Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.

Any process that stops, prevents, or reduces the frequency, rate or extent of the proliferation of neuroblasts.

The process by which an organism or tissue maintains a population of stem cells of a single type. This can be achieved by a number of mechanisms: stem cell asymmetric division maintains stem cell numbers; stem cell symmetric division increases them; maintenance of a stem cell niche maintains the conditions for commitment to the stem cell fate for some types of stem cell; stem cells may arise de novo from other cell types.

Any process that modulates the frequency, rate or extent of neurogenesis, the generation of cells in the nervous system.

Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.

Any process that decreases the rate, frequency or extent of neuron projection development. Neuron projection development is the process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites).

The process whose specific outcome is the progression of the forebrain over time, from its formation to the mature structure. The forebrain is the anterior of the three primary divisions of the developing chordate brain or the corresponding part of the adult brain (in vertebrates, includes especially the cerebral hemispheres, the thalamus, and the hypothalamus and especially in higher vertebrates is the main control center for sensory and associative information processing, visceral functions, and voluntary motor functions).

The process in which a specialized cell loses the structural or functional features that characterize it in the mature organism, or some other relatively stable phase of the organism's life history. Under certain conditions, these cells can revert back to the features of the stem cells that were their ancestors.

Any process that activates or increases the frequency, rate or extent of neuron differentiation.

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipopolysaccharide stimulus; lipopolysaccharide is a major component of the cell wall of gram-negative bacteria.

Any process that regulates transcription such that the target genes are involved in the transition between G1 and S phase of the mitotic cell cycle.

Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.

Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.

The process whose specific outcome is the progression of the peripheral nervous system over time, from its formation to the mature structure. The peripheral nervous system is one of the two major divisions of the nervous system. Nerves in the PNS connect the central nervous system (CNS) with sensory organs, other organs, muscles, blood vessels and glands.

Any process that stops, prevents or reduces the rate or extent of cell proliferation.

Any process that decreases the rate, frequency or extent of calcidiol 1-monooxygenase activity. Calcidiol 1-monooxygenase activity is the catalysis of the reaction: calcidiol + NADPH + H+ + O2 = calcitriol + NADP+ + H2O.

Any process that decreases the rate, frequency or extent of a vitamin D biosynthetic process. Vitamin D biosynthesis is the chemical reactions and pathways resulting in the formation of vitamin D, any of a group of related, fat-soluble compounds that are derived from delta-5,7 steroids and play a central role in calcium metabolism. Specific forms of vitamin D include calciferol (ergocalciferol; vitamin D2) and cholecalciferol (calciol; vitamin D3).

Any process that decreases the rate, frequency or extent of neuron projection development. Neuron projection development is the process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites).

A multi-organism process in which a virus is a participant. The other participant is the host. Includes infection of a host cell, replication of the viral genome, and assembly of progeny virus particles. In some cases the viral genetic material may integrate into the host genome and only subsequently, under particular circumstances, 'complete' its life cycle.

The process whose specific outcome is the progression of the telencephalon over time, from its formation to the mature structure. The telencephalon is the paired anteriolateral division of the prosencephalon plus the lamina terminalis from which the olfactory lobes, cerebral cortex, and subcortical nuclei are derived.

The creation of specific areas of progenitor domains along the anterior-posterior axis of the developing forebrain.

Any process that stops, prevents, or reduces the frequency, rate or extent of the activity of the transcription factor NF-kappaB.

Any process that modulates the frequency, rate, or extent of toll-like receptor signaling pathway.

Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.

Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.

Any process that modulates the frequency, rate or extent of neurogenesis, the generation of cells in the nervous system.

Any process that increases the rate, frequency or extent of the series of molecular events generated as a consequence of interleukin-6 binding to a cell surface receptor.

The characteristic movement of an immature neuron from germinal zones to specific positions where they will reside as they mature.

The process whose specific outcome is the progression of nervous tissue over time, from its formation to its mature state.

Any process that stops, prevents, or reduces the frequency, rate or extent of the proliferation of neuroblasts.

The chemotaxis process that directs the migration of an axon growth cone to a specific target site in response to a combination of attractive and repulsive cues.

The process in which an axon recognizes and binds to a set of cells with which it may form stable connections.

The collection of axons into a bundle of rods, known as a fascicle.

The specific movement from place to place of an organism in response to external or internal stimuli. Locomotion of a whole organism in a manner dependent upon some combination of that organism's internal state and external conditions.

Behavior that is dependent upon the sensation of a mechanical stimulus.

Any process that modulates the frequency, rate or extent of the Notch signaling pathway.

Any process that restricts, stops or prevents a cell from adopting a specific cell fate.

Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.

Any process that decreases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.

Any process that decreases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.

Any process that decreases the rate, frequency or extent of calcidiol 1-monooxygenase activity. Calcidiol 1-monooxygenase activity is the catalysis of the reaction: calcidiol + NADPH + H+ + O2 = calcitriol + NADP+ + H2O.

Any process that decreases the rate, frequency or extent of neuron projection development. Neuron projection development is the process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites).

The process whose specific outcome is the progression of the dendrite over time, from its formation to the mature structure.

The process whose specific outcome is the progression of the diencephalon over time, from its formation to the mature structure. The diencephalon is the paired caudal parts of the prosencephalon from which the thalamus, hypothalamus, epithalamus and subthalamus are derived; these regions regulate autonomic, visceral and endocrine function, and process information directed to the cerebral cortex.

The process whose specific outcome is the progression of the telencephalon over time, from its formation to the mature structure. The telencephalon is the paired anteriolateral division of the prosencephalon plus the lamina terminalis from which the olfactory lobes, cerebral cortex, and subcortical nuclei are derived.

The process whose specific outcome is the progression of the dentate gyrus over time, from its formation to the mature structure. The dentate gyrus is one of two interlocking gyri of the hippocampus. It contains granule cells, which project to the pyramidal cells and interneurons of the CA3 region of the ammon gyrus.

The process in which the anatomical structure of the medulla oblongata is generated and organized. The medulla oblongata lies directly above the spinal cord and controls vital autonomic functions such as digestion, breathing and the control of heart rate.

The progression of the mammillary body over time from its initial formation until its mature state. The mammillary body is a protrusion at the posterior end of the hypothalamus that contains hypothalamic nuclei.

The progression of the olfactory bulb over time from its initial formation until its mature state. The olfactory bulb coordinates neuronal signaling involved in the perception of smell. It receives input from the sensory neurons and outputs to the olfactory cortex.

The migration of GABAergic interneuron precursors from the subpallium to the cerebral cortex.

The progression of the hypothalamus region of the forebrain, from its initial formation to its mature state.

The process in which a relatively unspecialized cell acquires specialized features of a neuron that will reside in the forebrain.

The process in which a relatively unspecialized cell acquires specialized features of a neuron residing in the cerebral cortex.

The commitment of neuronal precursor cells to become specialized types of neurons in the forebrain.

The commitment of neuronal precursor cells to become specialized types of neurons in the forebrain.

The process whose specific outcome is the progression of a neuron whose cell body is located in the central nervous system, from initial commitment of the cell to a neuronal fate, to the fully functional differentiated neuron.

The process in which a relatively unspecialized myeloid precursor cell acquires the specialized features of any cell of the myeloid leukocyte, megakaryocyte, thrombocyte, or erythrocyte lineages.

The process in which a myeloid precursor cell acquires specializes features of an erythrocyte.

Any process that activates or increases the frequency, rate or extent of granulocyte differentiation.

Any process that stops, prevents, or reduces the frequency, rate or extent of the activity of the transcription factor NF-kappaB.

Any process that modulates the frequency, rate, or extent of toll-like receptor signaling pathway.

The process in which the anatomical structures of the inner ear are generated and organized. The inner ear is the structure in vertebrates that contains the organs of balance and hearing. It consists of soft hollow sensory structures (the membranous labyrinth) containing fluid (endolymph) surrounded by fluid (perilymph) and encased in a bony cavity (the bony labyrinth). It consists of two chambers, the sacculus and utriculus, from which arise the cochlea and semicircular canals respectively.

The process in which a relatively unspecialized inner cell acquires specialized features of an auditory hair cell.

Any process that activates or enables a cell to adopt a specific fate.

The commitment of cells to specific cell fates and their capacity to differentiate into particular kinds of cells. Positional information is established through protein signals that emanate from a localized source within a cell (the initial one-cell zygote) or within a developmental field.

Any process that modulates the frequency, rate or extent of erythrocyte differentiation.

Any process that stops, prevents, or reduces the frequency, rate or extent of neuron differentiation.

Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.

The process in which a cell becomes capable of differentiating autonomously into a neuron regardless of its environment; upon determination, the cell fate cannot be reversed.

Any process that stops, prevents, or reduces the frequency, rate or extent of the covalent addition of a methyl group to the lysine at position 4 of histone H3.

Any process that activates or increases the frequency, rate or extent of the covalent addition of a methyl group to the lysine at position 9 of histone H3.

A second wave of blood cell production that, in vertebrates, generates long-term hemopoietic stem cells that continously provide erythroid, myeloid and lymphoid lineages throughout adulthood.

A second wave of blood cell production that, in vertebrates, generates long-term hemopoietic stem cells that continously provide erythroid, myeloid and lymphoid lineages throughout adulthood.

The neurite development process that generates a long process of a neuron, as it invades a target tissue.

Any process that increases the rate, frequency or extent of the series of molecular events generated as a consequence of interleukin-6 binding to a cell surface receptor.

The process in which the migration of an axon growth cone of a commissural neuron is directed to its target in the brain in response to a combination of attractive and repulsive cues.

The chemotaxis process that directs the migration of a photoreceptor cell axon growth cone to its target in the optic lobe in response to a combination of attractive and repulsive cues.

Any process in by an organism or tissue maintains a population of neuronal stem cells.

Any process that modulates the frequency, rate or extent of axon guidance.

Any process that modulates the frequency, rate or extent of neuroblast proliferation.

Any process that modulates the frequency, rate or extent of neuroblast proliferation.

Any process that activates or increases the frequency, rate or extent of netrin-activated signaling pathway.

A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

A protein complex that possesses activity that prevents or downregulates transcription.

The dense fibrillar network lying on the inner side of the nuclear membrane.

The dense fibrillar network lying on the inner side of the nuclear membrane.

Extra-nucleolar nuclear domains usually visualized by confocal microscopy and fluorescent antibodies to specific proteins.

A protein complex that possesses activity that prevents or downregulates transcription.

A protein complex that is capable of associating with DNA by direct binding, or via other DNA-binding proteins or complexes, and regulating transcription.

The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.

The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.

Extra-nucleolar nuclear domains usually visualized by confocal microscopy and fluorescent antibodies to specific proteins.

A protein complex that possesses activity that prevents or downregulates transcription.

The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites.

The migrating motile tip of a growing nerve cell axon.