The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Classic Zinc Finger
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 294: Odd-skipped-related transciption factor 2

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 7 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Sequence-specific DNA binding GO:0043565
Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding.
5 E2QTV1 (/ISS) Q8N2R0 (/ISS) Q8N2R0 (/ISS) Q8N2R0 (/ISS) Q8N2R0 (/ISS)
DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
4 Q8N2R0 (/ISA) Q8N2R0 (/ISA) Q8N2R0 (/ISA) Q8N2R0 (/ISA)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
4 Q8N2R0 (/IPI) Q8N2R0 (/IPI) Q8N2R0 (/IPI) Q8N2R0 (/IPI)
DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
3 Q9VQS7 (/ISS) Q9VQU9 (/ISS) Q9VQU9 (/ISS)
RNA polymerase II regulatory region sequence-specific DNA binding GO:0000977
Interacting selectively and non-covalently with a specific sequence of DNA that is part of a regulatory region that controls the transcription of a gene or cistron by RNA polymerase II.
1 Q91ZD1 (/IDA)
DNA-binding transcription activator activity, RNA polymerase II-specific GO:0001228
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to activate or increase transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
1 Q91ZD1 (/IDA)
Sequence-specific DNA binding GO:0043565
Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding.
1 Q91ZD1 (/IDA)

There are 67 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Positive regulation of transcription, DNA-templated GO:0045893
Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.
8 E2QTV1 (/ISS) Q8N2R0 (/ISS) Q8N2R0 (/ISS) Q8N2R0 (/ISS) Q8N2R0 (/ISS) Q9VQS7 (/ISS) Q9VQU9 (/ISS) Q9VQU9 (/ISS)
Negative regulation of transcription by RNA polymerase II GO:0000122
Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.
7 Q8N2R0 (/ISS) Q8N2R0 (/ISS) Q8N2R0 (/ISS) Q8N2R0 (/ISS) Q9VQS7 (/ISS) Q9VQU9 (/ISS) Q9VQU9 (/ISS)
Positive regulation of transcription by RNA polymerase II GO:0045944
Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
7 Q8N2R0 (/ISS) Q8N2R0 (/ISS) Q8N2R0 (/ISS) Q8N2R0 (/ISS) Q9VQS7 (/ISS) Q9VQU9 (/ISS) Q9VQU9 (/ISS)
Metanephros development GO:0001656
The process whose specific outcome is the progression of the metanephros over time, from its formation to the mature structure. In mammals, the metanephros is the excretory organ of the fetus, which develops into the mature kidney and is formed from the rear portion of the nephrogenic cord. The metanephros is an endocrine and metabolic organ that filters the blood and excretes the end products of body metabolism in the form of urine.
5 E2QTV1 (/ISS) Q8N2R0 (/ISS) Q8N2R0 (/ISS) Q8N2R0 (/ISS) Q8N2R0 (/ISS)
Mesonephros development GO:0001823
The process whose specific outcome is the progression of the mesonephros over time, from its formation to the mature structure. In mammals, the mesonephros is the second of the three embryonic kidneys to be established and exists only transiently. In lower vertebrates such as fish and amphibia, the mesonephros will form the mature kidney.
5 E2QTV1 (/ISS) Q8N2R0 (/ISS) Q8N2R0 (/ISS) Q8N2R0 (/ISS) Q8N2R0 (/ISS)
Positive regulation of cell population proliferation GO:0008284
Any process that activates or increases the rate or extent of cell proliferation.
5 E2QTV1 (/ISS) Q8N2R0 (/ISS) Q8N2R0 (/ISS) Q8N2R0 (/ISS) Q8N2R0 (/ISS)
Embryo development ending in birth or egg hatching GO:0009792
The process whose specific outcome is the progression of an embryo over time, from zygote formation until the end of the embryonic life stage. The end of the embryonic life stage is organism-specific and may be somewhat arbitrary; for mammals it is usually considered to be birth, for insects the hatching of the first instar larva from the eggshell.
5 E2QTV1 (/ISS) Q8N2R0 (/ISS) Q8N2R0 (/ISS) Q8N2R0 (/ISS) Q8N2R0 (/ISS)
Positive regulation of gene expression GO:0010628
Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
5 E2QTV1 (/ISS) Q8N2R0 (/ISS) Q8N2R0 (/ISS) Q8N2R0 (/ISS) Q8N2R0 (/ISS)
Osteoblast proliferation GO:0033687
The multiplication or reproduction of osteoblasts, resulting in the expansion of an osteoblast cell population. An osteoblast is a bone-forming cell which secretes an extracellular matrix. Hydroxyapatite crystals are then deposited into the matrix to form bone.
5 E2QTV1 (/ISS) Q8N2R0 (/ISS) Q8N2R0 (/ISS) Q8N2R0 (/ISS) Q8N2R0 (/ISS)
Middle ear morphogenesis GO:0042474
The process in which the anatomical structures of the middle ear are generated and organized. The middle ear is the air-filled cavity within the skull of vertebrates that lies between the outer ear and the inner ear. It is linked to the pharynx (and therefore to outside air) via the Eustachian tube and in mammals contains the three ear ossicles, which transmit auditory vibrations from the outer ear (via the tympanum) to the inner ear (via the oval window).
5 E2QTV1 (/ISS) Q8N2R0 (/ISS) Q8N2R0 (/ISS) Q8N2R0 (/ISS) Q8N2R0 (/ISS)
Odontogenesis GO:0042476
The process whose specific outcome is the progression of a tooth or teeth over time, from formation to the mature structure(s). A tooth is any hard bony, calcareous, or chitinous organ found in the mouth or pharynx of an animal and used in procuring or masticating food.
5 E2QTV1 (/ISS) Q8N2R0 (/ISS) Q8N2R0 (/ISS) Q8N2R0 (/ISS) Q8N2R0 (/ISS)
Embryonic skeletal system morphogenesis GO:0048704
The process in which the anatomical structures of the skeleton are generated and organized during the embryonic phase.
5 E2QTV1 (/ISS) Q8N2R0 (/ISS) Q8N2R0 (/ISS) Q8N2R0 (/ISS) Q8N2R0 (/ISS)
Positive regulation of epithelial cell proliferation GO:0050679
Any process that activates or increases the rate or extent of epithelial cell proliferation.
5 E2QTV1 (/ISS) Q8N2R0 (/ISS) Q8N2R0 (/ISS) Q8N2R0 (/ISS) Q8N2R0 (/ISS)
Roof of mouth development GO:0060021
The biological process whose specific outcome is the progression of the roof of the mouth from an initial condition to its mature state. This process begins with the formation of the structure and ends with the mature structure. The roof of the mouth is the partition that separates the nasal and oral cavities.
5 E2QTV1 (/ISS) Q8N2R0 (/ISS) Q8N2R0 (/ISS) Q8N2R0 (/ISS) Q8N2R0 (/ISS)
Bone morphogenesis GO:0060349
The process in which bones are generated and organized.
5 E2QTV1 (/ISS) Q8N2R0 (/ISS) Q8N2R0 (/ISS) Q8N2R0 (/ISS) Q8N2R0 (/ISS)
Eyelid development in camera-type eye GO:0061029
The progression of the eyelid in a camera-type eye from its formation to the mature state. The eyelid is a membranous cover that helps protect and lubricate the eye.
5 E2QTV1 (/ISS) Q8N2R0 (/ISS) Q8N2R0 (/ISS) Q8N2R0 (/ISS) Q8N2R0 (/ISS)
Chondrocyte differentiation GO:0002062
The process in which a chondroblast acquires specialized structural and/or functional features of a chondrocyte. A chondrocyte is a polymorphic cell that forms cartilage.
4 Q8N2R0 (/ISS) Q8N2R0 (/ISS) Q8N2R0 (/ISS) Q8N2R0 (/ISS)
Cell differentiation GO:0030154
The process in which relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state.
4 Q8N2R0 (/ISS) Q8N2R0 (/ISS) Q8N2R0 (/ISS) Q8N2R0 (/ISS)
Positive regulation of bone mineralization GO:0030501
Any process that activates or increases the frequency, rate or extent of bone mineralization.
4 Q8N2R0 (/ISS) Q8N2R0 (/ISS) Q8N2R0 (/ISS) Q8N2R0 (/ISS)
Embryonic forelimb morphogenesis GO:0035115
The process, occurring in the embryo, by which the anatomical structures of the forelimb are generated and organized. The forelimbs are the front limbs of an animal, e.g. the arms of a human.
4 Q8N2R0 (/ISS) Q8N2R0 (/ISS) Q8N2R0 (/ISS) Q8N2R0 (/ISS)
Embryonic hindlimb morphogenesis GO:0035116
The process, occurring in the embryo, by which the anatomical structures of the hindlimbs are generated and organized. The hindlimbs are the posterior limbs of an animal.
4 Q8N2R0 (/ISS) Q8N2R0 (/ISS) Q8N2R0 (/ISS) Q8N2R0 (/ISS)
Embryonic skeletal limb joint morphogenesis GO:0036023
The process, occurring in the embryo, in which the anatomical structures of a skeletal limb joint are generated and organized. A skeletal limb joint is the connecting structure between the bones of a limb.
4 Q8N2R0 (/ISS) Q8N2R0 (/ISS) Q8N2R0 (/ISS) Q8N2R0 (/ISS)
Embryonic digit morphogenesis GO:0042733
The process, occurring in the embryo, by which the anatomical structures of the digit are generated and organized. A digit is one of the terminal divisions of an appendage, such as a finger or toe.
4 Q8N2R0 (/ISS) Q8N2R0 (/ISS) Q8N2R0 (/ISS) Q8N2R0 (/ISS)
Embryonic skeletal joint morphogenesis GO:0060272
The process in which the anatomical structures of skeletal joints are generated and organized during the embryonic phase. A skeletal joint is the connecting structure between the bones of the skeleton.
4 Q8N2R0 (/ISS) Q8N2R0 (/ISS) Q8N2R0 (/ISS) Q8N2R0 (/ISS)
Head development GO:0060322
The biological process whose specific outcome is the progression of a head from an initial condition to its mature state. The head is the anterior-most division of the body.
4 Q8N2R0 (/ISS) Q8N2R0 (/ISS) Q8N2R0 (/ISS) Q8N2R0 (/ISS)
Embryonic skeletal joint development GO:0072498
The process, occurring during the embryonic phase, whose specific outcome is the progression of the skeletal joints over time, from formation to mature structure.
4 Q8N2R0 (/ISS) Q8N2R0 (/ISS) Q8N2R0 (/ISS) Q8N2R0 (/ISS)
Imaginal disc-derived leg joint morphogenesis GO:0016348
The process in which the anatomical structures of an imaginal disc-derived leg joint are generated and organized. The leg joint is a flexible region that separates the rigid sections of a leg to allow movement in a controlled manner. An example of this is found in Drosophila melanogaster.
3 Q9VQS7 (/IMP) Q9VQU9 (/IMP) Q9VQU9 (/IMP)
Negative regulation of transcription, DNA-templated GO:0045892
Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.
3 Q9VQS7 (/ISS) Q9VQU9 (/ISS) Q9VQU9 (/ISS)
Terminal region determination GO:0007362
Specification of the terminal regions (the two non-segmented ends) of the embryo by the gap genes; exemplified in insects by the actions of huckebein and tailless gene products.
2 Q9VQU9 (/IMP) Q9VQU9 (/IMP)
Hindgut morphogenesis GO:0007442
The process in which the anatomical structures of the hindgut are generated and organized.
2 Q9VQU9 (/IMP) Q9VQU9 (/IMP)
Imaginal disc-derived leg morphogenesis GO:0007480
The process in which the anatomical structures of a leg derived from an imaginal disc are generated and organized. A leg is a limb on which an animal walks and stands. An example of this is found in Drosophila melanogaster.
2 Q9VQU9 (/IMP) Q9VQU9 (/IMP)
Embryonic pattern specification GO:0009880
The process that results in the patterns of cell differentiation that will arise in an embryo.
2 Q9VQU9 (/IMP) Q9VQU9 (/IMP)
Wing disc development GO:0035220
Progression of the wing disc over time, from its initial formation through to its metamorphosis to form adult structures including the wing hinge, wing blade and pleura.
2 Q9VQU9 (/IMP) Q9VQU9 (/IMP)
Embryonic foregut morphogenesis GO:0048617
The process in which the anatomical structures of the foregut are generated and organized, during the embryonic phase.
2 Q9VQU9 (/IMP) Q9VQU9 (/IMP)
Embryonic hindgut morphogenesis GO:0048619
The process in which the anatomical structures of the hindgut are generated and organized, during the embryonic phase.
2 Q9VQU9 (/IMP) Q9VQU9 (/IMP)
Negative regulation of transcription by RNA polymerase II GO:0000122
Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.
1 Q91ZD1 (/IGI)
Metanephros development GO:0001656
The process whose specific outcome is the progression of the metanephros over time, from its formation to the mature structure. In mammals, the metanephros is the excretory organ of the fetus, which develops into the mature kidney and is formed from the rear portion of the nephrogenic cord. The metanephros is an endocrine and metabolic organ that filters the blood and excretes the end products of body metabolism in the form of urine.
1 Q91ZD1 (/IEP)
Mesonephros development GO:0001823
The process whose specific outcome is the progression of the mesonephros over time, from its formation to the mature structure. In mammals, the mesonephros is the second of the three embryonic kidneys to be established and exists only transiently. In lower vertebrates such as fish and amphibia, the mesonephros will form the mature kidney.
1 Q91ZD1 (/IEP)
Chondrocyte differentiation GO:0002062
The process in which a chondroblast acquires specialized structural and/or functional features of a chondrocyte. A chondrocyte is a polymorphic cell that forms cartilage.
1 Q91ZD1 (/IGI)
Regulation of transcription, DNA-templated GO:0006355
Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
1 Q9VQS7 (/ISS)
Blastoderm segmentation GO:0007350
The hierarchical steps resulting in the progressive subdivision of the anterior/posterior axis of the embryo.
1 Q9VQS7 (/ISS)
Periodic partitioning by pair rule gene GO:0007366
Allocation of cells to parasegments in the embryo, through the action of overlapping series of pair rule gene activities.
1 Q9VQS7 (/ISS)
Positive regulation of cell population proliferation GO:0008284
Any process that activates or increases the rate or extent of cell proliferation.
1 Q91ZD1 (/IMP)
Embryo development ending in birth or egg hatching GO:0009792
The process whose specific outcome is the progression of an embryo over time, from zygote formation until the end of the embryonic life stage. The end of the embryonic life stage is organism-specific and may be somewhat arbitrary; for mammals it is usually considered to be birth, for insects the hatching of the first instar larva from the eggshell.
1 Q91ZD1 (/IEP)
Positive regulation of gene expression GO:0010628
Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
1 Q91ZD1 (/IMP)
Cell differentiation GO:0030154
The process in which relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state.
1 Q91ZD1 (/IGI)
Positive regulation of bone mineralization GO:0030501
Any process that activates or increases the frequency, rate or extent of bone mineralization.
1 Q91ZD1 (/IGI)
Osteoblast proliferation GO:0033687
The multiplication or reproduction of osteoblasts, resulting in the expansion of an osteoblast cell population. An osteoblast is a bone-forming cell which secretes an extracellular matrix. Hydroxyapatite crystals are then deposited into the matrix to form bone.
1 Q91ZD1 (/IMP)
Embryonic forelimb morphogenesis GO:0035115
The process, occurring in the embryo, by which the anatomical structures of the forelimb are generated and organized. The forelimbs are the front limbs of an animal, e.g. the arms of a human.
1 Q91ZD1 (/IEP)
Embryonic forelimb morphogenesis GO:0035115
The process, occurring in the embryo, by which the anatomical structures of the forelimb are generated and organized. The forelimbs are the front limbs of an animal, e.g. the arms of a human.
1 Q91ZD1 (/IGI)
Embryonic hindlimb morphogenesis GO:0035116
The process, occurring in the embryo, by which the anatomical structures of the hindlimbs are generated and organized. The hindlimbs are the posterior limbs of an animal.
1 Q91ZD1 (/IEP)
Embryonic hindlimb morphogenesis GO:0035116
The process, occurring in the embryo, by which the anatomical structures of the hindlimbs are generated and organized. The hindlimbs are the posterior limbs of an animal.
1 Q91ZD1 (/IGI)
Embryonic skeletal limb joint morphogenesis GO:0036023
The process, occurring in the embryo, in which the anatomical structures of a skeletal limb joint are generated and organized. A skeletal limb joint is the connecting structure between the bones of a limb.
1 Q91ZD1 (/IGI)
Middle ear morphogenesis GO:0042474
The process in which the anatomical structures of the middle ear are generated and organized. The middle ear is the air-filled cavity within the skull of vertebrates that lies between the outer ear and the inner ear. It is linked to the pharynx (and therefore to outside air) via the Eustachian tube and in mammals contains the three ear ossicles, which transmit auditory vibrations from the outer ear (via the tympanum) to the inner ear (via the oval window).
1 Q91ZD1 (/IMP)
Odontogenesis GO:0042476
The process whose specific outcome is the progression of a tooth or teeth over time, from formation to the mature structure(s). A tooth is any hard bony, calcareous, or chitinous organ found in the mouth or pharynx of an animal and used in procuring or masticating food.
1 Q91ZD1 (/IMP)
Embryonic digit morphogenesis GO:0042733
The process, occurring in the embryo, by which the anatomical structures of the digit are generated and organized. A digit is one of the terminal divisions of an appendage, such as a finger or toe.
1 Q91ZD1 (/IGI)
Positive regulation of transcription, DNA-templated GO:0045893
Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.
1 Q91ZD1 (/IMP)
Positive regulation of transcription by RNA polymerase II GO:0045944
Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
1 Q91ZD1 (/IDA)
Positive regulation of transcription by RNA polymerase II GO:0045944
Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
1 Q91ZD1 (/IGI)
Embryonic skeletal system morphogenesis GO:0048704
The process in which the anatomical structures of the skeleton are generated and organized during the embryonic phase.
1 Q91ZD1 (/IMP)
Positive regulation of epithelial cell proliferation GO:0050679
Any process that activates or increases the rate or extent of epithelial cell proliferation.
1 Q91ZD1 (/IMP)
Roof of mouth development GO:0060021
The biological process whose specific outcome is the progression of the roof of the mouth from an initial condition to its mature state. This process begins with the formation of the structure and ends with the mature structure. The roof of the mouth is the partition that separates the nasal and oral cavities.
1 Q91ZD1 (/IMP)
Embryonic skeletal joint morphogenesis GO:0060272
The process in which the anatomical structures of skeletal joints are generated and organized during the embryonic phase. A skeletal joint is the connecting structure between the bones of the skeleton.
1 Q91ZD1 (/IMP)
Head development GO:0060322
The biological process whose specific outcome is the progression of a head from an initial condition to its mature state. The head is the anterior-most division of the body.
1 Q91ZD1 (/IMP)
Bone morphogenesis GO:0060349
The process in which bones are generated and organized.
1 Q91ZD1 (/IMP)
Eyelid development in camera-type eye GO:0061029
The progression of the eyelid in a camera-type eye from its formation to the mature state. The eyelid is a membranous cover that helps protect and lubricate the eye.
1 Q91ZD1 (/IMP)
Embryonic skeletal joint development GO:0072498
The process, occurring during the embryonic phase, whose specific outcome is the progression of the skeletal joints over time, from formation to mature structure.
1 Q91ZD1 (/IGI)

There are 2 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
8 E2QTV1 (/ISS) Q8N2R0 (/ISS) Q8N2R0 (/ISS) Q8N2R0 (/ISS) Q8N2R0 (/ISS) Q9VQS7 (/ISS) Q9VQU9 (/ISS) Q9VQU9 (/ISS)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
1 Q91ZD1 (/IDA)
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