The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:
"Classic Zinc Finger
".
FunFam 141: C2H2 zinc finger protein
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 7 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
RNA polymerase II proximal promoter sequence-specific DNA binding GO:0000978
Interacting selectively and non-covalently with a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in the proximal promoter of a gene transcribed by RNA polymerase II. The proximal promoter is in cis with and relatively close to the core promoter.
|
2 | P07248 (/IDA) P07248 (/IDA) |
|
DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
|
2 | P07248 (/IDA) P07248 (/IDA) |
|
TFIIB-class transcription factor binding GO:0001093
Interacting selectively and non-covalently with a general RNA polymerase II transcription factor of the TFIIB class, one of the factors involved in formation of the preinitiation complex (PIC) by RNA polymerase II.
|
2 | P07248 (/IDA) P07248 (/IDA) |
|
TFIID-class transcription factor complex binding GO:0001094
Interacting selectively and non-covalently with a general RNA polymerase II transcription factor belonging to the TFIID complex, one of the factors involved in formation of the preinitiation complex (PIC) by RNA polymerase II.
|
2 | P07248 (/IDA) P07248 (/IDA) |
|
RNA polymerase II activating transcription factor binding GO:0001102
Interacting selectively and non-covalently with an RNA polymerase II transcription activating factor, a protein involved in positive regulation of transcription.
|
2 | P07248 (/IPI) P07248 (/IPI) |
|
Transcription coactivator activity GO:0003713
A protein or a member of a complex that interacts specifically and non-covalently with a DNA-bound DNA-binding transcription factor to activate the transcription of specific genes. Coactivators often act by altering chromatin structure and modifications. For example, one class of transcription coregulators modifies chromatin structure through covalent modification of histones. A second ATP-dependent class modifies the conformation of chromatin. Another type of coregulator activity is the bridging of a DNA-binding transcription factor to the basal transcription machinery. The Mediator complex, which bridges transcription factors and RNA polymerase, is also a transcription coactivator.
|
2 | P07248 (/IPI) P07248 (/IPI) |
|
Sequence-specific DNA binding GO:0043565
Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding.
|
2 | P07248 (/HDA) P07248 (/HDA) |
There are 19 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Chromatin organization GO:0006325
Any process that results in the specification, formation or maintenance of the physical structure of eukaryotic chromatin.
|
2 | P07248 (/IDA) P07248 (/IDA) |
|
Peroxisome organization GO:0007031
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a peroxisome. A peroxisome is a small, membrane-bounded organelle that uses dioxygen (O2) to oxidize organic molecules.
|
2 | P07248 (/IMP) P07248 (/IMP) |
|
Negative regulation of chromatin silencing GO:0031936
Any process that stops, prevents, or reduces the frequency, rate or extent of chromatin silencing.
|
2 | P07248 (/IDA) P07248 (/IDA) |
|
Positive regulation of transcription from RNA polymerase II promoter in response to ethanol GO:0061410
Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of an ethanol stimulus.
|
2 | P07248 (/IMP) P07248 (/IMP) |
|
Positive regulation of peroxisome organization by positive regulation of transcription from RNA polymerase II promoter GO:0061424
Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter and activates or increases the frequency, rate or extent of peroxisome organization.
|
2 | P07248 (/IMP) P07248 (/IMP) |
|
Positive regulation of ethanol catabolic process by positive regulation of transcription from RNA polymerase II promoter GO:0061425
Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter and activates or increases the frequency, rate or extent of an ethanol catabolic process.
|
2 | P07248 (/IMP) P07248 (/IMP) |
|
Positive regulation of transcription from RNA polymerase II promoter by oleic acid GO:0061429
Any process involving oleic acid that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
|
2 | P07248 (/IMP) P07248 (/IMP) |
|
Positive regulation of fatty acid beta-oxidation by positive regulation of transcription from RNA polymerase II promoter GO:0097235
Any process that activates or increases the frequency, rate or extent of fatty acid beta-oxidation by activating or increasing the frequency, rate or extent of transcription from an RNA polymerase II promoter.
|
2 | P07248 (/IMP) P07248 (/IMP) |
|
Cellular response to starvation GO:0009267
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of nourishment.
|
1 | Q5AF56 (/IMP) |
|
Filamentous growth GO:0030447
The process in which a multicellular organism, a unicellular organism or a group of unicellular organisms grow in a threadlike, filamentous shape.
|
1 | Q5AF56 (/IMP) |
|
Cellular response to oxidative stress GO:0034599
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals.
|
1 | Q4WPF5 (/IMP) |
|
Cellular response to heat GO:0034605
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a heat stimulus, a temperature stimulus above the optimal temperature for that organism.
|
1 | Q4WPF5 (/IMP) |
|
Cellular response to drug GO:0035690
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a drug stimulus. A drug is a substance used in the diagnosis, treatment or prevention of a disease.
|
1 | Q59RR3 (/IMP) |
|
Filamentous growth of a population of unicellular organisms in response to starvation GO:0036170
The process in which a group of unicellular organisms grow in a threadlike, filamentous shape in response to deprivation of nourishment.
|
1 | Q5AF56 (/IMP) |
|
Filamentous growth of a population of unicellular organisms in response to biotic stimulus GO:0036180
The process in which a group of unicellular organisms grow in a threadlike, filamentous shape in response to a biotic (living) stimulus.
|
1 | Q5AF56 (/IMP) |
|
Regulation of transcription from RNA polymerase II promoter in response to stress GO:0043618
Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a stimulus indicating the organism is under stress. The stress is usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation).
|
1 | Q59RR3 (/IMP) |
|
Cellular response to calcium ion GO:0071277
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a calcium ion stimulus.
|
1 | Q4WPF5 (/IMP) |
|
Cellular response to acetate GO:0071311
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an acetate stimulus.
|
1 | Q59RR3 (/IMP) |
|
Positive regulation of cellular response to oxidative stress GO:1900409
Any process that activates or increases the frequency, rate or extent of cellular response to oxidative stress.
|
1 | Q4WPF5 (/IMP) |
There are 4 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
4 | K4H1X2 (/IDA) P07248 (/IDA) P07248 (/IDA) Q4WPF5 (/IDA) |
|
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
|
2 | P07248 (/HDA) P07248 (/HDA) |
|
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
2 | P07248 (/HDA) P07248 (/HDA) |
|
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
1 | Q4WPF5 (/IDA) |
