The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Classic Zinc Finger
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 96: Zinc finger and BTB domain-containing protein 18 i...

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 16 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
8 B2RXF5 (/ISA) Q99592 (/ISA) Q9HBE1 (/ISA) Q9HBE1 (/ISA) Q9HBE1 (/ISA) Q9HBE1 (/ISA) Q9HBE1 (/ISA) Q9HBE1 (/ISA)
DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
6 Q9HBE1 (/ISM) Q9HBE1 (/ISM) Q9HBE1 (/ISM) Q9HBE1 (/ISM) Q9HBE1 (/ISM) Q9HBE1 (/ISM)
DNA binding GO:0003677
Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
6 Q9HBE1 (/NAS) Q9HBE1 (/NAS) Q9HBE1 (/NAS) Q9HBE1 (/NAS) Q9HBE1 (/NAS) Q9HBE1 (/NAS)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
6 Q5NBY9 (/IPI) Q5NBZ1 (/IPI) Q5NBZ2 (/IPI) Q80XS2 (/IPI) Q99592 (/IPI) Q9JMG9 (/IPI)
DNA binding GO:0003677
Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
5 Q5NBY9 (/IDA) Q5NBZ1 (/IDA) Q5NBZ2 (/IDA) Q80XS2 (/IDA) Q9JMG9 (/IDA)
Chromatin binding GO:0003682
Interacting selectively and non-covalently with chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase.
5 Q5NBY9 (/IDA) Q5NBZ1 (/IDA) Q5NBZ2 (/IDA) Q80XS2 (/IDA) Q9JMG9 (/IDA)
Sequence-specific DNA binding GO:0043565
Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding.
3 A0JN76 (/ISS) Q9JKY3 (/ISS) Q9WUK6 (/ISS)
RNA polymerase II proximal promoter sequence-specific DNA binding GO:0000978
Interacting selectively and non-covalently with a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in the proximal promoter of a gene transcribed by RNA polymerase II. The proximal promoter is in cis with and relatively close to the core promoter.
1 Q9JMG9 (/IDA)
DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
1 Q99592 (/NAS)
DNA-binding transcription activator activity, RNA polymerase II-specific GO:0001228
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to activate or increase transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
1 Q9JMG9 (/IDA)
DNA binding GO:0003677
Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
1 Q99592 (/TAS)
DNA-binding transcription factor activity GO:0003700
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
1 Q99592 (/TAS)
Transcription coactivator activity GO:0003713
A protein or a member of a complex that interacts specifically and non-covalently with a DNA-bound DNA-binding transcription factor to activate the transcription of specific genes. Coactivators often act by altering chromatin structure and modifications. For example, one class of transcription coregulators modifies chromatin structure through covalent modification of histones. A second ATP-dependent class modifies the conformation of chromatin. Another type of coregulator activity is the bridging of a DNA-binding transcription factor to the basal transcription machinery. The Mediator complex, which bridges transcription factors and RNA polymerase, is also a transcription coactivator.
1 Q99592 (/IDA)
Transcription coactivator activity GO:0003713
A protein or a member of a complex that interacts specifically and non-covalently with a DNA-bound DNA-binding transcription factor to activate the transcription of specific genes. Coactivators often act by altering chromatin structure and modifications. For example, one class of transcription coregulators modifies chromatin structure through covalent modification of histones. A second ATP-dependent class modifies the conformation of chromatin. Another type of coregulator activity is the bridging of a DNA-binding transcription factor to the basal transcription machinery. The Mediator complex, which bridges transcription factors and RNA polymerase, is also a transcription coactivator.
1 Q9WUK6 (/ISO)
Sequence-specific DNA binding GO:0043565
Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding.
1 Q99592 (/IDA)
Sequence-specific DNA binding GO:0043565
Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding.
1 Q9WUK6 (/ISO)

There are 28 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Negative regulation of transcription, DNA-templated GO:0045892
Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.
8 A0JN76 (/ISS) Q5NBY9 (/ISS) Q5NBZ1 (/ISS) Q5NBZ2 (/ISS) Q80XS2 (/ISS) Q99592 (/ISS) Q9JKY3 (/ISS) Q9JMG9 (/ISS)
Regulation of transcription, DNA-templated GO:0006355
Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
6 Q9HBE1 (/TAS) Q9HBE1 (/TAS) Q9HBE1 (/TAS) Q9HBE1 (/TAS) Q9HBE1 (/TAS) Q9HBE1 (/TAS)
Negative regulation of transcription, DNA-templated GO:0045892
Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.
6 Q9HBE1 (/TAS) Q9HBE1 (/TAS) Q9HBE1 (/TAS) Q9HBE1 (/TAS) Q9HBE1 (/TAS) Q9HBE1 (/TAS)
Regulation of transcription, DNA-templated GO:0006355
Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
5 Q5NBY9 (/IPI) Q5NBZ1 (/IPI) Q5NBZ2 (/IPI) Q80XS2 (/IPI) Q9JMG9 (/IPI)
Spermatogenesis GO:0007283
The process of formation of spermatozoa, including spermatocytogenesis and spermiogenesis.
5 Q5NBY9 (/IMP) Q5NBZ1 (/IMP) Q5NBZ2 (/IMP) Q80XS2 (/IMP) Q9JMG9 (/IMP)
Male gonad development GO:0008584
The process whose specific outcome is the progression of the male gonad over time, from its formation to the mature structure.
5 Q5NBY9 (/IMP) Q5NBZ1 (/IMP) Q5NBZ2 (/IMP) Q80XS2 (/IMP) Q9JMG9 (/IMP)
Regulation of gene expression GO:0010468
Any process that modulates the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
5 Q5NBY9 (/IDA) Q5NBZ1 (/IDA) Q5NBZ2 (/IDA) Q80XS2 (/IDA) Q9JMG9 (/IDA)
T cell differentiation GO:0030217
The process in which a precursor cell type acquires characteristics of a more mature T-cell. A T cell is a type of lymphocyte whose definin characteristic is the expression of a T cell receptor complex.
5 Q5NBY9 (/IDA) Q5NBZ1 (/IDA) Q5NBZ2 (/IDA) Q80XS2 (/IDA) Q9JMG9 (/IDA)
Positive regulation of transcription, DNA-templated GO:0045893
Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.
5 Q5NBY9 (/IDA) Q5NBZ1 (/IDA) Q5NBZ2 (/IDA) Q80XS2 (/IDA) Q9JMG9 (/IDA)
Negative regulation of transcription by RNA polymerase II GO:0000122
Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.
3 A0JN76 (/ISS) Q99592 (/ISS) Q9JKY3 (/ISS)
Skeletal muscle tissue development GO:0007519
The developmental sequence of events leading to the formation of adult skeletal muscle tissue. The main events are: the fusion of myoblasts to form myotubes that increase in size by further fusion to them of myoblasts, the formation of myofibrils within their cytoplasm and the establishment of functional neuromuscular junctions with motor neurons. At this stage they can be regarded as mature muscle fibers.
3 A0JN76 (/ISS) Q99592 (/ISS) Q9JKY3 (/ISS)
Negative regulation of transcription by RNA polymerase II GO:0000122
Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.
2 Q811H0 (/IDA) Q9WUK6 (/IDA)
Muscle organ development GO:0007517
The process whose specific outcome is the progression of the muscle over time, from its formation to the mature structure. The muscle is an organ consisting of a tissue made up of various elongated cells that are specialized to contract and thus to produce movement and mechanical work.
2 B1WBS3 (/ISS) Q811H0 (/ISS)
Positive regulation of transcription by RNA polymerase II GO:0045944
Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
2 Q99592 (/IDA) Q9JMG9 (/IDA)
Negative regulation of transcription by RNA polymerase II GO:0000122
Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.
1 Q99592 (/TAS)
In utero embryonic development GO:0001701
The process whose specific outcome is the progression of the embryo in the uterus over time, from formation of the zygote in the oviduct, to birth. An example of this process is found in Mus musculus.
1 Q9WUK6 (/IMP)
Muscle organ development GO:0007517
The process whose specific outcome is the progression of the muscle over time, from its formation to the mature structure. The muscle is an organ consisting of a tissue made up of various elongated cells that are specialized to contract and thus to produce movement and mechanical work.
1 B2RXF5 (/IMP)
Muscle organ development GO:0007517
The process whose specific outcome is the progression of the muscle over time, from its formation to the mature structure. The muscle is an organ consisting of a tissue made up of various elongated cells that are specialized to contract and thus to produce movement and mechanical work.
1 Q811H0 (/ISO)
Skeletal muscle tissue development GO:0007519
The developmental sequence of events leading to the formation of adult skeletal muscle tissue. The main events are: the fusion of myoblasts to form myotubes that increase in size by further fusion to them of myoblasts, the formation of myofibrils within their cytoplasm and the establishment of functional neuromuscular junctions with motor neurons. At this stage they can be regarded as mature muscle fibers.
1 Q9WUK6 (/IMP)
Negative regulation of endothelial cell migration GO:0010596
Any process that decreases the rate, frequency, or extent of the orderly movement of an endothelial cell into the extracellular matrix to form an endothelium.
1 Q5NBY9 (/IMP)
Cerebellum development GO:0021549
The process whose specific outcome is the progression of the cerebellum over time, from its formation to the mature structure. The cerebellum is the portion of the brain in the back of the head between the cerebrum and the pons. In mice, the cerebellum controls balance for walking and standing, modulates the force and range of movement and is involved in the learning of motor skills.
1 Q9WUK6 (/IMP)
Hippocampus development GO:0021766
The progression of the hippocampus over time from its initial formation until its mature state.
1 Q9WUK6 (/IMP)
Cerebral cortex development GO:0021987
The progression of the cerebral cortex over time from its initial formation until its mature state. The cerebral cortex is the outer layered region of the telencephalon.
1 Q9WUK6 (/IMP)
Negative regulation of transcription, DNA-templated GO:0045892
Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.
1 Q9WUK6 (/IDA)
Positive regulation of transcription by RNA polymerase II GO:0045944
Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
1 Q9WUK6 (/ISO)
Neuron development GO:0048666
The process whose specific outcome is the progression of a neuron over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell.
1 Q9WUK6 (/IMP)
Homeostasis of number of cells GO:0048872
Any biological process involved in the maintenance of the steady-state number of cells within a population of cells.
1 Q9WUK6 (/IMP)
Regulation of cell division GO:0051302
Any process that modulates the frequency, rate or extent of the physical partitioning and separation of a cell into daughter cells.
1 Q9WUK6 (/IMP)

There are 11 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
20 A0A024R1F8 (/IDA) A0A024R1F8 (/IDA) A0A024R1F8 (/IDA) A0A024R1F8 (/IDA) A0A024R1F8 (/IDA) A0A024R1H7 (/IDA) A0A024R1H7 (/IDA) A0A024R1M5 (/IDA) A0A024R1M5 (/IDA) A0A024R1M5 (/IDA)
(10 more)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
9 B2RXF5 (/IDA) Q5NBY9 (/IDA) Q5NBZ1 (/IDA) Q5NBZ2 (/IDA) Q80XS2 (/IDA) Q811H0 (/IDA) Q99592 (/IDA) Q9JMG9 (/IDA) Q9WUK6 (/IDA)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
7 Q99592 (/TAS) Q9HBE1 (/TAS) Q9HBE1 (/TAS) Q9HBE1 (/TAS) Q9HBE1 (/TAS) Q9HBE1 (/TAS) Q9HBE1 (/TAS)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
6 B1WBS3 (/ISS) Q5NBY9 (/ISS) Q5NBZ1 (/ISS) Q5NBZ2 (/ISS) Q80XS2 (/ISS) Q9JMG9 (/ISS)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
5 Q5NBY9 (/ISO) Q5NBZ1 (/ISO) Q5NBZ2 (/ISO) Q80XS2 (/ISO) Q9JMG9 (/ISO)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
2 Q811H0 (/ISO) Q9WUK6 (/ISO)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
2 B1WBS3 (/ISS) B2RXF5 (/ISS)
Nuclear chromosome GO:0000228
A chromosome that encodes the nuclear genome and is found in the nucleus of a eukaryotic cell during the cell cycle phases when the nucleus is intact.
1 Q99592 (/TAS)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
1 Q811H0 (/IDA)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
1 B2RXF5 (/IDA)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
1 Q811H0 (/ISO)
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