process in which a relatively unspecialized cell acquires specialized features of a white adipocyte, an animal connective tissue cell involved in energy storage. White adipocytes have cytoplasmic lipids arranged in a unique vacuole.	2	Q923E4 (/IMP) Q923E4 (/IMP)
White fat cell differentiation GO:0050872 The process in which a relatively unspecialized cell acquires specialized features of a white adipocyte, an animal connective tissue cell involved in energy storage. White adipocytes have cytoplasmic lipids arranged in a unique vacuole.	2	Q96EB6 (/ISS) Q96EB6 (/ISS)
Negative regulation of helicase activity GO:0051097 Any process that stops or reduces the activity of a helicase.	2	Q96EB6 (/IDA) Q96EB6 (/IDA)
Negative regulation of helicase activity GO:0051097 Any process that stops or reduces the activity of a helicase.	2	Q923E4 (/ISO) Q923E4 (/ISO)
Positive regulation of smooth muscle cell differentiation GO:0051152 Any process that activates or increases the frequency, rate or extent of smooth muscle cell differentiation.	2	Q923E4 (/IMP) Q923E4 (/IMP)
Positive regulation of histone H3-K9 methylation GO:0051574 Any process that activates or increases the frequency, rate or extent of the covalent addition of a methyl group to the lysine at position 9 of histone H3.	2	Q96EB6 (/IMP) Q96EB6 (/IMP)
Positive regulation of histone H3-K9 methylation GO:0051574 Any process that activates or increases the frequency, rate or extent of the covalent addition of a methyl group to the lysine at position 9 of histone H3.	2	Q923E4 (/ISO) Q923E4 (/ISO)
Negative regulation of protein kinase B signaling GO:0051898 Any process that stops, prevents, or reduces the frequency, rate or extent of protein kinase B signaling, a series of reactions mediated by the intracellular serine/threonine kinase protein kinase B.	2	Q923E4 (/ISO) Q923E4 (/ISO)
Fatty acid homeostasis GO:0055089 Any process involved in the maintenance of an internal steady state of fatty acid within an organism or cell.	2	Q923E4 (/IMP) Q923E4 (/IMP)
Fatty acid homeostasis GO:0055089 Any process involved in the maintenance of an internal steady state of fatty acid within an organism or cell.	2	Q96EB6 (/ISS) Q96EB6 (/ISS)
Negative regulation of growth hormone secretion GO:0060125 Any process that decreases or stops the frequency, rate or extent of the regulated release of growth hormone from a cell.	2	Q923E4 (/ISO) Q923E4 (/ISO)
Negative regulation of cell death GO:0060548 Any process that decreases the rate or frequency of cell death. Cell death is the specific activation or halting of processes within a cell so that its vital functions markedly cease, rather than simply deteriorating gradually over time, which culminates in cell death.	2	Q923E4 (/ISO) Q923E4 (/ISO)
Negative regulation of androgen receptor signaling pathway GO:0060766 Any process that decreases the rate, frequency, or extent of the androgen receptor signaling pathway.	2	Q96EB6 (/IMP) Q96EB6 (/IMP)
Negative regulation of androgen receptor signaling pathway GO:0060766 Any process that decreases the rate, frequency, or extent of the androgen receptor signaling pathway.	2	Q923E4 (/ISO) Q923E4 (/ISO)
Positive regulation of cell growth involved in cardiac muscle cell development GO:0061051 Any process that increases the rate, frequency, or extent of the growth of a cardiac muscle cell, where growth contributes to the progression of the cell over time from its initial formation to its mature state.	2	Q923E4 (/ISO) Q923E4 (/ISO)
Cellular response to hydrogen peroxide GO:0070301 Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hydrogen peroxide (H2O2) stimulus.	2	Q96EB6 (/IDA) Q96EB6 (/IDA)
Cellular response to hydrogen peroxide GO:0070301 Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hydrogen peroxide (H2O2) stimulus.	2	Q923E4 (/ISO) Q923E4 (/ISO)
Regulation of bile acid biosynthetic process GO:0070857 Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of bile acids.	2	Q923E4 (/IMP) Q923E4 (/IMP)
Regulation of bile acid biosynthetic process GO:0070857 Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of bile acids.	2	Q96EB6 (/ISS) Q96EB6 (/ISS)
UV-damage excision repair GO:0070914 A DNA repair process that is initiated by an endonuclease that introduces a single-strand incision immediately 5' of a UV-induced damage site. UV-damage excision repair acts on both cyclobutane pyrimidine dimers (CPDs) and pyrimidine-pyrimidone 6-4 photoproducts (6-4PPs).	2	Q96EB6 (/IMP) Q96EB6 (/IMP)
UV-damage excision repair GO:0070914 A DNA repair process that is initiated by an endonuclease that introduces a single-strand incision immediately 5' of a UV-induced damage site. UV-damage excision repair acts on both cyclobutane pyrimidine dimers (CPDs) and pyrimidine-pyrimidone 6-4 photoproducts (6-4PPs).	2	Q923E4 (/ISO) Q923E4 (/ISO)
Histone H3 deacetylation GO:0070932 The modification of histone H3 by the removal of one or more acetyl groups.	2	Q96EB6 (/IDA) Q96EB6 (/IDA)
Histone H3 deacetylation GO:0070932 The modification of histone H3 by the removal of one or more acetyl groups.	2	Q923E4 (/ISO) Q923E4 (/ISO)
Cellular response to tumor necrosis factor GO:0071356 Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a tumor necrosis factor stimulus.	2	Q96EB6 (/IDA) Q96EB6 (/IDA)
Cellular response to tumor necrosis factor GO:0071356 Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a tumor necrosis factor stimulus.	2	Q923E4 (/ISO) Q923E4 (/ISO)
Cellular response to tumor necrosis factor GO:0071356 Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a tumor necrosis factor stimulus.	2	Q923E4 (/ISS) Q923E4 (/ISS)
Negative regulation of histone H3-K14 acetylation GO:0071441 Any process that stops, prevents, or reduces the frequency, rate or extent of the addition of an acetyl group to histone H3 at position 14 of the histone.	2	Q96EB6 (/IMP) Q96EB6 (/IMP)
Negative regulation of histone H3-K14 acetylation GO:0071441 Any process that stops, prevents, or reduces the frequency, rate or extent of the addition of an acetyl group to histone H3 at position 14 of the histone.	2	Q923E4 (/ISO) Q923E4 (/ISO)
Cellular response to hypoxia GO:0071456 Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level.	2	Q96EB6 (/IMP) Q96EB6 (/IMP)
Cellular response to hypoxia GO:0071456 Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level.	2	Q923E4 (/ISO) Q923E4 (/ISO)
Cellular response to hypoxia GO:0071456 Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level.	2	Q923E4 (/ISS) Q923E4 (/ISS)
Cellular response to ionizing radiation GO:0071479 Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a ionizing radiation stimulus. Ionizing radiation is radiation with sufficient energy to remove electrons from atoms and may arise from spontaneous decay of unstable isotopes, resulting in alpha and beta particles and gamma rays. Ionizing radiation also includes X-rays.	2	Q923E4 (/IMP) Q923E4 (/IMP)
Cellular response to ionizing radiation GO:0071479 Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a ionizing radiation stimulus. Ionizing radiation is radiation with sufficient energy to remove electrons from atoms and may arise from spontaneous decay of unstable isotopes, resulting in alpha and beta particles and gamma rays. Ionizing radiation also includes X-rays.	2	Q96EB6 (/ISS) Q96EB6 (/ISS)
Regulation of protein serine/threonine kinase activity GO:0071900 Any process that modulates the rate, frequency, or extent of protein serine/threonine kinase activity.	2	Q96EB6 (/IMP) Q96EB6 (/IMP)
Regulation of protein serine/threonine kinase activity GO:0071900 Any process that modulates the rate, frequency, or extent of protein serine/threonine kinase activity.	2	Q923E4 (/ISO) Q923E4 (/ISO)
Positive regulation of protein deacetylation GO:0090312 Any process that increases the rate, frequency, or extent of protein deacetylation, the removal of an acetyl group from a protein amino acid. An acetyl group is CH3CO-, derived from acetic	2	Q923E4 (/ISO) Q923E4 (/ISO)
Regulation of brown fat cell differentiation GO:0090335 Any process that modulates the rate, frequency, or extent of brown fat cell differentiation. Brown fat cell differentiation is the process in which a relatively unspecialized cell acquires specialized features of a brown adipocyte, an animal connective tissue cell involved in adaptive thermogenesis. Brown adipocytes contain multiple small droplets of triglycerides and a high number of mitochondria.	2	Q923E4 (/IMP) Q923E4 (/IMP)
Regulation of brown fat cell differentiation GO:0090335 Any process that modulates the rate, frequency, or extent of brown fat cell differentiation. Brown fat cell differentiation is the process in which a relatively unspecialized cell acquires specialized features of a brown adipocyte, an animal connective tissue cell involved in adaptive thermogenesis. Brown adipocytes contain multiple small droplets of triglycerides and a high number of mitochondria.	2	Q96EB6 (/ISS) Q96EB6 (/ISS)
Stress-induced premature senescence GO:0090400 A cellular senescence process associated with the dismantling of a cell as a response to environmental factors such as hydrogen peroxide or X-rays.	2	Q96EB6 (/IMP) Q96EB6 (/IMP)
Stress-induced premature senescence GO:0090400 A cellular senescence process associated with the dismantling of a cell as a response to environmental factors such as hydrogen peroxide or X-rays.	2	Q923E4 (/ISO) Q923E4 (/ISO)
Energy homeostasis GO:0097009 Any process involved in the balance between food intake (energy input) and energy expenditure.	2	Q923E4 (/ISO) Q923E4 (/ISO)
Intrinsic apoptotic signaling pathway GO:0097193 A series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway starts with reception of an intracellular signal (e.g. DNA damage, endoplasmic reticulum stress, oxidative stress etc.), and ends when the execution phase of apoptosis is triggered. The intrinsic apoptotic signaling pathway is crucially regulated by permeabilization of the mitochondrial outer membrane (MOMP).	2	A7LKB1 (/IMP) B3FK65 (/IMP)
Positive regulation of blood vessel diameter GO:0097755 Any process that increases the diameter of blood vessels.	2	Q923E4 (/ISO) Q923E4 (/ISO)
Regulation of cellular response to heat GO:1900034 Any process that modulates the frequency, rate or extent of cellular response to heat.	2	Q96EB6 (/TAS) Q96EB6 (/TAS)
Negative regulation of histone H3-K9 trimethylation GO:1900113 Any process that stops, prevents or reduces the frequency, rate or extent of histone H3-K9 trimethylation.	2	Q923E4 (/IDA) Q923E4 (/IDA)
Negative regulation of protein localization to nucleus GO:1900181 Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to nucleus.	2	Q923E4 (/ISO) Q923E4 (/ISO)
Negative regulation of neuron death GO:1901215 Any process that stops, prevents or reduces the frequency, rate or extent of neuron death.	2	Q923E4 (/IGI) Q923E4 (/IGI)
Negative regulation of protein acetylation GO:1901984 Any process that stops, prevents or reduces the frequency, rate or extent of protein acetylation.	2	Q923E4 (/ISO) Q923E4 (/ISO)
Negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator GO:1902166 Any process that stops, prevents or reduces the frequency, rate or extent of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator.	2	Q923E4 (/IMP) Q923E4 (/IMP)
Negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator GO:1902166 Any process that stops, prevents or reduces the frequency, rate or extent of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator.	2	Q96EB6 (/ISS) Q96EB6 (/ISS)
Negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway GO:1902176 Any process that stops, prevents or reduces the frequency, rate or extent of an oxidative stress-induced intrinsic apoptotic signaling pathway.	2	Q96EB6 (/IMP) Q96EB6 (/IMP)
Negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway GO:1902176 Any process that stops, prevents or reduces the frequency, rate or extent of an oxidative stress-induced intrinsic apoptotic signaling pathway.	2	Q923E4 (/ISO) Q923E4 (/ISO)
Positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway GO:1902237 Any process that activates or increases the frequency, rate or extent of an endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway.	2	Q923E4 (/IMP) Q923E4 (/IMP)
Negative regulation of reactive oxygen species biosynthetic process GO:1903427 Any process that stops, prevents or reduces the frequency, rate or extent of reactive oxygen species biosynthetic process.	2	Q923E4 (/ISO) Q923E4 (/ISO)
Negative regulation of adipose tissue development GO:1904178 Any process that stops, prevents or reduces the frequency, rate or extent of adipose tissue development.	2	A7LKB1 (/IMP) B3FK65 (/IMP)
Positive regulation of adipose tissue development GO:1904179 Any process that activates or increases the frequency, rate or extent of adipose tissue development.	2	Q923E4 (/IMP) Q923E4 (/IMP)
Positive regulation of adipose tissue development GO:1904179 Any process that activates or increases the frequency, rate or extent of adipose tissue development.	2	Q96EB6 (/ISS) Q96EB6 (/ISS)
Cellular response to amyloid-beta GO:1904646 Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a amyloid-beta stimulus.	2	Q923E4 (/ISO) Q923E4 (/ISO)
Positive regulation of granulosa cell apoptotic process GO:1904710 Any process that activates or increases the frequency, rate or extent of granulosa cell apoptotic process.	2	A7LKB1 (/IDA) B3FK65 (/IDA)
Cellular response to leukemia inhibitory factor GO:1990830 Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a leukemia inhibitory factor stimulus.	2	Q923E4 (/IEP) Q923E4 (/IEP)
Positive regulation of macrophage apoptotic process GO:2000111 Any process that activates or increases the frequency, rate or extent of macrophage apoptotic process.	2	Q923E4 (/IMP) Q923E4 (/IMP)
Positive regulation of macrophage apoptotic process GO:2000111 Any process that activates or increases the frequency, rate or extent of macrophage apoptotic process.	2	Q96EB6 (/ISS) Q96EB6 (/ISS)
Negative regulation of fibroblast apoptotic process GO:2000270 Any process that stops, prevents or reduces the frequency, rate or extent of fibroblast apoptotic process.	2	Q923E4 (/ISO) Q923E4 (/ISO)
Negative regulation of cAMP-dependent protein kinase activity GO:2000480 Any process that stops, prevents or reduces the frequency, rate or extent of cAMP-dependent protein kinase activity.	2	Q96EB6 (/IDA) Q96EB6 (/IDA)
Negative regulation of cAMP-dependent protein kinase activity GO:2000480 Any process that stops, prevents or reduces the frequency, rate or extent of cAMP-dependent protein kinase activity.	2	Q923E4 (/ISO) Q923E4 (/ISO)
Negative regulation of cAMP-dependent protein kinase activity GO:2000480 Any process that stops, prevents or reduces the frequency, rate or extent of cAMP-dependent protein kinase activity.	2	Q923E4 (/ISS) Q923E4 (/ISS)
Positive regulation of cAMP-dependent protein kinase activity GO:2000481 Any process that activates or increases the frequency, rate or extent of cAMP-dependent protein kinase activity.	2	Q923E4 (/IDA) Q923E4 (/IDA)
Positive regulation of cAMP-dependent protein kinase activity GO:2000481 Any process that activates or increases the frequency, rate or extent of cAMP-dependent protein kinase activity.	2	Q96EB6 (/IMP) Q96EB6 (/IMP)
Positive regulation of cAMP-dependent protein kinase activity GO:2000481 Any process that activates or increases the frequency, rate or extent of cAMP-dependent protein kinase activity.	2	Q923E4 (/ISO) Q923E4 (/ISO)
Positive regulation of thyroid-stimulating hormone secretion GO:2000614 Any process that activates or increases the frequency, rate or extent of thyroid-stimulating hormone secretion.	2	Q923E4 (/ISO) Q923E4 (/ISO)
Negative regulation of histone H4-K16 acetylation GO:2000619 Any process that stops, prevents or reduces the frequency, rate or extent of histone H4-K16 acetylation.	2	Q96EB6 (/IMP) Q96EB6 (/IMP)
Negative regulation of histone H4-K16 acetylation GO:2000619 Any process that stops, prevents or reduces the frequency, rate or extent of histone H4-K16 acetylation.	2	Q923E4 (/ISO) Q923E4 (/ISO)
Negative regulation of cellular response to testosterone stimulus GO:2000655 Any process that stops, prevents or reduces the frequency, rate or extent of cellular response to testosterone stimulus.	2	Q96EB6 (/IMP) Q96EB6 (/IMP)
Negative regulation of cellular response to testosterone stimulus GO:2000655 Any process that stops, prevents or reduces the frequency, rate or extent of cellular response to testosterone stimulus.	2	Q923E4 (/ISO) Q923E4 (/ISO)
Negative regulation of peptidyl-lysine acetylation GO:2000757 Any process that stops, prevents or reduces the frequency, rate or extent of peptidyl-lysine acetylation.	2	Q96EB6 (/IDA) Q96EB6 (/IDA)
Negative regulation of peptidyl-lysine acetylation GO:2000757 Any process that stops, prevents or reduces the frequency, rate or extent of peptidyl-lysine acetylation.	2	Q923E4 (/ISO) Q923E4 (/ISO)
Negative regulation of peptidyl-lysine acetylation GO:2000757 Any process that stops, prevents or reduces the frequency, rate or extent of peptidyl-lysine acetylation.	2	Q923E4 (/ISS) Q923E4 (/ISS)
Negative regulation of cellular senescence GO:2000773 Any process that stops, prevents or reduces the frequency, rate or extent of cellular senescence.	2	Q96EB6 (/IDA) Q96EB6 (/IDA)
Negative regulation of cellular senescence GO:2000773 Any process that stops, prevents or reduces the frequency, rate or extent of cellular senescence.	2	Q923E4 (/ISO) Q923E4 (/ISO)
Negative regulation of cellular senescence GO:2000773 Any process that stops, prevents or reduces the frequency, rate or extent of cellular senescence.	2	Q923E4 (/ISS) Q923E4 (/ISS)
Positive regulation of cellular senescence GO:2000774 Any process that activates or increases the frequency, rate or extent of cellular senescence.	2	Q96EB6 (/IDA) Q96EB6 (/IDA)
Positive regulation of cellular senescence GO:2000774 Any process that activates or increases the frequency, rate or extent of cellular senescence.	2	Q923E4 (/ISO) Q923E4 (/ISO)
Positive regulation of cellular senescence GO:2000774 Any process that activates or increases the frequency, rate or extent of cellular senescence.	2	Q923E4 (/ISS) Q923E4 (/ISS)
Positive regulation of ATP biosynthetic process GO:2001171 Any process that activates or increases the frequency, rate or extent of ATP biosynthetic process.	2	A7LKB1 (/IMP) B3FK65 (/IMP)
Negative regulation of transcription by RNA polymerase II GO:0000122 Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.	1	O94640 (/IEP)
Vasculature development GO:0001944 The process whose specific outcome is the progression of the vasculature over time, from its formation to the mature structure. The vasculature is an interconnected tubular multi-tissue structure that contains fluid that is actively transported around the organism.	1	E7F8W3 (/IMP)
Cell migration involved in sprouting angiogenesis GO:0002042 The orderly movement of endothelial cells into the extracellular matrix in order to form new blood vessels involved in sprouting angiogenesis.	1	E7F8W3 (/IMP)
Chromatin silencing at telomere GO:0006348 Repression of transcription of telomeric DNA by altering the structure of chromatin.	1	O94640 (/IMP)
Regulation of transcription, DNA-templated GO:0006355 Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.	1	Q9VK34 (/IDA)
Autophagy GO:0006914 The cellular catabolic process in which cells digest parts of their own cytoplasm; allows for both recycling of macromolecular constituents under conditions of cellular stress and remodeling the intracellular structure for cell differentiation.	1	Q54GV7 (/IMP)
Cell aging GO:0007569 An aging process that has as participant a cell after a cell has stopped dividing. Cell aging may occur when a cell has temporarily stopped dividing through cell cycle arrest (GO:0007050) or when a cell has permanently stopped dividing, in which case it is undergoing cellular senescence (GO:0090398). May precede cell death (GO:0008219) and succeed cell maturation (GO:0048469).	1	A0A0G2JZ79 (/IEP)
Determination of adult lifespan GO:0008340 The control of viability and duration in the adult phase of the life-cycle.	1	Q9VK34 (/IMP)
Response to mycotoxin GO:0010046 Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a mycotoxin stimulus. A mycotoxin is a toxic chemical substance produced by fungi.	1	A0A0G2JZ79 (/IEP)
Positive regulation of heart rate GO:0010460 Any process that activates or increases the frequency or rate of heart contraction.	1	A0A0G2JZ79 (/IMP)
Negative regulation of cardiac muscle cell apoptotic process GO:0010667 Any process that decreases the rate or extent of cardiac cell apoptotic process, a form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases whose actions dismantle a cardiac muscle cell and result in its death.	1	A0A0G2JZ79 (/IMP)
Positive regulation of neuron projection development GO:0010976 Any process that increases the rate, frequency or extent of neuron projection development. Neuron projection development is the process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites).	1	A0A0G2JZ79 (/IMP)
Regulation of gliogenesis GO:0014013 Any process that modulates the frequency, rate or extent of gliogenesis, the formation of mature glia.	1	E7F8W3 (/IGI)
Regulation of gliogenesis GO:0014013 Any process that modulates the frequency, rate or extent of gliogenesis, the formation of mature glia.	1	E7F8W3 (/IMP)
Positive regulation of skeletal muscle cell proliferation GO:0014858 Any process that activates or increases the frequency, rate or extent of skeletal muscle cell proliferation.	1	A0A0G2JZ79 (/IMP)
Histone deacetylation GO:0016575 The modification of histones by removal of acetyl groups.	1	Q9VK34 (/IMP)
Chromatin silencing at silent mating-type cassette GO:0030466 Repression of transcription at silent mating-type loci by alteration of the structure of chromatin.	1	O94640 (/IGI)
Chromatin silencing at silent mating-type cassette GO:0030466 Repression of transcription at silent mating-type loci by alteration of the structure of chromatin.	1	O94640 (/IMP)
Sorocarp development GO:0030587 The process whose specific outcome is the progression of the sorocarp over time, from its formation to the mature structure. The process begins with the aggregation of individual cells and ends with the mature sorocarp. The sorocarp is a structure containing a spore-bearing sorus that sits on top of a stalk. An example of this process is found in Dictyostelium discoideum.	1	Q54GV7 (/IMP)
Chromatin silencing at centromere GO:0030702 Repression of transcription of centromeric DNA by altering the structure of chromatin.	1	O94640 (/IMP)
Positive regulation of heterochromatin assembly GO:0031453 Any process that activates or increases the frequency, rate or extent of heterochromatin formation.	1	O94640 (/EXP)
Response to nutrient levels GO:0031667 Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting the presence, absence, or concentration of nutrients.	1	A0A0G2JZ79 (/IEP)
Negative regulation of tumor necrosis factor production GO:0032720 Any process that stops, prevents, or reduces the frequency, rate, or extent of tumor necrosis factor production.	1	A0A0G2JZ79 (/IMP)
Cellular response to insulin stimulus GO:0032869 Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an insulin stimulus. Insulin is a polypeptide hormone produced by the islets of Langerhans of the pancreas in mammals, and by the homologous organs of other organisms.	1	Q9VK34 (/IMP)
Regulation of histone acetylation GO:0035065 Any process that modulates the frequency, rate or extent of the addition of an acetyl group to a histone protein.	1	Q9VK34 (/IMP)
Positive regulation of insulin secretion involved in cellular response to glucose stimulus GO:0035774 Any process that increases the frequency, rate or extent of the regulated release of insulin that contributes to the response of a cell to glucose.	1	A0A0G2JZ79 (/IMP)
Negative regulation of DNA binding GO:0043392 Any process that stops or reduces the frequency, rate or extent of DNA binding. DNA binding is any process in which a gene product interacts selectively with DNA (deoxyribonucleic acid).	1	A0A0G2JZ79 (/IMP)
Negative regulation of neuron apoptotic process GO:0043524 Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process in neurons.	1	A0A0G2JZ79 (/IMP)
Histone H3-K14 acetylation GO:0044154 The modification of histone H3 by the addition of an acetyl group to a lysine residue at position 14 of the histone.	1	O94640 (/IC)
Sorocarp spore cell differentiation GO:0044671 The process in which a relatively unspecialized cell acquires specialized features of a sorocarp spore cell, a cell of the sorocarp sorus. A sorocarp is the fruiting body characteristic of certain cellular slime moulds (e.g., Dictyosteliida) and consists of both stalk and a sorus (spore mass).	1	Q54GV7 (/IMP)
Response to ethanol GO:0045471 Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ethanol stimulus.	1	A0A0G2JZ79 (/IDA)
Positive regulation of gluconeogenesis GO:0045722 Any process that activates or increases the frequency, rate or extent of gluconeogenesis.	1	A0A0G2JZ79 (/IMP)
Behavioral response to ethanol GO:0048149 Any process that results in a change in the behavior of an organism as a result of an ethanol stimulus.	1	Q9VK34 (/IMP)
Regulation of histone H3-K9 methylation GO:0051570 Any process that modulates the frequency, rate or extent of the covalent addition of a methyl group to the lysine at position 9 of histone H3.	1	O94640 (/IMP)
Negative regulation of growth hormone secretion GO:0060125 Any process that decreases or stops the frequency, rate or extent of the regulated release of growth hormone from a cell.	1	A0A0G2JZ79 (/IMP)
Negative regulation of cell death GO:0060548 Any process that decreases the rate or frequency of cell death. Cell death is the specific activation or halting of processes within a cell so that its vital functions markedly cease, rather than simply deteriorating gradually over time, which culminates in cell death.	1	A0A0G2JZ79 (/IMP)
Positive regulation of cell growth involved in cardiac muscle cell development GO:0061051 Any process that increases the rate, frequency, or extent of the growth of a cardiac muscle cell, where growth contributes to the progression of the cell over time from its initial formation to its mature state.	1	A0A0G2JZ79 (/IMP)
Protein localization to chromosome, telomeric region GO:0070198 Any process in which a protein is transported to, or maintained at, the telomeric region of a chromosome.	1	O94640 (/IMP)
Cellular response to hydrogen peroxide GO:0070301 Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hydrogen peroxide (H2O2) stimulus.	1	A0A0G2JZ79 (/IEP)
Cellular response to antibiotic GO:0071236 Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an antibiotic stimulus. An antibiotic is a chemical substance produced by a microorganism which has the capacity to inhibit the growth of or to kill other microorganisms.	1	A0A0G2JZ79 (/IEP)
Cellular response to vitamin B3 GO:0071303 Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a vitamin B3 stimulus.	1	A0A0G2JZ79 (/IEP)
Cellular response to organic cyclic compound GO:0071407 Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organic cyclic compound stimulus.	1	A0A0G2JZ79 (/IEP)
Positive regulation of protein deacetylation GO:0090312 Any process that increases the rate, frequency, or extent of protein deacetylation, the removal of an acetyl group from a protein amino acid. An acetyl group is CH3CO-, derived from acetic	1	A0A0G2JZ79 (/IMP)
Positive regulation of blood vessel diameter GO:0097755 Any process that increases the diameter of blood vessels.	1	A0A0G2JZ79 (/IMP)
Negative regulation of protein localization to nucleus GO:1900181 Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to nucleus.	1	A0A0G2JZ79 (/IMP)
Regulation of response to ethanol GO:1901416 Any process that modulates the frequency, rate or extent of response to ethanol.	1	Q9VK34 (/IMP)
Response to fluoride GO:1902617 Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a fluoride stimulus.	1	A0A0G2JZ79 (/IEP)
Negative regulation of reactive oxygen species biosynthetic process GO:1903427 Any process that stops, prevents or reduces the frequency, rate or extent of reactive oxygen species biosynthetic process.	1	A0A0G2JZ79 (/IMP)
Response to kainic acid GO:1904373 Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a kainic acid stimulus.	1	A0A0G2JZ79 (/IEP)
Response to resveratrol GO:1904638 Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a resveratrol stimulus.	1	A0A0G2JZ79 (/IEP)
Cellular response to curcumin GO:1904644 Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a curcumin stimulus.	1	A0A0G2JZ79 (/IEP)
Cellular response to amyloid-beta GO:1904646 Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a amyloid-beta stimulus.	1	A0A0G2JZ79 (/IEP)
Cellular response to amyloid-beta GO:1904646 Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a amyloid-beta stimulus.	1	A0A0G2JZ79 (/IMP)
Cellular response to rotenone GO:1904648 Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a rotenone stimulus.	1	A0A0G2JZ79 (/IEP)
Histone H3-K4 deacetylation GO:1990596 The modification of histone H3 by the removal of an acetyl group from lysine at position 4 of the histone.	1	O94640 (/IMP)
Histone H3-K9 deacetylation GO:1990619 The modification of histone H3 by the removal of an acetyl group from lysine at position 9 of the histone.	1	O94640 (/IMP)
Histone H4-K16 deacetylation GO:1990678 The modification of histone H4 by the removal of an acetyl group from lysine at position 16 of the histone.	1	O94640 (/IMP)
Histone H4-K12 deacetylation GO:1990679 The modification of histone H4 by the removal of an acetyl group from lysine at position 12 of the histone.	1	O94640 (/IMP)
Positive regulation of feeding behavior GO:2000253 Any process that activates or increases the frequency, rate or extent of feeding behavior.	1	Q9VK34 (/IGI)
Positive regulation of feeding behavior GO:2000253 Any process that activates or increases the frequency, rate or extent of feeding behavior.	1	Q9VK34 (/IMP)
Negative regulation of fibroblast apoptotic process GO:2000270 Any process that stops, prevents or reduces the frequency, rate or extent of fibroblast apoptotic process.	1	A0A0G2JZ79 (/IMP)
Positive regulation of thyroid-stimulating hormone secretion GO:2000614 Any process that activates or increases the frequency, rate or extent of thyroid-stimulating hormone secretion.	1	A0A0G2JZ79 (/IMP)

There are 40 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

GO Term	Annotations	Evidence
Nucleus GO:0005634 A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.	12	A0A024QZQ1 (/IDA) A0A024QZQ1 (/IDA) A0A0G2JZ79 (/IDA) A7LKB1 (/IDA) B3FK65 (/IDA) O94640 (/IDA) Q54GV7 (/IDA) Q923E4 (/IDA) Q923E4 (/IDA) Q96EB6 (/IDA) (2 more)
Cytoplasm GO:0005737 All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.	7	A7LKB1 (/IDA) B3FK65 (/IDA) Q923E4 (/IDA) Q923E4 (/IDA) Q96EB6 (/IDA) Q96EB6 (/IDA) Q9VK34 (/IDA)
Mitochondrion GO:0005739 A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.	6	A0A024QZQ1 (/IDA) A0A024QZQ1 (/IDA) Q923E4 (/IDA) Q923E4 (/IDA) Q96EB6 (/IDA) Q96EB6 (/IDA)
Nucleoplasm GO:0005654 That part of the nuclear content other than the chromosomes or the nucleolus.	5	A0A024QZQ1 (/IDA) A0A024QZQ1 (/IDA) Q96EB6 (/IDA) Q96EB6 (/IDA) Q9VK34 (/IDA)
Cytosol GO:0005829 The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.	5	A0A024QZQ1 (/IDA) A0A024QZQ1 (/IDA) A0A0G2JZ79 (/IDA) Q96EB6 (/IDA) Q96EB6 (/IDA)
Nucleoplasm GO:0005654 That part of the nuclear content other than the chromosomes or the nucleolus.	4	Q923E4 (/TAS) Q923E4 (/TAS) Q96EB6 (/TAS) Q96EB6 (/TAS)
Nuclear heterochromatin GO:0005720 A condensed form of chromatin, occurring in the nucleus during interphase, that stains strongly with basophilic dyes. The DNA of heterochromatin is typically replicated at a later stage in the cell-division cycle than euchromatin.	4	Q923E4 (/IDA) Q923E4 (/IDA) Q96EB6 (/IDA) Q96EB6 (/IDA)
Nuclear chromatin GO:0000790 The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome in the nucleus.	3	O94640 (/IDA) Q96EB6 (/IDA) Q96EB6 (/IDA)
Chromatin GO:0000785 The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome.	2	Q923E4 (/IDA) Q923E4 (/IDA)
Nuclear chromatin GO:0000790 The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome in the nucleus.	2	Q923E4 (/ISO) Q923E4 (/ISO)
Nucleus GO:0005634 A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.	2	Q923E4 (/ISO) Q923E4 (/ISO)
Nuclear envelope GO:0005635 The double lipid bilayer enclosing the nucleus and separating its contents from the rest of the cytoplasm; includes the intermembrane space, a gap of width 20-40 nm (also called the perinuclear space).	2	Q96EB6 (/IDA) Q96EB6 (/IDA)
Nuclear envelope GO:0005635 The double lipid bilayer enclosing the nucleus and separating its contents from the rest of the cytoplasm; includes the intermembrane space, a gap of width 20-40 nm (also called the perinuclear space).	2	Q923E4 (/ISO) Q923E4 (/ISO)
Nuclear inner membrane GO:0005637 The inner, i.e. lumen-facing, lipid bilayer of the nuclear envelope.	2	Q96EB6 (/IDA) Q96EB6 (/IDA)
Nuclear inner membrane GO:0005637 The inner, i.e. lumen-facing, lipid bilayer of the nuclear envelope.	2	Q923E4 (/ISO) Q923E4 (/ISO)
Nuclear inner membrane GO:0005637 The inner, i.e. lumen-facing, lipid bilayer of the nuclear envelope.	2	Q923E4 (/ISS) Q923E4 (/ISS)
Nucleoplasm GO:0005654 That part of the nuclear content other than the chromosomes or the nucleolus.	2	Q923E4 (/ISO) Q923E4 (/ISO)
Nucleoplasm GO:0005654 That part of the nuclear content other than the chromosomes or the nucleolus.	2	Q923E4 (/ISS) Q923E4 (/ISS)
Chromatin silencing complex GO:0005677 Any protein complex that mediates changes in chromatin structure that result in transcriptional silencing.	2	Q96EB6 (/IDA) Q96EB6 (/IDA)
Chromatin silencing complex GO:0005677 Any protein complex that mediates changes in chromatin structure that result in transcriptional silencing.	2	Q923E4 (/ISO) Q923E4 (/ISO)
Nuclear euchromatin GO:0005719 The dispersed less dense form of chromatin in the interphase nucleus. It exists in at least two forms, a some being in the form of transcriptionally active chromatin which is the least condensed, while the rest is inactive euchromatin which is more condensed than active chromatin but less condensed than heterochromatin.	2	Q96EB6 (/IDA) Q96EB6 (/IDA)
Nuclear euchromatin GO:0005719 The dispersed less dense form of chromatin in the interphase nucleus. It exists in at least two forms, a some being in the form of transcriptionally active chromatin which is the least condensed, while the rest is inactive euchromatin which is more condensed than active chromatin but less condensed than heterochromatin.	2	Q923E4 (/ISO) Q923E4 (/ISO)
Nuclear euchromatin GO:0005719 The dispersed less dense form of chromatin in the interphase nucleus. It exists in at least two forms, a some being in the form of transcriptionally active chromatin which is the least condensed, while the rest is inactive euchromatin which is more condensed than active chromatin but less condensed than heterochromatin.	2	Q923E4 (/ISS) Q923E4 (/ISS)
Nuclear heterochromatin GO:0005720 A condensed form of chromatin, occurring in the nucleus during interphase, that stains strongly with basophilic dyes. The DNA of heterochromatin is typically replicated at a later stage in the cell-division cycle than euchromatin.	2	Q923E4 (/ISO) Q923E4 (/ISO)
Nucleolus GO:0005730 A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.	2	Q96EB6 (/IDA) Q96EB6 (/IDA)
Mitochondrion GO:0005739 A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.	2	Q923E4 (/ISO) Q923E4 (/ISO)
Cytosol GO:0005829 The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.	2	Q923E4 (/ISO) Q923E4 (/ISO)
PML body GO:0016605 A class of nuclear body; they react against SP100 auto-antibodies (PML, promyelocytic leukemia); cells typically contain 10-30 PML bodies per nucleus; alterations in the localization of PML bodies occurs after viral infection.	2	Q96EB6 (/IDA) Q96EB6 (/IDA)
PML body GO:0016605 A class of nuclear body; they react against SP100 auto-antibodies (PML, promyelocytic leukemia); cells typically contain 10-30 PML bodies per nucleus; alterations in the localization of PML bodies occurs after viral infection.	2	Q923E4 (/ISO) Q923E4 (/ISO)
Axon GO:0030424 The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter.	2	Q923E4 (/ISO) Q923E4 (/ISO)
Growth cone GO:0030426 The migrating motile tip of a growing neuron projection, where actin accumulates, and the actin cytoskeleton is the most dynamic.	2	Q923E4 (/ISO) Q923E4 (/ISO)
RDNA heterochromatin GO:0033553 A region of heterochromatin located at the rDNA repeats in a chromosome.	2	Q96EB6 (/IDA) Q96EB6 (/IDA)
RDNA heterochromatin GO:0033553 A region of heterochromatin located at the rDNA repeats in a chromosome.	2	Q923E4 (/ISO) Q923E4 (/ISO)
Nucleus GO:0005634 A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.	1	O94640 (/HDA)
Axon GO:0030424 The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter.	1	A0A0G2JZ79 (/IDA)
Growth cone GO:0030426 The migrating motile tip of a growing neuron projection, where actin accumulates, and the actin cytoskeleton is the most dynamic.	1	A0A0G2JZ79 (/IDA)
Nuclear pericentric heterochromatin GO:0031618 Nuclear heterochromatin that is located adjacent to the CENP-A rich centromere 'central core' and characterized by the modified histone H3K9me3.	1	O94640 (/IDA)
Mating-type region heterochromatin GO:0031934 Heterochromatic regions of the chromosome found at silenced mating-type loci.	1	O94640 (/IDA)
Nuclear rDNA heterochromatin GO:1902377 Any rDNA heterochromatin that is part of a nucleus.	1	O94640 (/IDA)
Nuclear subtelomeric heterochromatin GO:1990707 Heterochromatic regions of the chromosome found at the subtelomeric regions of a chromosome in the nucleus.	1	O94640 (/IDA)

CATH Superfamily 3.30.1600.10

SIR2/SIRT2 'Small Domain'

Functional Families

FunFam 3: NAD-dependent histone deacetylase sirtuin-1

There are 60 GO terms relating to "molecular function"

There are 344 GO terms relating to "biological process"

There are 40 GO terms relating to "cellular component"