The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Classic Zinc Finger
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 777: zinc finger and BTB domain-containing protein 21

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 3 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Methyl-CpG binding GO:0008327
Interacting selectively and non-covalently with a methylated cytosine/guanine dinucleotide.
9 E9Q3R9 (/ISO) E9Q444 (/ISO) G3X9A3 (/ISO) Q3UM76 (/ISO) Q6ZPV6 (/ISO) Q80XC5 (/ISO) Q8BSP5 (/ISO) Q8CDB1 (/ISO) Q8R0A4 (/ISO)
DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
1 Q9ULJ3 (/ISA)
Methyl-CpG binding GO:0008327
Interacting selectively and non-covalently with a methylated cytosine/guanine dinucleotide.
1 Q9ULJ3 (/IDA)

There are 11 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Negative regulation of transcription, DNA-templated GO:0045892
Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.
9 E9Q3R9 (/ISO) E9Q444 (/ISO) G3X9A3 (/ISO) Q3UM76 (/ISO) Q6ZPV6 (/ISO) Q80XC5 (/ISO) Q8BSP5 (/ISO) Q8CDB1 (/ISO) Q8R0A4 (/ISO)
Regulation of Notch signaling pathway GO:0008593
Any process that modulates the frequency, rate or extent of the Notch signaling pathway.
1 A0A2R8QF28 (/IMP)
Pronephric proximal tubule development GO:0035776
The progression of the pronephric proximal tubule over time, from its formation to the mature structure. A pronephric nephron tubule is an epithelial tube that is part of the pronephros.
1 A0A2R8QF28 (/IMP)
Pronephric distal tubule development GO:0035777
The process whose specific outcome is the progression of the pronephric distal tubule over time, from its formation to the mature structure. A pronephric nephron tubule is an epithelial tube that is part of the pronephros.
1 A0A2R8QF28 (/IMP)
Embryonic cranial skeleton morphogenesis GO:0048701
The process in which the anatomical structures of the cranial skeleton are generated and organized during the embryonic phase.
1 A0A2R8QF28 (/IMP)
Embryonic neurocranium morphogenesis GO:0048702
The process in which the anatomical structures of the neurocranium are generated and organized during the embryonic phase. The neurocranium is the portion of the vertebrate skull surrounding the brain.
1 A0A2R8QF28 (/IGI)
Embryonic viscerocranium morphogenesis GO:0048703
The process in which the anatomical structures of the viscerocranium are generated and organized during the embryonic phase. The viscerocranium is the part of the skull comprising the facial bones.
1 A0A2R8QF28 (/IGI)
Pronephros development GO:0048793
The process whose specific outcome is the progression of the pronephros over time, from its formation to the mature structure. In mammals, the pronephros is the first of the three embryonic kidneys to be established and exists only transiently. In lower vertebrates such as fish and amphibia, the pronephros is the fully functional embryonic kidney and is indispensable for larval life.
1 A0A2R8QF28 (/IMP)
Proximal/distal pattern formation involved in pronephric nephron development GO:0072196
The regionalization process in which specific areas of cell differentiation are determined along a proximal/distal axis of the pronephros.
1 A0A2R8QF28 (/IMP)
Endothelial to hematopoietic transition GO:0098508
The generation of hematopoietic stem cells from hemogenic endothelial cells by a process that includes tight-junction dissolution and loss of cell polarity followed by delamination from the endothelium.
1 A0A2R8QF28 (/IMP)
Multi-ciliated epithelial cell differentiation GO:1903251
The process in which a relatively unspecialized cell acquires the specialized features of a multi-ciliated epithelial cell.
1 A0A2R8QF28 (/IMP)

There are 6 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
9 E9Q3R9 (/ISO) E9Q444 (/ISO) G3X9A3 (/ISO) Q3UM76 (/ISO) Q6ZPV6 (/ISO) Q80XC5 (/ISO) Q8BSP5 (/ISO) Q8CDB1 (/ISO) Q8R0A4 (/ISO)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
9 E9Q3R9 (/ISO) E9Q444 (/ISO) G3X9A3 (/ISO) Q3UM76 (/ISO) Q6ZPV6 (/ISO) Q80XC5 (/ISO) Q8BSP5 (/ISO) Q8CDB1 (/ISO) Q8R0A4 (/ISO)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
9 E9Q3R9 (/ISO) E9Q444 (/ISO) G3X9A3 (/ISO) Q3UM76 (/ISO) Q6ZPV6 (/ISO) Q80XC5 (/ISO) Q8BSP5 (/ISO) Q8CDB1 (/ISO) Q8R0A4 (/ISO)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
1 Q9ULJ3 (/IDA)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
1 Q9ULJ3 (/IDA)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
1 Q9ULJ3 (/IDA)
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