The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:
"Classic Zinc Finger
".
FunFam 115: Zinc finger and BTB domain containing 7C
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 41 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
|
8 | O15156 (/IPI) O15156 (/IPI) O88939 (/IPI) O95365 (/IPI) O95365 (/IPI) Q64321 (/IPI) Q64321 (/IPI) Q8VCZ7 (/IPI) |
|
DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
|
7 | A1YPR0 (/ISA) A1YPR0 (/ISA) O15156 (/ISA) O15156 (/ISA) O95365 (/ISA) O95365 (/ISA) Q96JB3 (/ISA) |
|
DNA-binding transcription factor activity GO:0003700
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
|
6 | O88939 (/IDA) O95365 (/IDA) O95365 (/IDA) Q64321 (/IDA) Q64321 (/IDA) Q9QZ48 (/IDA) |
|
DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
|
5 | O15156 (/NAS) O15156 (/NAS) O95365 (/NAS) O95365 (/NAS) Q96JB3 (/NAS) |
|
Transcription corepressor binding GO:0001222
Interacting selectively and non-covalently with a transcription corepressor, any protein involved in negative regulation of transcription via protein-protein interactions with transcription factors and other proteins that negatively regulate transcription. Transcription corepressors do not bind DNA directly, but rather mediate protein-protein interactions between repressing transcription factors and the basal transcription machinery.
|
4 | O88939 (/ISS) O93567 (/ISS) O93567 (/ISS) Q9QZ48 (/ISS) |
|
DNA binding GO:0003677
Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
|
4 | O88939 (/IDA) Q64321 (/IDA) Q64321 (/IDA) Q70ZY9 (/IDA) |
|
Transcription corepressor activity GO:0003714
A protein or a member of a complex that interacts specifically and non-covalently with a DNA-bound DNA-binding transcription factor to repress the transcription of specific genes. Corepressors often act by altering chromatin structure and modifications. For example, one class of transcription coregulators modifies chromatin structure through covalent modification of histones. A second ATP-dependent class modifies the conformation of chromatin. A third class occludes DNA-binding transcription factor protein-protein interaction domains. A fourth class of corepressors prevents interactions of DNA bound DNA-binding transcription factor with coactivators.
|
4 | O88939 (/ISS) O93567 (/ISS) O93567 (/ISS) Q9QZ48 (/ISS) |
|
RNA polymerase II proximal promoter sequence-specific DNA binding GO:0000978
Interacting selectively and non-covalently with a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in the proximal promoter of a gene transcribed by RNA polymerase II. The proximal promoter is in cis with and relatively close to the core promoter.
|
3 | O88939 (/IDA) Q64321 (/IDA) Q64321 (/IDA) |
|
DNA binding GO:0003677
Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
|
3 | O95365 (/ISS) O95365 (/ISS) Q9QZ48 (/ISS) |
|
Histone acetyltransferase binding GO:0035035
Interacting selectively and non-covalently with the enzyme histone acetyltransferase.
|
3 | O95365 (/ISS) O95365 (/ISS) Q9QZ48 (/ISS) |
|
Enhancer sequence-specific DNA binding GO:0001158
Interacting selectively and non-covalently with a specific sequence of DNA that is part of an enhancer, a transcription regulatory region that is somewhat distal from the core promoter and which enhances transcription from that promoter.
|
2 | Q64321 (/IMP) Q64321 (/IMP) |
|
Enhancer sequence-specific DNA binding GO:0001158
Interacting selectively and non-covalently with a specific sequence of DNA that is part of an enhancer, a transcription regulatory region that is somewhat distal from the core promoter and which enhances transcription from that promoter.
|
2 | O15156 (/ISS) O15156 (/ISS) |
|
Transcription corepressor binding GO:0001222
Interacting selectively and non-covalently with a transcription corepressor, any protein involved in negative regulation of transcription via protein-protein interactions with transcription factors and other proteins that negatively regulate transcription. Transcription corepressors do not bind DNA directly, but rather mediate protein-protein interactions between repressing transcription factors and the basal transcription machinery.
|
2 | O95365 (/IDA) O95365 (/IDA) |
|
Transcription corepressor binding GO:0001222
Interacting selectively and non-covalently with a transcription corepressor, any protein involved in negative regulation of transcription via protein-protein interactions with transcription factors and other proteins that negatively regulate transcription. Transcription corepressors do not bind DNA directly, but rather mediate protein-protein interactions between repressing transcription factors and the basal transcription machinery.
|
2 | O95365 (/IPI) O95365 (/IPI) |
|
DNA-binding transcription activator activity, RNA polymerase II-specific GO:0001228
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to activate or increase transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
|
2 | Q64321 (/IDA) Q64321 (/IDA) |
|
DNA-binding transcription factor activity GO:0003700
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
|
2 | O93567 (/ISS) O93567 (/ISS) |
|
Transcription corepressor activity GO:0003714
A protein or a member of a complex that interacts specifically and non-covalently with a DNA-bound DNA-binding transcription factor to repress the transcription of specific genes. Corepressors often act by altering chromatin structure and modifications. For example, one class of transcription coregulators modifies chromatin structure through covalent modification of histones. A second ATP-dependent class modifies the conformation of chromatin. A third class occludes DNA-binding transcription factor protein-protein interaction domains. A fourth class of corepressors prevents interactions of DNA bound DNA-binding transcription factor with coactivators.
|
2 | O95365 (/IMP) O95365 (/IMP) |
|
Activating transcription factor binding GO:0033613
Interacting selectively and non-covalently with an activating transcription factor, any protein whose activity is required to initiate or upregulate transcription.
|
2 | O95365 (/IPI) O95365 (/IPI) |
|
Protein homodimerization activity GO:0042803
Interacting selectively and non-covalently with an identical protein to form a homodimer.
|
2 | Q64321 (/IDA) Q64321 (/IDA) |
|
Protein homodimerization activity GO:0042803
Interacting selectively and non-covalently with an identical protein to form a homodimer.
|
2 | Q64321 (/IPI) Q64321 (/IPI) |
|
Protein homodimerization activity GO:0042803
Interacting selectively and non-covalently with an identical protein to form a homodimer.
|
2 | O15156 (/ISS) O15156 (/ISS) |
|
Histone deacetylase binding GO:0042826
Interacting selectively and non-covalently with the enzyme histone deacetylase.
|
2 | Q64321 (/IPI) Q64321 (/IPI) |
|
SMAD binding GO:0046332
Interacting selectively and non-covalently with a SMAD signaling protein.
|
2 | O95365 (/IDA) O95365 (/IDA) |
|
SMAD binding GO:0046332
Interacting selectively and non-covalently with a SMAD signaling protein.
|
2 | O95365 (/IPI) O95365 (/IPI) |
|
SMAD binding GO:0046332
Interacting selectively and non-covalently with a SMAD signaling protein.
|
2 | O88939 (/ISS) Q9QZ48 (/ISS) |
|
Androgen receptor binding GO:0050681
Interacting selectively and non-covalently with an androgen receptor.
|
2 | O95365 (/IDA) O95365 (/IDA) |
|
Androgen receptor binding GO:0050681
Interacting selectively and non-covalently with an androgen receptor.
|
2 | O95365 (/IPI) O95365 (/IPI) |
|
Androgen receptor binding GO:0050681
Interacting selectively and non-covalently with an androgen receptor.
|
2 | O88939 (/ISS) Q9QZ48 (/ISS) |
|
Transcription corepressor binding GO:0001222
Interacting selectively and non-covalently with a transcription corepressor, any protein involved in negative regulation of transcription via protein-protein interactions with transcription factors and other proteins that negatively regulate transcription. Transcription corepressors do not bind DNA directly, but rather mediate protein-protein interactions between repressing transcription factors and the basal transcription machinery.
|
1 | O88939 (/ISO) |
|
DNA-binding transcription repressor activity, RNA polymerase II-specific GO:0001227
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to repress or decrease transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
|
1 | O88939 (/IDA) |
|
DNA binding GO:0003677
Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
|
1 | Q96JB3 (/NAS) |
|
DNA-binding transcription factor activity GO:0003700
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
|
1 | O88939 (/IMP) |
|
DNA-binding transcription factor activity GO:0003700
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
|
1 | O88939 (/ISO) |
|
Transcription corepressor activity GO:0003714
A protein or a member of a complex that interacts specifically and non-covalently with a DNA-bound DNA-binding transcription factor to repress the transcription of specific genes. Corepressors often act by altering chromatin structure and modifications. For example, one class of transcription coregulators modifies chromatin structure through covalent modification of histones. A second ATP-dependent class modifies the conformation of chromatin. A third class occludes DNA-binding transcription factor protein-protein interaction domains. A fourth class of corepressors prevents interactions of DNA bound DNA-binding transcription factor with coactivators.
|
1 | O88939 (/ISO) |
|
Protein C-terminus binding GO:0008022
Interacting selectively and non-covalently with a protein C-terminus, the end of any peptide chain at which the 1-carboxyl function of a constituent amino acid is not attached in peptide linkage to another amino-acid residue.
|
1 | Q96JB3 (/IPI) |
|
Protein C-terminus binding GO:0008022
Interacting selectively and non-covalently with a protein C-terminus, the end of any peptide chain at which the 1-carboxyl function of a constituent amino acid is not attached in peptide linkage to another amino-acid residue.
|
1 | Q9JLZ6 (/ISO) |
|
Activating transcription factor binding GO:0033613
Interacting selectively and non-covalently with an activating transcription factor, any protein whose activity is required to initiate or upregulate transcription.
|
1 | O88939 (/ISO) |
|
Histone acetyltransferase binding GO:0035035
Interacting selectively and non-covalently with the enzyme histone acetyltransferase.
|
1 | O88939 (/IPI) |
|
Sequence-specific DNA binding GO:0043565
Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding.
|
1 | O88939 (/IDA) |
|
SMAD binding GO:0046332
Interacting selectively and non-covalently with a SMAD signaling protein.
|
1 | O88939 (/ISO) |
|
Androgen receptor binding GO:0050681
Interacting selectively and non-covalently with an androgen receptor.
|
1 | O88939 (/ISO) |
There are 101 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Negative regulation of transcription, DNA-templated GO:0045892
Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.
|
5 | O93567 (/ISS) O93567 (/ISS) O95365 (/ISS) O95365 (/ISS) Q9QZ48 (/ISS) |
|
Chromatin remodeling GO:0006338
Dynamic structural changes to eukaryotic chromatin occurring throughout the cell division cycle. These changes range from the local changes necessary for transcriptional regulation to global changes necessary for chromosome segregation.
|
4 | O88939 (/ISS) O93567 (/ISS) O93567 (/ISS) Q9QZ48 (/ISS) |
|
Regulation of transcription regulatory region DNA binding GO:2000677
Any process that modulates the frequency, rate or extent of transcription regulatory region DNA binding.
|
4 | O88939 (/ISS) O93567 (/ISS) O93567 (/ISS) Q9QZ48 (/ISS) |
|
Transcription, DNA-templated GO:0006351
The cellular synthesis of RNA on a template of DNA.
|
3 | O88939 (/IMP) O95365 (/IMP) O95365 (/IMP) |
|
Regulation of transcription, DNA-templated GO:0006355
Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
|
3 | O95365 (/IDA) O95365 (/IDA) Q9QZ48 (/IDA) |
|
B cell differentiation GO:0030183
The process in which a precursor cell type acquires the specialized features of a B cell. A B cell is a lymphocyte of B lineage with the phenotype CD19-positive and capable of B cell mediated immunity.
|
3 | O95365 (/ISS) O95365 (/ISS) Q9QZ48 (/ISS) |
|
Erythrocyte maturation GO:0043249
A developmental process, independent of morphogenetic (shape) change, that is required for an erythrocyte to attain its fully functional state.
|
3 | O88939 (/IMP) O95365 (/IMP) O95365 (/IMP) |
|
Erythrocyte maturation GO:0043249
A developmental process, independent of morphogenetic (shape) change, that is required for an erythrocyte to attain its fully functional state.
|
3 | O95365 (/ISS) O95365 (/ISS) Q9QZ48 (/ISS) |
|
Negative regulation of Notch signaling pathway GO:0045746
Any process that stops, prevents, or reduces the frequency, rate or extent of the Notch signaling pathway.
|
3 | O95365 (/ISS) O95365 (/ISS) Q9QZ48 (/ISS) |
|
Negative regulation of transcription, DNA-templated GO:0045892
Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.
|
3 | O88939 (/IMP) O95365 (/IMP) O95365 (/IMP) |
|
Positive regulation of transcription by RNA polymerase II GO:0045944
Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
|
3 | Q64321 (/IDA) Q64321 (/IDA) Q8VCZ7 (/IDA) |
|
Regulation of DNA-binding transcription factor activity GO:0051090
Any process that modulates the frequency, rate or extent of the activity of a transcription factor, any factor involved in the initiation or regulation of transcription.
|
3 | O95365 (/ISS) O95365 (/ISS) Q9QZ48 (/ISS) |
|
Double-strand break repair via classical nonhomologous end joining GO:0097680
An instance of double-strand break repair via nonhomologous end joining that requires a number of factors important for V(D)J recombination, including the KU70/80 heterodimer (KU), XRCC4, ligase IV, and DNA-PKcs in mammals. It does not produce translocations (as opposed to the alternative nonhomologous end joining).
|
3 | O95365 (/ISS) O95365 (/ISS) Q9QZ48 (/ISS) |
|
Positive regulation of cold-induced thermogenesis GO:0120162
Any process that activates or increases the frequency, rate or extent of cold-induced thermogenesis.
|
3 | D4A579 (/ISS) O15156 (/ISS) O15156 (/ISS) |
|
Negative regulation of transcription by RNA polymerase II GO:0000122
Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.
|
2 | Q64321 (/IMP) Q64321 (/IMP) |
|
Negative regulation of transcription by RNA polymerase II GO:0000122
Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.
|
2 | O15156 (/ISS) O15156 (/ISS) |
|
Regulation of alternative mRNA splicing, via spliceosome GO:0000381
Any process that modulates the frequency, rate or extent of alternative splicing of nuclear mRNAs.
|
2 | O95365 (/IDA) O95365 (/IDA) |
|
Regulation of alternative mRNA splicing, via spliceosome GO:0000381
Any process that modulates the frequency, rate or extent of alternative splicing of nuclear mRNAs.
|
2 | O88939 (/ISS) Q9QZ48 (/ISS) |
|
NK T cell differentiation GO:0001865
The process in which a precursor cell type acquires the specialized features of a NK T cell.
|
2 | Q64321 (/IMP) Q64321 (/IMP) |
|
NK T cell differentiation GO:0001865
The process in which a precursor cell type acquires the specialized features of a NK T cell.
|
2 | O15156 (/ISS) O15156 (/ISS) |
|
Regulation of glycolytic process GO:0006110
Any process that modulates the frequency, rate or extent of glycolysis.
|
2 | O95365 (/IMP) O95365 (/IMP) |
|
Regulation of glycolytic process GO:0006110
Any process that modulates the frequency, rate or extent of glycolysis.
|
2 | O88939 (/ISS) Q9QZ48 (/ISS) |
|
Chromatin organization GO:0006325
Any process that results in the specification, formation or maintenance of the physical structure of eukaryotic chromatin.
|
2 | O95365 (/ISS) O95365 (/ISS) |
|
Chromatin remodeling GO:0006338
Dynamic structural changes to eukaryotic chromatin occurring throughout the cell division cycle. These changes range from the local changes necessary for transcriptional regulation to global changes necessary for chromosome segregation.
|
2 | O95365 (/IMP) O95365 (/IMP) |
|
Transcription by RNA polymerase II GO:0006366
The synthesis of RNA from a DNA template by RNA polymerase II (RNAP II), originating at an RNA polymerase II promoter. Includes transcription of messenger RNA (mRNA) and certain small nuclear RNAs (snRNAs).
|
2 | O15156 (/TAS) O15156 (/TAS) |
|
Ectoderm development GO:0007398
The process whose specific outcome is the progression of the ectoderm over time, from its formation to the mature structure. In animal embryos, the ectoderm is the outer germ layer of the embryo, formed during gastrulation.
|
2 | O15156 (/TAS) O15156 (/TAS) |
|
Lactation GO:0007595
The regulated release of milk from the mammary glands and the period of time that a mother lactates to feed her young.
|
2 | Q64321 (/IMP) Q64321 (/IMP) |
|
Lactation GO:0007595
The regulated release of milk from the mammary glands and the period of time that a mother lactates to feed her young.
|
2 | O15156 (/ISS) O15156 (/ISS) |
|
Negative regulation of cell population proliferation GO:0008285
Any process that stops, prevents or reduces the rate or extent of cell proliferation.
|
2 | A1YPR0 (/IDA) A1YPR0 (/IDA) |
|
Regulation of gene expression GO:0010468
Any process that modulates the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
|
2 | Q64321 (/IMP) Q64321 (/IMP) |
|
Positive regulation of gene expression GO:0010628
Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
|
2 | Q64321 (/IDA) Q64321 (/IDA) |
|
Positive regulation of gene expression GO:0010628
Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
|
2 | O15156 (/ISS) O15156 (/ISS) |
|
Negative regulation of gene expression GO:0010629
Any process that decreases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
|
2 | Q64321 (/IDA) Q64321 (/IDA) |
|
Negative regulation of gene expression GO:0010629
Any process that decreases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
|
2 | Q64321 (/IMP) Q64321 (/IMP) |
|
Negative regulation of gene expression GO:0010629
Any process that decreases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
|
2 | O15156 (/ISS) O15156 (/ISS) |
|
Negative regulation of transforming growth factor beta receptor signaling pathway GO:0030512
Any process that stops, prevents, or reduces the frequency, rate or extent of any TGF-beta receptor signaling pathway.
|
2 | O95365 (/IMP) O95365 (/IMP) |
|
Negative regulation of transforming growth factor beta receptor signaling pathway GO:0030512
Any process that stops, prevents, or reduces the frequency, rate or extent of any TGF-beta receptor signaling pathway.
|
2 | O88939 (/ISS) Q9QZ48 (/ISS) |
|
Positive regulation of histone deacetylation GO:0031065
Any process that activates or increases the frequency, rate or extent of the removal of acetyl groups from histones.
|
2 | Q64321 (/IMP) Q64321 (/IMP) |
|
Positive regulation of histone deacetylation GO:0031065
Any process that activates or increases the frequency, rate or extent of the removal of acetyl groups from histones.
|
2 | O15156 (/ISS) O15156 (/ISS) |
|
Response to insulin GO:0032868
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an insulin stimulus. Insulin is a polypeptide hormone produced by the islets of Langerhans of the pancreas in mammals, and by the homologous organs of other organisms.
|
2 | Q64321 (/IMP) Q64321 (/IMP) |
|
Response to insulin GO:0032868
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an insulin stimulus. Insulin is a polypeptide hormone produced by the islets of Langerhans of the pancreas in mammals, and by the homologous organs of other organisms.
|
2 | O15156 (/ISS) O15156 (/ISS) |
|
Protein localization to nucleus GO:0034504
A process in which a protein transports or maintains the localization of another protein to the nucleus.
|
2 | O95365 (/IMP) O95365 (/IMP) |
|
Regulation of apoptotic process GO:0042981
Any process that modulates the occurrence or rate of cell death by apoptotic process.
|
2 | O95365 (/IMP) O95365 (/IMP) |
|
Regulation of apoptotic process GO:0042981
Any process that modulates the occurrence or rate of cell death by apoptotic process.
|
2 | O88939 (/ISS) Q9QZ48 (/ISS) |
|
Regulation of CD4-positive, alpha-beta T cell differentiation GO:0043370
Any process that modulates the frequency, rate, or extent of CD4-positive, alpha-beta T cell differentiation.
|
2 | Q64321 (/IMP) Q64321 (/IMP) |
|
Positive regulation of CD4-positive, alpha-beta T cell differentiation GO:0043372
Any process that activates or increases the frequency, rate or extent of CD4-positive, alpha-beta T cell differentiation.
|
2 | Q64321 (/IMP) Q64321 (/IMP) |
|
Positive regulation of CD4-positive, alpha-beta T cell differentiation GO:0043372
Any process that activates or increases the frequency, rate or extent of CD4-positive, alpha-beta T cell differentiation.
|
2 | O15156 (/ISS) O15156 (/ISS) |
|
Regulation of CD8-positive, alpha-beta T cell differentiation GO:0043376
Any process that modulates the frequency, rate, or extent of CD8-positive, alpha-beta T cell differentiation.
|
2 | Q64321 (/IMP) Q64321 (/IMP) |
|
Negative regulation of CD8-positive, alpha-beta T cell differentiation GO:0043377
Any process that stops, prevents, or reduces the rate of CD8-positive, alpha-beta T cell differentiation.
|
2 | Q64321 (/IMP) Q64321 (/IMP) |
|
Negative regulation of CD8-positive, alpha-beta T cell differentiation GO:0043377
Any process that stops, prevents, or reduces the rate of CD8-positive, alpha-beta T cell differentiation.
|
2 | O15156 (/ISS) O15156 (/ISS) |
|
Fat cell differentiation GO:0045444
The process in which a relatively unspecialized cell acquires specialized features of an adipocyte, an animal connective tissue cell specialized for the synthesis and storage of fat.
|
2 | O95365 (/IMP) O95365 (/IMP) |
|
Fat cell differentiation GO:0045444
The process in which a relatively unspecialized cell acquires specialized features of an adipocyte, an animal connective tissue cell specialized for the synthesis and storage of fat.
|
2 | O88939 (/ISS) Q9QZ48 (/ISS) |
|
Negative regulation of transcription, DNA-templated GO:0045892
Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.
|
2 | O95365 (/IDA) O95365 (/IDA) |
|
Positive regulation of insulin receptor signaling pathway GO:0046628
Any process that increases the frequency, rate or extent of insulin receptor signaling.
|
2 | Q64321 (/IMP) Q64321 (/IMP) |
|
Positive regulation of insulin receptor signaling pathway GO:0046628
Any process that increases the frequency, rate or extent of insulin receptor signaling.
|
2 | O15156 (/ISS) O15156 (/ISS) |
|
Positive regulation of NF-kappaB transcription factor activity GO:0051092
Any process that activates or increases the frequency, rate or extent of activity of the transcription factor NF-kappaB.
|
2 | O95365 (/IDA) O95365 (/IDA) |
|
Positive regulation of NF-kappaB transcription factor activity GO:0051092
Any process that activates or increases the frequency, rate or extent of activity of the transcription factor NF-kappaB.
|
2 | O88939 (/ISS) Q9QZ48 (/ISS) |
|
Negative regulation of NK T cell proliferation GO:0051141
Any process that stops, prevents, or reduces the frequency, rate or extent of natural killer T cell proliferation.
|
2 | Q64321 (/IMP) Q64321 (/IMP) |
|
Negative regulation of NK T cell proliferation GO:0051141
Any process that stops, prevents, or reduces the frequency, rate or extent of natural killer T cell proliferation.
|
2 | O15156 (/ISS) O15156 (/ISS) |
|
Negative regulation of androgen receptor signaling pathway GO:0060766
Any process that decreases the rate, frequency, or extent of the androgen receptor signaling pathway.
|
2 | O95365 (/IMP) O95365 (/IMP) |
|
Negative regulation of androgen receptor signaling pathway GO:0060766
Any process that decreases the rate, frequency, or extent of the androgen receptor signaling pathway.
|
2 | O88939 (/ISS) Q9QZ48 (/ISS) |
|
Regulation of transcription involved in cell fate commitment GO:0060850
Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter that contributes to the commitment of a cell to a specific fate.
|
2 | Q64321 (/IMP) Q64321 (/IMP) |
|
Regulation of transcription involved in cell fate commitment GO:0060850
Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter that contributes to the commitment of a cell to a specific fate.
|
2 | O15156 (/ISS) O15156 (/ISS) |
|
Interleukin-17 secretion GO:0072615
The regulated release of any member of the interleukin-17 family of cytokines from a cell.
|
2 | Q64321 (/IMP) Q64321 (/IMP) |
|
Interleukin-17 secretion GO:0072615
The regulated release of any member of the interleukin-17 family of cytokines from a cell.
|
2 | O15156 (/ISS) O15156 (/ISS) |
|
Positive regulation of brown fat cell differentiation GO:0090336
Any process that increases the rate, frequency, or extent of brown fat cell differentiation. Brown fat cell differentiation is the process in which a relatively unspecialized cell acquires specialized features of a brown adipocyte, an animal connective tissue cell involved in adaptive thermogenesis. Brown adipocytes contain multiple small droplets of triglycerides and a high number of mitochondria.
|
2 | Q64321 (/IMP) Q64321 (/IMP) |
|
Positive regulation of brown fat cell differentiation GO:0090336
Any process that increases the rate, frequency, or extent of brown fat cell differentiation. Brown fat cell differentiation is the process in which a relatively unspecialized cell acquires specialized features of a brown adipocyte, an animal connective tissue cell involved in adaptive thermogenesis. Brown adipocytes contain multiple small droplets of triglycerides and a high number of mitochondria.
|
2 | O15156 (/ISS) O15156 (/ISS) |
|
Positive regulation of cold-induced thermogenesis GO:0120162
Any process that activates or increases the frequency, rate or extent of cold-induced thermogenesis.
|
2 | Q64321 (/IMP) Q64321 (/IMP) |
|
Adaptive thermogenesis GO:1990845
The regulated production of heat in response to short term environmental changes, such as stress, diet or reduced temperature.
|
2 | Q64321 (/IMP) Q64321 (/IMP) |
|
Adaptive thermogenesis GO:1990845
The regulated production of heat in response to short term environmental changes, such as stress, diet or reduced temperature.
|
2 | O15156 (/ISS) O15156 (/ISS) |
|
Negative regulation of T-helper 17 cell differentiation GO:2000320
Any process that stops, prevents or reduces the frequency, rate or extent of T-helper 17 cell differentiation.
|
2 | Q64321 (/IMP) Q64321 (/IMP) |
|
Positive regulation of SREBP signaling pathway GO:2000640
Any process that activates or increases the frequency, rate or extent of the SREBP signaling pathway.
|
2 | Q64321 (/IMP) Q64321 (/IMP) |
|
Positive regulation of SREBP signaling pathway GO:2000640
Any process that activates or increases the frequency, rate or extent of the SREBP signaling pathway.
|
2 | O15156 (/ISS) O15156 (/ISS) |
|
Regulation of transcription regulatory region DNA binding GO:2000677
Any process that modulates the frequency, rate or extent of transcription regulatory region DNA binding.
|
2 | O95365 (/IDA) O95365 (/IDA) |
|
Negative regulation of transcription by RNA polymerase II GO:0000122
Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.
|
1 | O88939 (/IDA) |
|
Regulation of alternative mRNA splicing, via spliceosome GO:0000381
Any process that modulates the frequency, rate or extent of alternative splicing of nuclear mRNAs.
|
1 | O88939 (/ISO) |
|
Regulation of glycolytic process GO:0006110
Any process that modulates the frequency, rate or extent of glycolysis.
|
1 | O88939 (/ISO) |
|
Chromatin organization GO:0006325
Any process that results in the specification, formation or maintenance of the physical structure of eukaryotic chromatin.
|
1 | O88939 (/IMP) |
|
Chromatin remodeling GO:0006338
Dynamic structural changes to eukaryotic chromatin occurring throughout the cell division cycle. These changes range from the local changes necessary for transcriptional regulation to global changes necessary for chromosome segregation.
|
1 | O88939 (/ISO) |
|
Transcription, DNA-templated GO:0006351
The cellular synthesis of RNA on a template of DNA.
|
1 | O88939 (/ISO) |
|
Regulation of transcription, DNA-templated GO:0006355
Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
|
1 | O88939 (/ISO) |
|
Negative regulation of cell population proliferation GO:0008285
Any process that stops, prevents or reduces the rate or extent of cell proliferation.
|
1 | Q8VCZ7 (/ISO) |
|
B cell differentiation GO:0030183
The process in which a precursor cell type acquires the specialized features of a B cell. A B cell is a lymphocyte of B lineage with the phenotype CD19-positive and capable of B cell mediated immunity.
|
1 | O88939 (/IMP) |
|
Negative regulation of transforming growth factor beta receptor signaling pathway GO:0030512
Any process that stops, prevents, or reduces the frequency, rate or extent of any TGF-beta receptor signaling pathway.
|
1 | O88939 (/ISO) |
|
Protein localization to nucleus GO:0034504
A process in which a protein transports or maintains the localization of another protein to the nucleus.
|
1 | O88939 (/ISO) |
|
Regulation of apoptotic process GO:0042981
Any process that modulates the occurrence or rate of cell death by apoptotic process.
|
1 | O88939 (/ISO) |
|
Erythrocyte maturation GO:0043249
A developmental process, independent of morphogenetic (shape) change, that is required for an erythrocyte to attain its fully functional state.
|
1 | O88939 (/ISO) |
|
Fat cell differentiation GO:0045444
The process in which a relatively unspecialized cell acquires specialized features of an adipocyte, an animal connective tissue cell specialized for the synthesis and storage of fat.
|
1 | O88939 (/ISO) |
|
Positive regulation of fat cell differentiation GO:0045600
Any process that activates or increases the frequency, rate or extent of adipocyte differentiation.
|
1 | Q8VCZ7 (/IMP) |
|
Regulation of osteoclast differentiation GO:0045670
Any process that modulates the frequency, rate or extent of osteoclast differentiation.
|
1 | Q9QZ48 (/IDA) |
|
Regulation of osteoclast differentiation GO:0045670
Any process that modulates the frequency, rate or extent of osteoclast differentiation.
|
1 | O88939 (/ISO) |
|
Negative regulation of Notch signaling pathway GO:0045746
Any process that stops, prevents, or reduces the frequency, rate or extent of the Notch signaling pathway.
|
1 | O88939 (/IMP) |
|
Negative regulation of transcription, DNA-templated GO:0045892
Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.
|
1 | O88939 (/ISO) |
|
Negative regulation of transcription, DNA-templated GO:0045892
Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.
|
1 | Q96JB3 (/NAS) |
|
Regulation of DNA-binding transcription factor activity GO:0051090
Any process that modulates the frequency, rate or extent of the activity of a transcription factor, any factor involved in the initiation or regulation of transcription.
|
1 | O88939 (/IMP) |
|
Positive regulation of NF-kappaB transcription factor activity GO:0051092
Any process that activates or increases the frequency, rate or extent of activity of the transcription factor NF-kappaB.
|
1 | O88939 (/ISO) |
|
Cartilage development GO:0051216
The process whose specific outcome is the progression of a cartilage element over time, from its formation to the mature structure. Cartilage elements are skeletal elements that consist of connective tissue dominated by extracellular matrix containing collagen type II and large amounts of proteoglycan, particularly chondroitin sulfate.
|
1 | O88939 (/NAS) |
|
Negative regulation of androgen receptor signaling pathway GO:0060766
Any process that decreases the rate, frequency, or extent of the androgen receptor signaling pathway.
|
1 | O88939 (/ISO) |
|
Double-strand break repair via classical nonhomologous end joining GO:0097680
An instance of double-strand break repair via nonhomologous end joining that requires a number of factors important for V(D)J recombination, including the KU70/80 heterodimer (KU), XRCC4, ligase IV, and DNA-PKcs in mammals. It does not produce translocations (as opposed to the alternative nonhomologous end joining).
|
1 | O88939 (/IDA) |
|
Regulation of RNA polymerase II regulatory region sequence-specific DNA binding GO:1903025
Any process that modulates the frequency, rate or extent of RNA polymerase II regulatory region sequence-specific DNA binding.
|
1 | Q8VCZ7 (/IDA) |
|
Regulation of transcription regulatory region DNA binding GO:2000677
Any process that modulates the frequency, rate or extent of transcription regulatory region DNA binding.
|
1 | O88939 (/ISO) |
There are 8 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
9 | O15156 (/IDA) O15156 (/IDA) O95365 (/IDA) O95365 (/IDA) Q64321 (/IDA) Q64321 (/IDA) Q8VCZ7 (/IDA) Q96JB3 (/IDA) Q9QZ48 (/IDA) |
|
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
4 | O88939 (/ISO) Q64321 (/ISO) Q64321 (/ISO) Q9JLZ6 (/ISO) |
|
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
4 | O88939 (/ISS) O93567 (/ISS) O93567 (/ISS) Q9JLZ6 (/ISS) |
|
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
|
2 | O15156 (/IDA) O15156 (/IDA) |
|
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
|
2 | Q64321 (/ISO) Q64321 (/ISO) |
|
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
|
2 | O95365 (/IDA) O95365 (/IDA) |
|
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
1 | O88939 (/NAS) |
|
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
|
1 | O88939 (/ISO) |
