The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Classic Zinc Finger
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 662: RE1-silencing transcription factor A

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 31 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
RNA polymerase II proximal promoter sequence-specific DNA binding GO:0000978
Interacting selectively and non-covalently with a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in the proximal promoter of a gene transcribed by RNA polymerase II. The proximal promoter is in cis with and relatively close to the core promoter.
6 D2H8J0 (/ISS) E1BCT1 (/ISS) F1PP47 (/ISS) F1RTW1 (/ISS) O54963 (/ISS) Q8VIG1 (/ISS)
Chromatin binding GO:0003682
Interacting selectively and non-covalently with chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase.
6 D2H8J0 (/ISS) E1BCT1 (/ISS) F1PP47 (/ISS) F1RTW1 (/ISS) O54963 (/ISS) Q13127 (/ISS)
Transcription regulatory region DNA binding GO:0044212
Interacting selectively and non-covalently with a DNA region that regulates the transcription of a region of DNA, which may be a gene, cistron, or operon. Binding may occur as a sequence specific interaction or as an interaction observed only once a factor has been recruited to the DNA by other factors.
6 D2H8J0 (/ISS) E1BCT1 (/ISS) F1PP47 (/ISS) F1RTW1 (/ISS) O54963 (/ISS) Q8VIG1 (/ISS)
DNA-binding transcription factor activity GO:0003700
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
5 D2H8J0 (/ISS) E1BCT1 (/ISS) F1PP47 (/ISS) F1RTW1 (/ISS) Q8VIG1 (/ISS)
DNA-binding transcription repressor activity, RNA polymerase II-specific GO:0001227
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to repress or decrease transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
4 D2H8J0 (/ISS) E1BCT1 (/ISS) F1PP47 (/ISS) F1RTW1 (/ISS)
DNA-binding transcription repressor activity, RNA polymerase II-specific GO:0001227
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to repress or decrease transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
3 O54963 (/IDA) Q13127 (/IDA) Q8VIG1 (/IDA)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
3 O54963 (/IPI) Q13127 (/IPI) Q8VIG1 (/IPI)
DNA binding GO:0003677
Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
2 O54963 (/IDA) Q8VIG1 (/IDA)
DNA-binding transcription factor activity GO:0003700
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
2 O54963 (/IDA) Q13127 (/IDA)
Transcription factor binding GO:0008134
Interacting selectively and non-covalently with a transcription factor, a protein required to initiate or regulate transcription.
2 O54963 (/IPI) Q13127 (/IPI)
Sequence-specific DNA binding GO:0043565
Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding.
2 O54963 (/IDA) Q8VIG1 (/IDA)
Transcription regulatory region sequence-specific DNA binding GO:0000976
Interacting selectively and non-covalently with a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon.
1 Q8VIG1 (/IDA)
Transcription regulatory region sequence-specific DNA binding GO:0000976
Interacting selectively and non-covalently with a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon.
1 O54963 (/ISS)
RNA polymerase II proximal promoter sequence-specific DNA binding GO:0000978
Interacting selectively and non-covalently with a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in the proximal promoter of a gene transcribed by RNA polymerase II. The proximal promoter is in cis with and relatively close to the core promoter.
1 Q13127 (/IDA)
RNA polymerase II proximal promoter sequence-specific DNA binding GO:0000978
Interacting selectively and non-covalently with a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in the proximal promoter of a gene transcribed by RNA polymerase II. The proximal promoter is in cis with and relatively close to the core promoter.
1 Q8VIG1 (/ISO)
RNA polymerase II core promoter sequence-specific DNA binding GO:0000979
Interacting selectively and non-covalently with a DNA sequence that is part of the core promoter of a RNA polymerase II-transcribed gene.
1 Q8VIG1 (/IDA)
DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
1 Q13127 (/ISA)
DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
1 Q13127 (/NAS)
DNA-binding transcription repressor activity, RNA polymerase II-specific GO:0001227
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to repress or decrease transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
1 Q8VIG1 (/ISO)
DNA-binding transcription activator activity, RNA polymerase II-specific GO:0001228
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to activate or increase transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
1 Q8VIG1 (/IDA)
DNA binding GO:0003677
Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
1 Q8VIG1 (/ISO)
Chromatin binding GO:0003682
Interacting selectively and non-covalently with chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase.
1 Q8VIG1 (/IDA)
DNA-binding transcription factor activity GO:0003700
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
1 Q8VIG1 (/ISO)
DNA-binding transcription factor activity GO:0003700
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
1 O54963 (/TAS)
Transcription factor binding GO:0008134
Interacting selectively and non-covalently with a transcription factor, a protein required to initiate or regulate transcription.
1 Q8VIG1 (/ISO)
Sequence-specific DNA binding GO:0043565
Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding.
1 Q8VIG1 (/ISO)
Sequence-specific DNA binding GO:0043565
Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding.
1 O54963 (/ISS)
Transcription regulatory region DNA binding GO:0044212
Interacting selectively and non-covalently with a DNA region that regulates the transcription of a region of DNA, which may be a gene, cistron, or operon. Binding may occur as a sequence specific interaction or as an interaction observed only once a factor has been recruited to the DNA by other factors.
1 Q13127 (/IDA)
Transcription regulatory region DNA binding GO:0044212
Interacting selectively and non-covalently with a DNA region that regulates the transcription of a region of DNA, which may be a gene, cistron, or operon. Binding may occur as a sequence specific interaction or as an interaction observed only once a factor has been recruited to the DNA by other factors.
1 Q8VIG1 (/ISO)
Protein-containing complex binding GO:0044877
Interacting selectively and non-covalently with a macromolecular complex.
1 O54963 (/IDA)
Protein-containing complex binding GO:0044877
Interacting selectively and non-covalently with a macromolecular complex.
1 Q8VIG1 (/ISO)

There are 106 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Negative regulation of cell population proliferation GO:0008285
Any process that stops, prevents or reduces the rate or extent of cell proliferation.
6 D2H8J0 (/ISS) E1BCT1 (/ISS) F1PP47 (/ISS) F1RTW1 (/ISS) O54963 (/ISS) Q8VIG1 (/ISS)
Negative regulation of gene expression GO:0010629
Any process that decreases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
6 D2H8J0 (/ISS) E1BCT1 (/ISS) F1PP47 (/ISS) F1RTW1 (/ISS) O54963 (/ISS) Q8VIG1 (/ISS)
Cellular response to drug GO:0035690
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a drug stimulus. A drug is a substance used in the diagnosis, treatment or prevention of a disease.
6 D2H8J0 (/ISS) E1BCT1 (/ISS) F1PP47 (/ISS) F1RTW1 (/ISS) O54963 (/ISS) Q8VIG1 (/ISS)
Positive regulation of apoptotic process GO:0043065
Any process that activates or increases the frequency, rate or extent of cell death by apoptotic process.
6 D2H8J0 (/ISS) E1BCT1 (/ISS) F1PP47 (/ISS) F1RTW1 (/ISS) O54963 (/ISS) Q8VIG1 (/ISS)
Positive regulation of cysteine-type endopeptidase activity involved in apoptotic process GO:0043280
Any process that activates or increases the activity of a cysteine-type endopeptidase involved in the apoptotic process.
6 D2H8J0 (/ISS) E1BCT1 (/ISS) F1PP47 (/ISS) F1RTW1 (/ISS) O54963 (/ISS) Q8VIG1 (/ISS)
Negative regulation by host of viral transcription GO:0043922
Any process in which a host organism stops, prevents, or reduces the frequency, rate or extent of viral transcription.
6 D2H8J0 (/ISS) E1BCT1 (/ISS) F1PP47 (/ISS) F1RTW1 (/ISS) O54963 (/ISS) Q8VIG1 (/ISS)
Negative regulation of neuron differentiation GO:0045665
Any process that stops, prevents, or reduces the frequency, rate or extent of neuron differentiation.
6 D2H8J0 (/ISS) E1BCT1 (/ISS) F1PP47 (/ISS) F1RTW1 (/ISS) O54963 (/ISS) Q8VIG1 (/ISS)
Negative regulation of transcription, DNA-templated GO:0045892
Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.
6 D2H8J0 (/ISS) E1BCT1 (/ISS) F1PP47 (/ISS) F1RTW1 (/ISS) Q2EI21 (/ISS) Q9PVG3 (/ISS)
Negative regulation of calcium ion-dependent exocytosis GO:0045955
Any process that stops, prevents, or reduces the frequency, rate or extent of calcium ion-dependent exocytosis.
6 D2H8J0 (/ISS) E1BCT1 (/ISS) F1PP47 (/ISS) F1RTW1 (/ISS) Q13127 (/ISS) Q8VIG1 (/ISS)
Negative regulation of insulin secretion GO:0046676
Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of insulin.
6 D2H8J0 (/ISS) E1BCT1 (/ISS) F1PP47 (/ISS) F1RTW1 (/ISS) O54963 (/ISS) Q8VIG1 (/ISS)
Negative regulation of neurogenesis GO:0050768
Any process that stops, prevents, or reduces the frequency, rate or extent of neurogenesis, the generation of cells within the nervous system.
6 D2H8J0 (/ISS) E1BCT1 (/ISS) F1PP47 (/ISS) F1RTW1 (/ISS) O54963 (/ISS) Q13127 (/ISS)
Cardiac muscle cell myoblast differentiation GO:0060379
The process in which a relatively unspecialized cell acquires specialized features of a cardiac myoblast. A cardiac myoblast is a precursor cell that has been committed to a cardiac muscle cell fate but retains the ability to divide and proliferate throughout life.
6 D2H8J0 (/ISS) E1BCT1 (/ISS) F1PP47 (/ISS) F1RTW1 (/ISS) O54963 (/ISS) Q13127 (/ISS)
Histone H4 deacetylation GO:0070933
The modification of histone H4 by the removal of one or more acetyl groups.
6 D2H8J0 (/ISS) E1BCT1 (/ISS) F1PP47 (/ISS) F1RTW1 (/ISS) O54963 (/ISS) Q8VIG1 (/ISS)
Cellular response to electrical stimulus GO:0071257
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an electrical stimulus.
6 D2H8J0 (/ISS) E1BCT1 (/ISS) F1PP47 (/ISS) F1RTW1 (/ISS) O54963 (/ISS) Q8VIG1 (/ISS)
Cellular response to glucocorticoid stimulus GO:0071385
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glucocorticoid stimulus. Glucocorticoids are hormonal C21 corticosteroids synthesized from cholesterol with the ability to bind with the cortisol receptor and trigger similar effects. Glucocorticoids act primarily on carbohydrate and protein metabolism, and have anti-inflammatory effects.
6 D2H8J0 (/ISS) E1BCT1 (/ISS) F1PP47 (/ISS) F1RTW1 (/ISS) O54963 (/ISS) Q8VIG1 (/ISS)
Negative regulation of dense core granule biogenesis GO:2000706
Any process that stops, prevents or reduces the frequency, rate or extent of dense core granule biogenesis.
6 D2H8J0 (/ISS) E1BCT1 (/ISS) F1PP47 (/ISS) F1RTW1 (/ISS) Q13127 (/ISS) Q8VIG1 (/ISS)
Negative regulation of amniotic stem cell differentiation GO:2000798
Any process that stops, prevents or reduces the frequency, rate or extent of amniotic stem cell differentiation.
6 D2H8J0 (/ISS) E1BCT1 (/ISS) F1PP47 (/ISS) F1RTW1 (/ISS) O54963 (/ISS) Q8VIG1 (/ISS)
Negative regulation of aldosterone biosynthetic process GO:0032348
Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of aldosterone.
5 D2H8J0 (/ISS) E1BCT1 (/ISS) F1PP47 (/ISS) F1RTW1 (/ISS) Q8VIG1 (/ISS)
Negative regulation of cortisol biosynthetic process GO:2000065
Any process that stops, prevents, or reduces the frequency, rate or extent of cortisol biosynthetic process.
5 D2H8J0 (/ISS) E1BCT1 (/ISS) F1PP47 (/ISS) F1RTW1 (/ISS) Q8VIG1 (/ISS)
Regulation of alternative mRNA splicing, via spliceosome GO:0000381
Any process that modulates the frequency, rate or extent of alternative splicing of nuclear mRNAs.
4 O54963 (/ISS) Q13127 (/ISS) Q2EI21 (/ISS) Q9PVG3 (/ISS)
Response to hypoxia GO:0001666
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level.
4 O54963 (/ISS) Q2EI21 (/ISS) Q8VIG1 (/ISS) Q9PVG3 (/ISS)
Positive regulation of neuron differentiation GO:0045666
Any process that activates or increases the frequency, rate or extent of neuron differentiation.
4 O54963 (/ISS) Q13127 (/ISS) Q2EI21 (/ISS) Q9PVG3 (/ISS)
Regulation of osteoblast differentiation GO:0045667
Any process that modulates the frequency, rate or extent of osteoblast differentiation.
4 O54963 (/ISS) Q13127 (/ISS) Q2EI21 (/ISS) Q9PVG3 (/ISS)
Negative regulation of gene expression GO:0010629
Any process that decreases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
3 O54963 (/IMP) Q13127 (/IMP) Q8VIG1 (/IMP)
Negative regulation of neuron differentiation GO:0045665
Any process that stops, prevents, or reduces the frequency, rate or extent of neuron differentiation.
3 O54963 (/IMP) Q13127 (/IMP) Q8VIG1 (/IMP)
Negative regulation of transcription, DNA-templated GO:0045892
Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.
3 O54963 (/IDA) Q13127 (/IDA) Q8VIG1 (/IDA)
Negative regulation of transcription, DNA-templated GO:0045892
Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.
3 O54963 (/IMP) Q13127 (/IMP) Q8VIG1 (/IMP)
Response to ischemia GO:0002931
Any process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a inadequate blood supply.
2 Q13127 (/ISS) Q8VIG1 (/ISS)
Negative regulation of aldosterone biosynthetic process GO:0032348
Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of aldosterone.
2 O54963 (/IMP) Q13127 (/IMP)
Somatic stem cell population maintenance GO:0035019
Any process by which an organism retains a population of somatic stem cells, undifferentiated cells in the embryo or adult which can undergo unlimited division and give rise to cell types of the body other than those of the germ-line.
2 O54963 (/ISS) Q13127 (/ISS)
Negative regulation of neuron differentiation GO:0045665
Any process that stops, prevents, or reduces the frequency, rate or extent of neuron differentiation.
2 Q13127 (/IDA) Q8VIG1 (/IDA)
Neuronal stem cell population maintenance GO:0097150
Any process in by an organism or tissue maintains a population of neuronal stem cells.
2 O54963 (/ISS) Q13127 (/ISS)
Modification of synaptic structure GO:0099563
Any process that modifies the structure/morphology of a synapse.
2 Q13127 (/ISS) Q8VIG1 (/ISS)
Positive regulation of stem cell population maintenance GO:1902459
Any process that activates or increases the frequency, rate or extent of stem cell population maintenance.
2 O54963 (/ISS) Q8VIG1 (/ISS)
Regulation of oxidative stress-induced neuron death GO:1903203
Any process that modulates the frequency, rate or extent of oxidative stress-induced neuron death.
2 Q13127 (/ISS) Q8VIG1 (/ISS)
Negative regulation of oxidative stress-induced neuron death GO:1903204
Any process that stops, prevents or reduces the frequency, rate or extent of oxidative stress-induced neuron death.
2 O54963 (/ISS) Q8VIG1 (/ISS)
Positive regulation of oxidative stress-induced neuron death GO:1903223
Any process that activates or increases the frequency, rate or extent of oxidative stress-induced neuron death.
2 Q13127 (/ISS) Q8VIG1 (/ISS)
Negative regulation of cortisol biosynthetic process GO:2000065
Any process that stops, prevents, or reduces the frequency, rate or extent of cortisol biosynthetic process.
2 O54963 (/IMP) Q13127 (/IMP)
Negative regulation of transcription by RNA polymerase II GO:0000122
Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.
1 Q13127 (/IDA)
Negative regulation of transcription by RNA polymerase II GO:0000122
Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.
1 O54963 (/IMP)
Negative regulation of transcription by RNA polymerase II GO:0000122
Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.
1 Q8VIG1 (/ISO)
Negative regulation of transcription by RNA polymerase II GO:0000122
Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.
1 Q8VIG1 (/ISS)
Negative regulation of transcription by RNA polymerase II GO:0000122
Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.
1 O54963 (/NAS)
Negative regulation of transcription by RNA polymerase II GO:0000122
Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.
1 Q13127 (/TAS)
Regulation of alternative mRNA splicing, via spliceosome GO:0000381
Any process that modulates the frequency, rate or extent of alternative splicing of nuclear mRNAs.
1 Q8VIG1 (/IMP)
Response to hypoxia GO:0001666
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level.
1 Q13127 (/IDA)
Response to hypoxia GO:0001666
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level.
1 Q8VIG1 (/ISO)
Hematopoietic progenitor cell differentiation GO:0002244
The process in which precursor cell type acquires the specialized features of a hematopoietic progenitor cell, a class of cell types including myeloid progenitor cells and lymphoid progenitor cells.
1 Q8VIG1 (/IMP)
Response to ischemia GO:0002931
Any process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a inadequate blood supply.
1 O54963 (/IDA)
Response to ischemia GO:0002931
Any process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a inadequate blood supply.
1 O54963 (/IEP)
Response to ischemia GO:0002931
Any process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a inadequate blood supply.
1 Q8VIG1 (/ISO)
Regulation of transcription, DNA-templated GO:0006355
Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
1 Q8VIG1 (/ISO)
Regulation of transcription, DNA-templated GO:0006355
Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
1 Q13127 (/NAS)
Negative regulation of cell population proliferation GO:0008285
Any process that stops, prevents or reduces the rate or extent of cell proliferation.
1 Q13127 (/IMP)
Negative regulation of cell population proliferation GO:0008285
Any process that stops, prevents or reduces the rate or extent of cell proliferation.
1 Q8VIG1 (/ISO)
Regulation of gene expression GO:0010468
Any process that modulates the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
1 Q8VIG1 (/IDA)
Negative regulation of gene expression GO:0010629
Any process that decreases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
1 Q8VIG1 (/IDA)
Negative regulation of gene expression GO:0010629
Any process that decreases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
1 Q8VIG1 (/ISO)
Neuron differentiation GO:0030182
The process in which a relatively unspecialized cell acquires specialized features of a neuron.
1 O54963 (/IEP)
Negative regulation of aldosterone biosynthetic process GO:0032348
Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of aldosterone.
1 Q8VIG1 (/ISO)
Somatic stem cell population maintenance GO:0035019
Any process by which an organism retains a population of somatic stem cells, undifferentiated cells in the embryo or adult which can undergo unlimited division and give rise to cell types of the body other than those of the germ-line.
1 Q8VIG1 (/IMP)
Cellular response to drug GO:0035690
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a drug stimulus. A drug is a substance used in the diagnosis, treatment or prevention of a disease.
1 Q13127 (/IMP)
Cellular response to drug GO:0035690
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a drug stimulus. A drug is a substance used in the diagnosis, treatment or prevention of a disease.
1 Q8VIG1 (/ISO)
Positive regulation of apoptotic process GO:0043065
Any process that activates or increases the frequency, rate or extent of cell death by apoptotic process.
1 Q13127 (/IMP)
Positive regulation of apoptotic process GO:0043065
Any process that activates or increases the frequency, rate or extent of cell death by apoptotic process.
1 Q8VIG1 (/ISO)
Positive regulation of cysteine-type endopeptidase activity involved in apoptotic process GO:0043280
Any process that activates or increases the activity of a cysteine-type endopeptidase involved in the apoptotic process.
1 Q13127 (/IMP)
Positive regulation of cysteine-type endopeptidase activity involved in apoptotic process GO:0043280
Any process that activates or increases the activity of a cysteine-type endopeptidase involved in the apoptotic process.
1 Q8VIG1 (/ISO)
Negative regulation by host of viral transcription GO:0043922
Any process in which a host organism stops, prevents, or reduces the frequency, rate or extent of viral transcription.
1 Q13127 (/IDA)
Negative regulation by host of viral transcription GO:0043922
Any process in which a host organism stops, prevents, or reduces the frequency, rate or extent of viral transcription.
1 Q8VIG1 (/ISO)
Negative regulation of neuron differentiation GO:0045665
Any process that stops, prevents, or reduces the frequency, rate or extent of neuron differentiation.
1 Q8VIG1 (/ISO)
Positive regulation of neuron differentiation GO:0045666
Any process that activates or increases the frequency, rate or extent of neuron differentiation.
1 Q8VIG1 (/IMP)
Regulation of osteoblast differentiation GO:0045667
Any process that modulates the frequency, rate or extent of osteoblast differentiation.
1 Q8VIG1 (/IMP)
Negative regulation of transcription, DNA-templated GO:0045892
Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.
1 Q8VIG1 (/ISO)
Negative regulation of transcription, DNA-templated GO:0045892
Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.
1 Q13127 (/NAS)
Positive regulation of transcription, DNA-templated GO:0045893
Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.
1 Q13127 (/IDA)
Positive regulation of transcription, DNA-templated GO:0045893
Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.
1 Q8VIG1 (/ISO)
Negative regulation of calcium ion-dependent exocytosis GO:0045955
Any process that stops, prevents, or reduces the frequency, rate or extent of calcium ion-dependent exocytosis.
1 O54963 (/IMP)
Negative regulation of calcium ion-dependent exocytosis GO:0045955
Any process that stops, prevents, or reduces the frequency, rate or extent of calcium ion-dependent exocytosis.
1 Q8VIG1 (/ISO)
Negative regulation of insulin secretion GO:0046676
Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of insulin.
1 Q13127 (/IMP)
Negative regulation of insulin secretion GO:0046676
Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of insulin.
1 Q8VIG1 (/ISO)
Negative regulation of neurogenesis GO:0050768
Any process that stops, prevents, or reduces the frequency, rate or extent of neurogenesis, the generation of cells within the nervous system.
1 Q8VIG1 (/IGI)
Cardiac muscle cell myoblast differentiation GO:0060379
The process in which a relatively unspecialized cell acquires specialized features of a cardiac myoblast. A cardiac myoblast is a precursor cell that has been committed to a cardiac muscle cell fate but retains the ability to divide and proliferate throughout life.
1 Q8VIG1 (/IDA)
Histone H4 deacetylation GO:0070933
The modification of histone H4 by the removal of one or more acetyl groups.
1 Q13127 (/IDA)
Histone H4 deacetylation GO:0070933
The modification of histone H4 by the removal of one or more acetyl groups.
1 Q8VIG1 (/ISO)
Cellular response to electrical stimulus GO:0071257
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an electrical stimulus.
1 Q13127 (/IMP)
Cellular response to electrical stimulus GO:0071257
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an electrical stimulus.
1 Q8VIG1 (/ISO)
Cellular response to glucocorticoid stimulus GO:0071385
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glucocorticoid stimulus. Glucocorticoids are hormonal C21 corticosteroids synthesized from cholesterol with the ability to bind with the cortisol receptor and trigger similar effects. Glucocorticoids act primarily on carbohydrate and protein metabolism, and have anti-inflammatory effects.
1 Q13127 (/IDA)
Cellular response to glucocorticoid stimulus GO:0071385
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glucocorticoid stimulus. Glucocorticoids are hormonal C21 corticosteroids synthesized from cholesterol with the ability to bind with the cortisol receptor and trigger similar effects. Glucocorticoids act primarily on carbohydrate and protein metabolism, and have anti-inflammatory effects.
1 Q8VIG1 (/ISO)
Neuronal stem cell population maintenance GO:0097150
Any process in by an organism or tissue maintains a population of neuronal stem cells.
1 Q8VIG1 (/IMP)
Modification of synaptic structure GO:0099563
Any process that modifies the structure/morphology of a synapse.
1 O54963 (/IMP)
Modification of synaptic structure GO:0099563
Any process that modifies the structure/morphology of a synapse.
1 Q8VIG1 (/ISO)
Positive regulation of stem cell population maintenance GO:1902459
Any process that activates or increases the frequency, rate or extent of stem cell population maintenance.
1 Q13127 (/IDA)
Positive regulation of stem cell population maintenance GO:1902459
Any process that activates or increases the frequency, rate or extent of stem cell population maintenance.
1 Q8VIG1 (/ISO)
Regulation of oxidative stress-induced neuron death GO:1903203
Any process that modulates the frequency, rate or extent of oxidative stress-induced neuron death.
1 O54963 (/IMP)
Regulation of oxidative stress-induced neuron death GO:1903203
Any process that modulates the frequency, rate or extent of oxidative stress-induced neuron death.
1 Q8VIG1 (/ISO)
Negative regulation of oxidative stress-induced neuron death GO:1903204
Any process that stops, prevents or reduces the frequency, rate or extent of oxidative stress-induced neuron death.
1 Q13127 (/IMP)
Negative regulation of oxidative stress-induced neuron death GO:1903204
Any process that stops, prevents or reduces the frequency, rate or extent of oxidative stress-induced neuron death.
1 Q8VIG1 (/ISO)
Positive regulation of oxidative stress-induced neuron death GO:1903223
Any process that activates or increases the frequency, rate or extent of oxidative stress-induced neuron death.
1 O54963 (/IMP)
Positive regulation of oxidative stress-induced neuron death GO:1903223
Any process that activates or increases the frequency, rate or extent of oxidative stress-induced neuron death.
1 Q8VIG1 (/ISO)
Negative regulation of cortisol biosynthetic process GO:2000065
Any process that stops, prevents, or reduces the frequency, rate or extent of cortisol biosynthetic process.
1 Q8VIG1 (/ISO)
Negative regulation of dense core granule biogenesis GO:2000706
Any process that stops, prevents or reduces the frequency, rate or extent of dense core granule biogenesis.
1 O54963 (/IMP)
Negative regulation of dense core granule biogenesis GO:2000706
Any process that stops, prevents or reduces the frequency, rate or extent of dense core granule biogenesis.
1 Q8VIG1 (/ISO)
Negative regulation of mesenchymal stem cell differentiation GO:2000740
Any process that stops, prevents or reduces the frequency, rate or extent of mesenchymal stem cell differentiation.
1 Q13127 (/IMP)
Negative regulation of mesenchymal stem cell differentiation GO:2000740
Any process that stops, prevents or reduces the frequency, rate or extent of mesenchymal stem cell differentiation.
1 Q8VIG1 (/ISO)
Negative regulation of amniotic stem cell differentiation GO:2000798
Any process that stops, prevents or reduces the frequency, rate or extent of amniotic stem cell differentiation.
1 Q13127 (/IMP)
Negative regulation of amniotic stem cell differentiation GO:2000798
Any process that stops, prevents or reduces the frequency, rate or extent of amniotic stem cell differentiation.
1 Q8VIG1 (/ISO)

There are 17 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
6 D2H8J0 (/ISS) E1BCT1 (/ISS) F1PP47 (/ISS) F1RTW1 (/ISS) Q2EI21 (/ISS) Q9PVG3 (/ISS)
Transcriptional repressor complex GO:0017053
A protein complex that possesses activity that prevents or downregulates transcription.
4 D2H8J0 (/ISS) E1BCT1 (/ISS) F1PP47 (/ISS) F1RTW1 (/ISS)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
3 O54963 (/IDA) Q13127 (/IDA) Q8VIG1 (/IDA)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
3 O54963 (/ISS) Q2EI21 (/ISS) Q9PVG3 (/ISS)
Transcriptional repressor complex GO:0017053
A protein complex that possesses activity that prevents or downregulates transcription.
3 O54963 (/IDA) Q13127 (/IDA) Q8VIG1 (/IDA)
Chromatin GO:0000785
The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome.
1 O54963 (/IDA)
Chromatin GO:0000785
The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome.
1 Q8VIG1 (/ISO)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
1 Q13127 (/IMP)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
1 Q8VIG1 (/ISO)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
1 Q13127 (/NAS)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
1 Q13127 (/TAS)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
1 Q13127 (/IDA)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
1 Q8VIG1 (/ISO)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
1 Q8VIG1 (/IDA)
Transcriptional repressor complex GO:0017053
A protein complex that possesses activity that prevents or downregulates transcription.
1 Q8VIG1 (/ISO)
Protein-containing complex GO:0032991
A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together.
1 O54963 (/IDA)
Protein-containing complex GO:0032991
A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together.
1 Q8VIG1 (/ISO)
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