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CATH Superfamily 3.30.1510.10

Domain 2, N(10)-formyltetrahydrofolate synthetase

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Domain 2, N(10)-formyltetrahydrofolate synthetase
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 9: Formate--tetrahydrofolate ligase

There are 3 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Formate--tetrahydrofolate ligase. [EC: 6.3.4.3]
ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.
  • In eukaryotes occurs as a trifunctional enzyme also having EC 1.5.1.5 and EC 3.5.4.9 activity.
 11 A0A3M1WH59 A0A3M1WH59 A0A3M1WH59 A9WIW3 A9WIW3 A9WIW3 B8GC03 B9LKW0 B9LKW0 B9LKW0
(1 more...)
Methylenetetrahydrofolate dehydrogenase (NADP(+)). [EC: 1.5.1.5]
5,10-methylenetetrahydrofolate + NADP(+) = 5,10- methenyltetrahydrofolate + NADPH.
    		 1 O43007
    Methenyltetrahydrofolate cyclohydrolase. [EC: 3.5.4.9]
    5,10-methenyltetrahydrofolate + H(2)O = 10-formyltetrahydrofolate.
      		 1 O43007