The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Classic Zinc Finger
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 211: PR domain zinc finger protein 1

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 12 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
DNA-binding transcription repressor activity, RNA polymerase II-specific GO:0001227
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to repress or decrease transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
3 M9PBR0 (/IDA) O75626 (/IDA) Q9VRN4 (/IDA)
DNA-binding transcription factor activity GO:0003700
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
3 Q5MB23 (/IDA) Q68EH4 (/IDA) Q6RI23 (/IDA)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
2 O75626 (/IPI) Q60636 (/IPI)
RNA polymerase II proximal promoter sequence-specific DNA binding GO:0000978
Interacting selectively and non-covalently with a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in the proximal promoter of a gene transcribed by RNA polymerase II. The proximal promoter is in cis with and relatively close to the core promoter.
1 O75626 (/IDA)
RNA polymerase II proximal promoter sequence-specific DNA binding GO:0000978
Interacting selectively and non-covalently with a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in the proximal promoter of a gene transcribed by RNA polymerase II. The proximal promoter is in cis with and relatively close to the core promoter.
1 Q60636 (/ISO)
DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
1 O75626 (/ISA)
DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
1 O75626 (/NAS)
Enhancer sequence-specific DNA binding GO:0001158
Interacting selectively and non-covalently with a specific sequence of DNA that is part of an enhancer, a transcription regulatory region that is somewhat distal from the core promoter and which enhances transcription from that promoter.
1 Q93560 (/IDA)
DNA-binding transcription repressor activity, RNA polymerase II-specific GO:0001227
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to repress or decrease transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
1 Q60636 (/ISO)
DNA-binding transcription factor activity GO:0003700
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
1 O75626 (/TAS)
Promoter-specific chromatin binding GO:1990841
Interacting selectively and non-covalently with a section of chromatin that is associated with gene promoter sequences of DNA.
1 Q60636 (/IDA)
Promoter-specific chromatin binding GO:1990841
Interacting selectively and non-covalently with a section of chromatin that is associated with gene promoter sequences of DNA.
1 O75626 (/ISS)

There are 56 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Negative regulation of transcription by RNA polymerase II GO:0000122
Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.
7 M9PBR0 (/IDA) O75626 (/IDA) Q5MB23 (/IDA) Q60636 (/IDA) Q68EH4 (/IDA) Q6RI23 (/IDA) Q9VRN4 (/IDA)
Negative regulation of gene expression GO:0010629
Any process that decreases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
4 Q5MB23 (/IMP) Q60636 (/IMP) Q68EH4 (/IMP) Q6RI23 (/IMP)
Embryonic axis specification GO:0000578
The establishment, maintenance and elaboration of a pattern along a line or a point in an embryo.
3 Q5MB23 (/IMP) Q68EH4 (/IMP) Q6RI23 (/IMP)
Muscle cell fate determination GO:0007521
The cell fate determination process in which a cell becomes capable of differentiating autonomously into a muscle cell regardless of its environment; upon determination, the cell fate cannot be reversed.
3 Q5MB23 (/IMP) Q68EH4 (/IMP) Q6RI23 (/IMP)
Neural crest cell development GO:0014032
The process aimed at the progression of a neural crest cell over time, from initial commitment of the cell to its specific fate, to the fully functional differentiated cell.
3 Q5MB23 (/IMP) Q68EH4 (/IMP) Q6RI23 (/IMP)
Neural crest cell differentiation GO:0014033
The process in which a relatively unspecialized cell acquires specialized features of a neural crest cell.
3 Q5MB23 (/IMP) Q68EH4 (/IMP) Q6RI23 (/IMP)
Fin development GO:0033333
The process whose specific outcome is the progression of a fin over time, from its formation to the mature structure.
3 Q5MB23 (/IMP) Q68EH4 (/IMP) Q6RI23 (/IMP)
Embryonic pectoral fin morphogenesis GO:0035118
The process, occurring in the embryo, by which the anatomical structures of the pectoral fin are generated and organized. Pectoral fins are bilaterally paired fins mounted laterally and located behind the gill covers of fish. These fins are used for lateral mobility and propulsion.
3 Q5MB23 (/IMP) Q68EH4 (/IMP) Q6RI23 (/IMP)
Pectoral fin morphogenesis GO:0035138
The process in which the anatomical structures of the pectoral fin are generated and organized. Pectoral fins are bilaterally paired fins mounted laterally and located behind the gill covers of fish. These fins are used for lateral mobility and propulsion.
3 Q5MB23 (/IMP) Q68EH4 (/IMP) Q6RI23 (/IMP)
Positive regulation of neuron differentiation GO:0045666
Any process that activates or increases the frequency, rate or extent of neuron differentiation.
3 Q5MB23 (/IMP) Q68EH4 (/IMP) Q6RI23 (/IMP)
Developmental pigmentation GO:0048066
The developmental process that results in the deposition of coloring matter in an organism, tissue or cell.
3 Q5MB23 (/IMP) Q68EH4 (/IMP) Q6RI23 (/IMP)
Embryonic cranial skeleton morphogenesis GO:0048701
The process in which the anatomical structures of the cranial skeleton are generated and organized during the embryonic phase.
3 Q5MB23 (/IMP) Q68EH4 (/IMP) Q6RI23 (/IMP)
Embryonic neurocranium morphogenesis GO:0048702
The process in which the anatomical structures of the neurocranium are generated and organized during the embryonic phase. The neurocranium is the portion of the vertebrate skull surrounding the brain.
3 Q5MB23 (/IGI) Q68EH4 (/IGI) Q6RI23 (/IGI)
Embryonic viscerocranium morphogenesis GO:0048703
The process in which the anatomical structures of the viscerocranium are generated and organized during the embryonic phase. The viscerocranium is the part of the skull comprising the facial bones.
3 Q5MB23 (/IGI) Q68EH4 (/IGI) Q6RI23 (/IGI)
Embryonic viscerocranium morphogenesis GO:0048703
The process in which the anatomical structures of the viscerocranium are generated and organized during the embryonic phase. The viscerocranium is the part of the skull comprising the facial bones.
3 Q5MB23 (/IMP) Q68EH4 (/IMP) Q6RI23 (/IMP)
Positive regulation of striated muscle cell differentiation GO:0051155
Any process that activates or increases the frequency, rate or extent of striated muscle cell differentiation.
3 Q5MB23 (/IMP) Q68EH4 (/IMP) Q6RI23 (/IMP)
Pharyngeal system development GO:0060037
The process whose specific outcome is the progression of the pharyngeal system over time, from its formation to the mature structure. The pharyngeal system is a transient embryonic complex that is specific to vertebrates. It comprises the pharyngeal arches, bulges of tissues of mesoderm and neural crest derivation through which pass nerves and pharyngeal arch arteries. The arches are separated internally by pharyngeal pouches, evaginations of foregut endoderm, and externally by pharyngeal clefts, invaginations of surface ectoderm. The development of the system ends when the stucture it contributes to are forming: the thymus, thyroid, parathyroids, maxilla, mandible, aortic arch, cardiac outflow tract, external and middle ear.
3 Q5MB23 (/IMP) Q68EH4 (/IMP) Q6RI23 (/IMP)
Cartilage development involved in endochondral bone morphogenesis GO:0060351
The process whose specific outcome is the progression of the cartilage that will provide a scaffold for mineralization of endochondral bones.
3 Q5MB23 (/IMP) Q68EH4 (/IMP) Q6RI23 (/IMP)
Pupation GO:0035074
The act of becoming a pupa, a resting stage in the life cycle of organisms with complete metamorphosis. This event marks the end of the prepupal period and the beginning of the pupal period.
2 M9PBR0 (/IMP) Q9VRN4 (/IMP)
Regulation of tube architecture, open tracheal system GO:0035152
Ensuring that tracheal cells form and maintain tubular structures with the correct size and shape for their position in the network. This is essential for efficient flow of gases through the tracheal network.
2 M9PBR0 (/IMP) Q9VRN4 (/IMP)
Cellular response to ecdysone GO:0071390
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a ecdysone stimulus.
2 M9PBR0 (/IEP) Q9VRN4 (/IEP)
Negative regulation of transcription by RNA polymerase II GO:0000122
Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.
1 Q93560 (/IMP)
Negative regulation of transcription by RNA polymerase II GO:0000122
Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.
1 Q60636 (/ISO)
Negative regulation of transcription by RNA polymerase II GO:0000122
Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.
1 O75626 (/TAS)
In utero embryonic development GO:0001701
The process whose specific outcome is the progression of the embryo in the uterus over time, from formation of the zygote in the oviduct, to birth. An example of this process is found in Mus musculus.
1 Q60636 (/IMP)
Morphogenesis of a branching structure GO:0001763
The process in which the anatomical structures of branches are generated and organized. A branch is a division or offshoot from a main stem. Examples in animals would include blood vessels, nerves, lymphatics and other endothelial or epithelial tubes.
1 Q60636 (/IMP)
Embryonic placenta development GO:0001892
The embryonically driven process whose specific outcome is the progression of the placenta over time, from its formation to the mature structure. The placenta is an organ of metabolic interchange between fetus and mother, partly of embryonic origin and partly of maternal origin.
1 Q60636 (/IMP)
Maternal placenta development GO:0001893
Maternally driven process whose specific outcome is the progression of the placenta over time, from its formation to the mature structure. The placenta is an organ of metabolic interchange between fetus and mother, partly of embryonic origin and partly of maternal origin.
1 Q60636 (/IMP)
Heart valve development GO:0003170
The progression of a heart valve over time, from its formation to the mature structure. A heart valve is a structure that restricts the flow of blood to different regions of the heart and forms from an endocardial cushion.
1 Q60636 (/IMP)
Cardiac septum development GO:0003279
The progression of a cardiac septum over time, from its initial formation to the mature structure.
1 Q60636 (/IMP)
Ventricular septum development GO:0003281
The progression of the ventricular septum over time from its formation to the mature structure.
1 Q60636 (/IMP)
Germ cell development GO:0007281
The process whose specific outcome is the progression of an immature germ cell over time, from its formation to the mature structure (gamete). A germ cell is any reproductive cell in a multicellular organism.
1 Q60636 (/IGI)
Determination of adult lifespan GO:0008340
The control of viability and duration in the adult phase of the life-cycle.
1 Q93560 (/IMP)
Post-embryonic development GO:0009791
The process whose specific outcome is the progression of the organism over time, from the completion of embryonic development to the mature structure. See embryonic development.
1 Q60636 (/IMP)
Positive regulation of gene expression GO:0010628
Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
1 Q60636 (/IDA)
Regulation of natural killer cell differentiation GO:0032823
Any process that modulates the frequency, rate or extent of natural killer cell differentiation.
1 Q60636 (/IMP)
Regulation of natural killer cell differentiation GO:0032823
Any process that modulates the frequency, rate or extent of natural killer cell differentiation.
1 O75626 (/ISS)
Regulation of extrathymic T cell differentiation GO:0033082
Any process that modulates the frequency, rate or extent of extrathymic T cell differentiation.
1 Q60636 (/IMP)
Regulation of extrathymic T cell differentiation GO:0033082
Any process that modulates the frequency, rate or extent of extrathymic T cell differentiation.
1 O75626 (/ISS)
Aorta development GO:0035904
The progression of the aorta over time, from its initial formation to the mature structure. An aorta is an artery that carries blood from the heart to other parts of the body.
1 Q60636 (/IMP)
Hermaphrodite genitalia development GO:0040035
The process whose specific outcome is the progression of the hermaphrodite genitalia over time, from formation to the mature structures.
1 Q93560 (/IMP)
Regulation of cell population proliferation GO:0042127
Any process that modulates the frequency, rate or extent of cell proliferation.
1 Q60636 (/IMP)
Eye photoreceptor cell development GO:0042462
Development of a photoreceptor, a sensory cell in the eye that reacts to the presence of light. They usually contain a pigment that undergoes a chemical change when light is absorbed, thus stimulating a nerve.
1 Q60636 (/IMP)
Dauer entry GO:0043053
Entry into the facultative diapause of the dauer (enduring) larval stage of nematode development.
1 Q93560 (/IMP)
Cell fate commitment GO:0045165
The commitment of cells to specific cell fates and their capacity to differentiate into particular kinds of cells. Positional information is established through protein signals that emanate from a localized source within a cell (the initial one-cell zygote) or within a developmental field.
1 Q60636 (/IMP)
Positive regulation of epidermis development GO:0045684
Any process that activates or increases the frequency, rate or extent of epidermis development.
1 Q93560 (/IMP)
Positive regulation of transcription by RNA polymerase II GO:0045944
Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
1 Q93560 (/IMP)
Artery morphogenesis GO:0048844
The process in which the anatomical structures of arterial blood vessels are generated and organized. Arteries are blood vessels that transport blood from the heart to the body and its organs.
1 Q60636 (/IGI)
Artery morphogenesis GO:0048844
The process in which the anatomical structures of arterial blood vessels are generated and organized. Arteries are blood vessels that transport blood from the heart to the body and its organs.
1 Q60636 (/IMP)
Regulation of NK T cell differentiation GO:0051136
Any process that modulates the frequency, rate or extent of natural killer T cell differentiation.
1 Q60636 (/IMP)
Regulation of NK T cell differentiation GO:0051136
Any process that modulates the frequency, rate or extent of natural killer T cell differentiation.
1 O75626 (/ISS)
Intestinal epithelial cell development GO:0060576
The process whose specific outcome is the progression of a columnar/cuboidal epithelial cell of the intestine over time, from its formation to the mature structure.
1 Q60636 (/IMP)
Trophoblast giant cell differentiation GO:0060707
The process in which a relatively unspecialized cell acquires specialized features of a trophoblast giant cell of the placenta. Trophoblast giant cells are the cell of the placenta that line the maternal decidua.
1 Q60636 (/IMP)
Coronary vasculature development GO:0060976
The process whose specific outcome is the progression of the blood vessels of the heart over time, from its formation to the mature structure.
1 Q60636 (/IMP)
Negative regulation of distal tip cell migration GO:1903355
Any process that stops, prevents or reduces the frequency, rate or extent of distal tip cell migration.
1 Q93560 (/IMP)
Sebum secreting cell proliferation GO:1990654
The multiplication or reproduction of sebocytes by cell division, resulting in the expansion of their population. A sebocyte is an epithelial cell that makes up the sebaceous glands, and secrete sebum.
1 Q60636 (/IDA)

There are 5 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
4 M9PBR0 (/IDA) Q60636 (/IDA) Q93560 (/IDA) Q9VRN4 (/IDA)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
2 O75626 (/IDA) Q93560 (/IDA)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
1 M9PBR0 (/HDA)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
1 O75626 (/TAS)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
1 Q60636 (/ISO)
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