The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Classic Zinc Finger
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 232: Krueppel-like factor 9

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 17 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
10 Q13886 (/ISA) Q13886 (/ISA) Q13886 (/ISA) Q13886 (/ISA) Q13886 (/ISA) Q13886 (/ISA) Q8TD94 (/ISA) Q9BXK1 (/ISA) Q9Y2Y9 (/ISA) Q9Y2Y9 (/ISA)
DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
9 Q13886 (/NAS) Q13886 (/NAS) Q13886 (/NAS) Q13886 (/NAS) Q13886 (/NAS) Q13886 (/NAS) Q9BXK1 (/NAS) Q9Y2Y9 (/NAS) Q9Y2Y9 (/NAS)
DNA-binding transcription factor activity GO:0003700
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
6 Q13886 (/TAS) Q13886 (/TAS) Q13886 (/TAS) Q13886 (/TAS) Q13886 (/TAS) Q13886 (/TAS)
DNA binding GO:0003677
Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
5 O35739 (/ISS) P58334 (/ISS) P58334 (/ISS) Q19A41 (/ISS) Q9JJZ6 (/ISS)
RNA polymerase II proximal promoter sequence-specific DNA binding GO:0000978
Interacting selectively and non-covalently with a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in the proximal promoter of a gene transcribed by RNA polymerase II. The proximal promoter is in cis with and relatively close to the core promoter.
3 P58334 (/IDA) P58334 (/IDA) Q9JJZ6 (/IDA)
DNA binding GO:0003677
Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
3 P58334 (/IDA) P58334 (/IDA) Q9JJZ6 (/IDA)
DNA-binding transcription repressor activity, RNA polymerase II-specific GO:0001227
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to repress or decrease transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
2 P58334 (/IDA) P58334 (/IDA)
DNA-binding transcription activator activity, RNA polymerase II-specific GO:0001228
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to activate or increase transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
2 O35739 (/IDA) Q9JJZ6 (/IDA)
DNA-binding transcription factor activity GO:0003700
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
2 P58334 (/IDA) P58334 (/IDA)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
2 Q9Y2Y9 (/IPI) Q9Y2Y9 (/IPI)
Sequence-specific DNA binding GO:0043565
Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding.
2 Q8TD94 (/IDA) Q9W1W2 (/IDA)
RNA polymerase II regulatory region sequence-specific DNA binding GO:0000977
Interacting selectively and non-covalently with a specific sequence of DNA that is part of a regulatory region that controls the transcription of a gene or cistron by RNA polymerase II.
1 O35739 (/IDA)
DNA-binding transcription repressor activity, RNA polymerase II-specific GO:0001227
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to repress or decrease transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
1 Q9W1W2 (/ISS)
DNA-binding transcription activator activity, RNA polymerase II-specific GO:0001228
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to activate or increase transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
1 Q8TD94 (/IC)
Chromatin binding GO:0003682
Interacting selectively and non-covalently with chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase.
1 Q19A41 (/IDA)
Transcription factor binding GO:0008134
Interacting selectively and non-covalently with a transcription factor, a protein required to initiate or regulate transcription.
1 Q19A41 (/IC)
Sequence-specific DNA binding GO:0043565
Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding.
1 Q19A41 (/ISO)

There are 30 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Negative regulation of keratinocyte proliferation GO:0010839
Any process that decreases the rate, frequency or extent of keratinocyte proliferation. Keratinocyte proliferation is the multiplication or reproduction of keratinocytes, resulting in the expansion of a cell population.
15 O35739 (/ISS) P79288 (/ISS) P79288 (/ISS) P79288 (/ISS) P79288 (/ISS) P79288 (/ISS) P79288 (/ISS) P79288 (/ISS) P79288 (/ISS) P79288 (/ISS)
(5 more)
Cellular response to cortisol stimulus GO:0071387
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cortisol stimulus. Cortisol is the major natural glucocorticoid synthesized in the zona fasciculata of the adrenal cortex; it affects the metabolism of glucose, protein, and fats and has appreciable mineralocorticoid activity. It also regulates the immune system and affects many other functions.
15 O35739 (/ISS) P79288 (/ISS) P79288 (/ISS) P79288 (/ISS) P79288 (/ISS) P79288 (/ISS) P79288 (/ISS) P79288 (/ISS) P79288 (/ISS) P79288 (/ISS)
(5 more)
Regulation of transcription by RNA polymerase II GO:0006357
Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II.
6 Q13886 (/TAS) Q13886 (/TAS) Q13886 (/TAS) Q13886 (/TAS) Q13886 (/TAS) Q13886 (/TAS)
Circadian rhythm GO:0007623
Any biological process in an organism that recurs with a regularity of approximately 24 hours.
6 Q13886 (/IEP) Q13886 (/IEP) Q13886 (/IEP) Q13886 (/IEP) Q13886 (/IEP) Q13886 (/IEP)
Negative regulation of keratinocyte proliferation GO:0010839
Any process that decreases the rate, frequency or extent of keratinocyte proliferation. Keratinocyte proliferation is the multiplication or reproduction of keratinocytes, resulting in the expansion of a cell population.
6 Q13886 (/IMP) Q13886 (/IMP) Q13886 (/IMP) Q13886 (/IMP) Q13886 (/IMP) Q13886 (/IMP)
Cellular response to cortisol stimulus GO:0071387
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cortisol stimulus. Cortisol is the major natural glucocorticoid synthesized in the zona fasciculata of the adrenal cortex; it affects the metabolism of glucose, protein, and fats and has appreciable mineralocorticoid activity. It also regulates the immune system and affects many other functions.
6 Q13886 (/IDA) Q13886 (/IDA) Q13886 (/IDA) Q13886 (/IDA) Q13886 (/IDA) Q13886 (/IDA)
Cellular response to thyroid hormone stimulus GO:0097067
A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a thyroid hormone stimulus.
6 Q13886 (/IDA) Q13886 (/IDA) Q13886 (/IDA) Q13886 (/IDA) Q13886 (/IDA) Q13886 (/IDA)
Regulation of transcription by RNA polymerase II GO:0006357
Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II.
3 P58334 (/IDA) P58334 (/IDA) Q9JJZ6 (/IDA)
Endocrine pancreas development GO:0031018
The process whose specific outcome is the progression of the endocrine pancreas over time, from its formation to the mature structure. The endocrine pancreas is made up of islet cells that produce insulin, glucagon and somatostatin.
3 A0JMC8 (/IMP) A8E7A9 (/IMP) Q08BN5 (/IMP)
Positive regulation of transcription by RNA polymerase II GO:0045944
Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
3 O35739 (/IDA) Q8TD94 (/IDA) Q9JJZ6 (/IDA)
Negative regulation of transcription by RNA polymerase II GO:0000122
Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.
2 P58334 (/IDA) P58334 (/IDA)
Transcription by RNA polymerase II GO:0006366
The synthesis of RNA from a DNA template by RNA polymerase II (RNAP II), originating at an RNA polymerase II promoter. Includes transcription of messenger RNA (mRNA) and certain small nuclear RNAs (snRNAs).
2 Q9Y2Y9 (/TAS) Q9Y2Y9 (/TAS)
Dopamine receptor signaling pathway GO:0007212
The series of molecular signals generated as a consequence of a dopamine receptor binding to one of its physiological ligands.
2 P58334 (/IDA) P58334 (/IDA)
Negative regulation of transcription by RNA polymerase II GO:0000122
Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.
1 Q9W1W2 (/ISS)
Regulation of transcription, DNA-templated GO:0006355
Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
1 O35739 (/IDA)
Transcription by RNA polymerase II GO:0006366
The synthesis of RNA from a DNA template by RNA polymerase II (RNAP II), originating at an RNA polymerase II promoter. Includes transcription of messenger RNA (mRNA) and certain small nuclear RNAs (snRNAs).
1 Q9JJZ6 (/ISS)
Embryo implantation GO:0007566
Attachment of the blastocyst to the uterine lining.
1 O35739 (/IDA)
Negative regulation of cell population proliferation GO:0008285
Any process that stops, prevents or reduces the rate or extent of cell proliferation.
1 Q9JJZ6 (/IMP)
Negative regulation of keratinocyte proliferation GO:0010839
Any process that decreases the rate, frequency or extent of keratinocyte proliferation. Keratinocyte proliferation is the multiplication or reproduction of keratinocytes, resulting in the expansion of a cell population.
1 O35739 (/ISO)
T cell proliferation GO:0042098
The expansion of a T cell population by cell division. Follows T cell activation.
1 A2BGS7 (/IMP)
Erythrocyte maturation GO:0043249
A developmental process, independent of morphogenetic (shape) change, that is required for an erythrocyte to attain its fully functional state.
1 A2BGS7 (/IMP)
Negative regulation of erythrocyte differentiation GO:0045647
Any process that stops, prevents, or reduces the frequency, rate or extent of erythrocyte differentiation.
1 Q9JJZ6 (/IMP)
Positive regulation of transcription by RNA polymerase II GO:0045944
Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
1 Q19A41 (/IGI)
Positive regulation of transcription by RNA polymerase II GO:0045944
Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
1 Q8TD94 (/IMP)
Positive regulation of transcription by RNA polymerase II GO:0045944
Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
1 Q19A41 (/ISO)
Progesterone receptor signaling pathway GO:0050847
Any series of molecular signals generated as a consequence of a progesterone binding to its receptor.
1 O35739 (/IDA)
Cellular response to cortisol stimulus GO:0071387
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cortisol stimulus. Cortisol is the major natural glucocorticoid synthesized in the zona fasciculata of the adrenal cortex; it affects the metabolism of glucose, protein, and fats and has appreciable mineralocorticoid activity. It also regulates the immune system and affects many other functions.
1 O35739 (/ISO)
Cellular response to thyroid hormone stimulus GO:0097067
A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a thyroid hormone stimulus.
1 O35739 (/ISO)
Cellular response to peptide GO:1901653
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a peptide stimulus.
1 Q01713 (/IEP)
Positive regulation of sphingolipid mediated signaling pathway GO:1902070
Any process that activates or increases the frequency, rate or extent of sphingolipid signaling.
1 Q19A41 (/IMP)

There are 9 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
15 P79288 (/ISS) P79288 (/ISS) P79288 (/ISS) P79288 (/ISS) P79288 (/ISS) P79288 (/ISS) P79288 (/ISS) P79288 (/ISS) P79288 (/ISS) P79288 (/ISS)
(5 more)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
12 A0A024R260 (/IDA) A0A024R260 (/IDA) A0A024R260 (/IDA) A0A024R260 (/IDA) A0A024R260 (/IDA) A0A024R260 (/IDA) Q13886 (/IDA) Q13886 (/IDA) Q13886 (/IDA) Q13886 (/IDA)
(2 more)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
12 A0A024R260 (/IDA) A0A024R260 (/IDA) A0A024R260 (/IDA) A0A024R260 (/IDA) A0A024R260 (/IDA) A0A024R260 (/IDA) Q13886 (/IDA) Q13886 (/IDA) Q13886 (/IDA) Q13886 (/IDA)
(2 more)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
12 A0A024R260 (/IDA) A0A024R260 (/IDA) A0A024R260 (/IDA) A0A024R260 (/IDA) A0A024R260 (/IDA) A0A024R260 (/IDA) Q13886 (/IDA) Q13886 (/IDA) Q13886 (/IDA) Q13886 (/IDA)
(2 more)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
7 O35739 (/IDA) Q13886 (/IDA) Q13886 (/IDA) Q13886 (/IDA) Q13886 (/IDA) Q13886 (/IDA) Q13886 (/IDA)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
1 O35739 (/ISO)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
1 O35739 (/ISO)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
1 O35739 (/ISO)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
1 O35739 (/ISO)
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