The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:
"Classic Zinc Finger
".
FunFam 594: Transcription factor HIVEP2
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 9 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Transcription coactivator activity GO:0003713
A protein or a member of a complex that interacts specifically and non-covalently with a DNA-bound DNA-binding transcription factor to activate the transcription of specific genes. Coactivators often act by altering chromatin structure and modifications. For example, one class of transcription coregulators modifies chromatin structure through covalent modification of histones. A second ATP-dependent class modifies the conformation of chromatin. Another type of coregulator activity is the bridging of a DNA-binding transcription factor to the basal transcription machinery. The Mediator complex, which bridges transcription factors and RNA polymerase, is also a transcription coactivator.
|
10 | B5U8M2 (/IMP) B5U8M3 (/IMP) Q22190 (/IMP) Q7JM42 (/IMP) Q7JM43 (/IMP) Q7JM44 (/IMP) Q7JM45 (/IMP) Q7JM46 (/IMP) Q7JM47 (/IMP) Q7JM48 (/IMP) |
|
Transcription corepressor activity GO:0003714
A protein or a member of a complex that interacts specifically and non-covalently with a DNA-bound DNA-binding transcription factor to repress the transcription of specific genes. Corepressors often act by altering chromatin structure and modifications. For example, one class of transcription coregulators modifies chromatin structure through covalent modification of histones. A second ATP-dependent class modifies the conformation of chromatin. A third class occludes DNA-binding transcription factor protein-protein interaction domains. A fourth class of corepressors prevents interactions of DNA bound DNA-binding transcription factor with coactivators.
|
10 | B5U8M2 (/IMP) B5U8M3 (/IMP) Q22190 (/IMP) Q7JM42 (/IMP) Q7JM43 (/IMP) Q7JM44 (/IMP) Q7JM45 (/IMP) Q7JM46 (/IMP) Q7JM47 (/IMP) Q7JM48 (/IMP) |
|
DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
|
6 | A0A0B4KFC0 (/IDA) A1Z8F4 (/IDA) Q0E9C5 (/IDA) Q24107 (/IDA) Q24605 (/IDA) Q8MQL7 (/IDA) |
|
RNA polymerase II activating transcription factor binding GO:0001102
Interacting selectively and non-covalently with an RNA polymerase II transcription activating factor, a protein involved in positive regulation of transcription.
|
6 | A0A0B4KFC0 (/IPI) A1Z8F4 (/IPI) Q0E9C5 (/IPI) Q24107 (/IPI) Q24605 (/IPI) Q8MQL7 (/IPI) |
|
DNA-binding transcription factor activity GO:0003700
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
|
6 | A0A0B4KFC0 (/ISS) A1Z8F4 (/ISS) Q0E9C5 (/ISS) Q24107 (/ISS) Q24605 (/ISS) Q8MQL7 (/ISS) |
|
Transcription coactivator activity GO:0003713
A protein or a member of a complex that interacts specifically and non-covalently with a DNA-bound DNA-binding transcription factor to activate the transcription of specific genes. Coactivators often act by altering chromatin structure and modifications. For example, one class of transcription coregulators modifies chromatin structure through covalent modification of histones. A second ATP-dependent class modifies the conformation of chromatin. Another type of coregulator activity is the bridging of a DNA-binding transcription factor to the basal transcription machinery. The Mediator complex, which bridges transcription factors and RNA polymerase, is also a transcription coactivator.
|
6 | A0A0B4KFC0 (/IDA) A1Z8F4 (/IDA) Q0E9C5 (/IDA) Q24107 (/IDA) Q24605 (/IDA) Q8MQL7 (/IDA) |
|
DNA binding GO:0003677
Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
|
4 | F1M9H4 (/IDA) Q12145 (/IDA) Q12145 (/IDA) Q12145 (/IDA) |
|
Sequence-specific DNA binding GO:0043565
Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding.
|
3 | Q12145 (/HDA) Q12145 (/HDA) Q12145 (/HDA) |
|
Transcription corepressor activity GO:0003714
A protein or a member of a complex that interacts specifically and non-covalently with a DNA-bound DNA-binding transcription factor to repress the transcription of specific genes. Corepressors often act by altering chromatin structure and modifications. For example, one class of transcription coregulators modifies chromatin structure through covalent modification of histones. A second ATP-dependent class modifies the conformation of chromatin. A third class occludes DNA-binding transcription factor protein-protein interaction domains. A fourth class of corepressors prevents interactions of DNA bound DNA-binding transcription factor with coactivators.
|
1 | A0A0B4KFC0 (/IDA) |
There are 31 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Transforming growth factor beta receptor signaling pathway GO:0007179
A series of molecular signals initiated by the binding of an extracellular ligand to a transforming growth factor beta receptor on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription.
|
10 | B5U8M2 (/IGI) B5U8M3 (/IGI) Q22190 (/IGI) Q7JM42 (/IGI) Q7JM43 (/IGI) Q7JM44 (/IGI) Q7JM45 (/IGI) Q7JM46 (/IGI) Q7JM47 (/IGI) Q7JM48 (/IGI) |
|
Positive regulation of multicellular organism growth GO:0040018
Any process that activates or increases the frequency, rate or extent of growth of an organism to reach its usual body size.
|
10 | B5U8M2 (/IMP) B5U8M3 (/IMP) Q22190 (/IMP) Q7JM42 (/IMP) Q7JM43 (/IMP) Q7JM44 (/IMP) Q7JM45 (/IMP) Q7JM46 (/IMP) Q7JM47 (/IMP) Q7JM48 (/IMP) |
|
Nematode male tail tip morphogenesis GO:0045138
The process in which the anatomical structure of the adult male tail tip is generated and organized. In some species of rhabitid nematodes, the male tail tip undergoes a morphological change such that the most posterior hypodermal cells in the tail (hyp8-11 in C. elegans) fuse and retract anteriorly, changing the shape of the tail from a pointed, tapered cone, or spike, to a rounded, blunt dome.
|
10 | B5U8M2 (/IMP) B5U8M3 (/IMP) Q22190 (/IMP) Q7JM42 (/IMP) Q7JM43 (/IMP) Q7JM44 (/IMP) Q7JM45 (/IMP) Q7JM46 (/IMP) Q7JM47 (/IMP) Q7JM48 (/IMP) |
|
Compound eye morphogenesis GO:0001745
The morphogenetic process in which the anatomical structures of the compound eye are generated and organized. The adult compound eye is a precise assembly of 700-800 ommatidia. Each ommatidium is composed of 20 cells, identified by cell type and position. An example of compound eye morphogenesis is found in Drosophila melanogaster.
|
6 | A0A0B4KFC0 (/NAS) A1Z8F4 (/NAS) Q0E9C5 (/NAS) Q24107 (/NAS) Q24605 (/NAS) Q8MQL7 (/NAS) |
|
Dorsal closure GO:0007391
The process during Drosophila embryogenesis whereby the ectodermal cells of the lateral epithelium stretch in a coordinated fashion to internalize the amnioserosa cells and close the embryo dorsally.
|
6 | A0A0B4KFC0 (/TAS) A1Z8F4 (/TAS) Q0E9C5 (/TAS) Q24107 (/TAS) Q24605 (/TAS) Q8MQL7 (/TAS) |
|
Ectoderm development GO:0007398
The process whose specific outcome is the progression of the ectoderm over time, from its formation to the mature structure. In animal embryos, the ectoderm is the outer germ layer of the embryo, formed during gastrulation.
|
6 | A0A0B4KFC0 (/IMP) A1Z8F4 (/IMP) Q0E9C5 (/IMP) Q24107 (/IMP) Q24605 (/IMP) Q8MQL7 (/IMP) |
|
Malpighian tubule morphogenesis GO:0007443
The process in which the anatomical structures of the Malpighian tubule are generated and organized. This process takes place entirely during the embryonic phase. A Malpighian tubule is a fine, thin-walled excretory tubule in insects which leads into the posterior part of the gut.
|
6 | A0A0B4KFC0 (/IMP) A1Z8F4 (/IMP) Q0E9C5 (/IMP) Q24107 (/IMP) Q24605 (/IMP) Q8MQL7 (/IMP) |
|
Midgut development GO:0007494
The process whose specific outcome is the progression of the midgut over time, from its formation to the mature structure. The midgut is the middle part of the alimentary canal from the stomach, or entrance of the bile duct, to, or including, the large intestine.
|
6 | A0A0B4KFC0 (/IMP) A1Z8F4 (/IMP) Q0E9C5 (/IMP) Q24107 (/IMP) Q24605 (/IMP) Q8MQL7 (/IMP) |
|
Negative regulation of salivary gland boundary specification GO:0045705
Any process that stops, prevents, or reduces the frequency, rate or extent of salivary gland determination.
|
6 | A0A0B4KFC0 (/TAS) A1Z8F4 (/TAS) Q0E9C5 (/TAS) Q24107 (/TAS) Q24605 (/TAS) Q8MQL7 (/TAS) |
|
Positive regulation of transcription by RNA polymerase II GO:0045944
Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
|
6 | A0A0B4KFC0 (/IDA) A1Z8F4 (/IDA) Q0E9C5 (/IDA) Q24107 (/IDA) Q24605 (/IDA) Q8MQL7 (/IDA) |
|
Wing disc dorsal/ventral pattern formation GO:0048190
The establishment, maintenance and elaboration of the dorsal/ventral axis of the wing disc, a precursor to the adult wing.
|
6 | A0A0B4KFC0 (/IGI) A1Z8F4 (/IGI) Q0E9C5 (/IGI) Q24107 (/IGI) Q24605 (/IGI) Q8MQL7 (/IGI) |
|
Dendrite morphogenesis GO:0048813
The process in which the anatomical structures of a dendrite are generated and organized.
|
6 | A0A0B4KFC0 (/IMP) A1Z8F4 (/IMP) Q0E9C5 (/IMP) Q24107 (/IMP) Q24605 (/IMP) Q8MQL7 (/IMP) |
|
Negative regulation of transcription by RNA polymerase II GO:0000122
Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.
|
1 | A0A0B4KFC0 (/IDA) |
|
Negative regulation of transcription by RNA polymerase II GO:0000122
Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.
|
1 | A0A0B4KFC0 (/IMP) |
|
Regulation of transcription by RNA polymerase II GO:0006357
Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II.
|
1 | F1M9H4 (/NAS) |
|
Dorsal closure GO:0007391
The process during Drosophila embryogenesis whereby the ectodermal cells of the lateral epithelium stretch in a coordinated fashion to internalize the amnioserosa cells and close the embryo dorsally.
|
1 | A0A0B4KFC0 (/IMP) |
|
Imaginal disc-derived wing morphogenesis GO:0007476
The process in which the anatomical structures of the imaginal disc-derived wing are generated and organized. The wing is an appendage modified for flying.
|
1 | A0A0B4KFC0 (/IGI) |
|
Imaginal disc-derived wing morphogenesis GO:0007476
The process in which the anatomical structures of the imaginal disc-derived wing are generated and organized. The wing is an appendage modified for flying.
|
1 | A0A0B4KFC0 (/IMP) |
|
Mesoderm development GO:0007498
The process whose specific outcome is the progression of the mesoderm over time, from its formation to the mature structure. The mesoderm is the middle germ layer that develops into muscle, bone, cartilage, blood and connective tissue.
|
1 | A0A0B4KFC0 (/IGI) |
|
Cell population proliferation GO:0008283
The multiplication or reproduction of cells, resulting in the expansion of a cell population.
|
1 | A0A0B4KFC0 (/IMP) |
|
Imaginal disc-derived wing vein morphogenesis GO:0008586
The process in which anatomical structures of the veins on an imaginal disc-derived wing are generated and organized.
|
1 | A0A0B4KFC0 (/IMP) |
|
Dorsal/ventral pattern formation GO:0009953
The regionalization process in which the areas along the dorsal/ventral axis are established that will lead to differences in cell differentiation. The dorsal/ventral axis is defined by a line that runs orthogonal to both the anterior/posterior and left/right axes. The dorsal end is defined by the upper or back side of an organism. The ventral end is defined by the lower or front side of an organism.
|
1 | A0A0B4KFC0 (/IMP) |
|
BMP signaling pathway GO:0030509
A series of molecular signals initiated by the binding of a member of the BMP (bone morphogenetic protein) family to a receptor on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription.
|
1 | A0A0B4KFC0 (/IDA) |
|
BMP signaling pathway GO:0030509
A series of molecular signals initiated by the binding of a member of the BMP (bone morphogenetic protein) family to a receptor on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription.
|
1 | A0A0B4KFC0 (/IGI) |
|
BMP signaling pathway GO:0030509
A series of molecular signals initiated by the binding of a member of the BMP (bone morphogenetic protein) family to a receptor on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription.
|
1 | A0A0B4KFC0 (/IMP) |
|
Regulation of mesodermal cell fate specification GO:0042661
Any process that modulates the frequency, rate or extent of mesoderm cell fate specification.
|
1 | B5U8M3 (/IGI) |
|
Regulation of mesodermal cell fate specification GO:0042661
Any process that modulates the frequency, rate or extent of mesoderm cell fate specification.
|
1 | B5U8M3 (/IMP) |
|
Positive regulation of transcription by RNA polymerase II GO:0045944
Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
|
1 | A0A0B4KFC0 (/IMP) |
|
Wing disc anterior/posterior pattern formation GO:0048100
The establishment, maintenance and elaboration of the anterior/posterior axis of the wing disc, a precursor to the wing.
|
1 | A0A0B4KFC0 (/IMP) |
|
Positive regulation of mesodermal cell fate specification GO:0048337
Any process that activates or increases the frequency, rate or extent of mesoderm cell fate specification.
|
1 | B5U8M3 (/IGI) |
|
Positive regulation of mesodermal cell fate specification GO:0048337
Any process that activates or increases the frequency, rate or extent of mesoderm cell fate specification.
|
1 | B5U8M3 (/IMP) |
There are 3 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
16 |
A0A0B4KFC0 (/IDA)
A1Z8F4 (/IDA)
B5U8M2 (/IDA)
B5U8M3 (/IDA)
Q0E9C5 (/IDA)
Q22190 (/IDA)
Q24107 (/IDA)
Q24605 (/IDA)
Q7JM42 (/IDA)
Q7JM43 (/IDA)
(6 more) |
|
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
6 | A0A0B4KFC0 (/NAS) A1Z8F4 (/NAS) Q0E9C5 (/NAS) Q24107 (/NAS) Q24605 (/NAS) Q8MQL7 (/NAS) |
|
RNA polymerase II transcription repressor complex GO:0090571
A protein complex, located in the nucleus, that possesses activity that prevents or downregulates transcription from a RNA polymerase II promoter.
|
1 | A0A0B4KFC0 (/IPI) |
