The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Classic Zinc Finger
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 94: Zinc finger protein 605

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 4 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
33 O43361 (/ISA) P17039 (/ISA) P17039 (/ISA) P17039 (/ISA) P17039 (/ISA) Q3KP31 (/ISA) Q3KP31 (/ISA) Q76KX8 (/ISA) Q76KX8 (/ISA) Q86T29 (/ISA)
(23 more)
Translation repressor activity, mRNA regulatory element binding GO:0000900
Antagonizes the ribosome-mediated translation of mRNA into a polypeptide via direct binding (through a selective and non-covalent interaction) to nucleic acid.
8 Q8NDQ6 (/IMP) Q8NDQ6 (/IMP) Q8NDQ6 (/IMP) Q8NDQ6 (/IMP) Q8NDQ6 (/IMP) Q8NDQ6 (/IMP) Q8NDQ6 (/IMP) Q8NDQ6 (/IMP)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
8 Q8NDQ6 (/IPI) Q8NDQ6 (/IPI) Q8NDQ6 (/IPI) Q8NDQ6 (/IPI) Q8NDQ6 (/IPI) Q8NDQ6 (/IPI) Q8NDQ6 (/IPI) Q8NDQ6 (/IPI)
DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
4 P17039 (/NAS) P17039 (/NAS) P17039 (/NAS) P17039 (/NAS)

There are 2 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Negative regulation of translation GO:0017148
Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA or circRNA.
8 Q8NDQ6 (/IMP) Q8NDQ6 (/IMP) Q8NDQ6 (/IMP) Q8NDQ6 (/IMP) Q8NDQ6 (/IMP) Q8NDQ6 (/IMP) Q8NDQ6 (/IMP) Q8NDQ6 (/IMP)
Negative regulation of transcription, DNA-templated GO:0045892
Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.
8 Q8NDQ6 (/IDA) Q8NDQ6 (/IDA) Q8NDQ6 (/IDA) Q8NDQ6 (/IDA) Q8NDQ6 (/IDA) Q8NDQ6 (/IDA) Q8NDQ6 (/IDA) Q8NDQ6 (/IDA)

There are 6 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
11 Q6ECI4 (/IDA) Q6ECI4 (/IDA) Q6ECI4 (/IDA) Q8NDQ6 (/IDA) Q8NDQ6 (/IDA) Q8NDQ6 (/IDA) Q8NDQ6 (/IDA) Q8NDQ6 (/IDA) Q8NDQ6 (/IDA) Q8NDQ6 (/IDA)
(1 more)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
8 Q8NDQ6 (/IDA) Q8NDQ6 (/IDA) Q8NDQ6 (/IDA) Q8NDQ6 (/IDA) Q8NDQ6 (/IDA) Q8NDQ6 (/IDA) Q8NDQ6 (/IDA) Q8NDQ6 (/IDA)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
8 Q8NDQ6 (/IDA) Q8NDQ6 (/IDA) Q8NDQ6 (/IDA) Q8NDQ6 (/IDA) Q8NDQ6 (/IDA) Q8NDQ6 (/IDA) Q8NDQ6 (/IDA) Q8NDQ6 (/IDA)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
8 Q8NDQ6 (/IDA) Q8NDQ6 (/IDA) Q8NDQ6 (/IDA) Q8NDQ6 (/IDA) Q8NDQ6 (/IDA) Q8NDQ6 (/IDA) Q8NDQ6 (/IDA) Q8NDQ6 (/IDA)
Intracellular membrane-bounded organelle GO:0043231
Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.
8 Q8NDQ6 (/IDA) Q8NDQ6 (/IDA) Q8NDQ6 (/IDA) Q8NDQ6 (/IDA) Q8NDQ6 (/IDA) Q8NDQ6 (/IDA) Q8NDQ6 (/IDA) Q8NDQ6 (/IDA)
Nuclear body GO:0016604
Extra-nucleolar nuclear domains usually visualized by confocal microscopy and fluorescent antibodies to specific proteins.
3 Q6ECI4 (/IDA) Q6ECI4 (/IDA) Q6ECI4 (/IDA)
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