The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:
"Classic Zinc Finger
".
FunFam 77: Sp8 transcription factor
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 16 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
DNA binding GO:0003677
Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
|
9 | Q64HY3 (/ISS) Q8BMJ8 (/ISS) Q8BMJ8 (/ISS) Q8TDD2 (/ISS) Q8TDD2 (/ISS) Q8VI67 (/ISS) Q8VI67 (/ISS) Q9ESX2 (/ISS) Q9ESX2 (/ISS) |
|
Sequence-specific DNA binding GO:0043565
Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding.
|
9 | A0A0B4KHC8 (/IDA) A8JUN6 (/IDA) M9PJG1 (/IDA) Q24266 (/IDA) Q2XXX8 (/IDA) Q8IRM5 (/IDA) Q9U1K4 (/IDA) Q9VCB2 (/IDA) R9PY21 (/IDA) |
|
DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
|
7 | P0CG40 (/ISA) Q3SY56 (/ISA) Q3SY56 (/ISA) Q3SY56 (/ISA) Q8IXZ3 (/ISA) Q8TDD2 (/ISA) Q8TDD2 (/ISA) |
|
DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
|
6 | P0CG40 (/NAS) Q3SY56 (/NAS) Q3SY56 (/NAS) Q3SY56 (/NAS) Q8TDD2 (/NAS) Q8TDD2 (/NAS) |
|
DNA-binding transcription factor activity GO:0003700
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
|
6 | A8JUN6 (/IDA) M9PJG1 (/IDA) Q24266 (/IDA) Q8IRM5 (/IDA) Q9U1K4 (/IDA) R9PY21 (/IDA) |
|
DNA-binding transcription factor activity GO:0003700
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
|
5 | A8JUN6 (/ISS) M9PJG1 (/ISS) Q8IRM5 (/ISS) Q9U1K4 (/ISS) R9PY21 (/ISS) |
|
RNA polymerase II proximal promoter sequence-specific DNA binding GO:0000978
Interacting selectively and non-covalently with a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in the proximal promoter of a gene transcribed by RNA polymerase II. The proximal promoter is in cis with and relatively close to the core promoter.
|
2 | Q8VI67 (/IDA) Q8VI67 (/IDA) |
|
DNA-binding transcription activator activity, RNA polymerase II-specific GO:0001228
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to activate or increase transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
|
2 | Q8VI67 (/IDA) Q8VI67 (/IDA) |
|
DNA binding GO:0003677
Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
|
2 | Q8VI67 (/IDA) Q8VI67 (/IDA) |
|
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
|
2 | Q8VI67 (/IPI) Q8VI67 (/IPI) |
|
DEAD/H-box RNA helicase binding GO:0017151
Interacting selectively and non-covalently with the enzyme DEAD/H-box RNA helicase.
|
2 | Q8VI67 (/IPI) Q8VI67 (/IPI) |
|
DEAD/H-box RNA helicase binding GO:0017151
Interacting selectively and non-covalently with the enzyme DEAD/H-box RNA helicase.
|
2 | Q8TDD2 (/ISS) Q8TDD2 (/ISS) |
|
DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
|
1 | Q24266 (/IDA) |
|
Double-stranded DNA binding GO:0003690
Interacting selectively and non-covalently with double-stranded DNA.
|
1 | Q6P0J3 (/IDA) |
|
DNA-binding transcription factor activity GO:0003700
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
|
1 | Q24266 (/IGI) |
|
Transcription factor binding GO:0008134
Interacting selectively and non-covalently with a transcription factor, a protein required to initiate or regulate transcription.
|
1 | Q24266 (/IPI) |
There are 31 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Embryonic limb morphogenesis GO:0030326
The process, occurring in the embryo, by which the anatomical structures of the limb are generated and organized. A limb is an appendage of an animal used for locomotion or grasping.
|
7 | Q64HY3 (/IMP) Q64HY4 (/IMP) Q64HY5 (/IMP) Q6NW96 (/IMP) Q6P0J3 (/IMP) Q8BMJ8 (/IMP) Q8BMJ8 (/IMP) |
|
Imaginal disc-derived leg morphogenesis GO:0007480
The process in which the anatomical structures of a leg derived from an imaginal disc are generated and organized. A leg is a limb on which an animal walks and stands. An example of this is found in Drosophila melanogaster.
|
6 | A8JUN6 (/IMP) M9PJG1 (/IMP) Q24266 (/IMP) Q8IRM5 (/IMP) Q9U1K4 (/IMP) R9PY21 (/IMP) |
|
Regulation of transcription, DNA-templated GO:0006355
Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
|
5 | A8JUN6 (/ISS) M9PJG1 (/ISS) Q8IRM5 (/ISS) Q9U1K4 (/ISS) R9PY21 (/ISS) |
|
Positive regulation of transcription by RNA polymerase II GO:0045944
Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
|
5 | Q24266 (/IDA) Q8TDD2 (/IDA) Q8TDD2 (/IDA) Q8VI67 (/IDA) Q8VI67 (/IDA) |
|
Osteoblast differentiation GO:0001649
The process whereby a relatively unspecialized cell acquires the specialized features of an osteoblast, a mesodermal or neural crest cell that gives rise to bone.
|
4 | F6P1R7 (/IMP) Q6U1J4 (/IMP) Q8VI67 (/IMP) Q8VI67 (/IMP) |
|
Regulation of gene silencing GO:0060968
Any process that modulates the rate, frequency, or extent of gene silencing, the transcriptional or post-transcriptional process carried out at the cellular level that results in long-term gene inactivation.
|
3 | A0A0B4KHC8 (/IMP) Q2XXX8 (/IMP) Q9VCB2 (/IMP) |
|
Osteoblast differentiation GO:0001649
The process whereby a relatively unspecialized cell acquires the specialized features of an osteoblast, a mesodermal or neural crest cell that gives rise to bone.
|
2 | Q8TDD2 (/IDA) Q8TDD2 (/IDA) |
|
Osteoblast differentiation GO:0001649
The process whereby a relatively unspecialized cell acquires the specialized features of an osteoblast, a mesodermal or neural crest cell that gives rise to bone.
|
2 | Q8VI67 (/ISO) Q8VI67 (/ISO) |
|
Osteoblast differentiation GO:0001649
The process whereby a relatively unspecialized cell acquires the specialized features of an osteoblast, a mesodermal or neural crest cell that gives rise to bone.
|
2 | Q8TDD2 (/ISS) Q8TDD2 (/ISS) |
|
Regulation of transcription by RNA polymerase II GO:0006357
Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II.
|
2 | Q8VI67 (/IDA) Q8VI67 (/IDA) |
|
Regulation of transcription by RNA polymerase II GO:0006357
Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II.
|
2 | Q8TDD2 (/ISS) Q8TDD2 (/ISS) |
|
Transcription by RNA polymerase II GO:0006366
The synthesis of RNA from a DNA template by RNA polymerase II (RNAP II), originating at an RNA polymerase II promoter. Includes transcription of messenger RNA (mRNA) and certain small nuclear RNAs (snRNAs).
|
2 | Q9ESX2 (/ISS) Q9ESX2 (/ISS) |
|
Dorsal/ventral pattern formation GO:0009953
The regionalization process in which the areas along the dorsal/ventral axis are established that will lead to differences in cell differentiation. The dorsal/ventral axis is defined by a line that runs orthogonal to both the anterior/posterior and left/right axes. The dorsal end is defined by the upper or back side of an organism. The ventral end is defined by the lower or front side of an organism.
|
2 | Q8BMJ8 (/IMP) Q8BMJ8 (/IMP) |
|
Proximal/distal pattern formation GO:0009954
The regionalization process in which specific areas of cell differentiation are determined along a proximal/distal axis. The proximal/distal axis is defined by a line that runs from main body (proximal end) of an organism outward (distal end).
|
2 | Q8BMJ8 (/IMP) Q8BMJ8 (/IMP) |
|
Regulation of osteoblast proliferation GO:0033688
Any process that modulates the frequency, rate or extent of osteoblast proliferation.
|
2 | F6P1R7 (/IMP) Q6U1J4 (/IMP) |
|
Embryonic pectoral fin morphogenesis GO:0035118
The process, occurring in the embryo, by which the anatomical structures of the pectoral fin are generated and organized. Pectoral fins are bilaterally paired fins mounted laterally and located behind the gill covers of fish. These fins are used for lateral mobility and propulsion.
|
2 | Q6NW96 (/IMP) Q6P0J3 (/IMP) |
|
Regulation of odontogenesis GO:0042481
Any process that modulates the frequency, rate or extent of the formation and development of a tooth or teeth.
|
2 | Q9ESX2 (/IMP) Q9ESX2 (/IMP) |
|
Positive regulation of fibroblast growth factor receptor signaling pathway GO:0045743
Any process that activates or increases the frequency, rate or extent of fibroblast growth factor receptor signaling pathway activity.
|
2 | Q6NW96 (/IMP) Q6P0J3 (/IMP) |
|
Positive regulation of transcription by RNA polymerase II GO:0045944
Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
|
2 | Q8VI67 (/ISO) Q8VI67 (/ISO) |
|
Hematopoietic stem cell differentiation GO:0060218
The process in which a relatively unspecialized cell acquires specialized features of a hematopoietic stem cell. A stem cell is a cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into specialized cells.
|
2 | Q8TDD2 (/IDA) Q8TDD2 (/IDA) |
|
Hematopoietic stem cell differentiation GO:0060218
The process in which a relatively unspecialized cell acquires specialized features of a hematopoietic stem cell. A stem cell is a cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into specialized cells.
|
2 | Q8VI67 (/ISO) Q8VI67 (/ISO) |
|
Cranial suture morphogenesis GO:0060363
The process in which any suture between cranial bones is generated and organized.
|
2 | F6P1R7 (/IMP) Q6U1J4 (/IMP) |
|
Dentinogenesis GO:0097187
The process whose specific outcome is the formation of dentin, the mineralized tissue that constitutes the major bulk of teeth. Dentin may be one of three types: primary dentin, secondary dentin, and tertiary dentin.
|
2 | F6P1R7 (/IMP) Q6U1J4 (/IMP) |
|
Positive regulation of stem cell differentiation GO:2000738
Any process that activates or increases the frequency, rate or extent of stem cell differentiation.
|
2 | Q8TDD2 (/IDA) Q8TDD2 (/IDA) |
|
Positive regulation of stem cell differentiation GO:2000738
Any process that activates or increases the frequency, rate or extent of stem cell differentiation.
|
2 | Q8VI67 (/ISO) Q8VI67 (/ISO) |
|
Negative regulation of transcription by RNA polymerase II GO:0000122
Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.
|
1 | Q24266 (/IMP) |
|
Cephalic furrow formation GO:0007376
Formation of a partial necklace of inturning tissue on the lateral sides of the embryo, along the dorsal-ventral axis. This furrow demarcates head from thorax in the developing protostome.
|
1 | Q24266 (/IMP) |
|
Anterior head segmentation GO:0035288
Partitioning the insect head anlage into procephalic (labral, (ocular), antennal and intercalary) segments. The procephalic segments lie anterior to the gnathal (posterior head) segments, and are pattered by different segmentation gene cascades to the abdominal, thoracic and posterior head (gnathal) segments.
|
1 | Q24266 (/TAS) |
|
Posterior head segmentation GO:0035289
Partitioning the posterior region of the insect head anlage into gnathal (mandibular, maxillary and labial) segments. Unlike the anterior head (procephalic) segments, formation of the posterior head (gnathal) segments occurs by a similar mechanism to trunk segmentation, where a cascade of gap genes, pair-rule genes and segment-polarity genes subdivide the embryo into progressively smaller domains.
|
1 | Q24266 (/TAS) |
|
Regulation of neuron differentiation GO:0045664
Any process that modulates the frequency, rate or extent of neuron differentiation.
|
1 | Q24266 (/IGI) |
|
Regulation of neuroblast proliferation GO:1902692
Any process that modulates the frequency, rate or extent of neuroblast proliferation.
|
1 | Q24266 (/IGI) |
There are 10 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
8 | A0A0B4KHC8 (/IDA) D3ZT88 (/IDA) Q2XXX8 (/IDA) Q8TDD2 (/IDA) Q8TDD2 (/IDA) Q8VI67 (/IDA) Q8VI67 (/IDA) Q9VCB2 (/IDA) |
|
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
5 | A8JUN6 (/ISS) M9PJG1 (/ISS) Q8IRM5 (/ISS) Q9U1K4 (/ISS) R9PY21 (/ISS) |
|
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
4 | Q8VI67 (/ISO) Q8VI67 (/ISO) Q9ESX2 (/ISO) Q9ESX2 (/ISO) |
|
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
|
4 | Q8TDD2 (/IDA) Q8TDD2 (/IDA) Q8VI67 (/IDA) Q8VI67 (/IDA) |
|
Polytene chromosome band GO:0005704
A stretch of densely packed chromatin along the polytene chromosome, visible as a morphologically distinct band.
|
3 | A0A0B4KHC8 (/IDA) Q2XXX8 (/IDA) Q9VCB2 (/IDA) |
|
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
|
2 | Q8VI67 (/TAS) Q8VI67 (/TAS) |
|
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
|
2 | Q8VI67 (/ISO) Q8VI67 (/ISO) |
|
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
2 | Q9ESX2 (/ISO) Q9ESX2 (/ISO) |
|
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
1 | A0A0B4KHC8 (/HDA) |
|
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
1 | D3ZT88 (/IDA) |
