The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Classic Zinc Finger
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 111: GLI family zinc finger 4

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 14 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
24 P10075 (/ISA) P17097 (/ISA) Q5JNZ3 (/ISA) Q5JNZ3 (/ISA) Q6DD87 (/ISA) Q6ZN19 (/ISA) Q6ZN19 (/ISA) Q6ZN19 (/ISA) Q6ZN19 (/ISA) Q6ZN19 (/ISA)
(14 more)
DNA-binding transcription repressor activity, RNA polymerase II-specific GO:0001227
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to repress or decrease transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
14 P24399 (/ISO) Q6PG13 (/ISO) Q6PG13 (/ISO) Q6PG13 (/ISO) Q6PG13 (/ISO) Q6PG13 (/ISO) Q6PG13 (/ISO) Q6PG13 (/ISO) Q8CGG0 (/ISO) Q8CGG0 (/ISO)
(4 more)
RNA polymerase II regulatory region sequence-specific DNA binding GO:0000977
Interacting selectively and non-covalently with a specific sequence of DNA that is part of a regulatory region that controls the transcription of a gene or cistron by RNA polymerase II.
13 Q6PG13 (/ISO) Q6PG13 (/ISO) Q6PG13 (/ISO) Q6PG13 (/ISO) Q6PG13 (/ISO) Q6PG13 (/ISO) Q6PG13 (/ISO) Q8CGG0 (/ISO) Q8CGG0 (/ISO) Q8CGG0 (/ISO)
(3 more)
DNA-binding transcription activator activity, RNA polymerase II-specific GO:0001228
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to activate or increase transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
13 Q6PG13 (/ISO) Q6PG13 (/ISO) Q6PG13 (/ISO) Q6PG13 (/ISO) Q6PG13 (/ISO) Q6PG13 (/ISO) Q6PG13 (/ISO) Q8CGG0 (/ISO) Q8CGG0 (/ISO) Q8CGG0 (/ISO)
(3 more)
DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
3 P17097 (/NAS) Q9Y473 (/NAS) Q9Y473 (/NAS)
RNA polymerase II regulatory region sequence-specific DNA binding GO:0000977
Interacting selectively and non-covalently with a specific sequence of DNA that is part of a regulatory region that controls the transcription of a gene or cistron by RNA polymerase II.
2 Q9Y473 (/IDA) Q9Y473 (/IDA)
DNA-binding transcription repressor activity, RNA polymerase II-specific GO:0001227
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to repress or decrease transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
2 Q9Y473 (/IDA) Q9Y473 (/IDA)
DNA-binding transcription activator activity, RNA polymerase II-specific GO:0001228
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to activate or increase transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
2 Q9Y473 (/IDA) Q9Y473 (/IDA)
DNA-binding transcription factor activity GO:0003700
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
2 Q9Y473 (/TAS) Q9Y473 (/TAS)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
2 Q9Y473 (/IPI) Q9Y473 (/IPI)
RNA polymerase II proximal promoter sequence-specific DNA binding GO:0000978
Interacting selectively and non-covalently with a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in the proximal promoter of a gene transcribed by RNA polymerase II. The proximal promoter is in cis with and relatively close to the core promoter.
1 P24399 (/ISO)
DNA binding GO:0003677
Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
1 P17097 (/TAS)
DNA-binding transcription factor activity GO:0003700
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
1 Q7M6X7 (/ISO)
RNA binding GO:0003723
Interacting selectively and non-covalently with an RNA molecule or a portion thereof.
1 Q8NAF0 (/HDA)

There are 10 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Negative regulation of transcription by RNA polymerase II GO:0000122
Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.
14 P24399 (/ISO) Q6PG13 (/ISO) Q6PG13 (/ISO) Q6PG13 (/ISO) Q6PG13 (/ISO) Q6PG13 (/ISO) Q6PG13 (/ISO) Q6PG13 (/ISO) Q8CGG0 (/ISO) Q8CGG0 (/ISO)
(4 more)
Positive regulation of transcription by RNA polymerase II GO:0045944
Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
13 Q6PG13 (/ISO) Q6PG13 (/ISO) Q6PG13 (/ISO) Q6PG13 (/ISO) Q6PG13 (/ISO) Q6PG13 (/ISO) Q6PG13 (/ISO) Q8CGG0 (/ISO) Q8CGG0 (/ISO) Q8CGG0 (/ISO)
(3 more)
Inflammatory response to antigenic stimulus GO:0002437
An inflammatory response to an antigenic stimulus, which can be include any number of T cell or B cell epitopes.
6 P15620 (/IMP) P15620 (/IMP) P15620 (/IMP) P15620 (/IMP) P15620 (/IMP) P15620 (/IMP)
Negative regulation of type 2 immune response GO:0002829
Any process that stops, prevents, or reduces the frequency, rate, or extent of a type 2 immune response.
6 P15620 (/IMP) P15620 (/IMP) P15620 (/IMP) P15620 (/IMP) P15620 (/IMP) P15620 (/IMP)
Negative regulation of T-helper 2 cell differentiation GO:0045629
Any process that stops, prevents, or reduces the frequency, rate or extent of T-helper 2 cell differentiation.
6 P15620 (/IMP) P15620 (/IMP) P15620 (/IMP) P15620 (/IMP) P15620 (/IMP) P15620 (/IMP)
Negative regulation of transcription by RNA polymerase II GO:0000122
Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.
2 Q9Y473 (/IDA) Q9Y473 (/IDA)
Positive regulation of transcription by RNA polymerase II GO:0045944
Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
2 Q9Y473 (/IDA) Q9Y473 (/IDA)
Multicellular organism development GO:0007275
The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult).
1 P17097 (/TAS)
Negative regulation of transcription, DNA-templated GO:0045892
Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.
1 Q7M6X7 (/ISO)
Negative regulation of transposon integration GO:0070895
Any process that stops, prevents, or reduces the frequency, rate or extent of transposon integration, a process in which a transposable element is incorporated into another DNA molecule.
1 Q7M6X7 (/ISO)

There are 7 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
13 Q6PG13 (/ISO) Q6PG13 (/ISO) Q6PG13 (/ISO) Q6PG13 (/ISO) Q6PG13 (/ISO) Q6PG13 (/ISO) Q6PG13 (/ISO) Q8CGG0 (/ISO) Q8CGG0 (/ISO) Q8CGG0 (/ISO)
(3 more)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
13 Q6PG13 (/ISO) Q6PG13 (/ISO) Q6PG13 (/ISO) Q6PG13 (/ISO) Q6PG13 (/ISO) Q6PG13 (/ISO) Q6PG13 (/ISO) Q8CGG0 (/ISO) Q8CGG0 (/ISO) Q8CGG0 (/ISO)
(3 more)
Intermediate filament cytoskeleton GO:0045111
Cytoskeletal structure made from intermediate filaments, typically organized in the cytosol as an extended system that stretches from the nuclear envelope to the plasma membrane. Some intermediate filaments run parallel to the cell surface, while others traverse the cytosol; together they form an internal framework that helps support the shape and resilience of the cell.
13 Q6PG13 (/ISO) Q6PG13 (/ISO) Q6PG13 (/ISO) Q6PG13 (/ISO) Q6PG13 (/ISO) Q6PG13 (/ISO) Q6PG13 (/ISO) Q8CGG0 (/ISO) Q8CGG0 (/ISO) Q8CGG0 (/ISO)
(3 more)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
3 Q6ECI4 (/IDA) Q9Y473 (/IDA) Q9Y473 (/IDA)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
2 Q9Y473 (/IDA) Q9Y473 (/IDA)
Intermediate filament cytoskeleton GO:0045111
Cytoskeletal structure made from intermediate filaments, typically organized in the cytosol as an extended system that stretches from the nuclear envelope to the plasma membrane. Some intermediate filaments run parallel to the cell surface, while others traverse the cytosol; together they form an internal framework that helps support the shape and resilience of the cell.
2 Q9Y473 (/IDA) Q9Y473 (/IDA)
Nuclear body GO:0016604
Extra-nucleolar nuclear domains usually visualized by confocal microscopy and fluorescent antibodies to specific proteins.
1 Q6ECI4 (/IDA)
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