The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Classic Zinc Finger
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 402: IKAROS family zinc finger 5

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 9 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
RNA polymerase II regulatory region sequence-specific DNA binding GO:0000977
Interacting selectively and non-covalently with a specific sequence of DNA that is part of a regulatory region that controls the transcription of a gene or cistron by RNA polymerase II.
17 Q9H5V7 (/IDA) Q9H5V7 (/IDA) Q9H5V7 (/IDA) Q9H5V7 (/IDA) Q9H5V7 (/IDA) Q9H5V7 (/IDA) Q9H5V7 (/IDA) Q9H5V7 (/IDA) Q9H5V7 (/IDA) Q9H5V7 (/IDA)
(7 more)
DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
17 Q9H5V7 (/ISA) Q9H5V7 (/ISA) Q9H5V7 (/ISA) Q9H5V7 (/ISA) Q9H5V7 (/ISA) Q9H5V7 (/ISA) Q9H5V7 (/ISA) Q9H5V7 (/ISA) Q9H5V7 (/ISA) Q9H5V7 (/ISA)
(7 more)
DNA-binding transcription repressor activity, RNA polymerase II-specific GO:0001227
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to repress or decrease transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
17 Q9H5V7 (/IDA) Q9H5V7 (/IDA) Q9H5V7 (/IDA) Q9H5V7 (/IDA) Q9H5V7 (/IDA) Q9H5V7 (/IDA) Q9H5V7 (/IDA) Q9H5V7 (/IDA) Q9H5V7 (/IDA) Q9H5V7 (/IDA)
(7 more)
Zinc ion binding GO:0008270
Interacting selectively and non-covalently with zinc (Zn) ions.
17 Q9H5V7 (/IMP) Q9H5V7 (/IMP) Q9H5V7 (/IMP) Q9H5V7 (/IMP) Q9H5V7 (/IMP) Q9H5V7 (/IMP) Q9H5V7 (/IMP) Q9H5V7 (/IMP) Q9H5V7 (/IMP) Q9H5V7 (/IMP)
(7 more)
Protein domain specific binding GO:0019904
Interacting selectively and non-covalently with a specific domain of a protein.
17 Q9H5V7 (/IPI) Q9H5V7 (/IPI) Q9H5V7 (/IPI) Q9H5V7 (/IPI) Q9H5V7 (/IPI) Q9H5V7 (/IPI) Q9H5V7 (/IPI) Q9H5V7 (/IPI) Q9H5V7 (/IPI) Q9H5V7 (/IPI)
(7 more)
RNA polymerase II regulatory region sequence-specific DNA binding GO:0000977
Interacting selectively and non-covalently with a specific sequence of DNA that is part of a regulatory region that controls the transcription of a gene or cistron by RNA polymerase II.
1 Q8BU00 (/ISO)
DNA-binding transcription repressor activity, RNA polymerase II-specific GO:0001227
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to repress or decrease transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
1 Q8BU00 (/ISO)
Zinc ion binding GO:0008270
Interacting selectively and non-covalently with zinc (Zn) ions.
1 Q8BU00 (/ISO)
Protein domain specific binding GO:0019904
Interacting selectively and non-covalently with a specific domain of a protein.
1 Q8BU00 (/ISO)

There are 8 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Negative regulation of transcription by RNA polymerase II GO:0000122
Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.
17 Q9H5V7 (/IDA) Q9H5V7 (/IDA) Q9H5V7 (/IDA) Q9H5V7 (/IDA) Q9H5V7 (/IDA) Q9H5V7 (/IDA) Q9H5V7 (/IDA) Q9H5V7 (/IDA) Q9H5V7 (/IDA) Q9H5V7 (/IDA)
(7 more)
Protein heterooligomerization GO:0051291
The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of component monomers that are not all identical. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer.
17 Q9H5V7 (/IMP) Q9H5V7 (/IMP) Q9H5V7 (/IMP) Q9H5V7 (/IMP) Q9H5V7 (/IMP) Q9H5V7 (/IMP) Q9H5V7 (/IMP) Q9H5V7 (/IMP) Q9H5V7 (/IMP) Q9H5V7 (/IMP)
(7 more)
Negative regulation of transcription by RNA polymerase II GO:0000122
Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.
1 Q8BU00 (/ISO)
Determination of left/right asymmetry in lateral mesoderm GO:0003140
The establishment of the lateral mesoderm with respect to the left and right halves.
1 Q6DBW0 (/IMP)
Determination of left/right symmetry GO:0007368
The establishment of an organism's body plan or part of an organism with respect to the left and right halves. The pattern can either be symmetric, such that the halves are mirror images, or asymmetric where the pattern deviates from this symmetry.
1 Q6DBW0 (/IMP)
Determination of pancreatic left/right asymmetry GO:0035469
Determination of the asymmetric location of the pancreas with respect to the left and right halves of the organism.
1 Q6DBW0 (/IMP)
Protein heterooligomerization GO:0051291
The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of component monomers that are not all identical. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer.
1 Q8BU00 (/ISO)
Determination of intestine left/right asymmetry GO:0071908
Determination of the asymmetric location of the intestine loops with respect to the left and right halves of the organism.
1 Q6DBW0 (/IMP)

There are 2 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein-containing complex GO:0032991
A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together.
17 Q9H5V7 (/IMP) Q9H5V7 (/IMP) Q9H5V7 (/IMP) Q9H5V7 (/IMP) Q9H5V7 (/IMP) Q9H5V7 (/IMP) Q9H5V7 (/IMP) Q9H5V7 (/IMP) Q9H5V7 (/IMP) Q9H5V7 (/IMP)
(7 more)
Protein-containing complex GO:0032991
A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together.
1 Q8BU00 (/ISO)
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