The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:
"Classic Zinc Finger
".
FunFam 124: IKAROS family zinc finger 4
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 12 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
|
18 |
Q13422 (/ISA)
Q13422 (/ISA)
Q13422 (/ISA)
Q13422 (/ISA)
Q13422 (/ISA)
Q13422 (/ISA)
Q13422 (/ISA)
Q13422 (/ISA)
Q13422 (/ISA)
Q13422 (/ISA)
(8 more) |
|
Protein domain specific binding GO:0019904
Interacting selectively and non-covalently with a specific domain of a protein.
|
17 |
Q13422 (/IPI)
Q13422 (/IPI)
Q13422 (/IPI)
Q13422 (/IPI)
Q13422 (/IPI)
Q13422 (/IPI)
Q13422 (/IPI)
Q13422 (/IPI)
Q13422 (/IPI)
Q13422 (/IPI)
(7 more) |
|
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
|
13 |
Q13422 (/IPI)
Q13422 (/IPI)
Q13422 (/IPI)
Q13422 (/IPI)
Q13422 (/IPI)
Q13422 (/IPI)
Q13422 (/IPI)
Q13422 (/IPI)
Q13422 (/IPI)
Q13422 (/IPI)
(3 more) |
|
DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
|
12 |
Q13422 (/NAS)
Q13422 (/NAS)
Q13422 (/NAS)
Q13422 (/NAS)
Q13422 (/NAS)
Q13422 (/NAS)
Q13422 (/NAS)
Q13422 (/NAS)
Q13422 (/NAS)
Q13422 (/NAS)
(2 more) |
|
DNA binding GO:0003677
Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
|
12 |
Q13422 (/IDA)
Q13422 (/IDA)
Q13422 (/IDA)
Q13422 (/IDA)
Q13422 (/IDA)
Q13422 (/IDA)
Q13422 (/IDA)
Q13422 (/IDA)
Q13422 (/IDA)
Q13422 (/IDA)
(2 more) |
|
DNA binding GO:0003677
Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
|
12 |
Q13422 (/TAS)
Q13422 (/TAS)
Q13422 (/TAS)
Q13422 (/TAS)
Q13422 (/TAS)
Q13422 (/TAS)
Q13422 (/TAS)
Q13422 (/TAS)
Q13422 (/TAS)
Q13422 (/TAS)
(2 more) |
|
DNA-binding transcription factor activity GO:0003700
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
|
5 | Q9H2S9 (/TAS) Q9H2S9 (/TAS) Q9H2S9 (/TAS) Q9H2S9 (/TAS) Q9H2S9 (/TAS) |
|
Zinc ion binding GO:0008270
Interacting selectively and non-covalently with zinc (Zn) ions.
|
5 | Q9H2S9 (/IMP) Q9H2S9 (/IMP) Q9H2S9 (/IMP) Q9H2S9 (/IMP) Q9H2S9 (/IMP) |
|
Protein homodimerization activity GO:0042803
Interacting selectively and non-covalently with an identical protein to form a homodimer.
|
1 | P81183 (/IPI) |
|
Protein homodimerization activity GO:0042803
Interacting selectively and non-covalently with an identical protein to form a homodimer.
|
1 | A2VDW9 (/ISS) |
|
Sequence-specific DNA binding GO:0043565
Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding.
|
1 | A2VDW9 (/ISS) |
|
Protein heterodimerization activity GO:0046982
Interacting selectively and non-covalently with a nonidentical protein to form a heterodimer.
|
1 | A2VDW9 (/ISS) |
There are 14 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Protein heterooligomerization GO:0051291
The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of component monomers that are not all identical. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer.
|
17 |
Q13422 (/IMP)
Q13422 (/IMP)
Q13422 (/IMP)
Q13422 (/IMP)
Q13422 (/IMP)
Q13422 (/IMP)
Q13422 (/IMP)
Q13422 (/IMP)
Q13422 (/IMP)
Q13422 (/IMP)
(7 more) |
|
Mesoderm development GO:0007498
The process whose specific outcome is the progression of the mesoderm over time, from its formation to the mature structure. The mesoderm is the middle germ layer that develops into muscle, bone, cartilage, blood and connective tissue.
|
12 |
Q13422 (/TAS)
Q13422 (/TAS)
Q13422 (/TAS)
Q13422 (/TAS)
Q13422 (/TAS)
Q13422 (/TAS)
Q13422 (/TAS)
Q13422 (/TAS)
Q13422 (/TAS)
Q13422 (/TAS)
(2 more) |
|
Lymphocyte differentiation GO:0030098
The process in which a relatively unspecialized precursor cell acquires specialized features of a lymphocyte. A lymphocyte is a leukocyte commonly found in the blood and lymph that has the characteristics of a large nucleus, a neutral staining cytoplasm, and prominent heterochromatin.
|
12 |
Q13422 (/IMP)
Q13422 (/IMP)
Q13422 (/IMP)
Q13422 (/IMP)
Q13422 (/IMP)
Q13422 (/IMP)
Q13422 (/IMP)
Q13422 (/IMP)
Q13422 (/IMP)
Q13422 (/IMP)
(2 more) |
|
Erythrocyte differentiation GO:0030218
The process in which a myeloid precursor cell acquires specializes features of an erythrocyte.
|
12 |
Q13422 (/IMP)
Q13422 (/IMP)
Q13422 (/IMP)
Q13422 (/IMP)
Q13422 (/IMP)
Q13422 (/IMP)
Q13422 (/IMP)
Q13422 (/IMP)
Q13422 (/IMP)
Q13422 (/IMP)
(2 more) |
|
Negative regulation of transcription, DNA-templated GO:0045892
Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.
|
12 |
Q13422 (/ISS)
Q13422 (/ISS)
Q13422 (/ISS)
Q13422 (/ISS)
Q13422 (/ISS)
Q13422 (/ISS)
Q13422 (/ISS)
Q13422 (/ISS)
Q13422 (/ISS)
Q13422 (/ISS)
(2 more) |
|
Negative regulation of transcription, DNA-templated GO:0045892
Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.
|
5 | Q9H2S9 (/TAS) Q9H2S9 (/TAS) Q9H2S9 (/TAS) Q9H2S9 (/TAS) Q9H2S9 (/TAS) |
|
Protein homooligomerization GO:0051260
The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of identical component monomers. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer.
|
5 | Q9H2S9 (/IMP) Q9H2S9 (/IMP) Q9H2S9 (/IMP) Q9H2S9 (/IMP) Q9H2S9 (/IMP) |
|
B cell differentiation GO:0030183
The process in which a precursor cell type acquires the specialized features of a B cell. A B cell is a lymphocyte of B lineage with the phenotype CD19-positive and capable of B cell mediated immunity.
|
2 | B8A603 (/IMP) O93581 (/IMP) |
|
T cell differentiation in thymus GO:0033077
The process in which a precursor cell type acquires the specialized features of a T cell via a differentiation pathway dependent upon transit through the thymus.
|
2 | B8A603 (/IMP) O93581 (/IMP) |
|
Regulation of B cell proliferation GO:0030888
Any process that modulates the frequency, rate or extent of B cell proliferation.
|
1 | A2VDW9 (/ISS) |
|
Regulation of apoptotic process GO:0042981
Any process that modulates the occurrence or rate of cell death by apoptotic process.
|
1 | A2VDW9 (/ISS) |
|
Regulation of B cell differentiation GO:0045577
Any process that modulates the frequency, rate or extent of B cell differentiation.
|
1 | A2VDW9 (/ISS) |
|
Regulation of lymphocyte differentiation GO:0045619
Any process that modulates the frequency, rate or extent of lymphocyte differentiation.
|
1 | A2VDW9 (/ISS) |
|
Positive regulation of transcription by RNA polymerase II GO:0045944
Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
|
1 | P81183 (/IDA) |
There are 7 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
|
22 |
F8VPL6 (/IDA)
F8VPL6 (/IDA)
F8VPL6 (/IDA)
F8VPL6 (/IDA)
F8VPL6 (/IDA)
Q13422 (/IDA)
Q13422 (/IDA)
Q13422 (/IDA)
Q13422 (/IDA)
Q13422 (/IDA)
(12 more) |
|
Protein-containing complex GO:0032991
A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together.
|
17 |
Q13422 (/IMP)
Q13422 (/IMP)
Q13422 (/IMP)
Q13422 (/IMP)
Q13422 (/IMP)
Q13422 (/IMP)
Q13422 (/IMP)
Q13422 (/IMP)
Q13422 (/IMP)
Q13422 (/IMP)
(7 more) |
|
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
13 |
P81183 (/IDA)
Q13422 (/IDA)
Q13422 (/IDA)
Q13422 (/IDA)
Q13422 (/IDA)
Q13422 (/IDA)
Q13422 (/IDA)
Q13422 (/IDA)
Q13422 (/IDA)
Q13422 (/IDA)
(3 more) |
|
Nuclear pericentric heterochromatin GO:0031618
Nuclear heterochromatin that is located adjacent to the CENP-A rich centromere 'central core' and characterized by the modified histone H3K9me3.
|
12 |
Q13422 (/IDA)
Q13422 (/IDA)
Q13422 (/IDA)
Q13422 (/IDA)
Q13422 (/IDA)
Q13422 (/IDA)
Q13422 (/IDA)
Q13422 (/IDA)
Q13422 (/IDA)
Q13422 (/IDA)
(2 more) |
|
Protein-containing complex GO:0032991
A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together.
|
12 |
Q13422 (/IDA)
Q13422 (/IDA)
Q13422 (/IDA)
Q13422 (/IDA)
Q13422 (/IDA)
Q13422 (/IDA)
Q13422 (/IDA)
Q13422 (/IDA)
Q13422 (/IDA)
Q13422 (/IDA)
(2 more) |
|
Nuclear body GO:0016604
Extra-nucleolar nuclear domains usually visualized by confocal microscopy and fluorescent antibodies to specific proteins.
|
10 | F8VPL6 (/IDA) F8VPL6 (/IDA) F8VPL6 (/IDA) F8VPL6 (/IDA) F8VPL6 (/IDA) Q9H2S9 (/IDA) Q9H2S9 (/IDA) Q9H2S9 (/IDA) Q9H2S9 (/IDA) Q9H2S9 (/IDA) |
|
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
5 | Q9H2S9 (/TAS) Q9H2S9 (/TAS) Q9H2S9 (/TAS) Q9H2S9 (/TAS) Q9H2S9 (/TAS) |
