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CATH Superfamily 3.30.1600.10

SIR2/SIRT2 'Small Domain'

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
SIR2/SIRT2 'Small Domain'
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 2: NAD-dependent protein deacylase

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 5 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
 27 P75960 (/IPI) P75960 (/IPI) P75960 (/IPI) P75960 (/IPI) P75960 (/IPI) P75960 (/IPI) P75960 (/IPI) P75960 (/IPI) P75960 (/IPI) P75960 (/IPI)
(17 more)
NAD-dependent protein deacetylase activity GO:0034979
Catalysis of the removal of one or more acetyl groups from a protein, requiring NAD.
 27 P75960 (/IDA) P75960 (/IDA) P75960 (/IDA) P75960 (/IDA) P75960 (/IDA) P75960 (/IDA) P75960 (/IDA) P75960 (/IDA) P75960 (/IDA) P75960 (/IDA)
(17 more)
NAD-dependent protein deacetylase activity GO:0034979
Catalysis of the removal of one or more acetyl groups from a protein, requiring NAD.
 27 P75960 (/IMP) P75960 (/IMP) P75960 (/IMP) P75960 (/IMP) P75960 (/IMP) P75960 (/IMP) P75960 (/IMP) P75960 (/IMP) P75960 (/IMP) P75960 (/IMP)
(17 more)
Protein-succinyllysine desuccinylase activity GO:0036055
Catalysis of the reaction: protein-succinyllysine + H2O => protein-lysine + succinate. This reaction is the removal of a succinyl group (CO-CH2-CH2-CO) from a succinylated lysine residue of a protein or peptide.
 27 P75960 (/IDA) P75960 (/IDA) P75960 (/IDA) P75960 (/IDA) P75960 (/IDA) P75960 (/IDA) P75960 (/IDA) P75960 (/IDA) P75960 (/IDA) P75960 (/IDA)
(17 more)
Deacetylase activity GO:0019213
Catalysis of the hydrolysis of an acetyl group or groups from a substrate molecule.
 1 Q5LUS5 (/ISS)

There are 8 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Chemotaxis GO:0006935
The directed movement of a motile cell or organism, or the directed growth of a cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis).
 27 P75960 (/IMP) P75960 (/IMP) P75960 (/IMP) P75960 (/IMP) P75960 (/IMP) P75960 (/IMP) P75960 (/IMP) P75960 (/IMP) P75960 (/IMP) P75960 (/IMP)
(17 more)
Peptidyl-lysine deacetylation GO:0034983
The removal of an acetyl group from an acetylated lysine residue in a peptide or protein.
 27 P75960 (/IDA) P75960 (/IDA) P75960 (/IDA) P75960 (/IDA) P75960 (/IDA) P75960 (/IDA) P75960 (/IDA) P75960 (/IDA) P75960 (/IDA) P75960 (/IDA)
(17 more)
Peptidyl-lysine deacetylation GO:0034983
The removal of an acetyl group from an acetylated lysine residue in a peptide or protein.
 27 P75960 (/IMP) P75960 (/IMP) P75960 (/IMP) P75960 (/IMP) P75960 (/IMP) P75960 (/IMP) P75960 (/IMP) P75960 (/IMP) P75960 (/IMP) P75960 (/IMP)
(17 more)
Peptidyl-lysine desuccinylation GO:0036049
The removal of a succinyl group (CO-CH2-CH2-CO) from a succinylated lysine residue in a peptide or protein.
 27 P75960 (/IDA) P75960 (/IDA) P75960 (/IDA) P75960 (/IDA) P75960 (/IDA) P75960 (/IDA) P75960 (/IDA) P75960 (/IDA) P75960 (/IDA) P75960 (/IDA)
(17 more)
Defense response to virus GO:0051607
Reactions triggered in response to the presence of a virus that act to protect the cell or organism.
 27 P75960 (/IMP) P75960 (/IMP) P75960 (/IMP) P75960 (/IMP) P75960 (/IMP) P75960 (/IMP) P75960 (/IMP) P75960 (/IMP) P75960 (/IMP) P75960 (/IMP)
(17 more)
Posttranscriptional regulation of gene expression GO:0010608
Any process that modulates the frequency, rate or extent of gene expression after the production of an RNA transcript.
 2 Q584D5 (/IDA) Q584D5 (/IDA)
Cobalamin biosynthetic process GO:0009236
The chemical reactions and pathways resulting in the formation of cobalamin (vitamin B12), a water-soluble vitamin characterized by possession of a corrin nucleus containing a cobalt atom.
 1 Q5LUS5 (/ISS)
Posttranscriptional regulation of gene expression GO:0010608
Any process that modulates the frequency, rate or extent of gene expression after the production of an RNA transcript.
 1 Q4Q2Y6 (/ISO)

There are 2 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
 3 Q4Q2Y6 (/ISO) Q584D5 (/ISO) Q584D5 (/ISO)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
 2 Q584D5 (/IDA) Q584D5 (/IDA)